LOCUS       NM_144844               2603 bp    mRNA    linear   ROD 10-NOV-2023
DEFINITION  Mus musculus propionyl-Coenzyme A carboxylase, alpha polypeptide
            (Pcca), transcript variant 1, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_144844
VERSION     NM_144844.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2603)
  AUTHORS   Soria LR, Makris G, D'Alessio AM, De Angelis A, Boffa I, Pravata
            VM, Rufenacht V, Attanasio S, Nusco E, Arena P, Ferenbach AT, Paris
            D, Cuomo P, Motta A, Nitzahn M, Lipshutz GS, Martinez-Pizarro A,
            Richard E, Desviat LR, Haberle J, van Aalten DMF and
            Brunetti-Pierri N.
  TITLE     O-GlcNAcylation enhances CPS1 catalytic efficiency for ammonia and
            promotes ureagenesis
  JOURNAL   Nat Commun 13 (1), 5212 (2022)
   PUBMED   36064721
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2603)
  AUTHORS   Jiang L, Park JS, Yin L, Laureano R, Jacquinet E, Yang J, Liang S,
            Frassetto A, Zhuo J, Yan X, Zhu X, Fortucci S, Hoar K, Mihai C,
            Tunkey C, Presnyak V, Benenato KE, Lukacs CM, Martini PGV and Guey
            LT.
  TITLE     Dual mRNA therapy restores metabolic function in long-term studies
            in mice with propionic acidemia
  JOURNAL   Nat Commun 11 (1), 5339 (2020)
   PUBMED   33087718
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2603)
  AUTHORS   Tamayo M, Fulgencio-Covian A, Navarro-Garcia JA, Val-Blasco A,
            Ruiz-Hurtado G, Gil-Fernandez M, Martin-Nunes L, Lopez JA, Desviat
            LR, Delgado C, Richard E and Fernandez-Velasco M.
  TITLE     Intracellular calcium mishandling leads to cardiac dysfunction and
            ventricular arrhythmias in a mouse model of propionic acidemia
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1866 (1), 165586 (2020)
   PUBMED   31678161
REFERENCE   4  (bases 1 to 2603)
  AUTHORS   Suzuki T, Kikuguchi C, Nishijima S, Nagashima T, Takahashi A, Okada
            M and Yamamoto T.
  TITLE     Postnatal liver functional maturation requires Cnot
            complex-mediated decay of mRNAs encoding cell cycle and immature
            liver genes
  JOURNAL   Development 146 (4) (2019)
   PUBMED   30733279
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2603)
  AUTHORS   Collard R, Majtan T, Park I and Kraus JP.
  TITLE     Import of TAT-Conjugated Propionyl Coenzyme A Carboxylase Using
            Models of Propionic Acidemia
  JOURNAL   Mol Cell Biol 38 (6), e00491-17 (2018)
   PUBMED   29378828
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2603)
  AUTHORS   Guenzel AJ, Hofherr SE, Hillestad M, Barry M, Weaver E, Venezia S,
            Kraus JP, Matern D and Barry MA.
  TITLE     Generation of a hypomorphic model of propionic acidemia amenable to
            gene therapy testing
  JOURNAL   Mol Ther 21 (7), 1316-1323 (2013)
   PUBMED   23648696
REFERENCE   7  (bases 1 to 2603)
  AUTHORS   Bailey PJ, Klos JM, Andersson E, Karlen M, Kallstrom M, Ponjavic J,
            Muhr J, Lenhard B, Sandelin A and Ericson J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   8  (bases 1 to 2603)
  AUTHORS   Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber
            G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong
            WH and Cepko CL.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 2603)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 2603)
  AUTHORS   Miyazaki T, Ohura T, Kobayashi M, Shigematsu Y, Yamaguchi S, Suzuki
            Y, Hata I, Aoki Y, Yang X, Minjares C, Haruta I, Uto H, Ito Y and
            Muller U.
  TITLE     Fatal propionic acidemia in mice lacking propionyl-CoA carboxylase
            and its rescue by postnatal, liver-specific supplementation via a
            transgene
  JOURNAL   J Biol Chem 276 (38), 35995-35999 (2001)
   PUBMED   11461925
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY263345.1 and AK148002.1.
            
            [WARNING] On Nov 22, 2023 this sequence was replaced by
            NM_144844.3.
            
            On Jul 21, 2009 this sequence version replaced NM_144844.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148002.1, AY046947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BY263345.1         1-11
            12-2603             AK148002.1         2-2593
FEATURES             Location/Qualifiers
     source          1..2603
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 65.99 cM"
     gene            1..2603
                     /gene="Pcca"
                     /note="propionyl-Coenzyme A carboxylase, alpha
                     polypeptide"
                     /db_xref="GeneID:110821"
                     /db_xref="MGI:MGI:97499"
     exon            1..132
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..2214
                     /gene="Pcca"
                     /EC_number="6.4.1.3"
                     /note="propionyl-CoA carboxylase alpha chain,
                     mitochondrial; propanoyl-CoA:carbon dioxide ligase subunit
                     alpha; propionyl CoA-carboxylase alpha; PCCase subunit
                     alpha"
                     /codon_start=1
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial precursor"
                     /protein_id="NP_659093.2"
                     /db_xref="CCDS:CCDS27350.1"
                     /db_xref="GeneID:110821"
                     /db_xref="MGI:MGI:97499"
                     /translation="MAGQWVRTVALLAARRHWRRSSQQQLLGTLKHAPVYSYQCLVVS
                     RSLSSVEYEPKEKTFDKILIANRGEIACRVIKTCKKMGIKTVAIHSDVDASSVHVKMA
                     DEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFAKRLAAEDVTFI
                     GPDTHAIQAMGDKIESKLLAKRAKVNTIPGFDGVVKDADEAVRIAREIGYPVMIKASA
                     GGGGKGMRIAWDDEETRDGFRFSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHG
                     NALWLNERECSIQRRNQKVVEEAPSIFLDPETRQAMGEQAVALAKAVKYSSAGTVEFL
                     VDSQKNFYFLEMNTRLQVEHPVTECITGLDLVQEMILVAKGYPLRHKQEDIPISGWAV
                     ECRVYAEDPYKSFGLPSIGRLSQYQEPIHLPGVRVDSGIQPGSDISIYYDPMISKLVT
                     YGSDRAEALKRMEDALDNYVIRGVTHNIPLLREVIINTRFVKGDISTKFLSDVYPDGF
                     KGHTLTLSERNQLLAIASSVFVASQLRAQRFQEHSRVPVIRPDVAKWELSVKLHDEDH
                     TVVASNNGPAFTVEVDGSKLNVTSTWNLASPLLSVNVDGTQRTVQCLSREAGGNMSIQ
                     FLGTVYKVHILTKLAAELNKFMLEKVPKDTSSTLCSPMPGVVVAVSVKPGDMVAEGQE
                     ICVIEAMKMQNSMTAGKMGKVKLVHCKAGDTVGEGDLLVELE"
     exon            133..210
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            211..258
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            259..327
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            328..441
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            442..495
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            496..627
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            628..664
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            665..743
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            744..846
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            847..941
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1092
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1236
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1311
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1380
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1456
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1567
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1670
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1773
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1872
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1926
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2067
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2145
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2603
                     /gene="Pcca"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgagaggt cagcagccgg caagtctgcg gggtggacga tggcggggca gtgggtcagg
       61 accgtggcgc tgttggcggc caggcggcat tggcggcggt cctcgcagca gcaattgctg
      121 gggacgctga agcatgctcc agtctattca taccaatgcc tagtggtgtc cagaagtctc
      181 agttctgtgg aatatgagcc taaagaaaag acttttgata aaattctcat tgctaacaga
      241 ggagaaattg cctgtagggt tattaaaact tgcaagaaga tgggcatcaa gacagttgcc
      301 attcacagtg atgttgatgc cagttctgtt cacgtgaaaa tggcggatga ggctgtctgt
      361 gttggcccag ctcccaccag taaaagctac ctcaacatgg atgccatcat ggaagccatt
      421 aagaaaacca gggcccaagc tgtacaccca gggtatggat tcctgtcaga aaacaaagag
      481 tttgcaaagc gtctggcagc agaagatgtc actttcattg gacctgatac tcatgctatt
      541 caagccatgg gtgacaagat agaaagcaaa ctattagcca agagagcaaa ggtcaacaca
      601 atccctggtt ttgatggggt agtaaaggat gcagatgaag ctgtcagaat tgcaagggaa
      661 attggctacc ctgtgatgat caaggcctca gcaggcggtg gtgggaaagg catgcgcatc
      721 gcctgggatg acgaagagac cagggatggc tttagatttt catcccagga agctgcttct
      781 agttttggtg atgatagact actaatagaa aaatttatcg ataaccctcg tcatatagaa
      841 atccaggttt taggggataa acatggcaat gctctgtggc tcaatgagag ggagtgctcg
      901 atccagagaa ggaaccagaa ggtggtagag gaggcgccaa gcatttttct ggatcctgaa
      961 actcgccaag caatgggaga gcaggccgtg gctttggcta aagccgtgaa gtattcttct
     1021 gctggaactg tggaatttct tgtggactcc cagaagaatt tttacttctt ggagatgaat
     1081 acaagactac aggtcgaaca tcctgtcaca gagtgcatta ctggcctgga cttagtccaa
     1141 gaaatgatcc ttgttgctaa gggttaccca ctcaggcaca agcaagagga tattcccatc
     1201 agtggctggg cagttgaatg tcgggtttat gctgaggacc cctacaagtc tttcggttta
     1261 ccgtctattg ggaggctgtc ccagtaccaa gagccgatac atctacctgg tgtccgagtt
     1321 gacagtggca tccaaccagg aagtgacatc agcatctatt atgatcctat gatttcaaag
     1381 ctagtcacat atgggtctga cagagcagaa gccctgaaga ggatggaaga cgcactggac
     1441 aattatgtga tccggggtgt tacacacaac atcccattgc tccgggaggt gataatcaac
     1501 acacgttttg tgaaaggaga catcagcact aagtttctct ctgatgtgta tcctgatggc
     1561 ttcaaagggc acacgttaac actgagtgag agaaaccagt tattggccat tgcatcatct
     1621 gtatttgtgg catcccagct acgagctcag cgcttccaag aacattcaag agtaccagtt
     1681 attaggcctg atgtggctaa gtgggagctc tcggtaaagt tacatgatga agatcatact
     1741 gtcgtggcat ctaacaatgg gccggcattt accgtggaag ttgatggctc gaaactaaat
     1801 gtgaccagta cgtggaacct ggcgtcaccc ttattgtctg tcaacgttga tggcacgcag
     1861 aggactgtgc agtgtctttc tcgggaagca ggtggaaaca tgagcatcca gtttcttggc
     1921 acagtgtaca aagtgcacat tttaaccaag cttgctgcag agctgaacaa attcatgctt
     1981 gaaaaagtgc ccaaggacac cagcagcact ctgtgctccc cgatgcctgg agtggtggtg
     2041 gccgtttctg tcaagcctgg agacatggta gcagaaggtc aggaaatctg tgtgattgaa
     2101 gctatgaaaa tgcagaacag tatgacagct gggaaaatgg gcaaggtgaa attggtgcac
     2161 tgcaaagctg gagacacagt tggtgaagga gacctgcttg tggagctgga atgaagtatt
     2221 tctagccttt ccgtcagcac tgctcactgc tttaactggc gtctccatta ttctctaacc
     2281 ctcaatttgc gcaagcattt acaggagcac tcctgtgcag gaggttctac agcctcctgt
     2341 ttattcctca gaagaggcaa aaccgacatt ctgccaacaa atcaccaatg gaaattcttg
     2401 atataaatac ttgtacatat gatttgtact tctgctgaga tttcctagtg tcaaaattaa
     2461 atcaataaaa ccaagcattt gtctaaatat tagtttgccc ttttttccga atgaagacaa
     2521 tatacacaga ggcgacaggc tgtgccaatt gactgtaaat attagcattt cattgtgatt
     2581 ctttaaaaat ttatataaat tcc
//
