LOCUS       NM_001098172            4241 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus protocadherin 10 (Pcdh10), transcript variant 2, mRNA.
ACCESSION   NM_001098172
VERSION     NM_001098172.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4241)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4241)
  AUTHORS   Li,W., Plante,J.A., Lin,C., Basu,H., Plung,J.S., Fan,X.,
            Boeckers,J.M., Oros,J., Buck,T.K., Anekal,P.V., Hanson,W.A.,
            Varnum,H., Wells,A., Mann,C.J., Tjang,L.V., Yang,P., Reyna,R.A.,
            Mitchell,B.M., Shinde,D.P., Walker,J.L., Choi,S.Y., Brusic,V.,
            Llopis,P.M., Weaver,S.C., Umemori,H., Chiu,I.M., Plante,K.S. and
            Abraham,J.
  TITLE     Shifts in receptors during submergence of an encephalitic arbovirus
  JOURNAL   Nature 632 (8025), 614-621 (2024)
   PUBMED   39048821
  REMARK    GeneRIF: Shifts in receptors during submergence of an encephalitic
            arbovirus.
REFERENCE   3  (bases 1 to 4241)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4241)
  AUTHORS   Yang,J., Hou,C., Wang,H., Perez,E.A., Do-Umehara,H.C., Dong,H.,
            Arunagiri,V., Tong,F., Van Scoyk,M., Cho,M., Liu,X., Ge,X.,
            Winn,R.A., Ridge,K.M., Wang,X., Chandel,N.S. and Liu,J.
  TITLE     Miz1 promotes KRAS-driven lung tumorigenesis by repressing the
            protocadherin Pcdh10
  JOURNAL   Cancer Lett 555, 216025 (2023)
   PUBMED   36538983
  REMARK    GeneRIF: Miz1 promotes KRAS-driven lung tumorigenesis by repressing
            the protocadherin Pcdh10.
REFERENCE   5  (bases 1 to 4241)
  AUTHORS   van de Haar,L.L., Riga,D., Boer,J.E., Garritsen,O., Adolfs,Y.,
            Sieburgh,T.E., van Dijk,R.E., Watanabe,K., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Posthuma,D., Meye,F.J., Basak,O. and
            Pasterkamp,R.J.
  TITLE     Molecular signatures and cellular diversity during mouse habenula
            development
  JOURNAL   Cell Rep 40 (1), 111029 (2022)
   PUBMED   35793630
REFERENCE   6  (bases 1 to 4241)
  AUTHORS   Croci,L., Chung,S.H., Masserdotti,G., Gianola,S., Bizzoca,A.,
            Gennarini,G., Corradi,A., Rossi,F., Hawkes,R. and Consalez,G.G.
  TITLE     A key role for the HLH transcription factor EBF2COE2,O/E-3 in
            Purkinje neuron migration and cerebellar cortical topography
  JOURNAL   Development 133 (14), 2719-2729 (2006)
   PUBMED   16774995
REFERENCE   7  (bases 1 to 4241)
  AUTHORS   Yamamoto,M., Fujinuma,M., Hirano,S., Hayakawa,Y., Clagett-Dame,M.,
            Zhang,J. and McCaffery,P.
  TITLE     Retinoic acid influences the development of the inferior olivary
            nucleus in the rodent
  JOURNAL   Dev Biol 280 (2), 421-433 (2005)
   PUBMED   15882583
REFERENCE   8  (bases 1 to 4241)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (bases 1 to 4241)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   10 (bases 1 to 4241)
  AUTHORS   Hirano,S., Yan,Q. and Suzuki,S.T.
  TITLE     Expression of a novel protocadherin, OL-protocadherin, in a subset
            of functional systems of the developing mouse brain
  JOURNAL   J Neurosci 19 (3), 995-1005 (1999)
   PUBMED   9920663
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC037259.1, AK081977.1 and AA386527.1.
            
            Transcript Variant: This variant (2) has a distinct 3' UTR and
            contains an alternate 3' coding exon, as compared to variant 1. The
            resulting protein (isoform 2) is shorter and has a distinct
            C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081621.1, AK081977.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3174              BC037259.1         1-3174
            3175-4130           AK081977.1         3171-4126
            4131-4241           AA386527.1         1-111               c
FEATURES             Location/Qualifiers
     source          1..4241
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 20.35 cM"
     gene            1..4241
                     /gene="Pcdh10"
                     /gene_synonym="6430521D13Rik; 6430703F07Rik; mKIAA1400;
                     OL-pc; Olpc"
                     /note="protocadherin 10"
                     /db_xref="GeneID:18526"
                     /db_xref="MGI:MGI:1338042"
     exon            1..3486
                     /gene="Pcdh10"
                     /gene_synonym="6430521D13Rik; 6430703F07Rik; mKIAA1400;
                     OL-pc; Olpc"
                     /inference="alignment:Splign:2.1.0"
     CDS             856..3999
                     /gene="Pcdh10"
                     /gene_synonym="6430521D13Rik; 6430703F07Rik; mKIAA1400;
                     OL-pc; Olpc"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; OL-protocadherin"
                     /codon_start=1
                     /product="protocadherin-10 isoform 2 precursor"
                     /protein_id="NP_001091642.1"
                     /db_xref="CCDS:CCDS50901.1"
                     /db_xref="GeneID:18526"
                     /db_xref="MGI:MGI:1338042"
                     /translation="MIVLLFFALLWMVDGVFSQLHYTVQEEQEHGTFVGNIAEDLGLD
                     ITKLSARRFQTVANSRTPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENP
                     LELFRVEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYE
                     ITPNSYFSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGGGEGGGG
                     GGGAGLPPQQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATD
                     PDEGQNGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLG
                     PNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQ
                     VQCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQ
                     VQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAKLTYSILECQIQ
                     GMSVFTYVSINSDNGYLYALRSFDYEQIKDFSFQVEARDAGSPQALAGNATVNILIVD
                     QNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGN
                     EMNLFRLDWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVDGA
                     VEPQGGGGDRGGGSGEHLRPSRSGGGETSLDLTLILIIALGSVSFIFLLAMIVLAVRC
                     QKEKKLNIYTCLASDCCLCCCCCGNGSSTCCGRQARARKKKLSKSDIMLVQSANVPSN
                     PAQVPVEESGGFGSHHHNQNYCYQVCLTPESAKTDLMFLKPCSPSRSTDAEHNPCGAI
                     VTGYSDQQPDIISNGSILSNENKHQRAELSYLVDRPRRVNSSAFQEADIVSSKDSGHG
                     DSEQGDSDHDVTNRGQSAGMDLFSNCTEECKALGHSDRCWMPSFVPSDGRQAADYRSN
                     LHVPGMDSVPDTEVFEPPEVQPGAERSFSTFGKEKALHGTLERKELDGLLSNTRAPYK
                     PPYLNHFHPLSCFAHWK"
     exon            3487..3545
                     /gene="Pcdh10"
                     /gene_synonym="6430521D13Rik; 6430703F07Rik; mKIAA1400;
                     OL-pc; Olpc"
                     /inference="alignment:Splign:2.1.0"
     exon            3546..3652
                     /gene="Pcdh10"
                     /gene_synonym="6430521D13Rik; 6430703F07Rik; mKIAA1400;
                     OL-pc; Olpc"
                     /inference="alignment:Splign:2.1.0"
     exon            3653..3958
                     /gene="Pcdh10"
                     /gene_synonym="6430521D13Rik; 6430703F07Rik; mKIAA1400;
                     OL-pc; Olpc"
                     /inference="alignment:Splign:2.1.0"
     exon            3959..4234
                     /gene="Pcdh10"
                     /gene_synonym="6430521D13Rik; 6430703F07Rik; mKIAA1400;
                     OL-pc; Olpc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4217..4222
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcdh10"
                     /gene_synonym="6430521D13Rik; 6430703F07Rik; mKIAA1400;
                     OL-pc; Olpc"
                     /note="hexamer: ATTAAA"
     polyA_site      4234
                     /gene="Pcdh10"
                     /gene_synonym="6430521D13Rik; 6430703F07Rik; mKIAA1400;
                     OL-pc; Olpc"
                     /note="major polyA site"
ORIGIN      
        1 cggagctcag aaactgccag ccgagatcac aagcattggg gctgaagcag gaggcaggat
       61 ggactgagag gagaagaggc aggttagagg gagagaggct tgcaaaggaa acagcagaaa
      121 agaaatagct ggttgtgttc acgcaaagcc agagccagtg aagttgagaa tagacacaag
      181 actatgaaag ccaagagatg caaagagaga cagagggaag aaaatgacaa gaggaacgtc
      241 catccggaga aatgaagaga atgaaagttt tatgctgcag aacggctccg tgtttttcca
      301 gcaaaaattt ttctcgctgt ctttaacccc gctcgcgttt gccagccgtt gatatcaaga
      361 ggcatgttca gtggtgccgg cagcatctcc tctaccttct tttcctcttc atcttcctcc
      421 ttctcctctt cttcctcctc cacattctcc tcccatcagc aggaagacaa acctaggaca
      481 gtcttgaaat atcgaaattt cctccttggg atttgccagc gccgcgttgc gccaacactg
      541 tcggaataaa ggaggctgac tattgtatga tcgttatttt attaattggt cagtgggaag
      601 attacggctg agcatagggg acatctgtca ccctttctgc gctaagattg aaaaatgagg
      661 ctcgatttgg agacgctcta aaatgaagca aaaggaatca aaattttaat acagccacag
      721 gagccccccc cccacgcagc acacttttat ttatattttt tagattatta ttattctttt
      781 tgtggtggtg gttggggggc ggtgatcggg gtggctggct ggctacaggg gagctgcttc
      841 cttttccttt tggaaatgat tgtgctgtta ttctttgcct tgctctggat ggtggacgga
      901 gtcttttccc agcttcatta tactgtgcag gaagagcagg aacatggcac tttcgtgggg
      961 aatatcgctg aagacctggg cttggacatt acaaaacttt cagctcgcag gtttcagacg
     1021 gtggccaact cacggacccc ttacttggac ctcaatctgg agaccggggt tctgtacgta
     1081 aacgagaaga tagatcgcga gcaaatctgt aagcagagcc cctcttgtgt cctgcacctg
     1141 gaggtctttc tggagaaccc gctggagctg ttccgagtgg agatcgaagt gctggacatc
     1201 aatgacaacc ctccctcctt cccagagccc gacctgacag tggagatctc agagagcgcc
     1261 acgccaggca cccgctttcc cttggagagc gccttcgacc cagacgtggg gaccaactcc
     1321 ttgcgagact acgagataac cccaaatagc tacttctcgc tagacgtaca gacccaggga
     1381 gatggcaacc gattcgccga actggtcctg gagaagccac tggaccgaga acagcaagcg
     1441 gtgcaccgct acgtgctgac cgcggtggac gggggaggag ggggaggagg aggggaagga
     1501 gggggaggcg gtgggggagc cggcctgccc ccccagcagc agcgtactgg cacggccttg
     1561 ctcaccatcc gagtgctcga ctccaacgac aatgtgcccg cttttgacca acccgtctac
     1621 acagtttccc taccagagaa ttctccccct ggcacgctag tgatccagct taatgccacc
     1681 gaccctgatg aaggccagaa tggcgaggtc gtgtactcgt tcagtagtca catttcaccc
     1741 agggctcggg agctcttcgg actgtcgccg cgcaccggcc ggctggaggt gagcggcgag
     1801 ctggactatg aagagagccc agtgtatcag gtgtatgtcc aagccaagga cttgggtccc
     1861 aatgctgtgc ctgcgcactg caaggttctg gtgagagtgc tggatgccaa cgacaacgca
     1921 ccagagatca gcttcagcac agtgaaagag gcggtgagcg agggtgcggc ccctggcacg
     1981 gtggtggctc tgttcagcgt gaccgatcgg gactcagagg agaacgggca ggtgcagtgt
     2041 gagcttctgg gagacgtgcc gttccgcctc aagtcttcct tcaagaatta ctacactatc
     2101 gtgaccgaag cccccttgga ccgagaggct ggggactcct acaccctgac cgtggtggcc
     2161 cgcgaccggg gcgagcctgc actctccacc agtaagtcga tccaggttca agtgtcagat
     2221 gtgaatgaca atgcgccgcg cttcagccag ccggtctacg acgtgtatgt gacagaaaac
     2281 aatgtgccgg gtgcctacat ttacgcggtg agcgccacgg accgcgacga aggggccaat
     2341 gcaaaattaa cctactctat cctagagtgc cagatccaag gaatgagtgt cttcacctac
     2401 gtgtccatca actcagacaa cggctacttg tacgccctga gatccttcga ctatgagcag
     2461 atcaaggact tcagctttca agtagaagcc cgggacgccg gcagtcccca ggcgctggcc
     2521 ggcaatgcca cggtcaacat cttgatagtg gatcagaacg acaacgcccc cgccatcgtg
     2581 gcgccccttc cggggcgcaa cgggactcca gcccgcgagg tgctgccgcg ctctgccgaa
     2641 cccggctacc tgctcactcg tgtggccgca gtggacgcgg acgacggcga gaacgccagg
     2701 ctcacctaca gcatagtgcg gggcaacgaa atgaacctct ttcgactgga ctggcgcacc
     2761 ggagagctcc gcaccgcgcg ccgggtccca gccaagcgcg acccccagcg gccttatgag
     2821 ctggtgatcg aggtgcgcga ccacgggcag ccgcccctgt cctccacagc caccctggtg
     2881 gttcagctgg tggatggagc ggtggagcca cagggcgggg gcggggaccg aggcggaggg
     2941 tctggggaac acctgcgtcc cagccgctct ggcggcgggg aaacttcact ggacctcaca
     3001 cttatcctta tcatcgccct gggctcggtg tccttcatct tcctgctggc catgatcgtg
     3061 ttggccgtgc gctgtcagaa agagaaaaaa ctcaacatct acacgtgtct cgcgagcgat
     3121 tgctgcctct gctgctgctg ctgcggcaat gggagctcca cctgctgcgg ccgccaagcc
     3181 cgggcgcgca agaagaaact cagcaagtca gatatcatgt tggtgcagag cgccaacgtc
     3241 cctagcaacc cggcccaggt gccggtagag gagtccggag gcttcggttc ccatcaccac
     3301 aatcagaact attgctatca ggtctgcctc accccggagt ccgccaagac cgacctgatg
     3361 ttcctgaagc cctgcagccc ttcccggagt acagatgctg agcacaatcc ctgcggagcc
     3421 atcgtcaccg ggtacagcga ccagcaacca gacatcattt ccaacggaag cattttgtcc
     3481 aacgagaata aacaccagcg agcagagctc agctatctag ttgacagacc tcgccgagtt
     3541 aacagttctg cattccagga agctgacata gtaagctcta aggacagtgg tcatggagac
     3601 agtgaacagg gagacagtga tcatgatgtc accaaccgtg gccagtcagc tggtatggat
     3661 cttttctcca actgcaccga ggaatgtaaa gcactgggcc actctgaccg atgctggatg
     3721 ccttcttttg tcccttcgga tggacgccag gctgcagatt accgcagcaa cctgcatgtc
     3781 cccggcatgg actctgttcc agacaccgag gtctttgaac ctccagaagt ccagcctggg
     3841 gcagagcgct ccttctccac tttcggcaaa gagaaggccc tgcatggcac cctggagagg
     3901 aaggagttgg acggattgct gtctaataca cgagcgcctt acaaaccacc atatttgaat
     3961 catttccacc ctctttcttg ttttgcacat tggaagtaaa cccatttaag catttgtcca
     4021 tcttaagagt ctaacaaaag aagattacca attaaaccat aagtagaatt gttaaatgaa
     4081 aaggaacgcc tacatatgga attattttcc ctgctgcatc acactgagga tttctgaacc
     4141 aacatatgaa tactttaagt tataaatatc ttgtagataa tcctggaata tgcaaattga
     4201 tttgcctata aatataatta aacaatattc aataaaaaaa a
//
