LOCUS       NM_021568               2175 bp    mRNA    linear   ROD 15-APR-2024
DEFINITION  Mus musculus poly(rC) binding protein 3 (Pcbp3), transcript variant
            1, mRNA.
ACCESSION   NM_021568
VERSION     NM_021568.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2175)
  AUTHORS   Kang,D.H., Song,K.Y., Choi,H.S., Law,P.Y., Wei,L.N. and Loh,H.H.
  TITLE     Novel dual-binding function of a poly (C)-binding protein 3,
            transcriptional factor which binds the double-strand and
            single-stranded DNA sequence
  JOURNAL   Gene 501 (1), 33-38 (2012)
   PUBMED   22521865
  REMARK    GeneRIF: This study demonstrates for the first time that PCBP3 can
            function as a repressor dependent on binding to single-strand and
            double-stranded poly(C) sequences.
REFERENCE   2  (bases 1 to 2175)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   3  (bases 1 to 2175)
  AUTHORS   Choi,H.S., Kim,C.S., Hwang,C.K., Song,K.Y., Law,P.Y., Wei,L.N. and
            Loh,H.H.
  TITLE     Novel function of the poly(C)-binding protein alpha CP3 as a
            transcriptional repressor of the mu opioid receptor gene
  JOURNAL   FASEB J 21 (14), 3963-3973 (2007)
   PUBMED   17625070
  REMARK    GeneRIF: Represses mu opioid receptor gene promoter at the
            transcriptional level.
REFERENCE   4  (bases 1 to 2175)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2175)
  AUTHORS   Hirano,M. and Noda,T.
  TITLE     Genomic organization of the mouse Msh4 gene producing bicistronic,
            chimeric and antisense mRNA
  JOURNAL   Gene 342 (1), 165-177 (2004)
   PUBMED   15527976
REFERENCE   6  (bases 1 to 2175)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 2175)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2175)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   9  (bases 1 to 2175)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   10 (bases 1 to 2175)
  AUTHORS   Makeyev,A.V. and Liebhaber,S.A.
  TITLE     Identification of two novel mammalian genes establishes a subfamily
            of KH-domain RNA-binding proteins
  JOURNAL   Genomics 67 (3), 301-316 (2000)
   PUBMED   10936052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY275026.1, BY277145.1, AK079564.1 and BB267036.2.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_021568.3.
            
            On Apr 2, 2008 this sequence version replaced NM_021568.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF176327.1, SRR7652917.1293120.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-385               BY275026.1         1-385
            386-432             BY277145.1         386-432
            433-2170            AK079564.1         475-2212
            2171-2175           BB267036.2         673-677
FEATURES             Location/Qualifiers
     source          1..2175
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2175
                     /gene="Pcbp3"
                     /gene_synonym="AlphaCP-3"
                     /note="poly(rC) binding protein 3"
                     /db_xref="GeneID:59093"
                     /db_xref="MGI:MGI:1890470"
     exon            1..200
                     /gene="Pcbp3"
                     /gene_synonym="AlphaCP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            201..300
                     /gene="Pcbp3"
                     /gene_synonym="AlphaCP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            301..433
                     /gene="Pcbp3"
                     /gene_synonym="AlphaCP-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             424..1539
                     /gene="Pcbp3"
                     /gene_synonym="AlphaCP-3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     alpha-CP3"
                     /codon_start=1
                     /product="poly(rC)-binding protein 3 isoform 1"
                     /protein_id="NP_067543.2"
                     /db_xref="CCDS:CCDS35946.2"
                     /db_xref="GeneID:59093"
                     /db_xref="MGI:MGI:1890470"
                     /translation="MGEGDAIWAPPILPHSTLGTLSHHPELHFGGKMESKVSEGGLNV
                     TLTIRLLMHGKEVGSIIGKKGETVKKMREESGARINISEGNCPERIVTITGPTDAIFK
                     AFAMIAYKFEEDIINSMSNSPATSKPPVTLRLVVPASQCGSLIGKGGSKIKEIRESTG
                     AQVQVAGDMLPNSTERAVTISGTPDAIIQCVKQICVVMLESPPKGATIPYRPKPASTP
                     VIFAGGQAYTIQGQYAIPHPDQLTKLHQLAMQQTPFPPLGQTNPAFPGEKLPLHSSEE
                     AQNLMGQSSGLDASPPASTHELTIPNDLIGCIIGRQGTKINEIRQMSGAQIKIANATE
                     GSSERQITITGTPANISLAQYLINARLTSEVTGMGAL"
     exon            434..588
                     /gene="Pcbp3"
                     /gene_synonym="AlphaCP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            589..612
                     /gene="Pcbp3"
                     /gene_synonym="AlphaCP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            613..645
                     /gene="Pcbp3"
                     /gene_synonym="AlphaCP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            646..762
                     /gene="Pcbp3"
                     /gene_synonym="AlphaCP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            763..894
                     /gene="Pcbp3"
                     /gene_synonym="AlphaCP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1023
                     /gene="Pcbp3"
                     /gene_synonym="AlphaCP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1098
                     /gene="Pcbp3"
                     /gene_synonym="AlphaCP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1140
                     /gene="Pcbp3"
                     /gene_synonym="AlphaCP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1219
                     /gene="Pcbp3"
                     /gene_synonym="AlphaCP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1279
                     /gene="Pcbp3"
                     /gene_synonym="AlphaCP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1332
                     /gene="Pcbp3"
                     /gene_synonym="AlphaCP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1502
                     /gene="Pcbp3"
                     /gene_synonym="AlphaCP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..2175
                     /gene="Pcbp3"
                     /gene_synonym="AlphaCP-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2150..2155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcbp3"
                     /gene_synonym="AlphaCP-3"
                     /note="putative"
ORIGIN      
        1 ggagggggcg ggtcctcgcc gcgcgcagtg cttcggccag agctcgaggc gctgcttacc
       61 gtcgcctgag ctaggagacg ccgcggccgc cgctgggtcg catcgggctt cgcgtcgcgc
      121 cgtgtacgcc tcctctgccc cacccgaccg gcagcatagg ctctacctgg tccgcggcct
      181 ccctgtccgc ggcggggcag gtggttttcc tgcggtgaac tcctgccctg ccttccggta
      241 gctggctcgt ggctcccaac tctgagctct cggtgaacct gggaagggga tgagaacagg
      301 gtaggtgagc tccagccaag ccagccctgc cagagacctt cagtttcggt ggctggtgct
      361 ctgagccaca gtgcgcttca gcatttggat ctatgggcct gctttgaacc atagagcctg
      421 cctatggggg aaggtgacgc catctgggcc ccacccatcc ttcctcacag caccctcggc
      481 accttaagcc accaccctga gctacatttt ggagggaaga tggaatctaa ggtctcggaa
      541 ggtggcctga acgtaaccct gaccatccgc ctactgatgc atggaaagga agttggaagc
      601 atcatcggga agaaaggaga aacagtaaag aagatgcgtg aagagagtgg cgccaggatc
      661 aacatctcag agggaaactg cccagagaga atcgttacaa tcacaggccc aactgacgcc
      721 atcttcaagg cctttgctat gatcgcgtac aagtttgagg aggacatcat taattccatg
      781 agcaacagcc ctgccaccag caagcctcca gtgacactgc gactagtggt ccctgccagc
      841 cagtgtgggt ccctgatcgg caaaggtggc tccaagatca aggagatccg ggagtccaca
      901 ggtgctcagg tccaggtggc aggtgacatg ctgcccaact ccacagagcg ggcagtgact
      961 atctcaggga ccccagacgc catcatccag tgtgtgaaac agatctgtgt ggtcatgctg
     1021 gagtccccac cgaaaggtgc caccattccc taccgcccaa agcccgcctc cacccctgtc
     1081 atttttgcag gtggtcaggc ctacacaatc cagggacagt acgccatccc ccacccagat
     1141 cagttgacca agctccacca gttggccatg cagcaaaccc cctttcctcc cctcggacag
     1201 accaaccccg ctttccccgg agaaaagctg cctttacact cctccgaaga agctcaaaat
     1261 ctgatgggcc agtcgtcagg tctggatgcc agcccaccgg ccagcactca tgagctcacc
     1321 attcccaatg atcttatagg ctgcataatt ggacgccaag gcaccaaaat caatgaaatc
     1381 cgacagatgt ctggagctca gatcaaaatc gccaatgcca ctgaagggtc gtcagagcgc
     1441 cagattacca tcacagggac cccagccaac atcagccttg cccagtatct catcaacgct
     1501 aggctgacgt ctgaggtcac cgggatgggt gcactctaac ctacccaagg tcctccactg
     1561 cacacatcgg atggctccag cccgcagcct caccagctgg cacactgtac agactgcctg
     1621 tccttccttg cagatatgaa tagagcgttt tctttacaaa cagatgatag tgcgtgtctg
     1681 cccactcagg ccctgtgcgc tccgtgttag tgtagccctc cacgcattgg catgcagctc
     1741 tttactttac tgctcaacgt attcccaaat gtgatgtttc agagatttat tcctcagtat
     1801 ccatgtgact gtctgtttaa aagttggttt gatgctttaa cagcacttcc tatgtcctgc
     1861 tgtcccttgt tctcagagac cctcctctct cacccagtct actgactcat ttccgcccta
     1921 ggttgtatgc agggatcaga ggtactttta ttgcaacctg cagggagtgt ctggaagagg
     1981 agggacttgg gggtgtatct aaggagcagg gtagagtgcc agagggtggg gtgggaccct
     2041 gacttcactg ggatatctcg gggagggggc acttgtgccc tccaggtgtc ttccaagatg
     2101 gctaagaaca aggacttgcc agaaagttca tctgcaccca tcagagttta ataaatgtcg
     2161 tgttcctccc ccatg
//
