LOCUS       NM_025835               2306 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus propionyl Coenzyme A carboxylase, beta polypeptide
            (Pccb), transcript variant 1, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_025835
VERSION     NM_025835.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2306)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2306)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 2306)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   4  (bases 1 to 2306)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 2306)
  AUTHORS   Schrick,J.J. and Lingrel,J.B.
  TITLE     cDNA cloning, mapping and expression of the mouse propionyl CoA
            carboxylase beta (pccb), the gene for human type II propionic
            acidaemia
  JOURNAL   Gene 264 (1), 147-152 (2001)
   PUBMED   11245989
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050366.1, AK004976.1 and AC134825.5.
            
            On Jul 25, 2015 this sequence version replaced NM_025835.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055946.1, AK050366.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AK050366.1         2-10
            10-2300             AK004976.1         2-2292
            2301-2306           AC134825.5         77938-77943
FEATURES             Location/Qualifiers
     source          1..2306
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 53.09 cM"
     gene            1..2306
                     /gene="Pccb"
                     /gene_synonym="1300012P06Rik"
                     /note="propionyl Coenzyme A carboxylase, beta polypeptide"
                     /db_xref="GeneID:66904"
                     /db_xref="MGI:MGI:1914154"
     exon            1..216
                     /gene="Pccb"
                     /gene_synonym="1300012P06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1653
                     /gene="Pccb"
                     /gene_synonym="1300012P06Rik"
                     /EC_number="6.4.1.3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; propionyl-CoA carboxylase beta chain,
                     mitochondrial; PCCase subunit beta; propanoyl-CoA:carbon
                     dioxide ligase subunit beta"
                     /codon_start=1
                     /product="propionyl-CoA carboxylase beta chain,
                     mitochondrial isoform 1 precursor"
                     /protein_id="NP_080111.1"
                     /db_xref="CCDS:CCDS23442.1"
                     /db_xref="GeneID:66904"
                     /db_xref="MGI:MGI:1914154"
                     /translation="MAAAIRIRAVAAGARLSVLNCGLGITTRGLCSQPVSVKERIDNK
                     RHAALLGGGQRRIDAQHKRGKLTARERISLLLDPGSFMESDMFVEHRCADFGMAADKN
                     KFPGDSVVTGRGRINGRLVYVFSQDFTVFGGSLSGAHAQKICKIMDQAITVGAPVIGL
                     NDSGGARIQEGVESLAGYADIFLRNVTASGVIPQISLIMGPCAGGAVYSPALTDFTFM
                     VKDTSYLFITGPEVVKSVTNEDVTQEQLGGAKTHTTVSGVAHRAFDNDVDALCNLREF
                     FNFLPLSSQDPAPIRECHDPSDRLVPELDTVVPLESSKAYNMLDIIHAVIDEREFFEI
                     MPSYAKNIVVGFARMNGRTVGIVGNQPNVASGCLDINSSVKGARFVRFCDAFNIPLIT
                     FVDVPGFLPGTAQEYGGIIRHGAKLLYAFAEATVPKITVITRKAYGGAYDVMSSKHLL
                     GDTNYAWPTAEIAVMGAKGAVEIIFKGHQDVEAAQAEYVEKFANPFPAAVRGFVDDII
                     QPSSTRARICCDLEVLASKKVHRPWRKHANIPL"
     exon            217..336
                     /gene="Pccb"
                     /gene_synonym="1300012P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            337..405
                     /gene="Pccb"
                     /gene_synonym="1300012P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            406..462
                     /gene="Pccb"
                     /gene_synonym="1300012P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            463..576
                     /gene="Pccb"
                     /gene_synonym="1300012P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            577..687
                     /gene="Pccb"
                     /gene_synonym="1300012P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            688..796
                     /gene="Pccb"
                     /gene_synonym="1300012P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            797..917
                     /gene="Pccb"
                     /gene_synonym="1300012P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            918..999
                     /gene="Pccb"
                     /gene_synonym="1300012P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1123
                     /gene="Pccb"
                     /gene_synonym="1300012P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1231
                     /gene="Pccb"
                     /gene_synonym="1300012P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1332
                     /gene="Pccb"
                     /gene_synonym="1300012P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1431
                     /gene="Pccb"
                     /gene_synonym="1300012P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1531
                     /gene="Pccb"
                     /gene_synonym="1300012P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..2306
                     /gene="Pccb"
                     /gene_synonym="1300012P06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2282..2287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pccb"
                     /gene_synonym="1300012P06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2302
                     /gene="Pccb"
                     /gene_synonym="1300012P06Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggcagtcaaa aaaaaaaaaa aaaaaaaatg gcggcggcga ttaggattcg ggcggtggcg
       61 gctggagcga ggctcagcgt tctgaattgc ggcctcggca tcacgacccg cggcctttgc
      121 agccagccgg tttcagttaa agagcgcatc gacaacaagc gccatgcagc gttgctggga
      181 ggaggccagc gccgcatcga cgcgcagcac aagcgaggga agctaacagc cagggagcgg
      241 atcagtcttc tgctggatcc tggcagcttc atggagagcg acatgtttgt ggaacacaga
      301 tgtgccgact tcggaatggc tgctgataag aataagtttc ccggagatag tgtggtcact
      361 ggacggggcc gaatcaatgg acgattggtt tatgtcttca gtcaggattt tacagttttt
      421 ggaggcagtc tgtcaggagc acatgctcaa aagatctgca aaatcatgga ccaggccata
      481 acagtggggg ctccagtgat cgggctcaat gactccgggg gcgccagaat ccaggagggg
      541 gtggagtcct tggctggcta cgcggacatc ttcctgagga atgtcacagc gtctggagtc
      601 atcccgcaga tttctctgat catgggcccg tgtgctggtg gggccgtcta ctcccctgcc
      661 ctaacagact tcacattcat ggtgaaggac acatcttacc tgtttatcac tggccctgaa
      721 gttgtgaagt ctgttaccaa tgaggatgtc actcaagagc agctgggtgg tgccaagacc
      781 cacaccactg tgtcaggtgt ggcccataga gctttcgaca atgatgttga tgctctgtgt
      841 aacctgcgtg aattcttcaa tttcctgccc ctcagcagcc aggacccggc tcccatccga
      901 gagtgccatg accccagtga ccgtctggtt cctgagctgg acacagttgt ccctttggag
      961 tcaagcaaag cctacaacat gctggacatc atccacgcag tgattgacga gagagagttt
     1021 tttgagataa tgcccagtta cgcaaaaaat attgtcgttg gcttcgcaag aatgaatggg
     1081 aggaccgttg gaattgtcgg caaccagccc aatgtggcct cagggtgctt ggacattaat
     1141 tcatccgtga agggggctcg ttttgtcaga ttctgtgacg cattcaacat tcccctcatc
     1201 actttcgttg acgtccctgg cttcctgcct ggcacggcgc aggagtatgg gggcatcatc
     1261 aggcatggtg ccaagctgct ctacgcgttc gccgaggcaa ctgtgcccaa aatcacagtc
     1321 atcaccagga aggcctatgg aggtgcctat gatgtcatga gctccaaaca ccttcttggt
     1381 gacaccaact atgcctggcc cacagctgag attgcggtca tgggagcaaa gggtgctgtg
     1441 gagatcatct tcaaaggaca ccaagatgtg gaagccgccc aggcagagta tgtggagaag
     1501 ttcgccaacc ctttcccagc agccgtgaga gggtttgtgg atgacatcat ccagccatcc
     1561 tctactcgtg ctcggatatg ctgtgacctg gaagtcctgg ccagcaagaa ggtccatcgt
     1621 ccctggagga aacatgcaaa tatcccactg tgagcagatg gaagggacta gagcaacagt
     1681 tgaaaagctg gccttttgca gcgtacccct ccctgccttt tacaatcatg aaaaaatgga
     1741 tctatgtatc ttggacactg attgatttgc ataaagagtt cttgggcctg gagtaaaact
     1801 atgtgctcta ttaaaatcat tggtactttt tgaataaata tttcattgtt atagtaaaaa
     1861 tctcaatctt atacaagaaa gccagaagga ggcgggggat ggaatcatag ttgactgaat
     1921 caggctctgg ttcacactga tgtgggtatg atttttgtgg ccctcagagg tcgacatgct
     1981 ggagcttgaa ctccgtgtgg ggtagtgaga gcagagagat agtgggagat gctgtggtca
     2041 gctgggctgg gctctgtgct gaagaggcta agagttctta gtctttcccc agctgctcga
     2101 tagctatgtg atgtctcgat attcccccac cccatgcggg ctccacggtg tgatacacca
     2161 ggagggttgt caccagagct tcaccgatgg tagtgccttg ccattggatc tcagaattat
     2221 gagctaatta aaccccatac ctcttcataa aattaacctg ccttcaagat tttgttatag
     2281 taataaaagc ggattaattc aacata
//
