LOCUS       NP_080111                541 aa            linear   ROD 30-APR-2024
DEFINITION  propionyl-CoA carboxylase beta chain, mitochondrial isoform 1
            precursor [Mus musculus].
ACCESSION   NP_080111
VERSION     NP_080111.1
DBSOURCE    REFSEQ: accession NM_025835.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 541)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 541)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (residues 1 to 541)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   4  (residues 1 to 541)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (residues 1 to 541)
  AUTHORS   Schrick,J.J. and Lingrel,J.B.
  TITLE     cDNA cloning, mapping and expression of the mouse propionyl CoA
            carboxylase beta (pccb), the gene for human type II propionic
            acidaemia
  JOURNAL   Gene 264 (1), 147-152 (2001)
   PUBMED   11245989
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050366.1, AK004976.1 and AC134825.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055946.1, AK050366.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..541
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 53.09 cM"
     Protein         1..541
                     /product="propionyl-CoA carboxylase beta chain,
                     mitochondrial isoform 1 precursor"
                     /EC_number="6.4.1.3"
                     /note="propionyl-CoA carboxylase beta chain,
                     mitochondrial; PCCase subunit beta; propanoyl-CoA:carbon
                     dioxide ligase subunit beta"
                     /calculated_mol_wt=55601
     transit_peptide 1..28
                     /note="Mitochondrion. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q99MN9.2)"
                     /calculated_mol_wt=2826
     mat_peptide     29..541
                     /product="Propionyl-CoA carboxylase beta chain,
                     mitochondrial. /id=PRO_0000000294"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MN9.2)"
                     /calculated_mol_wt=55601
     Region          34..535
                     /region_name="Carboxyltransferase.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01138"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MN9.2)"
     Region          39..539
                     /region_name="MmdA"
                     /note="Acetyl-CoA carboxylase, carboxyltransferase
                     component [Lipid transport and metabolism]; COG4799"
                     /db_xref="CDD:443827"
     Site            73
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P05166; propagated from
                     UniProtKB/Swiss-Prot (Q99MN9.2)"
     Site            101
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q99MN9.2)"
     Region          327..360
                     /region_name="Acyl-CoA binding. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MN9.2)"
     Site            476
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q99MN9.2)"
     Site            491
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q99MN9.2)"
     CDS             1..541
                     /gene="Pccb"
                     /gene_synonym="1300012P06Rik"
                     /coded_by="NM_025835.3:28..1653"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS23442.1"
                     /db_xref="GeneID:66904"
                     /db_xref="MGI:MGI:1914154"
ORIGIN      
        1 maaairirav aagarlsvln cglgittrgl csqpvsvker idnkrhaall gggqrridaq
       61 hkrgkltare risllldpgs fmesdmfveh rcadfgmaad knkfpgdsvv tgrgringrl
      121 vyvfsqdftv fggslsgaha qkickimdqa itvgapvigl ndsggariqe gveslagyad
      181 iflrnvtasg vipqislimg pcaggavysp altdftfmvk dtsylfitgp evvksvtned
      241 vtqeqlggak thttvsgvah rafdndvdal cnlreffnfl plssqdpapi rechdpsdrl
      301 vpeldtvvpl esskaynmld iihavidere ffeimpsyak nivvgfarmn grtvgivgnq
      361 pnvasgcldi nssvkgarfv rfcdafnipl itfvdvpgfl pgtaqeyggi irhgakllya
      421 faeatvpkit vitrkaygga ydvmsskhll gdtnyawpta eiavmgakga veiifkghqd
      481 veaaqaeyve kfanpfpaav rgfvddiiqp sstrariccd levlaskkvh rpwrkhanip
      541 l
//
