LOCUS       NM_001105246           10165 bp    mRNA    linear   ROD 17-NOV-2024
DEFINITION  Mus musculus protocadherin 19 (Pcdh19), transcript variant 2, mRNA.
ACCESSION   NM_001105246
VERSION     NM_001105246.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10165)
  AUTHORS   de Nys,R., Gardner,A., van Eyk,C., Mincheva-Tasheva,S., Thomas,P.,
            Bhattacharjee,R., Jolly,L., Martinez-Garay,I., Fox,I.W.J.,
            Kamath,K.S., Kumar,R. and Gecz,J.
  TITLE     Proteomic analysis of the developing mammalian brain links PCDH19
            to the Wnt/beta-catenin signalling pathway
  JOURNAL   Mol Psychiatry 29 (7), 2199-2210 (2024)
   PUBMED   38454084
  REMARK    GeneRIF: Proteomic analysis of the developing mammalian brain links
            PCDH19 to the Wnt/beta-catenin signalling pathway.
REFERENCE   2  (bases 1 to 10165)
  AUTHORS   Giansante,G., Mazzoleni,S., Zippo,A.G., Ponzoni,L., Ghilardi,A.,
            Maiellano,G., Lewerissa,E., van Hugte,E., Nadif Kasri,N.,
            Francolini,M., Sala,M., Murru,L., Bassani,S. and Passafaro,M.
  TITLE     Neuronal network activity and connectivity are impaired in a
            conditional knockout mouse model with PCDH19 mosaic expression
  JOURNAL   Mol Psychiatry 29 (6), 1710-1725 (2024)
   PUBMED   36997609
  REMARK    GeneRIF: Neuronal network activity and connectivity are impaired in
            a conditional knockout mouse model with PCDH19 mosaic expression.
REFERENCE   3  (bases 1 to 10165)
  AUTHORS   Martinez,A.P., Chung,A.C., Huang,S., Bisogni,A.J., Lin,Y., Cao,Y.,
            Williams,E.O., Kim,J.Y., Yang,J.Y.H. and Lin,D.M.
  TITLE     Pcdh19 mediates olfactory sensory neuron coalescence during
            postnatal stages and regeneration
  JOURNAL   iScience 26 (11), 108220 (2023)
   PUBMED   37965156
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10165)
  AUTHORS   Pancho,A., Mitsogiannis,M.D., Aerts,T., Dalla Vecchia,M.,
            Ebert,L.K., Geenen,L., Noterdaeme,L., Vanlaer,R., Stulens,A.,
            Hulpiau,P., Staes,K., Van Roy,F., Dedecker,P., Schermer,B. and
            Seuntjens,E.
  TITLE     Modifying PCDH19 levels affects cortical interneuron migration
  JOURNAL   Front Neurosci 16, 887478 (2022)
   PUBMED   36389226
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10165)
  AUTHORS   Lamers,D., Landi,S., Mezzena,R., Baroncelli,L., Pillai,V.,
            Cruciani,F., Migliarini,S., Mazzoleni,S., Pasqualetti,M.,
            Passafaro,M., Bassani,S. and Ratto,G.M.
  TITLE     Perturbation of Cortical Excitability in a Conditional Model of
            PCDH19 Disorder
  JOURNAL   Cells 11 (12), 1939 (2022)
   PUBMED   35741068
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10165)
  AUTHORS   Hertel,N. and Redies,C.
  TITLE     Absence of layer-specific cadherin expression profiles in the
            neocortex of the reeler mutant mouse
  JOURNAL   Cereb Cortex 21 (5), 1105-1117 (2011)
   PUBMED   20847152
REFERENCE   7  (bases 1 to 10165)
  AUTHORS   Georgas,K., Rumballe,B., Valerius,M.T., Chiu,H.S.,
            Thiagarajan,R.D., Lesieur,E., Aronow,B.J., Brunskill,E.W.,
            Combes,A.N., Tang,D., Taylor,D., Grimmond,S.M., Potter,S.S.,
            McMahon,A.P. and Little,M.H.
  TITLE     Analysis of early nephron patterning reveals a role for distal RV
            proliferation in fusion to the ureteric tip via a cap
            mesenchyme-derived connecting segment
  JOURNAL   Dev Biol 332 (2), 273-286 (2009)
   PUBMED   19501082
REFERENCE   8  (bases 1 to 10165)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 10165)
  AUTHORS   Gaitan,Y. and Bouchard,M.
  TITLE     Expression of the delta-protocadherin gene Pcdh19 in the developing
            mouse embryo
  JOURNAL   Gene Expr Patterns 6 (8), 893-899 (2006)
   PUBMED   16682261
  REMARK    GeneRIF: Pcdh19 gene is developmentally regulated during mouse
            organogenesis and shows a unique expression profile among
            protocadherins.
REFERENCE   10 (bases 1 to 10165)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ120621.1, AK046726.1, AL713863.7, BC118529.1 and AW493375.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849381, SAMN01164135
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               CJ120621.1         1-151
            152-1135            AK046726.1         1-984
            1136-2356           AL713863.7         170595-171815       c
            2357-5130           BC118529.1         546-3319
            5131-9948           AL713863.7         67020-71837         c
            9949-10165          AW493375.1         1-217               c
FEATURES             Location/Qualifiers
     source          1..10165
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 55.21 cM"
     gene            1..10165
                     /gene="Pcdh19"
                     /gene_synonym="B530002L05Rik; Gm717; mKIAA1313"
                     /note="protocadherin 19"
                     /db_xref="GeneID:279653"
                     /db_xref="MGI:MGI:2685563"
     exon            1..3876
                     /gene="Pcdh19"
                     /gene_synonym="B530002L05Rik; Gm717; mKIAA1313"
                     /inference="alignment:Splign:2.1.0"
     exon            3877..4204
                     /gene="Pcdh19"
                     /gene_synonym="B530002L05Rik; Gm717; mKIAA1313"
                     /inference="alignment:Splign:2.1.0"
     exon            4205..4263
                     /gene="Pcdh19"
                     /gene_synonym="B530002L05Rik; Gm717; mKIAA1313"
                     /inference="alignment:Splign:2.1.0"
     exon            4264..4433
                     /gene="Pcdh19"
                     /gene_synonym="B530002L05Rik; Gm717; mKIAA1313"
                     /inference="alignment:Splign:2.1.0"
     exon            4434..10151
                     /gene="Pcdh19"
                     /gene_synonym="B530002L05Rik; Gm717; mKIAA1313"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10110..10115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcdh19"
                     /gene_synonym="B530002L05Rik; Gm717; mKIAA1313"
                     /note="hexamer: ATTAAA"
     polyA_site      10135
                     /gene="Pcdh19"
                     /gene_synonym="B530002L05Rik; Gm717; mKIAA1313"
                     /note="major polyA site"
ORIGIN      
        1 gtggccagta gtttgcggca tcgggaggag gagcagcaac agcagcagta gcggcagcgg
       61 ctggctgaga ggggagacgg gcgagcgggt gcagacggca gcaccagcta ccgctcacca
      121 tgcccggctt gcccagaggg cactggcatt cacttcccta gcccctcgcg ggctgcggcg
      181 cagtgtcctc cctggctttc cagctgagcc gattcatctg agacccgaac ctctcgcccc
      241 aaacccattc cttcctgctc tccccctctc tctcatactc cacattcgca cttcccatcc
      301 acacattcac tcttcctctc tttcgaacat ccacgaacag acctcccctg cgcgcgagcg
      361 ccggggaggg aggaagccct aagcagggct gatagcgctt ctcctggagg atgggatcca
      421 gaagctcccg caagtaaact ttggagccga cagaagccct cgaccctggc agctgcccag
      481 gcggacccca acaacatgcg gctgaactaa ggagggcttt ctttggcggc ggcggcggcg
      541 gcggcggcgg cagcggcagc ggcggcagcg gcggcggcag cggcggctgc tgcggtcctt
      601 gaagctacac cccagcccaa acccaggaag gcaaagaagc cccgggtacc cgcgactgca
      661 gccccgcctc ttctggccgg tactgtagta gcttcctttc ttcaccttcc cattccccgt
      721 gtcccctccc ccttccccgg ggcaattgga aagagcagga ctttgatttt cttggacaaa
      781 ttgccatctt cccgttttta gaaacttaag gcggaggcct gggctgcgtt ggcaactttg
      841 atttccgaga tataaacgcc cgcagacccg caactgctct gtgggaggaa ccctgcgccc
      901 acctcggatc ctgggcagac gcacccccca ccccacgccc tcggacacca acctcagcgc
      961 ccgggagagt gctctcgcat ctctcccctc ccccttcctc tgcccgcccc gggacagccc
     1021 tccagctctg ccaaatccct gggagcccac ggatcttgcc aggaactcag acttctgcct
     1081 gcgatccccc ctttccctct aacaggcctt gaagaggcca gagggccccc cccccccgga
     1141 tcccggaggg tgcgtaccag gcgggagctc cctccgcagt gagctgggcg cgctgggggg
     1201 aggtccttgc gcatgccagg tgcacagact gcgcgctcgc ctgccccagt gccggtgcgc
     1261 tgcggcgggt ccggcagtgc ctgagaggct gcgcccccac agccttccac gtccgcgccc
     1321 cgagtccact accgactctg ctgcttgtgg ccctctgggg cgtgcgagcg ccgctcgaac
     1381 cgcagccctg cgctgctgcg gccagtcccg cctggctaac tttgaaaggg gaaaactgag
     1441 tagccgggct ggagggaggg ggctcggggc tgcgcggcgc tccctgggca ccccggagcc
     1501 cccggccccc cagacagtct ctgctgagac cactgcaatc tcagcattgg agcctgcgcg
     1561 ggttcctccc gcgcgcctcc gggccgccct gggcgggact cctcccgcgg cctccggggc
     1621 cacggggcgc gcgcaacagg cggcccgagc cggcgggaag ctggagcgcc ggcggcgtcg
     1681 gtctcggagg ggtgtggaga ggcgaggcaa ggcagagccc cgcgcagcca tggagtctct
     1741 cctgctgccg gtgctattgc tgctggctgt actgtggacg caggcggctg ccctgattaa
     1801 ccttaaatac tcggtcgaag aggagcagcg cgccgggacg gtgatcgcta acgtggccaa
     1861 ggacgcgcgg gaggccggct tcgcgctgga cccccgacag gcttctgctt tccgcgtggt
     1921 gtccaactcg gctccgcacc tggtggacat caaccccagc tcgggcctct tggtcaccaa
     1981 gcagaagatt gaccgagacc tgctgtgccg ccagagcccc aagtgtatca tctcgctcga
     2041 ggtcatgtcc agctcaatgg agatctgtgt gattaaggtg gagatcaaag acctgaacga
     2101 caatgctccc agttttccgg ccgcacagat agagctggag atctctgagg cagccagccc
     2161 cggcacccgc atcccactgg acagtgcata tgacccggac tccggcagct ttggtgtgca
     2221 gacctacgag ctcacgccca acgagctgtt tggcctggaa ataaagacgc ggggtgacgg
     2281 ttcgcgcttt gctgaactgg tggtggagaa gagcctggac cgtgagacac agtcacatta
     2341 cagctttcgc attacggctc tcgacggagg cgacccacca cacatgggca cagttggcct
     2401 cagcatcaag gtgaccgatt cgaatgacaa caacccagtg tttggcgagt ccacctactc
     2461 agtgagcgtg cctgaaaatt cacctcccaa tacacccgtc atccgcctca atgccagcga
     2521 tccagatgag ggcaccaatg gccaagtggt ctattccttc tatggttatg tcaatgaccg
     2581 tacgcgtgaa ctcttccaaa ttgacccaca cagcggcctg gtcaccgtca ccggtgcgct
     2641 agactatgaa gagggccatg tgtacgaact ggatgtgcaa gccaaagacc tggggcccaa
     2701 ctctatccct gcacactgca aagtcacagt cagcgtactt gatactaatg acaacccgcc
     2761 aattatcaac ctcctgtcgg tcaatagcga gcttgtggag gtgagcgaga gcgccccccc
     2821 gggctatgtg attgccctgg ttcgggtgtc tgatcgcgac tccgggctca atggacgtgt
     2881 gcagtgccgc ttgctgggca atgtcccctt tcgactgcag gagtatgaga gcttctccac
     2941 tattcttgtg gatgggaggc tggaccgaga gcagcatgac cagtacaatc tcactattca
     3001 ggctcgagac agcggtgtgc ctatgctgca gagtgccaag tcgttcactg tgcgtatcac
     3061 agatgagaat gacaaccacc cacacttctc caagccttac taccaagtca ttgtacagga
     3121 gaacaacact cctggtgcct atctgctctc agtgtctgcc cgcgaccctg acatgggtct
     3181 taatggcagt gtctcctatc aaattgtgcc atcacaggtg cgagacatgc cagtcttcac
     3241 ctatgtctca atcaatccca actctggtga catctatgcg ctccgttcct ttaaccatga
     3301 gcagaccaag gcgtttgaat tcaaggtcct ggccaaggat ggcggcttgc cctccctgca
     3361 aagcaatgcc actgtgaggg tcattatcct cgacgtcaat gacaatacac cggtcatcac
     3421 tgccccacct ctgatcaatg gcactgctga ggtctacatt cctcgaaact ctggcatagg
     3481 ctatttggtg actgtagtta aggcagacga ttatgatgag ggcgaaaatg gccgagtcac
     3541 ctatgacatg acagaaggtg accgaggttt cttcgaaata gaccaggtca atggagaagt
     3601 cagaaccact cgtaccttta atgagaactc caagccttcc tatgagctta tagtggtggc
     3661 ccatgaccat ggcaagacat ctctctctgc ttctgccctt gtcctaatat acctgtcccc
     3721 agctcttgat gcccaagagt caatgggctc tgtgaactta tccctgattt tcattattgc
     3781 tctgggctcc attgcgggca ttctctttgt cactatgatc ttcgtggcaa tcaaatgcaa
     3841 gcgtgacaac aaagagatcc ggacctacaa ttgcagaatc gctgagtact cctatgggca
     3901 tcaaaagaaa tcaagtaaga agaaaaaaat tagtaagaat gacatccgcc ttgtacctcg
     3961 ggacgtggag gagacagaca agatgaatgt tgtcagttgc tcctccctta cttcgtccct
     4021 caactatttc gactaccacc agcagacact gcccctgggc tgtcgtcgct ctgagagcac
     4081 tttcctgaat gtggagaacc agaatacccg taacaccact gccagccaca tctaccatca
     4141 ctccttcaac agccagggcc cacagcagcc agacctgatc atcaatggtg tgcccctgcc
     4201 tgagactgaa aactattctt ttgactctaa ctacgtgaat agccgtgccc atttaatcaa
     4261 aagctccacc ttcaaggacc tagagggcaa cagcctgaag gatagtgggc atgaggagag
     4321 tgaccagact gacagtgagc atgatgtcca gaggagcctg tactgcgata ctgctgtgaa
     4381 tgatgtcctg aacaccagtg tgacttccat gggatctcag atgcctgacc atgaccagaa
     4441 tgaaggattt cattgcaggg aagaatgccg gattcttggc cactctgata gatgctggat
     4501 gcctcggaat cccatgccca cccgctccaa gtcacctgag cacgtgagga acatcatcgc
     4561 tctgtccatt gaagctactg ctgctgatgt tgaggcttat gacgactgcg gccccaccaa
     4621 gcggactttc gcgacctttg gaaaagatgt cagtagccac cgggctgagg agcgtcccat
     4681 cctgaaaggc aagcggactg tcgatgtgac catctgcagc cccaaagtca acagcgctat
     4741 ccgggaggca ggcaatgggt gtgaagctat tagccctgtc acctccccac tccacctgaa
     4801 gagccctctg cccaccaagc cttctatatc ttacaccgtc gccctggctc ctccagctca
     4861 cgatctggag caccatgcca acagtggcgc ctctcgtcct tctgaggctg agccccgtgg
     4921 agccgacaac gagaaagtga tgcatgaggt caaccctatt cggaaggatg gtcgtgacaa
     4981 ggaatctcct agcgtgaagc gtctgaagga tatcgttctc taaagccatc tgggttcgag
     5041 gaagagagaa cagaaaccac actggctagt gaagatgtag cagctgctca ttttaattgc
     5101 tcaccaatgg ttggctcttg agtggctgca ttgcagagct ttccctaaat gtattgtgta
     5161 taagtgacta tcattctgtg acaatccctc tcgtttcaac aggcagtagg ggtgttcagt
     5221 tggagcaaat tagctttggc ttgagttgta catgaggcct tgatgttggg gaaacagagg
     5281 caaattcagt tgtgaaaaag tattatgtat taagtgtttg aatttatata tttttatatg
     5341 tcaaaatgat aatataaatt accattgttt gtgaagaatt acatttaaaa aaagcaaaaa
     5401 gaaaaaaaaa gaaaaaaaaa aacaacaaca aagctctgga cacctttaag aagctcgcca
     5461 ctgttttttt gtagtgtaga caagttactg gtcatttatt gtgtacaatt cattgtttca
     5521 gtgatgtgaa atcgagcccc caaaaggttg tttctgaagc tcgagtactt tccaatgccg
     5581 ctactttgct gtggatgccc ctgctttaag aacccttttg ctagctgtgc tgttgttgta
     5641 tttgatattg caaattgcta tgtgtgtggt gatggcaaaa ggcttttaaa ggttgatgtt
     5701 ttcttttctt aaaaaaacta ataaaaatac agataaaaaa aatatcaaac aaacaaaatg
     5761 cgaacaatgg aggcagcaaa tgagtttagc gacaccatgc ctagaggtcg aggacttggt
     5821 ggctgcacac atggtgtgat tgctcaccac gttgaggagg atttctcccg cctttcagtc
     5881 ttctgcctcg gtctgtcgct agatcattgt agaaagtcat ttttggattt gctgctatct
     5941 aatttgcagt tgtcagaaat actgtgctga aaattttatg agatacatta tatatttttt
     6001 ttctaatttt caggccctgc acaggaaagt tactcccaaa gttatcagtt ttcaggctga
     6061 gaaattccct gtctccaatc atctaaaact catgcaacat gactgagtct atttttgaga
     6121 tctaaattac catcttttta gatacacact tcctgattca gtgttttccc aatcatgatt
     6181 ggacttagat ggtaaagtgc atcatgggct ggaatcaagg gctccatatt gctctttatc
     6241 ttacttataa ataatgatag agtaagcagt atgaagtgta cacatacgta aagacaggtg
     6301 ataacatcac taatctaatt actgtgcctt ctaaatggag acactcagac acttgaacgc
     6361 atctttttat gactaatact tttttgatta aaaatgtgaa caagaaatta ttaagacaaa
     6421 acttctttag atttagctaa ctctttttat tttctgtagg ctaggaatat gccttttaac
     6481 actaacaaac cggacattct ttttgttgtt attgttttaa cactgcacaa gtgcccctat
     6541 tttatcatgt ctattaatat tcactagcca acatagtatt cttgcagcct aagagttcat
     6601 tatttaaaat aaactaaaca aacatgtcac ctttcctctg cctttgtctt aaaagaattg
     6661 tttctaaaga acaagttttt ttggttcttc tctcttttgt aattcaagaa tacttaaaaa
     6721 gaaaggctag aagttagagc gctagaattc aaaagagaat ttattttctt aagtttagta
     6781 gatacagtca gctttttgaa atgttttcat tatttttatc tgagttccta gctttataca
     6841 ttactaggaa tactttcttt tgtgggaggt gggagggtct taagggaggg ggtgggtaag
     6901 gcactgggga tggggttagg taagggagaa gatttctgga aaaaaaagac acctataatg
     6961 aagctacaaa tccatcctca tttcctattc tgtactgaat actacctcat gcaaaatatt
     7021 ggcatggctg caaatttccc cctgacactg acagagatca gttgtccttc catcttcttc
     7081 ttgccttagt taattttctc tcatatattt tctcctattc tgatttactt tattttagtg
     7141 tagtagatta tgaattagct atttattttt gttcttccag atgactattt aatgaacacg
     7201 ttcagctttt tacaagtgtc ctttaagtta ggaagactgc ctatagaatt tccactgctc
     7261 ttcaccatga tccatctgat agtatcttgt tagctagcgc ctcaaggtca ctttgtagtc
     7321 agactgtaca gttttctaca ggtgtatttc ttactagaga gtttgaaaga ttgtggaaga
     7381 tggaaatgga aggttggaat gtagagcagc cactgcctgc aatagtctta ccagccactt
     7441 aaaaacagta gcggtggcat tgattttttt tgccttttac ctttttttaa aaaagcaact
     7501 aaatttctta aattttatcc ccagaattta ctttcaagct ttagattcat ccttttaccc
     7561 tatctaaaac attgttctca gtgggcagtc agatgttttt tttctgtttc taaactatta
     7621 tgttcagaga atttttctca ttaaggaaat tccccctgcc ccctccaacc ctccaattgt
     7681 ctgatggaag tacaagtgca tcctaggagg gcgggttcta agggcaggct gtgcttgcaa
     7741 atcggacttt tgcacaaggg tcttaaattt cccaccaaat tgggattctt cccctcccct
     7801 tttaatacat gtgatgaaag gctacctagg ccaatggggc aattatcttt tcctctttat
     7861 ttatttattt ttctgcaaac atgttacaca caaatgggaa caattttagt tcccaagtcc
     7921 tagggaattc tactcattct gatgtccctt ggtcatgaag tgtaacatgc ttaaattttt
     7981 tctggccagg taaacgtctt tattcagtat agggaatcta gtttgcattg attgattgct
     8041 ttctcacaaa cataggaaca tgctattcag taagacatag ggagaagtga tccacaatgc
     8101 cctgtggaaa gttttctttt ccctacgcag actagtaaat gaaactgttc agattgaaac
     8161 ttagagttcc gttgatcctc tgaagccagt agaaaaagtg aaggtttatc ttggtactga
     8221 atagatagtg ggctttggaa ttcagtactt cctgcagaac agtggttctc aaaatactgt
     8281 ctcagagcaa catcacttag gaacttgtta gaaatgataa ttctctatcc ctgcctagaa
     8341 tgactgtata agaaatacta aggaactggc ccagaaaccc atataaatca gaggcccatt
     8401 caagtttgag ggcttgtaaa agcacaggtt tgtagagcct aatccttaga gtttattatt
     8461 cagttgtttt gtggtaggaa ctcttttcct atctacagat gcctaggaga tactgaggag
     8521 acaatgctcc agaggaaact tgcctcatag gactaactgc atctaaagtg gccatttata
     8581 cagatttgtt gatgtggtga ccacctgatc actaatgaaa gatgtagttc tgaactctga
     8641 aactggaaag tacccagagt accttccaga tgctgtcatc tcagcatatg gctggtagag
     8701 gggaattcag atgacttttc ctctacatct cccatttcac tcaaaaggaa acacaaatgg
     8761 ttcacttgac gtggcaaaga caaggagcag tttggggaga ggcagggatg gaaggaatag
     8821 cttttttggg cattcaaggt ggagaaagga ttattactgt atataatcca ttttatgggg
     8881 atcattttga tgtcaaatgt tcccccaaga cactctcagc aagtctggtc cacttggctc
     8941 ttttcacagg gtaataaaac ccttctgact ttgacaaact ggcataaatg agctgaagaa
     9001 gtccattgta tacagtccta gtgtttgcct tcttggtaaa attacatttt aaggatgtca
     9061 tttcatgagt caaattgtat ctgctgacac taaagtgtat tgagatgttg ttctttagtt
     9121 taagtatgta tcaaagtaat attcaaaggg gatgttatgg gggtgggact gggactgggt
     9181 ggctttatat tgatattgaa atattccaga gcaaaacaca ttgtcctaat gaagttgtta
     9241 cagctctctt tgttttcttg tgaagctgga attggcctgt gggcctcttg ttgtgcaaaa
     9301 gtgaattaat ttcaaatagg aatcacattg cttttgtaaa acaaagaaaa tcaaccacct
     9361 tgtctgaagt ataagttgta aggctctctt ggtaaggaac aacccagaaa cacctgacct
     9421 tgattggaaa gcattgtagg tcattaggga aatctgatga tgctgactgg tgttccagct
     9481 gtgttggcaa ttaaagatga ccttgttact aactgaatgt tgctgtcaac tttagcaaac
     9541 aaaccagcta acacctttac agcaccagtt aagaagatgt ttactggcac tggttggtat
     9601 tcagctgagg aaggctaaga tacagactaa ggaccaagag ccagactagg tctagctaga
     9661 aattcagcaa caaatacctc cttgtgctat ttgaatgcta aggtattagt tgcaaaaggc
     9721 ttacgccttc gctcctctag tgaggggaat gagcctgatg acactattac tgtttacctg
     9781 tcaaaccagg gtggcgattt agaaggatgc aagtacagta tgtctcatta agcagtctct
     9841 gttgctgatt atatgaagat gaaatggttg tatatgctga tctgtatgtt atgtacattt
     9901 tcacagtgat tgaatcattg taaaaacaaa aaagacaaaa aagaatcacc actctgtcta
     9961 ttttatgaag atgataaagc agctttatta aattattaca gttctgtttt aaatggtgtt
    10021 acctgccaca ttgtttcctt ttatctggtg gttccctgtt ttcctcttaa atgtgttttc
    10081 tctgcttcaa aagtttaatg cattttagta ttaaaggcta ttatggaaaa agtaatgaag
    10141 ttttggtgaa aaaaaaaaaa aaaaa
//
