LOCUS       NM_001411550            2184 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus poly(rC) binding protein 2 (Pcbp2), transcript variant
            18, mRNA.
ACCESSION   NM_001411550 XM_011245498
VERSION     NM_001411550.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2184)
  AUTHORS   Martinelli,M., Aguilar,G., Lee,D.S.M., Kromer,A., Nguyen,N.,
            Wilkins,B.J., Akimova,T., Beier,U.H. and Ghanem,L.R.
  TITLE     The poly(C)-binding protein Pcbp2 is essential for CD4+ T cell
            activation and proliferation
  JOURNAL   iScience 26 (1), 105860 (2022)
   PUBMED   36632062
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2184)
  AUTHORS   Ghosh,G., Samui,S., Das,S., Singh,V., Pal,D., Das,S., Naskar,J.,
            Sinha Roy,S. and Basu,U.
  TITLE     Poly C Binding Protein 2 dependent nuclear retention of the
            utrophin-A mRNA in C2C12 cells
  JOURNAL   RNA Biol 18 (sup2), 612-622 (2021)
   PUBMED   34904931
  REMARK    GeneRIF: Poly C Binding Protein 2 dependent nuclear retention of
            the utrophin-A mRNA in C2C12 cells.
REFERENCE   3  (bases 1 to 2184)
  AUTHORS   Ji,X., Jha,A., Humenik,J., Ghanem,L.R., Kromer,A., Duncan-Lewis,C.,
            Traxler,E., Weiss,M.J., Barash,Y. and Liebhaber,S.A.
  TITLE     RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of
            Murine Erythropoiesis
  JOURNAL   Mol Cell Biol 41 (9), e0066820 (2021)
   PUBMED   34180713
  REMARK    GeneRIF: RNA-Binding Proteins PCBP1 and PCBP2 Are Critical
            Determinants of Murine Erythropoiesis.
REFERENCE   4  (bases 1 to 2184)
  AUTHORS   Mosleh,E., Ou,K., Haemmerle,M.W., Tembo,T., Yuhas,A.,
            Carboneau,B.A., Townsend,S.E., Bosma,K.J., Gannon,M., O'Brien,R.M.,
            Stoffers,D.A. and Golson,M.L.
  TITLE     Ins1-Cre and Ins1-CreER Gene Replacement Alleles Are Susceptible To
            Silencing By DNA Hypermethylation
  JOURNAL   Endocrinology 161 (8) (2020)
   PUBMED   32267917
REFERENCE   5  (bases 1 to 2184)
  AUTHORS   Yabe-Wada,T., Philpott,C.C. and Onai,N.
  TITLE     PCBP2 post-transcriptionally regulates sortilin expression by
            binding to a C-rich element in its 3' UTR
  JOURNAL   FEBS Open Bio 10 (3), 407-413 (2020)
   PUBMED   31961070
  REMARK    GeneRIF: PCBP2 post-transcriptionally regulates sortilin expression
            by binding to a C-rich element in its 3' UTR.
REFERENCE   6  (bases 1 to 2184)
  AUTHORS   Makeyev,A.V., Chkheidze,A.N. and Liebhaber,S.A.
  TITLE     A set of highly conserved RNA-binding proteins, alphaCP-1 and
            alphaCP-2, implicated in mRNA stabilization, are coexpressed from
            an intronless gene and its intron-containing paralog
  JOURNAL   J Biol Chem 274 (35), 24849-24857 (1999)
   PUBMED   10455157
REFERENCE   7  (bases 1 to 2184)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   8  (bases 1 to 2184)
  AUTHORS   Funke,B., Zuleger,B., Benavente,R., Schuster,T., Goller,M.,
            Stevenin,J. and Horak,I.
  TITLE     The mouse poly(C)-binding protein exists in multiple isoforms and
            interacts with several RNA-binding proteins
  JOURNAL   Nucleic Acids Res 24 (19), 3821-3828 (1996)
   PUBMED   8871564
REFERENCE   9  (bases 1 to 2184)
  AUTHORS   Goller,M., Funke,B., Gehe-Becker,C., Kroger,B., Lottspeich,F. and
            Horak,I.
  TITLE     Murine protein which binds preferentially to oligo-C-rich
            single-stranded nucleic acids
  JOURNAL   Nucleic Acids Res 22 (10), 1885-1889 (1994)
   PUBMED   8208614
REFERENCE   10 (bases 1 to 2184)
  AUTHORS   Hahm,K., Kim,G., Turck,C.W. and Smale,S.T.
  TITLE     Isolation of a murine gene encoding a nucleic acid-binding protein
            with homology to hnRNP K
  JOURNAL   Nucleic Acids Res 21 (16), 3894 (1993)
   PUBMED   8367306
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137156.3.
            
            On Aug 26, 2022 this sequence version replaced XM_011245498.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3688091.1,
                                           SRR13422600.927393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               AC137156.3         126957-127221
            266-407             AC137156.3         129679-129820
            408-431             AC137156.3         130549-130572
            432-464             AC137156.3         130665-130697
            465-581             AC137156.3         130993-131109
            582-713             AC137156.3         135034-135165
            714-842             AC137156.3         139578-139706
            843-917             AC137156.3         140584-140658
            918-1010            AC137156.3         142366-142458
            1011-1052           AC137156.3         143506-143547
            1053-1125           AC137156.3         144623-144695
            1126-1164           AC137156.3         145194-145232
            1165-1220           AC137156.3         146170-146225
            1221-1390           AC137156.3         147052-147221
            1391-2184           AC137156.3         150079-150872
FEATURES             Location/Qualifiers
     source          1..2184
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.61 cM"
     gene            1..2184
                     /gene="Pcbp2"
                     /gene_synonym="alphaCP-2; Hnrpx"
                     /note="poly(rC) binding protein 2"
                     /db_xref="GeneID:18521"
                     /db_xref="MGI:MGI:108202"
     exon            1..265
                     /gene="Pcbp2"
                     /gene_synonym="alphaCP-2; Hnrpx"
                     /inference="alignment:Splign:2.1.0"
     exon            266..407
                     /gene="Pcbp2"
                     /gene_synonym="alphaCP-2; Hnrpx"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..1742
                     /gene="Pcbp2"
                     /gene_synonym="alphaCP-2; Hnrpx"
                     /note="isoform 11 is encoded by transcript variant 18;
                     CBP; CTBP; hnRNP X; alpha-CP2; putative heterogeneous
                     nuclear ribonucleoprotein X"
                     /codon_start=1
                     /product="poly(rC)-binding protein 2 isoform 11"
                     /protein_id="NP_001398479.1"
                     /db_xref="GeneID:18521"
                     /db_xref="MGI:MGI:108202"
                     /translation="MDTGVIEGGLNVTLTIRLLMHGKEVGSIIGKKGESVKKMREESG
                     ARINISEGNCPERIITLAGPTNAIFKAFAMIIDKLEEDISSSMTNSTAASRPPVTLRL
                     VVPASQCGSLIGKGGCKIKEIRESTGAQVQVAGDMLPNSTERAITIAGIPQSIIECVK
                     QICVVMLESPPKGVTIPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDL
                     EGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIESSSPEVKGYWA
                     GLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTI
                     TGSAASISLAQYLINVSLENAKPSSQAASVTIPDHLSINLSQPSTPSSSSSSSTTTPS
                     LATAGTSDAPSSLPNPLPTAPCVSSLLGMKPIPLLALNVVSAAKGTGASATTTTTSTV
                     PCVTNKLKGEKQRFSPY"
     exon            408..431
                     /gene="Pcbp2"
                     /gene_synonym="alphaCP-2; Hnrpx"
                     /inference="alignment:Splign:2.1.0"
     exon            432..464
                     /gene="Pcbp2"
                     /gene_synonym="alphaCP-2; Hnrpx"
                     /inference="alignment:Splign:2.1.0"
     exon            465..581
                     /gene="Pcbp2"
                     /gene_synonym="alphaCP-2; Hnrpx"
                     /inference="alignment:Splign:2.1.0"
     exon            582..713
                     /gene="Pcbp2"
                     /gene_synonym="alphaCP-2; Hnrpx"
                     /inference="alignment:Splign:2.1.0"
     exon            714..842
                     /gene="Pcbp2"
                     /gene_synonym="alphaCP-2; Hnrpx"
                     /inference="alignment:Splign:2.1.0"
     exon            843..917
                     /gene="Pcbp2"
                     /gene_synonym="alphaCP-2; Hnrpx"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1010
                     /gene="Pcbp2"
                     /gene_synonym="alphaCP-2; Hnrpx"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1052
                     /gene="Pcbp2"
                     /gene_synonym="alphaCP-2; Hnrpx"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1125
                     /gene="Pcbp2"
                     /gene_synonym="alphaCP-2; Hnrpx"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1164
                     /gene="Pcbp2"
                     /gene_synonym="alphaCP-2; Hnrpx"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1220
                     /gene="Pcbp2"
                     /gene_synonym="alphaCP-2; Hnrpx"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1390
                     /gene="Pcbp2"
                     /gene_synonym="alphaCP-2; Hnrpx"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..2184
                     /gene="Pcbp2"
                     /gene_synonym="alphaCP-2; Hnrpx"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2054..2059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcbp2"
                     /gene_synonym="alphaCP-2; Hnrpx"
                     /note="hexamer: AATAAA"
     polyA_site      2072
                     /gene="Pcbp2"
                     /gene_synonym="alphaCP-2; Hnrpx"
                     /note="major polyA site"
     regulatory      2158..2163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcbp2"
                     /gene_synonym="alphaCP-2; Hnrpx"
                     /note="hexamer: AATAAA"
     polyA_site      2184
                     /gene="Pcbp2"
                     /gene_synonym="alphaCP-2; Hnrpx"
ORIGIN      
        1 cccagaccag cagaggcagc agccggagca gccgcagcct gcgccctctc ccgcccgccc
       61 gccctccgcc cgcccgcccg ccctccgccg ccctccaccc gccccggggt ctctctcccc
      121 cttcctcctc ctcacccccc cctcctccgc ccgctagcgg ggcccccctc gccttcccgc
      181 ccgcccctat tgttccgccc ccggcctccc gcccttcccc ttcccgcccg ctcccctttt
      241 cccctcagtc gactcgcgcc tccagttttt ggctttcact cttcaccagt gaccaaagac
      301 ttgaccactc aaagtccagc tccctgtaac tgctagacat ggacaccggt gtgattgaag
      361 gtggattaaa tgtcactctc accatcaggc tacttatgca tggaaaggaa gttggcagta
      421 tcatcggaaa gaaaggagaa tctgttaaga agatgcgcga ggagagtggt gcacgtatca
      481 acatctcaga agggaattgt cctgagagaa ttatcacttt ggctggaccg actaatgcca
      541 tcttcaaagc ctttgctatg atcattgaca aactggaaga ggacataagc agctctatga
      601 ccaatagtac agctgccagt agacccccgg ttaccttacg gctggtggtt cctgctagtc
      661 agtgtggctc tcttattgga aaaggtggtt gcaagatcaa ggaaataaga gagagtacag
      721 gggctcaggt ccaggtggca ggggatatgc tccccaactc aactgagcgg gcaatcacta
      781 ttgctggcat tccgcagtcc atcattgagt gtgtcaaaca gatctgcgtg gtcatgttgg
      841 agtccccccc gaagggcgtg accatcccgt accggcccaa gccctccagt tctccagtca
      901 tctttgcagg tggtcaggac aggtacagca caggcagcga cagtgcgagc tttccccaca
      961 ccaccccgtc catgtgcctc aaccctgacc tggagggacc acctctagag gcctatacca
     1021 ttcaaggaca gtatgccatt ccacagccag atttgaccaa gctgcaccag ttggcaatgc
     1081 aacagtctca ttttcccatg acccatggca acaccggatt cagtggcatt gaatccagct
     1141 ctccagaggt gaaaggctat tgggcaggtt tggatgcatc tgctcaaact acttctcatg
     1201 aactcaccat tccaaatgat ttgattggct gcataatcgg gcgtcaaggc gccaaaatca
     1261 atgagatccg tcagatgtct ggggcgcaga tcaaaattgc aaacccagtg gaaggatcta
     1321 ctgatcggca ggttaccatc actggatctg ctgccagcat tagcctggct cagtatctaa
     1381 tcaatgtcag tttagaaaac gctaaaccct cctcccaggc agcctccgtc acgatccctg
     1441 atcacctcag catcaacctc tctcaaccct ccaccccttc ttcttcttct tcctcttcca
     1501 ccaccacccc ctcgctcgcc acagcgggga cttccgacgc accctccagc ctccccaacc
     1561 ctcttccgac cgccccttgt gtctccagtc tgcttggcat gaaacccatc cctctcctgg
     1621 ctctaaatgt tgtgtctgct gctaagggta ccggggcttc agctaccacc accaccacct
     1681 ctactgtgcc atgtgtaact aacaaactga aaggcgagaa gcagagattc tctccctact
     1741 gagtgcttat cttggcattt cctcaagtgt ttgtttattt tgtttttctt tgttaacatt
     1801 ggtgagaacc aaactattgt gagcttgtga tcattttctt tttactactt tgggggataa
     1861 ctgggtggga atggaaacag gggtaatact tgtttagggt taggtcttca cagctcagtg
     1921 cctgttcaga gtctgacttg ttgattgaaa tctctatcta gagccacagt tcttactctt
     1981 taattctgtt atactttttt gtagctttat tctgccttgc aatataaaaa atgtgttagg
     2041 ctctgtgttg atgaataaaa gcttctcctt tagtcctttc tttttttttt aactttaaat
     2101 catttaatgg ttaaagctgt cagctggact tcttggctga atctgtgttc tagttataat
     2161 aaagttgcca cagtaagaac agta
//
