LOCUS       NM_017378               5587 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus protocadherin 12 (Pcdh12), mRNA.
ACCESSION   NM_017378
VERSION     NM_017378.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5587)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   2  (bases 1 to 5587)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5587)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5587)
  AUTHORS   Chen,X., Tang,A.T., Tober,J., Yang,J., Leu,N.A., Sterling,S.,
            Chen,M., Yang,Y., Mericko-Ishizuka,P., Speck,N.A. and Kahn,M.L.
  TITLE     Mouse placenta fetal macrophages arise from endothelial cells
            outside the placenta
  JOURNAL   Dev Cell 57 (23), 2652-2660 (2022)
   PUBMED   36473461
REFERENCE   5  (bases 1 to 5587)
  AUTHORS   Rusidze,M., Faure,M.C., Sicard,P., Raymond-Letron,I., Giton,F.,
            Vessieres,E., Prevot,V., Henrion,D., Arnal,J.F., Cornil,C.A. and
            Lenfant,F.
  TITLE     Loss of function of the maternal membrane oestrogen receptor
            ERalpha alters expansion of trophoblast cells and impacts mouse
            fertility
  JOURNAL   Development 149 (19) (2022)
   PUBMED   36239412
REFERENCE   6  (bases 1 to 5587)
  AUTHORS   Christoforou,N., Miller,R.A., Hill,C.M., Jie,C.C., McCallion,A.S.
            and Gearhart,J.D.
  TITLE     Mouse ES cell-derived cardiac precursor cells are multipotent and
            facilitate identification of novel cardiac genes
  JOURNAL   J Clin Invest 118 (3), 894-903 (2008)
   PUBMED   18246200
REFERENCE   7  (bases 1 to 5587)
  AUTHORS   Bouillot,S., Rampon,C., Tillet,E. and Huber,P.
  TITLE     Tracing the glycogen cells with protocadherin 12 during mouse
            placenta development
  JOURNAL   Placenta 27 (8), 882-888 (2006)
   PUBMED   16269175
REFERENCE   8  (bases 1 to 5587)
  AUTHORS   Masinde,G.L., Li,R., Nguyen,B., Yu,H., Srivastava,A.K.,
            Edderkaoui,B., Wergedal,J.E., Baylink,D.J. and Mohan,S.
  TITLE     New quantitative trait loci that regulate wound healing in an
            intercross progeny from DBA/1J and 129 x 1/SvJ inbred strains of
            mice
  JOURNAL   Funct Integr Genomics 6 (2), 157-163 (2006)
   PUBMED   16208538
REFERENCE   9  (bases 1 to 5587)
  AUTHORS   Rampon,C., Prandini,M.H., Bouillot,S., Pointu,H., Tillet,E.,
            Frank,R., Vernet,M. and Huber,P.
  TITLE     Protocadherin 12 (VE-cadherin 2) is expressed in endothelial,
            trophoblast, and mesangial cells
  JOURNAL   Exp Cell Res 302 (1), 48-60 (2005)
   PUBMED   15541725
  REMARK    GeneRIF: PCDH12 has a unique expression pattern and its deficiency
            does not lead to conspicuous abnormalities; it is the first
            specific marker for both glycogen-rich trophoblasts and mesangial
            cells.
REFERENCE   10 (bases 1 to 5587)
  AUTHORS   Telo',P., Breviario,F., Huber,P., Panzeri,C. and Dejana,E.
  TITLE     Identification of a novel cadherin (vascular endothelial
            cadherin-2) located at intercellular junctions in endothelial cells
  JOURNAL   J Biol Chem 273 (28), 17565-17572 (1998)
   PUBMED   9651350
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028374.1, Y08715.1, AK048100.1 and AK165819.1.
            
            On Dec 30, 2006 this sequence version replaced NM_017378.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y08715.1, BI103573.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               AK028374.1         3-177
            176-2767            Y08715.1           141-2732
            2768-2926           AK048100.1         2767-2925
            2927-3360           Y08715.1           2892-3325
            3361-5091           AK165819.1         181-1911
            5092-5587           AK028374.1         2208-2703
FEATURES             Location/Qualifiers
     source          1..5587
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 20.17 cM"
     gene            1..5587
                     /gene="Pcdh12"
                     /gene_synonym="Pcdh14; VE-cad-2"
                     /note="protocadherin 12"
                     /db_xref="GeneID:53601"
                     /db_xref="MGI:MGI:1855700"
     exon            1..3211
                     /gene="Pcdh12"
                     /gene_synonym="Pcdh14; VE-cad-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3212..3312
                     /gene="Pcdh12"
                     /gene_synonym="Pcdh14; VE-cad-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3313..3467
                     /gene="Pcdh12"
                     /gene_synonym="Pcdh14; VE-cad-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3468..5587
                     /gene="Pcdh12"
                     /gene_synonym="Pcdh14; VE-cad-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tactaactgt ttggaagtca aatccctaca tcctgcttta ctaggtcaag tctctcttag
       61 accggtactt gcccatcact gctaagtgga ccagctggtg ctgtggcgga gcaggaatct
      121 cttccagcaa tttatctgtt ctgggacctc tcacttgtca cggagatggc cttgcttggg
      181 aatcctgctc cttacagcat cttctaatta tgggacagag ttgtaacagc aggtctgaag
      241 tgggagatcc aggctgacca agccattcag gaactactgg ggacaagctc tgcctttgaa
      301 aaactccagt ccagcctacc tgccggtaag catgatgcta cttctgccat tcctgctagg
      361 gctcttaggg ccaggaagct acttgttcat ttcaggggat tgtcaggagg tggccactgt
      421 catggtgaaa ttccaagtga cagaggaagt gccgtctggc acggtgatag ggaaactgtc
      481 ccaagaacta agagtggagg agaggcgtgg gaaggcagga gatgccttcc agattctgca
      541 gctgcctcag gcactgccgg ttcagatgaa ctctgaggac ggcctgctca gcacttccag
      601 ccggctggat cgggagaagc tatgtcggca ggaagatccc tgtctggtgt catttgacgt
      661 gcttgccaca ggggcgtctg ctctaattca tgtggagatt caggtgctag acatcaatga
      721 ccaccagcca cagtttccca aagacgagca ggaactggaa atctcagaga gtgcctctct
      781 gcacacacga atccccttgg acagagctct tgaccaagac acgggtccta acagcttata
      841 ttcctactcc ctgtctccca gtgaacactt tgccctggat gttattgtgg gccctgatga
      901 gaccaaacat gcagagcttg tggtggtgaa ggagttggac agggaactcc actcatattt
      961 tgatctggtg ctgaccgcct atgacaatgg gaatccccct aagtcaggaa tcagcgtggt
     1021 caaggtcaat gtcctggact ccaatgacaa tagtccagtg tttgctgaga gttcactagc
     1081 actagaaatc ccagaagaca ctgttcctgg tactcttctc ataaacctga ctgctacaga
     1141 tcccgaccaa ggacccaatg gggaggtaga gttcttcttt ggcaagcatg tgtccccaga
     1201 ggtgatgaac acctttggca tagatgccaa gacaggccag atcattctgc gccaagccct
     1261 agattacgag aagaaccctg cctatgaggt ggatgtccag gcaagggatt tgggtcccaa
     1321 ttccatccca ggccattgca aagttcttat caaagttctg gatgtcaatg acaatgcccc
     1381 aagcatcctc atcacgtggg cctcccagac gtcgctggtg tcagaagatc ttcccaggga
     1441 tagcttcatt gcccttgtca gtgcgaatga cttggactca ggaaacaacg gtctcgtcca
     1501 ctgttggctg aatcaagagc tgggccactt cagactgaaa aggactaacg gcaacacgta
     1561 catgctgctc accaatgcca cactggacag agagcagtgg cccatatata ctctcactgt
     1621 gtttgcccaa gaccaaggac cccagccctt atcagctgag aaggagctcc aaattcaggt
     1681 tagtgatgtc aatgacaatg cccctgtgtt tgagaagagc cggtacgagg tctccacttg
     1741 ggaaaataac ccaccctctc ttcacctcat cacgctcaaa gcgcatgatg ctgacttggg
     1801 cagtaatgga aaagtgtcat accgtatcaa ggactccccc gtttctcact tagtcattat
     1861 tgactttgaa acaggagaag tcactgctca gaggtcactg gactatgaac agatggcagg
     1921 ctttgagttc caggtgatag cagaggacag agggcaaccc cagctcgcat ccagcatctc
     1981 ggtgtgggtt agcctcttgg atgccaatga taatgcccca gaagtgattc agcctgtgct
     2041 cagtgaaggc aaagccaccc tttcggtgct tgtaaatgcc tccacgggcc accttctgtt
     2101 gcccattgag aatcccagtg gcatggatcc agcaggtact ggtataccac caaaggctac
     2161 ccacagcccc tggtctttcc ttttgttaac aatcgtggct agggatgcag actcgggggc
     2221 caatggggaa ctcttctaca gcattcaaag tgggaatgat gctcatctct ttttcctcag
     2281 cccttccttg gggcagctat tcattaatgt caccaatgcc agcagcctca tcgggagtca
     2341 gtgggacctg gggatagtgg tagaggacca gggcagcccc tccttgcaga cccaagtttc
     2401 attgaaggtc gtgtttgtca ccagtgtgga ccacctaagg gattctgctc atgagcccgg
     2461 agttctgagc acaccagcac tggctttgat ctgcctggct gtactgctgg ccatctttgg
     2521 attgctctta gccctgttcg tgtccatctg caggacagag agaaaggata atagggccta
     2581 caactgtcga gaagctgagt cgtcataccg ccaccagccc aagaggcccc agaaacacat
     2641 tcagaaggca gatatccacc tggtgcctgt gcttagggcc cacgagaatg agactgatga
     2701 agtcaggcca tctcacaagg ataccagcaa ggagacactg atggaggcag gctgggactc
     2761 ttgcctgcag gcccccttcc acctcacacc aaccctatac aggaccctgc gtaaccaagg
     2821 caaccaggga gaactggcag agagccagga ggtactgcag gacaccttca actttctctt
     2881 taaccatccc aggcagagga atgcctcccg ggagaaccta aaccttcctg agtccccacc
     2941 tgctgtacgc caaccactct taaggcctct gaaggtgcct ggtagcccca tagcgagggc
     3001 gactggagac caagacaagg aggaggcccc acagagccca ccagcgtcct ctgcaaccct
     3061 aagacgacag cggaatttca atggcaaagt gtctcctaga ggagagtccg gtcctcatca
     3121 gattctgagg agcctggtta ggctctctgt ggctgctttt gcggaacgga acccggtgga
     3181 ggagcctgct ggggactctc ctcctgtcca gcaaatctcc cagctgctgt ccttgctgca
     3241 ccagggccaa ttccagccca aaccaaacca ccgaggaaat aaatacttgg ccaagcccgg
     3301 cggcagcagc aggggtacca tcccagacac agagggcctt gtaggcctca agcctagtgg
     3361 tcaagcagaa cctgacctgg aagaagggcc cccgagcccg gaggaggacc tttctgtaaa
     3421 gcgacttcta gaagaagagc tgtcgagcct gttggaccct aatacaggtc tagccctgga
     3481 caagctgagt ccgcctgacc cagcctggat ggcgagattg tcattgcccc tcaccaccaa
     3541 ttaccgagac aacttgtctt cccccgatgc tacaacgtca gaggaaccga gaaccttcca
     3601 gacattcggc aagacagttg gaccgggacc cgagctgagc ccaacaggca cgcgcctggc
     3661 cagcactttc gtctcggaga tgagctctct gctggaaatg ttgttggggc agcacacggt
     3721 accagtggaa gctgcgtccg cggctttgcg gaggctctcg gtgtgcggga ggaccctcag
     3781 tctagaccta gccaccagtg gggcctcagc ttcagaagca cagggtagaa agaaggcagc
     3841 tgagagcaga cttggctgtg gcaggaatct atgaacatgt ttggttggga tgtgtttgga
     3901 tccaggacct gggtcccctg ggaaatgtta gggcactcgg gtcttgagga tctcagggaa
     3961 taagctggtt tttaaaattt gtggaattca ttggacagag atatccctaa ctttagggca
     4021 acttatgcta tgctgttcct cacagaggaa gcaggagtcc aggactacca agcaactgac
     4081 tagggcagac cttgtaatgg tctgcgtggc tgagctttac ggacaacagg gacagcttgt
     4141 ttcactccta ggagtttgca gtaaaacaca taaagaggtg gccctcagga ggaacagata
     4201 ccacaaagtg tagtatccta agcagaggga tggcctcact ggacactgaa ggccgagggt
     4261 gggctcttgg aagagccagg caatgccttc tgacctacta ataaagggaa aactgcagct
     4321 cactctgttt ggagtgagag ctgtttgtca tcaaattcct ggcatgaaac tcttgttggg
     4381 tcatgacagg catgggtcac actggtttga agtgacaggt acgcagacga tggacatgtg
     4441 tgtccttgac cccactccac tatgctatcc aacaatatgc atctcagcta gaaaaatcag
     4501 gacgttagga aagcaagact gtaaatagag tatttatatg agccaggcac taggctttaa
     4561 tttgattccc cacccccacc ccagccctgc ccagtgctag gtcggtagta ttttcatacc
     4621 cattttacag gaatgaagct tgggaacatt gagggttctt ccccaagatt gagcaaggag
     4681 tagaggcaga ctcaggattt gtgctcaggc tggcccaaag ccaaagccca tgtcatcaac
     4741 catggcactg gattgcaaac aaaggaacgg aagaggaaaa gtccctgaga tgaagacttg
     4801 cagacagaag acactcagtt ccgaattagt ccgctcttac aagcacaggg taaaaggagc
     4861 tcgcatctgc ccagtcccag tcccttcctt ttccagggag cagcccttct tgtgcataca
     4921 gtagtcttac ctgacacccc atctggggaa gtcttgctct atcggcaggc ttgggtctgt
     4981 gaattgaggc cccagaggat ggtgtgtgaa ctagaactag aaaatccata ctgacagcag
     5041 ccagcttttc aggggtgggg agagtgaaga aagagctaat attttcccaa gacttttttt
     5101 tatccttaaa atttccaagc agccacagct agcttaggat agtaggagat ggggtggggt
     5161 ggggctctcc tggacaccag aggcagaaga tattgtctgc ttcatttgtc atctccggga
     5221 gatcagggct cttgactctc atctgtagac aggccagccg ggctggtgcc acctcgggct
     5281 ggtgacagtc acacactttg gaatgcagtg atgttattcc atcttacaga tgaggagtat
     5341 gagacctgga gaagttaagc attttcagag gcaaggtctg agtctctgat cacctcactc
     5401 cggtcagggt gatcttgtaa gacctgcgat tgtcaagctg gttcacagag ctgttgggtt
     5461 ccaggccact gagagaggtc atgagaacca agcaagcagg agctccatct tacgtagcca
     5521 ggtgcctggc acaggtgaca cttgaaacac ttgttgagtt gatacatggt tgaataaatg
     5581 ggtaaac
//
