LOCUS       NM_021567               2099 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus poly(rC) binding protein 4 (Pcbp4), mRNA.
ACCESSION   NM_021567 XM_975004
VERSION     NM_021567.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2099)
  AUTHORS   Rutledge,E.A., Benazet,J.D. and McMahon,A.P.
  TITLE     Cellular heterogeneity in the ureteric progenitor niche and
            distinct profiles of branching morphogenesis in organ development
  JOURNAL   Development 144 (17), 3177-3188 (2017)
   PUBMED   28705898
REFERENCE   2  (bases 1 to 2099)
  AUTHORS   Yan,W., Scoumanne,A., Jung,Y.S., Xu,E., Zhang,J., Zhang,Y., Ren,C.,
            Sun,P. and Chen,X.
  TITLE     Mice deficient in poly(C)-binding protein 4 are susceptible to
            spontaneous tumors through increased expression of ZFP871 that
            targets p53 for degradation
  JOURNAL   Genes Dev 30 (5), 522-534 (2016)
   PUBMED   26915821
  REMARK    GeneRIF: the p53-PCBP4-ZFP871 axis represents a novel feedback loop
            in the p53 pathway.
REFERENCE   3  (bases 1 to 2099)
  AUTHORS   Zheng,S., Damoiseaux,R., Chen,L. and Black,D.L.
  TITLE     A broadly applicable high-throughput screening strategy identifies
            new regulators of Dlg4 (Psd-95) alternative splicing
  JOURNAL   Genome Res 23 (6), 998-1007 (2013)
   PUBMED   23636947
REFERENCE   4  (bases 1 to 2099)
  AUTHORS   Scoumanne,A., Cho,S.J., Zhang,J. and Chen,X.
  TITLE     The cyclin-dependent kinase inhibitor p21 is regulated by
            RNA-binding protein PCBP4 via mRNA stability
  JOURNAL   Nucleic Acids Res 39 (1), 213-224 (2011)
   PUBMED   20817677
REFERENCE   5  (bases 1 to 2099)
  AUTHORS   Makeyev,A.V. and Liebhaber,S.A.
  TITLE     Identification of two novel mammalian genes establishes a subfamily
            of KH-domain RNA-binding proteins
  JOURNAL   Genomics 67 (3), 301-316 (2000)
   PUBMED   10936052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ162439.1, CJ174803.1, AK005383.1, AK077632.1 and CA321789.1.
            
            On Dec 8, 2011 this sequence version replaced NM_021567.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF176328.1, AK082005.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 CJ162439.1         1-8
            9-372               CJ174803.1         4-367
            373-1157            AK005383.1         322-1106
            1158-2034           AK077632.1         1108-1984
            2035-2099           CA321789.1         222-286
FEATURES             Location/Qualifiers
     source          1..2099
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 57.54 cM"
     gene            1..2099
                     /gene="Pcbp4"
                     /gene_synonym="1200003L19Rik; AlphaCP-4"
                     /note="poly(rC) binding protein 4"
                     /db_xref="GeneID:59092"
                     /db_xref="MGI:MGI:1890471"
     exon            1..170
                     /gene="Pcbp4"
                     /gene_synonym="1200003L19Rik; AlphaCP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            171..315
                     /gene="Pcbp4"
                     /gene_synonym="1200003L19Rik; AlphaCP-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..1446
                     /gene="Pcbp4"
                     /gene_synonym="1200003L19Rik; AlphaCP-4"
                     /note="alpha-CP4"
                     /codon_start=1
                     /product="poly(rC)-binding protein 4"
                     /protein_id="NP_067542.3"
                     /db_xref="CCDS:CCDS23479.1"
                     /db_xref="GeneID:59092"
                     /db_xref="MGI:MGI:1890471"
                     /translation="MSSSDAGLEEGPELSITLTLRMLMHGKEVGSIIGKKGETVKRIR
                     EQSSARITISEGSCPERITTITGSTAAVFHAVSMIAFKLDEDLCAAPANGGSVSRPPV
                     TLRLVIPASQCGSLIGKAGTKIKEIRETTGAQVQVAGDLLPNSTERAVTVSGVPDAII
                     LCVRQICAVILESPPKGATIPYHPSLSLGTVLLSANQGFSVQGQYGAVTPAEVTKLQQ
                     LSGHAVPFASPSVVPGLDPSTQTSSQEFLVPNDLIGCVIGRQGSKISEIRQMSGAHIK
                     IGNQAEGAGERHVTITGSPVSIALAQYLITACLETAKSTSGGTPGSAPADLPTPFSPP
                     LTALPTAPPGLLGTPYAISLSNFIGLKPVPFLALPPASPGPPPGLAAYTAKMAAANGS
                     KKAERQKFSPY"
     exon            316..339
                     /gene="Pcbp4"
                     /gene_synonym="1200003L19Rik; AlphaCP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            340..372
                     /gene="Pcbp4"
                     /gene_synonym="1200003L19Rik; AlphaCP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            373..489
                     /gene="Pcbp4"
                     /gene_synonym="1200003L19Rik; AlphaCP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            490..621
                     /gene="Pcbp4"
                     /gene_synonym="1200003L19Rik; AlphaCP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            622..750
                     /gene="Pcbp4"
                     /gene_synonym="1200003L19Rik; AlphaCP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            751..825
                     /gene="Pcbp4"
                     /gene_synonym="1200003L19Rik; AlphaCP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            826..870
                     /gene="Pcbp4"
                     /gene_synonym="1200003L19Rik; AlphaCP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            871..934
                     /gene="Pcbp4"
                     /gene_synonym="1200003L19Rik; AlphaCP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            935..987
                     /gene="Pcbp4"
                     /gene_synonym="1200003L19Rik; AlphaCP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1157
                     /gene="Pcbp4"
                     /gene_synonym="1200003L19Rik; AlphaCP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..2039
                     /gene="Pcbp4"
                     /gene_synonym="1200003L19Rik; AlphaCP-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2015..2020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcbp4"
                     /gene_synonym="1200003L19Rik; AlphaCP-4"
                     /note="hexamer: AATAAA"
     polyA_site      2039
                     /gene="Pcbp4"
                     /gene_synonym="1200003L19Rik; AlphaCP-4"
                     /note="major polyA site"
ORIGIN      
        1 gggtgggggg gcgcggagcc gggctccggg ccggccgggc tccgcgcctg tcaaacccct
       61 cattgttcgc agctgatgtc actcgcagtt gtgagcggcc gcctttcccg gggacaatgt
      121 gggactgagc ggcccagccg ctgccgccgc cgcagaacag ccccagcgag agctagctga
      181 gccacagtgt ggacacactc ccaggccgct gcggccccag ccccgcctga caggatgagc
      241 agttcagatg cggggctgga ggaggggccc gagcttagta tcaccctcac cctgcggatg
      301 ctgatgcacg ggaaggaagt gggcagcatc attgggaaga agggagagac tgtaaagcga
      361 atccgggaac agagcagtgc ccggatcacc atctcggagg gctcctgccc cgagcgaatc
      421 accaccatca caggctctac ggctgccgtc ttccacgcgg tctccatgat tgccttcaag
      481 ctggatgagg acctttgtgc tgctcctgca aatggtggca gtgtctccag acctccagtg
      541 accttgcgcc ttgtcatccc tgccagccag tgtggatcac tgattgggaa ggcaggcacc
      601 aaaatcaagg agatccgaga gactacagga gcccaggtgc aggtggcagg ggacctgctc
      661 ccaaattcca cagagcgtgc tgtcactgtg tccggggtgc ctgacgccat catcctgtgt
      721 gtgcgccaga tctgtgctgt tattctggag tccccaccca aaggagccac aatcccgtat
      781 catccgagcc tctccctagg tactgtcctc ctctcggcca accagggttt ctctgtccag
      841 ggtcagtatg gagcagtgac ccctgcagag gtcaccaagc tccagcagct ctcaggccac
      901 gccgttccct ttgcatcacc cagtgtggtg ccaggactgg atcccagcac acagaccagc
      961 tcacaggagt ttctggttcc caatgatctg attggctgtg tgatcggacg ccagggcagc
     1021 aagatcagcg agatccggca gatgtcgggg gcacatatta agatcgggaa ccaagcggag
     1081 ggtgctgggg agcggcatgt gaccatcact ggctcaccgg tctccatcgc cctggctcag
     1141 tacctcatca ctgcctgtct agagacggcc aagtctacct ctggggggac gcctggctca
     1201 gcccccgcag acctgcccac ccctttctcg ccacccctga cggccctgcc cacagctccc
     1261 ccaggcctgc tgggcacacc ttatgccatc tccctctcca acttcatcgg cctcaagcct
     1321 gtgcccttcc tggctctacc acctgcttcc ccagggccac cgccgggctt ggcggcctac
     1381 actgccaaga tggcagcggc caatgggagc aagaaagctg aacggcagaa attctccccc
     1441 tactgaggcc ggccggctga ggcaccggca ggggcaggca ggaccgccgg caggggctgc
     1501 ctccacatcc ttcctgccca aggagactcc accatggggt ctcaagcgcc agtaatgcca
     1561 gacgcatgga tgcaccccct accctgcccc atctttggag atcctcctct gagaggggac
     1621 agtttctggc ccagggttct aggagtatgg cagccccagg gcaggggccc cacctctaca
     1681 gacctatgct tggatgcaga gaatggccag gggctctctg gagccctgct gtgggagggg
     1741 ttactcatgt cccctccatc cctttgggct tcatcctgct gtcccagtgg gaattggagg
     1801 agagtgaggg gcggccaggg ccaagcttct cctcatcccc tgtagatcct gctgcttcta
     1861 ctgataccct tttgactgga atagactggc tgggcttgtc cgggggaggg caacccaaag
     1921 agagggctct gcctgcctgt aggtgtggcc tggggggcag gggcccagtc tcagcagcag
     1981 acactctgta cagttttttc aatccctgtt tttgaataaa tattctcagc gaccagaaaa
     2041 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
