LOCUS       NM_009961               5242 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus protocadherin alpha 10 (Pcdha10), mRNA.
ACCESSION   NM_009961
VERSION     NM_009961.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5242)
  AUTHORS   Mancia Leon,W.R., Spatazza,J., Rakela,B., Chatterjee,A., Pande,V.,
            Maniatis,T., Hasenstaub,A.R., Stryker,M.P. and Alvarez-Buylla,A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5242)
  AUTHORS   Elbert,A., Vogt,D., Watson,A., Levy,M., Jiang,Y., Brule,E.,
            Rowland,M.E., Rubenstein,J. and Berube,N.G.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   3  (bases 1 to 5242)
  AUTHORS   Fan,L., Lu,Y., Shen,X., Shao,H., Suo,L. and Wu,Q.
  TITLE     Alpha protocadherins and Pyk2 kinase regulate cortical neuron
            migration and cytoskeletal dynamics via Rac1 GTPase and WAVE
            complex in mice
  JOURNAL   Elife 7, e35242 (2018)
   PUBMED   29911975
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5242)
  AUTHORS   Toyoda,S., Kawaguchi,M., Kobayashi,T., Tarusawa,E., Toyama,T.,
            Okano,M., Oda,M., Nakauchi,H., Yoshimura,Y., Sanbo,M.,
            Hirabayashi,M., Hirayama,T., Hirabayashi,T. and Yagi,T.
  TITLE     Developmental epigenetic modification regulates stochastic
            expression of clustered protocadherin genes, generating single
            neuron diversity
  JOURNAL   Neuron 82 (1), 94-108 (2014)
   PUBMED   24698270
REFERENCE   5  (bases 1 to 5242)
  AUTHORS   Esumi,S., Kakazu,N., Taguchi,Y., Hirayama,T., Sasaki,A.,
            Hirabayashi,T., Koide,T., Kitsukawa,T., Hamada,S. and Yagi,T.
  TITLE     Monoallelic yet combinatorial expression of variable exons of the
            protocadherin-alpha gene cluster in single neurons
  JOURNAL   Nat Genet 37 (2), 171-176 (2005)
   PUBMED   15640798
REFERENCE   6  (bases 1 to 5242)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   7  (bases 1 to 5242)
  AUTHORS   Sugino,H., Hamada,S., Yasuda,R., Tuji,A., Matsuda,Y., Fujita,M. and
            Yagi,T.
  TITLE     Genomic organization of the family of CNR cadherin genes in mice
            and humans
  JOURNAL   Genomics 63 (1), 75-87 (2000)
   PUBMED   10662547
REFERENCE   8  (bases 1 to 5242)
  AUTHORS   Senzaki,K., Ogawa,M. and Yagi,T.
  TITLE     Proteins of the CNR family are multiple receptors for Reelin
  JOURNAL   Cell 99 (6), 635-647 (1999)
   PUBMED   10612399
REFERENCE   9  (bases 1 to 5242)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
REFERENCE   10 (bases 1 to 5242)
  AUTHORS   Kohmura,N., Senzaki,K., Hamada,S., Kai,N., Yasuda,R., Watanabe,M.,
            Ishii,H., Yasuda,M., Mishina,M. and Yagi,T.
  TITLE     Diversity revealed by a novel family of cadherins expressed in
            neurons at a synaptic complex
  JOURNAL   Neuron 20 (6), 1137-1151 (1998)
   PUBMED   9655502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY013757.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY013757.1, BC079625.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5242
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.46 cM"
     gene            1..5242
                     /gene="Pcdha10"
                     /gene_synonym="Cnr3; Cnr8; Crnr3; Crnr8; Pcdha14"
                     /note="protocadherin alpha 10"
                     /db_xref="GeneID:12943"
                     /db_xref="MGI:MGI:1298408"
     CDS             1..2841
                     /gene="Pcdha10"
                     /gene_synonym="Cnr3; Cnr8; Crnr3; Crnr8; Pcdha14"
                     /note="cadherin-related neuronal receptor 3; protocadherin
                     alpha 14; PCDH-alpha-10"
                     /codon_start=1
                     /product="protocadherin alpha-10 precursor"
                     /protein_id="NP_034091.1"
                     /db_xref="CCDS:CCDS37778.1"
                     /db_xref="GeneID:12943"
                     /db_xref="MGI:MGI:1298408"
                     /translation="MSCVAMKYCHESWCLLLSLLLFAIWEPGSGQLRYSVPEEAKHGT
                     FVGRIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVNSRIDREELCGRSAE
                     CSIHLEVIVDRPLQVFHVEVEVRDINDNPPVFPTTEKNLFVSESRALDPHFSLEGASD
                     ADIGTNALLTYRLSPSEYFSLEVPTTDELVKPLQLVLKKPLDRERASELHLVVKATDG
                     GKPELTGTLELHITVLDANDNAPAFDRAIYRVKLVENARNGTVVIRLNASDLDEGSNG
                     QILYSFAADVSPKTEATFHIDSVSGEIKVNGKIDFEETNLWKIQAEAVDKGSPPMFGH
                     CTILIEVLDINDNAPKIIVTSLSLPVQEDAPVGTVIALISVMDPDSTVNGQVTCSLSP
                     HVPFKLVSTFKNYYSLVLDSALDRETTADYKVVVTARDGGSPALWATASVSVEVADVN
                     DNAPAFAQSEYTVFVKENNPPGVHVFTVLAMDADAQENALVSYSLVERRVGERLLSSY
                     VSVHAESGKVFALQPLDHEELELLQFQVTAKDAGVPALGSNVTLQVFVLDENDNAPTL
                     LPHGAVGAGGAVSELVPRSVGSGHVVAKVRAVDADSGYNAWLSYELQFRAGSVRSPFR
                     VGLYTGEISITRALDEADAPRQRLLVLVKDHGEPALTATATVLVSLVESNQAPKASSR
                     VLGPAASESSVVDVNVYLIIAICAVSSLLVLTLVLYTALRCSALPTEVTCGPGKPMLV
                     CSSAVGSWSYSQQRRQRVCSGEGPPKTDLMAFSPSVPPGLGSGDSGVQQEIFENPRQP
                     NPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGA
                     GVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPANNQIDKSDFITFGK
                     KEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ"
     exon            1..2382
                     /gene="Pcdha10"
                     /gene_synonym="Cnr3; Cnr8; Crnr3; Crnr8; Pcdha14"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2441
                     /gene="Pcdha10"
                     /gene_synonym="Cnr3; Cnr8; Crnr3; Crnr8; Pcdha14"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2530
                     /gene="Pcdha10"
                     /gene_synonym="Cnr3; Cnr8; Crnr3; Crnr8; Pcdha14"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..5242
                     /gene="Pcdha10"
                     /gene_synonym="Cnr3; Cnr8; Crnr3; Crnr8; Pcdha14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtcctgtg tcgccatgaa atactgccat gaatcctggt gcctgctgct ctcacttttg
       61 ctgttcgcaa tctgggagcc tgggagtggc cagctccgct actccgtccc agaggaggcc
      121 aaacacggca ccttcgtggg ccgcatcgcg caggacctgg ggctggagct gacggagctg
      181 gtgccccgcc tgttcagggt ggcgtccaag gaccgcgggg accttctgga ggtaaatctg
      241 cagaatggca ttttgtttgt gaattctcgg atcgaccggg aggagctgtg cgggcggagc
      301 gcggagtgca gcatccacct ggaggtgatc gtggacaggc cgctgcaggt tttccacgtg
      361 gaggtggagg tgagggatat taatgacaac cctcccgtgt ttccaacgac agaaaagaat
      421 ctctttgttt cggaatcgag agctctagat cctcattttt cactagaggg cgcttcggat
      481 gcagacatcg gaactaatgc tcttctgact tacagactga gtcccagtga atatttctcc
      541 ctggaagtac caaccacaga tgagttggta aaaccactcc aactagtgtt aaagaaacct
      601 ttagacagag agcgagcttc agagcttcac ttagtggtta aagccacgga tgggggcaaa
      661 cctgagctca caggcacctt ggagttacat attacagttc tagatgcaaa tgacaatgcg
      721 ccagcattcg acagagcaat ctatcgggtg aagctggtag aaaatgcaag aaatggtacc
      781 gtggtcatta gacttaatgc ctcggatttg gacgaaggtt caaatggtca aattctttat
      841 tcctttgcag cggatgtttc ccctaagacc gaagccactt ttcatataga ttcagtcagt
      901 ggagaaatta aagtcaatgg aaaaatagat tttgaagaaa ctaatttatg gaagattcaa
      961 gcagaagcag ttgacaaagg tagtcctcca atgtttggtc actgcacaat cttaattgaa
     1021 gtcctggaca tcaatgataa tgctcccaag ataatagtaa catcattatc gctccctgtt
     1081 caagaggacg ctccagtggg gacagttatt gccttaatca gtgtgatgga tcctgactct
     1141 acagtcaacg ggcaagtgac ctgctccctg tctcctcatg tccccttcaa gcttgtgtcc
     1201 accttcaaga attattattc cctcgtgctg gacagtgctt tggatcgaga gacaacagct
     1261 gactataaag tggtggtgac agcccgggat gggggctctc ccgcgctgtg ggccacagcc
     1321 agtgtgtccg tggaggtggc tgacgtgaac gacaatgctc ctgcattcgc acagtcggaa
     1381 tacacggtgt tcgtgaagga gaacaacccg cctggagtgc acgtcttcac agtattggcg
     1441 atggacgcgg atgcgcagga gaatgcgctg gtgtcctact cgctggtgga gcggagggtg
     1501 ggcgagcgct tgctgtcgag ctatgtgtct gtgcacgcgg aaagcggcaa ggtgttcgcg
     1561 ctgcagcctc tggaccatga ggagctggag ctgctgcagt tccaggtaac tgcgaaggat
     1621 gctggtgtgc ctgccctggg cagcaatgtg actctgcagg tgtttgtgct ggatgagaac
     1681 gacaatgcac ccaccctgct gccccacgga gctgtcggag ctggcggggc agtgagtgag
     1741 cttgtgccta ggtcagtggg ttcagggcat gtagtggcga aggtgcgggc agtagatgcg
     1801 gactctggtt acaatgcttg gttgtcatat gagctccagt tcagagctgg cagtgtgcgc
     1861 agtcccttcc gtgtgggact atacacgggt gagatcagta tcactcgcgc tctggatgaa
     1921 gcagatgcgc cgcgccaacg cctgttggtg ttggtgaagg accatggcga gcccgcgttg
     1981 actgccacag ccacagtgct ggtttctctg gttgagagca accaggcacc aaaggcctct
     2041 tcacgggtgt tgggtccagc agcctctgaa tcatctgtag tggatgtcaa cgtgtatttg
     2101 atcatcgcca tctgtgcggt gtccagtctg ttggtgctca cactggtgtt gtacactgcc
     2161 ctgcgatgct ctgcattgcc cactgaggtc acctgtggac ccgggaaacc catgctggta
     2221 tgttccagcg cggtgggaag ctggtcttac tctcagcaaa ggaggcagag ggtgtgttca
     2281 ggagagggcc caccgaagac agatctcatg gccttcagtc ccagtgttcc tcctggtttg
     2341 ggttctggag atagtggagt ccagcaagag atctttgaga atccccggca gcccaaccct
     2401 gactggcgct actctgcctc gctaagagca ggcatgcaca gctctgtgca cctggaggag
     2461 gctggcattc tacgggctgg tccaggaggg cctgatcagc agtggccaac agtatccagt
     2521 gcaacaccag aacctgaggc aggagaggtg tcccctccgg tgggcgccgg tgtcaacagc
     2581 aacagctgga cctttaaata cggaccaggc aaccccaaac agtccggtcc cggtgagttg
     2641 ccagacaaat tcattatccc aggatctcct gcaatcatct ccatccggca ggagcctgct
     2701 aacaaccaaa ttgacaaaag cgattttata accttcggca aaaaggagga gaccaagaaa
     2761 aagaagaaaa agaagaaggg taacaagacc caggagaaaa aagagaaagg gaacagcacg
     2821 acggacaaca gtgaccagtg aggccaccaa atggaaacaa gccacttagc cagtttttgt
     2881 aataatggca aatctctccc atgtagcaac tccccgctcc tttctcctat gacatgagcc
     2941 ctcagaaatc tgcagaaagt tccctgtgtc tgtcttgatc gcatttaaca ggttttgtct
     3001 taaaaagctt tcctaagtct ggtgttaact ctctctctct ccactctggc ttgttttcag
     3061 aacctaaaaa gcagacccag gtttcctttc tcccccgccg caaaggagaa gcttcccagc
     3121 cccgccagtg agagttggac tctctgccct gtgcttcaag catcctgtct tgatgatatt
     3181 tgcagggcag gctgaaaggt attcaggttg agcagttggg tgtttgtggt cactgggtat
     3241 gtgtggctac caagagtgtt ggagagcctg gtattggctg ggatggtcca gattagacta
     3301 gttaacacaa ggagggctgg ggctcaaagg cacatcaaca ccgggagtct ttcatctgga
     3361 gggggaaaat gtgaaactta caaggaccag actttctcaa tctctcaact agacatatga
     3421 tggccatcct ctaacagaca aaaccatccc caccggcaaa gctttaggag cccctcaagt
     3481 gtgctggcta taacatcact gtattcaaaa cctgcagtat gcacacgagc cagcagttca
     3541 agcgtttaac aagagggtcg gccagggcaa cagaagcaga tctgatgtgt ttcctgtaca
     3601 cgtccttgtg ctcacgctat taaaaattct tttgcacaca atgtttatga aaaggtctca
     3661 tccttttcca acaacacata tgcaaaagca aaagaaaaac ccaagacctc actttatgct
     3721 gtttgttgtt tgatagattt attaaaaaga aaagagaaag tcgatagcta taaatcttta
     3781 aaggaatatg atgaatacaa tccccccaac cttccctcaa aagagaatcc agtctacagc
     3841 catttgaaat gatcgttgct gctacagaag tgctttaaga gaattgcctg gaacatctgt
     3901 attatcccgg ccacctgcca atcacagctt tactctttca ggtcactctg gggctgcctc
     3961 ttgcatgtat taattactaa atagaaggat ctttctctct tttctaagaa aaatgatgtg
     4021 cactttgatt acacaacctt ctctaaccca cgatatcaag acccagaaac tgaagaaaaa
     4081 tcttgttttc tcatgcatac agtgagcaga cttttcattc ctctggttct gtggttgtct
     4141 cggtgtgcta gcctacacct ccaccttgtt tagctttcct tttctagaac actctgaatt
     4201 gctaacctta ctaacaccta tgatgttacc tgaatcaatc tcccatatgt atgctgtatg
     4261 ctattataag actcctgaga tatacttact ctgtgcttgt gtatgtgaat gttaatgcaa
     4321 ctattaccta gagtgaactt taagctttat tgttgaatgt aagcccatta tatttccttt
     4381 tgtacacctg tggaaaagtg gaatagtgtt ttttttaaaa ccattgttaa tcagcttttg
     4441 tgtatgaaag acacagtaaa atttctttct taaatcaaga tgctggtgat tcaaggaatt
     4501 ttatttatgg tcagccaagg gctgtctctt gccaagaatc ctgctggcaa gggaaaatgg
     4561 ataaagctgg tttttttttt tcctagtaag aattctggaa taaatactga agaaagtccc
     4621 tgagggtatg caagcacaaa attgtaccaa tctgacctct ttgaatttgc agactgcttt
     4681 gaaatgctat ccggaatatc agcttgtaga aagtaataaa atttactgtt accataaata
     4741 agacatttta agtttattgt gcacaactta gatgtttgat taattatatt atctacttaa
     4801 aagcatataa aagaggtagg agtctgtttt aaaaggcata aaaaatctca aaaaaaaaaa
     4861 acctgtcttg tctactttta gcttcattct cccatatttt gaagggtgtg taacttcagc
     4921 tctgcaggat tgcatggggt aaaactcgtt gacagcgcat gtgaaccatt gctacattgt
     4981 aggttgtgat cattttgccc cactgaagcc catgtaactg accttacgtg ccttttgaac
     5041 taggagaatc gggctataat ttattaatga tgataatgat aatgtatatg tacagcactt
     5101 tttaacctta caaagtgctt tccaattcgt gttagttatt agttattaca gctgtaagga
     5161 taaaacacgt catgtggatt catttttaat tggtgctatt ggtatttcct ctgttcttgc
     5221 taataaatgg aaatggtggt gt
//
