LOCUS       NM_001013753            9509 bp    mRNA    linear   ROD 10-JUN-2024
DEFINITION  Mus musculus protocadherin 17 (Pcdh17), mRNA.
ACCESSION   NM_001013753 XM_127786
VERSION     NM_001013753.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9509)
  AUTHORS   Yu,L., Zeng,F., Fan,M., Zhang,K., Duan,J., Tan,Y., Liao,P., Wen,J.,
            Wang,C., Wang,M., Yuan,J., Pang,X., Huang,Y., Zhang,Y., Li,J.D.,
            Zhang,Z. and Hu,Z.
  TITLE     PCDH17 restricts dendritic spine morphogenesis by regulating
            ROCK2-dependent control of the actin cytoskeleton, modulating
            emotional behavior
  JOURNAL   Zool Res 45 (3), 535-550 (2024)
   PUBMED   38747058
  REMARK    GeneRIF: PCDH17 restricts dendritic spine morphogenesis by
            regulating ROCK2-dependent control of the actin cytoskeleton,
            modulating emotional behavior.
REFERENCE   2  (bases 1 to 9509)
  AUTHORS   Martinez,A.P., Chung,A.C., Huang,S., Bisogni,A.J., Lin,Y., Cao,Y.,
            Williams,E.O., Kim,J.Y., Yang,J.Y.H. and Lin,D.M.
  TITLE     Pcdh19 mediates olfactory sensory neuron coalescence during
            postnatal stages and regeneration
  JOURNAL   iScience 26 (11), 108220 (2023)
   PUBMED   37965156
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9509)
  AUTHORS   Goodyer,W.R., Beyersdorf,B.M., Duan,L., van den Berg,N.S.,
            Mantri,S., Galdos,F.X., Puluca,N., Buikema,J.W., Lee,S., Salmi,D.,
            Robinson,E.R., Rogalla,S., Cogan,D.P., Khosla,C., Rosenthal,E.L.
            and Wu,S.M.
  TITLE     In vivo visualization and molecular targeting of the cardiac
            conduction system
  JOURNAL   J Clin Invest 132 (20), e156955 (2022)
   PUBMED   35951416
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9509)
  AUTHORS   Long,Y., Wang,L. and Li,Z.
  TITLE     SP1-induced SNHG14 aggravates hypertrophic response in in vitro
            model of cardiac hypertrophy via up-regulation of PCDH17
  JOURNAL   J Cell Mol Med 24 (13), 7115-7126 (2020)
   PUBMED   32436661
  REMARK    GeneRIF: SP1-induced SNHG14 aggravates hypertrophic response in in
            vitro model of cardiac hypertrophy via up-regulation of PCDH17.
REFERENCE   5  (bases 1 to 9509)
  AUTHORS   Harrington,A.J., Raissi,A., Rajkovich,K., Berto,S., Kumar,J.,
            Molinaro,G., Raduazzo,J., Guo,Y., Loerwald,K., Konopka,G.,
            Huber,K.M. and Cowan,C.W.
  TITLE     MEF2C regulates cortical inhibitory and excitatory synapses and
            behaviors relevant to neurodevelopmental disorders
  JOURNAL   Elife 5, e20059 (2016)
   PUBMED   27779093
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9509)
  AUTHORS   Lu,C.C., Appler,J.M., Houseman,E.A. and Goodrich,L.V.
  TITLE     Developmental profiling of spiral ganglion neurons reveals insights
            into auditory circuit assembly
  JOURNAL   J Neurosci 31 (30), 10903-10918 (2011)
   PUBMED   21795542
REFERENCE   7  (bases 1 to 9509)
  AUTHORS   Biswas,S. and Jontes,J.D.
  TITLE     Cloning and characterization of zebrafish protocadherin-17
  JOURNAL   Dev Genes Evol 219 (5), 265-271 (2009)
   PUBMED   19449025
REFERENCE   8  (bases 1 to 9509)
  AUTHORS   Abrahams,B.S., Tentler,D., Perederiy,J.V., Oldham,M.C., Coppola,G.
            and Geschwind,D.H.
  TITLE     Genome-wide analyses of human perisylvian cerebral cortical
            patterning
  JOURNAL   Proc Natl Acad Sci U S A 104 (45), 17849-17854 (2007)
   PUBMED   17978184
REFERENCE   9  (bases 1 to 9509)
  AUTHORS   Vanhalst,K., Kools,P., Staes,K., van Roy,F. and Redies,C.
  TITLE     delta-Protocadherins: a gene family expressed differentially in the
            mouse brain
  JOURNAL   Cell Mol Life Sci 62 (11), 1247-1259 (2005)
   PUBMED   15905963
REFERENCE   10 (bases 1 to 9509)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK142358.1, AK147265.1,
            AK139275.1, BC089004.1, AK045478.1 and AK046505.1.
            
            On Oct 8, 2009 this sequence version replaced NM_001013753.1.
            
            Summary: This gene belongs to the protocadherin gene family, a
            subfamily of the cadherin superfamily. The encoded protein contains
            six extracellular cadherin domains, a transmembrane domain, and a
            cytoplasmic tail differing from those of the classical cadherins.
            The encoded protein may play a role in the establishment and
            function of specific cell-cell connections in the brain. [provided
            by RefSeq, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147265.1, SRR1660813.181429.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               AK142358.1         2-249
            249-1330            AK147265.1         250-1331
            1331-1374           AK142358.1         1330-1373
            1375-1762           AK147265.1         1376-1763
            1763-3837           AK139275.1         24-2098
            3838-6650           BC089004.1         1727-4539
            6651-8250           AK045478.1         643-2242
            8251-9368           AK046505.1         2169-3286
            9369-9509           AK147265.1         9371-9511
FEATURES             Location/Qualifiers
     source          1..9509
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 43.54 cM"
     gene            1..9509
                     /gene="Pcdh17"
                     /gene_synonym="C030033F14Rik; Gm78"
                     /note="protocadherin 17"
                     /db_xref="GeneID:219228"
                     /db_xref="MGI:MGI:2684924"
     exon            1..5091
                     /gene="Pcdh17"
                     /gene_synonym="C030033F14Rik; Gm78"
                     /inference="alignment:Splign:2.1.0"
     CDS             2533..6006
                     /gene="Pcdh17"
                     /gene_synonym="C030033F14Rik; Gm78"
                     /note="protocadherin 68"
                     /codon_start=1
                     /product="protocadherin-17 precursor"
                     /protein_id="NP_001013775.2"
                     /db_xref="CCDS:CCDS27304.1"
                     /db_xref="GeneID:219228"
                     /db_xref="MGI:MGI:2684924"
                     /translation="MYLSICCCFLLWAPALTLKNLNYSVPEEQGAGTVIGNIGKDARL
                     QPGLPPAERGSGSGRSKSGSYRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAK
                     CQLSLEVFANDKEICMIKVEIQDINDNAPSFPSDQIEMDISENAAPGTRFPLTSAHDP
                     DAGENGLRTYLLTRDDHGLFALDVKSRGDGTKFPELVIQKALDRELQNHHTLVLTALD
                     GGEPPRSATVQINVKVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPN
                     GEVLYSFSSYVPDRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPA
                     HCKVTVKLIDRNDNAPSIGFVSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRV
                     LGGGGTGGGLGGPGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPL
                     NSTKSFAVKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYS
                     ILPSHIGDVSIYTYVSVNPTNGAIYALRSFNYEQTKAFEFKVLAKDSGAPAHLESNAT
                     VRVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYE
                     IVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLIIRSV
                     SGSLPEGVPRVNGEQHHWDMSLPLIVTLSTISIILLAAMITIAVKCKRENKEIRTYNC
                     RIAEYSHPQLGGGKGKKKKINKNDIMLVQSEVEERNAMNVMNVVSSPSLATSPMYFDY
                     QTRLPLSSPRSEVMYLKPASNNLTVPQGHAGCHTSFTGQGTNSSETPATRMSIIQTDN
                     FPAEPNYMGSRQQFVQSSSTFKDPERASLRDSGHGDSDQADSDQDTNKGSCCDMSVRE
                     ALKMKTTSTKSQPLEQEPEECINCTDECRVLGHSDRCWMPQFPAANQAENADYRTNLF
                     VPTVEANVETETYETVNPTGKKTFCTFGKDKREHTILIANVKPYLKAKRALSPLLQEV
                     PSASSSPTKACIEPCASTKGSLDGCEAKPGPLAEASSSYLPTDSQYPSPSKQPRDPSF
                     MASDQMARVFADVHSRARRASSEMGAVLEQLEQPNRDLGRESVDAEEVVREIDKLLQD
                     CRGNDPVAVRK"
     exon            5092..5150
                     /gene="Pcdh17"
                     /gene_synonym="C030033F14Rik; Gm78"
                     /inference="alignment:Splign:2.1.0"
     exon            5151..5323
                     /gene="Pcdh17"
                     /gene_synonym="C030033F14Rik; Gm78"
                     /inference="alignment:Splign:2.1.0"
     exon            5324..9509
                     /gene="Pcdh17"
                     /gene_synonym="C030033F14Rik; Gm78"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7135..7140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcdh17"
                     /gene_synonym="C030033F14Rik; Gm78"
                     /note="hexamer: AATATA"
     polyA_site      7156
                     /gene="Pcdh17"
                     /gene_synonym="C030033F14Rik; Gm78"
                     /note="major polyA site"
     regulatory      7422..7427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcdh17"
                     /gene_synonym="C030033F14Rik; Gm78"
                     /note="hexamer: ATTAAA"
     polyA_site      7444
                     /gene="Pcdh17"
                     /gene_synonym="C030033F14Rik; Gm78"
     regulatory      7971..7976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcdh17"
                     /gene_synonym="C030033F14Rik; Gm78"
                     /note="hexamer: AATAAA"
     polyA_site      7994
                     /gene="Pcdh17"
                     /gene_synonym="C030033F14Rik; Gm78"
ORIGIN      
        1 agtcagcaag agacgctggg gagagaatcc ggactgcgag cccggcggct gccgcagcgg
       61 aggagggcgg ctcggagacg gtactccaac tgttgaattg aatttttcac cttccatttc
      121 ctccgcgtct tggctggcgg agatggattt attcggtttg aaacctgcac gtctttctca
      181 ggctttgggg tgatcctgac aggcaccgca ctagactgaa agagaccact cgtgacagaa
      241 aaaaaaaaaa ggaggaatta aaatttaaaa aaaacctcca caacagactg cacaattagc
      301 tatgcacacc gatgctggac tttgtgaaca gagaccgttg ggaggaaaat cttgaactat
      361 gatcctgggc taagctgtga atcattactg gaaacgtgcc cccaccccta agactgagag
      421 atttgggggc atctcacgcc taaccaagtg gaaaggtttt ttttaaaaaa caaataaata
      481 ttcgtaagca aagcagacgc cttgttttgc agagcctcgg actccggccg aaagaggtag
      541 agtaaaagtg ttcctggatt cagctttgcc ttcctccccc cacgcttttt ctcgtttttc
      601 ttcccccacc cccgacgtga ttccggcttt tttgttgttg ttgtttgttt tttttttgtt
      661 tttgtttttg tttttcctat tgagtggtca gagaaagcct taagaagaag cctcaactaa
      721 ggactgcgaa gggaggaccg tgaggggaga gtgaatacga ttcgttccgc tgcttctgac
      781 tcatcccgca gatgagaaca cctgcatttc tggatgtgtc attcccgtat accgaggcgc
      841 tgggagaagc ggaaataatg tgtagatcaa cccgtgccta acctcccctc ggaggtggag
      901 gaggtagttt ccccgggtgg gcgccctggc agaaccgcgg tggctgcagc tcctcaccct
      961 ctctgccttt cccaagtcga ccagagaccg tgtgtgagcc agactgcaga atgcatcacg
     1021 ccaagccttg atgtattccg tcgactctac tcctccaatt taaaataata ataataataa
     1081 ggggggaaaa agcctacact gttattctct tcaaatattc accactcttg ttcctcgcca
     1141 aggttttcct ttctagatga aaaggaggct gggccactgg aaggaggtgc tgaatagaaa
     1201 gaaaagagag ccacttgaca gcccagccct gtgaatgcag agactgtttc ccttctagcg
     1261 agagacaggg cagtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgctaggac
     1321 tgggagggta gctccctcct cctttctagt ctgccctccc ccctcccccc ccccctcaaa
     1381 tctgcacgtc taaccatgag ttgcctgttg atttcctttc gcctggcaag aaaagcaaac
     1441 tggaattaaa ctgcagggag agaagtcttt gcttgctgga agaggatggg atggtagtgg
     1501 cggctcccgg attggcatag agacacacca gagtgttcta cgaacagagg cggagatata
     1561 tctctatatt tttctcctcc caataggctc tcggcgcaaa tgctgatcag gctgtggctt
     1621 tcttgatttt gggggagaac cctctccgag gaagagaggg aggagcttgg tagggggagg
     1681 aaactacaaa tcgggacact tttttttcct ctgcatttcc tcccctccct ctggctgctc
     1741 ggaaagaaga gagaaaaaga agagggagag agaaaaaaag acttggctcg gagatgcagt
     1801 ccgctgccgc cgccgcctaa accagcaagg caagattaga tctttaaatg cagcaataca
     1861 ctgcctgaaa gccgagcatc ctgcatagcg agcagacatt tctccgtgtg ccagggcagc
     1921 ctcaaatata catatgtatc tgtgactctt tcttcgtccc tattcattcc catcaatcgc
     1981 atcaccgaat aagagtaact aaaggattcc actttctgat ctgcctggag acacacctcc
     2041 cgaagccctc ccccaccgga tttgaagagt attctgtagg ctgccggagg gagtggattt
     2101 tgcagcgcct agcgggagtg aggaaaacca agcaattctt cagctcatta tcatctcttc
     2161 cagactccga tttccttttt atcgccagcc tcatcacgca agtttgaacc tcccgaagtc
     2221 caggcgggag agacaaagcc tttagcttgc cttcagccgc agggagtcgc cgcctggctc
     2281 cgagctgctg cagcttcgct gcgcggctgc atctctccca gtgcgaatgc tgtagatcaa
     2341 caggttcggg caacttgagc ggaataagga gagactgcct ggtgccgcag cccgggtgcg
     2401 gagggaagga aagactcgca gacttgtggc tcgctccgag ctcgtacgct ccgccccggt
     2461 tccagactgg cgcgcaccca ccagctagca cctccagtcc ggctgctcct gttcccaccc
     2521 caccggtctg ggatgtacct ttccatctgt tgctgcttcc ttttgtgggc ccctgccctg
     2581 acactcaaaa acctcaatta ctcagtgcca gaggagcaag gggccggcac ggtgattggc
     2641 aacatcggca aggatgcccg actgcagccc gggcttccgc cggctgagcg cggcagcggc
     2701 agcgggagga gcaagtctgg cagttaccgg gtgctggaga actccgcacc gcatctgctg
     2761 gacgtggacg ccgacagcgg gctcctctac accaaacagc gcatcgaccg tgagtcctta
     2821 tgccgccaca atgccaagtg ccagctctcc ctagaggttt tcgctaacga caaggagatt
     2881 tgcatgatca aggtagagat ccaggacatc aacgacaacg ctccctcttt cccctcggat
     2941 cagatagaaa tggacatctc agagaacgcg gcacccggca cccgcttccc cctcacgagc
     3001 gcacacgacc cagacgctgg cgagaacggg ctccgcacct atctgctcac ccgcgatgat
     3061 catggcctct ttgccctgga cgtcaagtcc cgcggcgacg gcaccaagtt cccagagctg
     3121 gtcatccaaa aggcactgga ccgcgagctg cagaaccacc acactctggt gctgaccgcc
     3181 ctagatggcg gggagcctcc acgctccgcc accgtacaga tcaatgtgaa ggtgatcgat
     3241 tccaatgaca acagtccagt cttcgaggct ccgtcatact tggtggaact gcccgagaac
     3301 gctccactgg gtaccgtggt cattgatttg aacgccactg atgctgatga aggtcccaac
     3361 ggagaagtcc tctactcctt cagcagctat gtgcccgacc gcgtgcggga gctcttctcc
     3421 atcgatccta aaactggcct gatccgcgtt aagggcaacc tggactatga ggagaacggc
     3481 atgttggaga tcgacgtgca ggccagagac ctaggaccta acccaatccc agcccactgc
     3541 aaggtcacag tcaagcttat cgaccggaac gataacgcgc cgtccattgg tttcgtctcc
     3601 gtgcgccagg gggcgctgag tgaggccgcc ccgcccggca cagtcatcgc cctagtgcgg
     3661 gtcactgacc gggactcagg caagaatggg cagcttcagt gtcgggttct aggtggagga
     3721 gggactggag gtggcctggg gggtcccggt tccgtcccct tcaagcttga agagaactat
     3781 gacaacttct ataccgtggt gactgaccgt ccactggacc gtgagacaca agacgagtac
     3841 aatgtgacca ttgtggcccg ggacgggggc tcccctccac ttaactccac caagtccttc
     3901 gccgtcaaga ttctggatga gaatgacaat ccgcctcggt tcaccaaagg actttacgtg
     3961 ctccaagtac acgagaacaa cattccagga gaatacctcg ggtcagtgct agcccaggat
     4021 cccgacctgg gccaaaatgg gacagtgtca tactccattc ttccttcaca catcggcgac
     4081 gtgtctattt acacctatgt gtccgtgaac cccactaacg gggccatata tgccctacgc
     4141 tcctttaact atgaacaaac gaaggctttt gaattcaaag tactggctaa ggactcaggg
     4201 gcgccagcgc acttggagag caacgccacg gtgagggtga cggttttaga cgtgaacgac
     4261 aacgctccag tgattgtgct tcccacgcta cagaatgaca cagctgagct gcaggtcccg
     4321 cgcaatgctg gcctggggta cctggtaagc accgtgcgcg ccctggacag cgactttgga
     4381 gagagcgggc gcctcaccta tgagatcgtg gatggcaacg atgaccacct gtttgagatc
     4441 gatccgtcca gcggcgagat ccgcacgctg caccccttct gggaggatgt gaccccagtg
     4501 gtggagcttg tggtgaaggt gaccgatcat ggcaagccca ccctttccgc tgtggccaaa
     4561 cttatcatcc gctcagtgag cggctccctg cctgaagggg taccgcgagt gaatggcgag
     4621 cagcaccact gggacatgtc cctgcctctc atagtgacac tgagcacgat ttctatcatc
     4681 ctcctagcgg ccatgatcac catcgctgtc aagtgtaaac gggaaaacaa ggagattcgc
     4741 acttacaact gccgcatcgc cgagtacagc caccctcagc taggcggggg gaagggcaag
     4801 aagaagaaaa tcaacaaaaa cgatatcatg ctggtgcaga gcgaggtgga ggagaggaac
     4861 gccatgaacg tcatgaacgt ggtgagcagt ccctccctgg ccacctcccc tatgtacttc
     4921 gactaccaaa cccgcctgcc cctcagctcg ccccggtcag aggtgatgta tcttaagcca
     4981 gcctccaaca acctgactgt cccgcagggg cacgcaggct gccacaccag cttcaccgga
     5041 caagggacta attcgagcga gacccctgcc actcggatgt ccataattca gacagacaat
     5101 tttcccgcag agcccaatta catgggcagc aggcagcagt ttgttcaaag tagctccacg
     5161 tttaaggacc cagaaagagc cagcctgaga gacagtgggc acggggacag cgatcaggcg
     5221 gacagtgacc aagacactaa caaaggctcc tgctgtgaca tgtcggttag ggaggcactc
     5281 aagatgaaaa ctacttcaac taaaagtcag ccactcgaac aagaaccaga agagtgcatt
     5341 aattgcacag atgaatgccg agtgcttggt cattctgata ggtgttggat gccacagttc
     5401 cctgcagcca atcaggctga aaatgcagat taccgcacaa atctctttgt acccacagtt
     5461 gaagctaatg ttgagactga gacttacgaa actgtgaatc ccactgggaa aaagactttt
     5521 tgtacatttg gaaaagacaa gcgagagcac actattctca ttgccaatgt gaaaccttat
     5581 ttaaaagcca aacgtgccct gagccctctc ctccaagagg tcccctcagc atctagcagc
     5641 ccaaccaagg catgcattga gccttgcgcc tcaacaaaag gctccctgga tggctgtgaa
     5701 gcaaaacctg ggcccttagc agaagcaagc agctcctacc tgcccactga cagtcagtac
     5761 ccttcaccca gtaagcaacc aagagaccct tccttcatgg cttctgatca gatggcaagg
     5821 gtcttcgcgg atgtgcattc cagagcccgt agggcttcca gcgagatggg agctgtgttg
     5881 gagcagctgg agcagcccaa cagggatctg ggccgagagt ccgtggatgc cgaagaagtt
     5941 gtgagagaga ttgataagct cttgcaggac tgccggggaa atgaccctgt ggctgtgaga
     6001 aagtgagggg gaaaaggcat tggtgttttc ttgtctcttc tgttgatttg aaaatgatca
     6061 cttccggtga aaacccactt tacagggatg gcaaaggacc agtgctgctt taaggctttt
     6121 agtgaacatc tgaagtgccc acaagtatgt tcttttcact gctgtttctt ttacagaaat
     6181 aacaatggtt ttgaccaaac ttatattagg acagaattaa tgatgcttaa ggagaaagga
     6241 gaaaagagag agagagaaga aattggaaag acgcaaaaag gaggatgaga caagttacct
     6301 tttgacaatc tgttaggaag gtatgcagtg tgagacttaa cgtatttctg atcactctaa
     6361 gactgtcctc ccacgagatt gatgctgact taactgttta cctataaacc catacaaagc
     6421 agggtcatat ttgttatctg tggtggacta ctagctgaca tcacaggctt ctactgaaag
     6481 tcccgaaaag accttgcagt agtccaagct acaccaaaca ttaacccata tttgtggtaa
     6541 acatttctgt ataaagtacc tgccaagcat agaaacacaa agaccattcc ataccattag
     6601 tcagaaagca aaagaaaaaa tatgtaataa taacaaaacg gaaaaaaaaa gataaaacaa
     6661 caaaaaccct tggtcatttg taagacacct catgtcatat aaaagttcaa tgtaaaaaga
     6721 tatagtctgt gttgtcctga acacatgtag acctattcac ttcattaaag aagaaaattt
     6781 tgaaaattta aaatgtctat ttagcatttt agtgtccaac aaagatataa gtaatggtga
     6841 gtttatttta catttgaaca gttctgaatt atgggttatc actgagtagt aatactgaga
     6901 gaaaattaac aaaactaaaa tgttttactc agtttttgga cactaaaata gctcaggaaa
     6961 gtgaaaaaaa aagacttaga cataacaaat catatgacca tttaaatgtg cagatgtaag
     7021 aagattcaat gtgtttacat caaatgacat atttttattg atttattgca gattctgtgc
     7081 atatgagcca aattgttgag tgtataagag ctatattgtg tattttatta aattaatata
     7141 tagttgtgtt gcaaaactct ttgggcttat attgtaaatg gcgagtgttg cctcggtagc
     7201 tgtcgaactc tatgagtttt gtttttcctg cttccttttc cccatggagc gtggggagca
     7261 gggcctcaga gcaaagtctc tcgtttaatg tatagtctac caagtataca gtacacaatt
     7321 ctgttcaaag tgtgtttgag tgagccgata aagctaactg aaagaccaga aaaatacatc
     7381 tgtcagtcat agttctgtga aagtccttgt agaaagcttt gattaaagtc atgctaaatc
     7441 acaagaaggt tccccccctt actctccata ccatgaagct tctgcctatg tagatatcat
     7501 aacattggtt ggctctcaaa gtatcttcag tggttccggt gtgtgtacac atcatattcg
     7561 taagcgtacg aaatgttcaa atgcatgtgt agggccagtg ctggttacat gcattgtgtg
     7621 ctgtgtctca agaggtctgg gtcttaaaca aaatgtgctt tttaacttta tctctgtgct
     7681 cttctgcctg tttttatttg tgttctttga gactaatgcc tattattcca tcattggttt
     7741 caccttttcc tgtggcattt agcaagtttc caacctactt ccttatgagg ctaagaaaac
     7801 tctaatttca ggaattggga aaaataaaat tagcactcac agaagtagta gcagatgggg
     7861 aaatgccttg attgacattt cccttcagca tttaattttt tttttcagca tttaacagct
     7921 tcatggcaaa cagtttgagc ccataccttg gaaaatgtgg tgctgagtta aataaaggct
     7981 gtttgtgctc tgaagcagga aaaaatttat tatttgtaaa ctgggaggga tttctgtgcc
     8041 ttcttttctt gccaccaagc cagtatagaa acagtataaa tgtcaaaaat aataataacc
     8101 ttatactaaa aacaaacaga aaagcaaaac aaactttgaa ctaaattaag ttctttaact
     8161 aataataaaa aaaaatctgc tggaaatctt tccatcattt caggaaagtt ttagattgta
     8221 cgttttagat tggatggcac cccccccccc caggcccctt attctcttga gaactgcatt
     8281 ggggtcttgg taagagcctc tctacatctc tactcctgcc ttttgttatc catccatgtt
     8341 taaattagaa aagaggggat cttttacatg tgaaatccaa ctgaccctat attttggacc
     8401 atttatgtag ctacaatgtg tgtctctgtt ctatgatgtt acttttacca ggagactaca
     8461 aattgattta gcttgatagg tagttgaaag ttgctgaaaa actgtttcca tgtagtcatc
     8521 ttgagctttg cctctctcac tattcagata accactttag tgacatctca agcagtgtgc
     8581 aaggaaactc aacacaaaca ataggtttat ttttcaaaac ttcttagttc taagtaacca
     8641 gctgttcaat gtattgttaa gcgtctgaaa cattgaaaca ccatacaagt ctcagaactg
     8701 gttgtgccaa catgtgatgg attgactcta agctgtcact agtggtctgc tagtgttagc
     8761 tgtttaatac attatctgta cttaatagtg attatttatt tacaagttgg tggtagttca
     8821 agtcaggact ctgagctttt ttagttgagg gaatcttgtt tttattcatc tccctgggac
     8881 ctgcctttaa cacagaactc tggtgcttgg cttccaagga agcctttgtg atgccaaaat
     8941 catacctttg aggaaacaat ggctgtaatg gatggtacat aattgggggg agttgagggg
     9001 tttctgcaat ttaaaatgct ttacatacac acacacacac acacacacac acacacacac
     9061 acacacacat tgaaaaaaaa aagtccttta attctttaga ggtatttaag cagaggaaaa
     9121 ctgtcaattt tgggaaattt tagtaaaaga cacaaaacaa aaaaaagaaa tgcgtagtgg
     9181 tgaactaaag acaaaacatc agtaatgaaa tattttcccc atttgttaat gaggaatatg
     9241 ttttcattaa aattcaacat agtacgaatc actgttacgc tatatcaaag taaacaccga
     9301 agggacatct atattctcaa agaagattgt cacgttgttt ctttactaga caaacttata
     9361 cttatggcaa acaacacaaa aaactagacc ttgttccatc gattcactga attactggga
     9421 gagaaattga ttgttgcttt cccgaaatta cctaggctct tgtaaaacat gactttcctt
     9481 ttaaggatgt aggcactgct caaattaac
//
