LOCUS       NM_178685               5237 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus protocadherin 20 (Pcdh20), mRNA.
ACCESSION   NM_178685
VERSION     NM_178685.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5237)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5237)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   3  (bases 1 to 5237)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5237)
  AUTHORS   Hirose,F., Takai,S., Takahashi,I. and Shigemura,N.
  TITLE     Expression of protocadherin-20 in mouse taste buds
  JOURNAL   Sci Rep 10 (1), 2051 (2020)
   PUBMED   32029864
  REMARK    GeneRIF: Expression of protocadherin-20 in mouse taste buds.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5237)
  AUTHORS   Shrestha,B.R., Chia,C., Wu,L., Kujawa,S.G., Liberman,M.C. and
            Goodrich,L.V.
  TITLE     Sensory Neuron Diversity in the Inner Ear Is Shaped by Activity
  JOURNAL   Cell 174 (5), 1229-1246 (2018)
   PUBMED   30078709
REFERENCE   6  (bases 1 to 5237)
  AUTHORS   Huang,W.H., Guenthner,C.J., Xu,J., Nguyen,T., Schwarz,L.A.,
            Wilkinson,A.W., Gozani,O., Chang,H.Y., Shamloo,M. and Luo,L.
  TITLE     Molecular and Neural Functions of Rai1, the Causal Gene for
            Smith-Magenis Syndrome
  JOURNAL   Neuron 92 (2), 392-406 (2016)
   PUBMED   27693255
REFERENCE   7  (bases 1 to 5237)
  AUTHORS   Fossat,N., Ip,C.K., Jones,V.J., Studdert,J.B., Khoo,P.L.,
            Lewis,S.L., Power,M., Tourle,K., Loebel,D.A., Kwan,K.M.,
            Behringer,R.R. and Tam,P.P.
  TITLE     Context-specific function of the LIM homeobox 1 transcription
            factor in head formation of the mouse embryo
  JOURNAL   Development 142 (11), 2069-2079 (2015)
   PUBMED   25977363
REFERENCE   8  (bases 1 to 5237)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   9  (bases 1 to 5237)
  AUTHORS   Cheng,T.W. and Gong,Q.
  TITLE     Secreted TARSH regulates olfactory mitral cell dendritic complexity
  JOURNAL   Eur J Neurosci 29 (6), 1083-1095 (2009)
   PUBMED   19302145
REFERENCE   10 (bases 1 to 5237)
  AUTHORS   Lee,W., Cheng,T.W. and Gong,Q.
  TITLE     Olfactory sensory neuron-specific and sexually dimorphic expression
            of protocadherin 20
  JOURNAL   J Comp Neurol 507 (1), 1076-1086 (2008)
   PUBMED   18095321
  REMARK    GeneRIF: The gender difference in PCDH20 expression may reflect
            olfactory receptor expression differences for gender-specific
            social discrimination
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK083114.1, BC079605.1 and
            AC164553.2.
            
            On Oct 8, 2009 this sequence version replaced NM_178685.4.
            
            Summary: This gene belongs to the protocadherin gene family, a
            subfamily of the cadherin superfamily. The encoded protein contains
            six extracellular cadherin domains, a transmembrane domain, and a
            cytoplasmic tail differing from those of the classical cadherins.
            The encoded protein may play a role in cell adhesion in the nervous
            system and has been shown to be specifically expressed in newly
            differentiated olfactory sensory neurons and their axons during
            development. In adult mice, the expression of this protein in the
            olfactory system is more restricted but shows a gender difference
            with higher expression in the male than in the female. [provided by
            RefSeq, Sep 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083114.1, BB653201.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2279              AK083114.1         2-2280
            2280-4515           BC079605.1         2137-4372
            4516-5237           AC164553.2         138529-139250       c
FEATURES             Location/Qualifiers
     source          1..5237
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 44.43 cM"
     gene            1..5237
                     /gene="Pcdh20"
                     /gene_synonym="C630015B17Rik; Pcdh13"
                     /note="protocadherin 20"
                     /db_xref="GeneID:219257"
                     /db_xref="MGI:MGI:2443376"
     exon            1..16
                     /gene="Pcdh20"
                     /gene_synonym="C630015B17Rik; Pcdh13"
                     /inference="alignment:Splign:2.1.0"
     exon            17..253
                     /gene="Pcdh20"
                     /gene_synonym="C630015B17Rik; Pcdh13"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..2980
                     /gene="Pcdh20"
                     /gene_synonym="C630015B17Rik; Pcdh13"
                     /note="protocadherin 13"
                     /codon_start=1
                     /product="protocadherin-20 precursor"
                     /protein_id="NP_848800.3"
                     /db_xref="CCDS:CCDS27306.1"
                     /db_xref="GeneID:219257"
                     /db_xref="MGI:MGI:2443376"
                     /translation="MRGRGNARSLLVQAVSLRPATWHPCLDMGHLHRPSSRTSHRNLP
                     HVFLLFLFVGPFNCLASYSRATELLYSLNEGLPAGVLIGSLAEDLRLLPRASGRQNQQ
                     LLHPERTASEGNPPLSFSLASGGLSGQYVTLNNRSGELHTSAQEIDREALCLDGGGGA
                     AWAGSTSIASSPSSDSCLLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPISEISVW
                     VPENSPVNTRLAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVM
                     GALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFIDSQINVTVYGNA
                     TVGTPVATVQAVDRDLGTNAQITYSYSQKVPQETKDLFHLDEVTGVIKLSSKIGGSVL
                     QTHKLTILANGPGCIPAVITALVSIIKVVFRPPEIVPRYIANEVDGVVYLKELEPVNT
                     PIAFFTIRDPEGKYKINCFLDGEGPFRLAPYKPYNNEYLLETTKPMDYEVQSFYEIAV
                     VAWNSEGFHVKRIIKVQLLDDNDNAPVFLQPLIELTIEENNAPNAFLTKLYATDADSG
                     EMGRVSYFLGPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGTPPRESVA
                     TVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVMNQ
                     SDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTTKITILLLDINDNP
                     PLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRI
                     DPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIES
                     LLRKEPEINIEEKEPQISIEPTHRKVESMSCMPTLVALSVISLGSITLVTGMGIYICL
                     RKGKKHHREDDNLEVQIPLKGKIDLCMRERKPVDISNI"
     exon            254..5237
                     /gene="Pcdh20"
                     /gene_synonym="C630015B17Rik; Pcdh13"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3942
                     /gene="Pcdh20"
                     /gene_synonym="C630015B17Rik; Pcdh13"
ORIGIN      
        1 ggttttgtgg gaacagacca gtgactattg gctgaagttc cccggcgatt tgcatgaaca
       61 gagagggagt gtcctctgcc accctccctt ctggagcgct ctgactgcag cctcccaggg
      121 aatgcgcggc cgagggaacg cgcgcagctt gctggtccag gcagtgagct tgcgcccggc
      181 gacctggcac ccgtgcctgg atatggggca tctacatcgt cccagcagca ggaccagcca
      241 caggaacctg ccgcatgttt ttctgctttt cctcttcgtg ggacccttca attgcctcgc
      301 gagttacagc cgtgctaccg agcttctgta cagcctaaat gagggactgc ccgccggagt
      361 gctcataggc agcctggcgg aggacctgag gctgctgcct cgggcctctg ggagacagaa
      421 ccagcagttg ctgcatccag agcgcactgc ctctgagggg aacccccctc tctctttcag
      481 cttggcctcc gggggactga gtggccagta tgtgacccta aacaaccgct ccggcgagct
      541 gcacacttct gcacaggaga tcgacagaga agcattgtgc ctggatgggg gcggtggggc
      601 tgcctgggcc ggcagtacct ccattgcctc ctctccttct tctgactctt gccttttgct
      661 tctggacgtg ctggtcctgc ctcaggaata ttttcggttt gtgaaggtga aaattgccat
      721 cagggatatc aatgacaatg ctccgcagtt ccccatttct gaaatctctg tttgggtccc
      781 agaaaattca cctgtaaata cccgattggc tatagagcat cctgctgtgg accctgatgt
      841 aggcattaac ggtgtgcaaa cctatcgctt actagactac catggcatgt ttaccctgga
      901 cgtggaggag aatgagaacg gggagcgcac accctacttg attgtcatgg gtgctttgga
      961 cagagaaacc caggaccagt atgtgagcat catcatagct gaggatggtg ggtctccacc
     1021 actgctgggc agtgccaccc tcaccattgg cataagtgac attaatgaca attgtcctct
     1081 ctttatagac tcacaaatta atgtcaccgt ttatgggaat gctacagtgg gcaccccagt
     1141 tgcaacagtc caggctgtgg atagagactt ggggacaaat gcacagatca cttacagtta
     1201 cagccagaaa gttccacagg aaaccaagga tttattccac ctggatgaag ttactggagt
     1261 cattaagctt tccagtaaga ttggcgggag tgtcctacag acacataagc tcaccatcct
     1321 agctaatgga cctggctgta tccctgcagt gatcactgct cttgtatcga tcatcaaagt
     1381 cgttttcaga cccccagaaa tcgtcccacg ttatatcgca aatgaggtgg atggtgttgt
     1441 gtacctgaaa gaactggagc ctgttaatac tccaattgcg ttttttacca tcagagatcc
     1501 agaaggtaaa tacaagatta actgcttctt ggatggtgaa gggccattca ggctggcacc
     1561 ctacaagccg tacaacaatg aatatttgtt ggagaccaca aagcctatgg actatgaagt
     1621 gcagtccttc tatgaaatag ctgtagtggc ctggaactca gagggatttc atgtcaagag
     1681 aatcattaaa gtacaacttt tagacgacaa tgacaatgcc cctgttttcc ttcagccctt
     1741 gatagaattg accattgaag aaaacaacgc acccaatgcc tttctgacaa agctctacgc
     1801 tacagatgct gacagtggag agatgggacg agtttcctac ttcttgggac ctgatgctcc
     1861 gtcatacttt tccttagaca gtgtcacagg gattctgaca gtttctactc agctggacag
     1921 agaagagaaa gagaagtaca ggtatactgt ccgagcagtg gactgtggga cgccacccag
     1981 agaatcagtg gctacagtgg ccctcactgt gttggataaa aatgacaaca gtccgaggtt
     2041 catcaacaag gacttcagct tttttgtccc agaaaacttt ccggggtatg gtgaaattgg
     2101 agtcatcagt gtaacagatg ccgatgctgg aaggaacgga tgggtagccc tgtccgtaat
     2161 gaaccagagt gacatttttg tcatagacac aggcaagggt atgttgagag ctaaagtctc
     2221 tttagacaga gaacagcaaa gctcttacac tctgtgggtg gaggctgttg acgggggtga
     2281 gcctgccctt tcctctacca caaaaatcac aattcttctt ctggacatca acgataaccc
     2341 tcctcttgtt ttattccctc aatctaatat gtcttatttg ctggtcctac cttctactct
     2401 ccctggctca ccagtaacag aagtctatgc ggttgacaaa gacacaggca tgaatgctgt
     2461 catagcttat agcatcatag ggagaagagg tcccaggcct gagtctttca gaattgaccc
     2521 caagactggc aacatcactc tggaggaagc cttgcttcag acagattatg ggttgcatcg
     2581 cttactggtg aaagtgagtg atcacggata ccctgagcct ctccactcca cagtcatggt
     2641 gaacttattt gtcaatgaca ctgtcagtaa cgagagctac attgagagcc ttttgagaaa
     2701 ggagccagaa attaatatag aagagaaaga accacaaatc tcaatagagc caactcatag
     2761 gaaggtagaa tctatgtcct gtatgcccac attggtagct ctgtcagtca taagcttggg
     2821 ctccatcaca ctagttacag ggatgggaat atacatctgc ttacggaaag gtaaaaagca
     2881 tcacagggaa gatgacaatt tggaagtaca gattccattg aaaggaaaaa ttgacttgtg
     2941 tatgagagag agaaaaccag tggatatttc taacatttga tatgccattg tggaataaca
     3001 tggagggaca ttgtaactgc cataggtagt ctttgtcaag cagacaacat tgtgctgaca
     3061 cagttccact aaaggacaat taatttataa cttgtactat attgtaaata gctgtttaca
     3121 ggtttttaat gcaaaatcag aagttataaa atgtgtacag aatttttaaa tgaaaattag
     3181 tactaacagc tatatcattg ttatttatat atatatataa atacctatat gtaaaatgtt
     3241 ggatataact ggcagctcta atacaccaag cagatgactg tcaaaactca agactaaggt
     3301 aagagaagta catttttgtt gtttctaaaa tgtcttttca ccacaagagg gcaccagctt
     3361 cccctttgca gggatctgtg gcattgtaca tgatagttgt tgtacaggaa attaaggaga
     3421 gagtatattt taaatatatt gtttttaaca ttaaatgtaa aattaaggta aactgaattc
     3481 tctgcttaaa tatatgacaa gaaagaaaag aaatccactt gcaaacagaa aatgtattac
     3541 ctcataggta caccgatttt agtttgaaag agaaggcatt ttgaaaagaa gtacaattat
     3601 ttaggggcaa gcatcaaaac acattgccat gtgttataaa cttgacctgc tgaagagtgc
     3661 gatgtttcgt gtaacgcctc ctgctctctg tttgctttcc tcctgcactt gctagaatta
     3721 aatggggtta ggaaccatct gtgtattctt ccgttcgtga aaagcatcta gacattgtac
     3781 tcagtaaaag atcaagacac acatcagtgt ctcaatctct acttgcttgc ttggtgttta
     3841 tgatatctta gtgcactctt cgctggtcag cagcaagttt tccgtgggtt ttatgttagc
     3901 gtgggtccac ttctgttcat ctaccctata agaaaaataa aagttgtatt cagattgaat
     3961 tcttcaaaag gctactgtac gctgttggtt gtttgagtta ggcattttat atgaaagtta
     4021 cactttttgt agttgttttg gacgattagc taaagttctg gcttccctat ttgcttctgg
     4081 aatacatcca aagttttatt tgtaagccca tctgcagatt attttgatga tttagttttt
     4141 accagtcttt tgcaatgaag aaacctggtt tgtcggtgat ttctatcgct tccttctttg
     4201 catgagatgg ggattttatt ttatgtaaga actgtagcaa agttgtctgt gtaaacaaga
     4261 aatgtgttag cttcaaagtg agtcgcttta cttatcaccc tcatgtgtct gtaccatacc
     4321 aaaattgttt atatgtctgc aaattaaaag tttatatttt cacattttct tgattatttt
     4381 taccatttta tatttgaaca ctggcttgtt ctttcactga agtgcctgct attggtgtct
     4441 gtttctagga ttaagtgtga gaaatagtgg tattctgcta tgctaaagtt tatattaaac
     4501 taatccatga cctaattaag cactgggtaa attattaagg gtgtgtaaat tgtagacata
     4561 tatagaagag aatttgctta tatgtttaag ttcctatgaa aatttgcatt catgcatgac
     4621 tatattccca ttagctaatt atagacttaa tatcactgtg agtgttccct cacatcccag
     4681 caacctctgt gcttattgtg tttcactaac ttgcaatatt ttaagataat agcacacgat
     4741 aaaaaagctt aaatataaac acaggacata ttagatttat attaattgct tattcttgtt
     4801 ttcttcactt tgataatata gataaataaa tatataaggc aacagaatct aagacaaaaa
     4861 attcaatata ttttcatgaa tgctcctttt gtatgataga cacttgaaat aaaagactta
     4921 taagaccatc aaagcccata aactgttcat tcacaactct tacataacaa agaagcaaca
     4981 cattttttac agtcagtttg tttagttttt ttttttttaa taaaaggaga agctacataa
     5041 aagacatgag gcagcattaa taaaataaat aaatcctcca caagcttcat gacttttagc
     5101 atcattataa aaagagaaaa cattctattc atttcacaat ttgagcatgg ttcatgtgtt
     5161 tgggggcggt ttggttattg aacttcattt cttgcatgag aaatatcaat gaccttaata
     5221 aaattatgta ttcataa
//
