LOCUS       NM_028281                574 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus pterin 4 alpha carbinolamine dehydratase/dimerization
            cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 (Pcbd2),
            mRNA.
ACCESSION   NM_028281 XM_484264
VERSION     NM_028281.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 574)
  AUTHORS   Thompson,A.C., Capellini,T.D., Guenther,C.A., Chan,Y.F.,
            Infante,C.R., Menke,D.B. and Kingsley,D.M.
  TITLE     A novel enhancer near the Pitx1 gene influences development and
            evolution of pelvic appendages in vertebrates
  JOURNAL   Elife 7, e38555 (2018)
   PUBMED   30499775
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 574)
  AUTHORS   Kazgan,N., Metukuri,M.R., Purushotham,A., Lu,J., Rao,A., Lee,S.,
            Pratt-Hyatt,M., Lickteig,A., Csanaky,I.L., Zhao,Y., Dawson,P.A. and
            Li,X.
  TITLE     Intestine-specific deletion of SIRT1 in mice impairs
            DCoH2-HNF-1alpha-FXR signaling and alters systemic bile acid
            homeostasis
  JOURNAL   Gastroenterology 146 (4), 1006-1016 (2014)
   PUBMED   24389307
  REMARK    GeneRIF: Deletion of intestinal SIRT1 impairs DCoH2-HNF-1alpha-FXR
            signaling and alters systemic bile acid homeostasis.
REFERENCE   3  (bases 1 to 574)
  AUTHORS   Rose,R.B., Pullen,K.E., Bayle,J.H., Crabtree,G.R. and Alber,T.
  TITLE     Biochemical and structural basis for partially redundant enzymatic
            and transcriptional functions of DCoH and DCoH2
  JOURNAL   Biochemistry 43 (23), 7345-7355 (2004)
   PUBMED   15182178
  REMARK    GeneRIF: HNF1alpha binding kinetics may distinguish regulation by
            DCoH2, under thermodynamic control, from regulation by DCoH, under
            kinetic control
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA013784.1, BY157602.1 and BC028642.1.
            
            On Sep 23, 2004 this sequence version replaced XM_484264.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX523044.1, BY711597.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AA013784.1         3-3
            2-28                BY157602.1         2-28
            29-240              BY157602.1         30-241
            241-574             BC028642.1         197-530
FEATURES             Location/Qualifiers
     source          1..574
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 30.06 cM"
     gene            1..574
                     /gene="Pcbd2"
                     /gene_synonym="2700061N24Rik; Dcoh2; Dcohm"
                     /note="pterin 4 alpha carbinolamine
                     dehydratase/dimerization cofactor of hepatocyte nuclear
                     factor 1 alpha (TCF1) 2"
                     /db_xref="GeneID:72562"
                     /db_xref="MGI:MGI:1919812"
     exon            1..107
                     /gene="Pcbd2"
                     /gene_synonym="2700061N24Rik; Dcoh2; Dcohm"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..416
                     /gene="Pcbd2"
                     /gene_synonym="2700061N24Rik; Dcoh2; Dcohm"
                     /EC_number="4.2.1.96"
                     /note="dimerization cofactor of hepatocyte nuclear factor
                     1 (HNF1) from muscle; PHS 2; dcoH-like protein DCoHm;
                     HNF-1-alpha dimerization cofactor;
                     4-alpha-hydroxy-tetrahydropterin dehydratase 2;
                     dimerization cofactor of hepatocyte nuclear factor 1 from
                     muscle"
                     /codon_start=1
                     /product="pterin-4-alpha-carbinolamine dehydratase 2"
                     /protein_id="NP_082557.1"
                     /db_xref="CCDS:CCDS26554.1"
                     /db_xref="GeneID:72562"
                     /db_xref="MGI:MGI:1919812"
                     /translation="MVAAAAVAVAAVGARSAGRWLAALRSPGASRAAMSSDAQWLTAE
                     ERDQLIPGLKAAGWSELSERDAIYKEFSFKNFNQAFGFMSRVALQAEKMNHHPEWFNV
                     YNKVQITLTSHDCGGLTKRDVKLAQFIEKAAASL"
     exon            108..239
                     /gene="Pcbd2"
                     /gene_synonym="2700061N24Rik; Dcoh2; Dcohm"
                     /inference="alignment:Splign:2.1.0"
     exon            240..320
                     /gene="Pcbd2"
                     /gene_synonym="2700061N24Rik; Dcoh2; Dcohm"
                     /inference="alignment:Splign:2.1.0"
     exon            321..546
                     /gene="Pcbd2"
                     /gene_synonym="2700061N24Rik; Dcoh2; Dcohm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      524..529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcbd2"
                     /gene_synonym="2700061N24Rik; Dcoh2; Dcohm"
                     /note="hexamer: AATACA"
     polyA_site      546
                     /gene="Pcbd2"
                     /gene_synonym="2700061N24Rik; Dcoh2; Dcohm"
                     /note="major polyA site"
ORIGIN      
        1 ggaccatggt ggcggcagcg gcggtggctg tagcggcggt gggagcgcgt agcgcggggc
       61 ggtggctggc ggcgctgcgc agcccgggcg cgagcagggc ggccatgtct tcagatgcac
      121 agtggttgac ggcagaggag agggaccaac ttattcctgg cttgaaagca gcagggtggt
      181 cggaactgag tgagagagat gccatctaca aagagttctc cttcaaaaat ttcaatcagg
      241 cgtttggctt tatgtccagg gttgccctgc aagcagagaa gatgaatcac cacccggaat
      301 ggttcaacgt ctacaacaaa gtccagataa ccctcacctc gcatgactgt ggcggcctga
      361 ccaagcggga tgtgaagttg gcccagttca ttgaaaaagc tgctgcatct ctgtgatctg
      421 cgcctgcctt gtctgcagcg ttgtttgcaa gccacttatg ttaataaatt gtcataaagt
      481 agttcatagt tacatgtata cattgttgta tgattgatgc tcaaatacag aatgatttga
      541 agccaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
