LOCUS       NM_025273                822 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus pterin 4 alpha carbinolamine dehydratase/dimerization
            cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1 (Pcbd1),
            mRNA.
ACCESSION   NM_025273
VERSION     NM_025273.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 822)
  AUTHORS   Abdellatif,A.M., Oishi,H., Itagaki,T., Jung,Y., Shawki,H.H.,
            Okita,Y., Hasegawa,Y., Suzuki,H., El-Morsy,S.E., El-Sayed,M.A.,
            Shoaib,M.B., Sugiyama,F. and Takahashi,S.
  TITLE     beta-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine
            Cell Development
  JOURNAL   PLoS One 11 (2), e0150010 (2016)
   PUBMED   26901059
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 822)
  AUTHORS   Simaite,D., Kofent,J., Gong,M., Ruschendorf,F., Jia,S., Arn,P.,
            Bentler,K., Ellaway,C., Kuhnen,P., Hoffmann,G.F., Blau,N.,
            Spagnoli,F.M., Hubner,N. and Raile,K.
  TITLE     Recessive mutations in PCBD1 cause a new type of early-onset
            diabetes
  JOURNAL   Diabetes 63 (10), 3557-3564 (2014)
   PUBMED   24848070
REFERENCE   3  (bases 1 to 822)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 822)
  AUTHORS   De Angelis,M.T., Russo,F., D'Angelo,F., Federico,A., Gemei,M., Del
            Vecchio,L., Ceccarelli,M., De Felice,M. and Falco,G.
  TITLE     Novel pancreas organogenesis markers refine the pancreatic
            differentiation roadmap of embryonic stem cells
  JOURNAL   Stem Cell Rev Rep 10 (2), 269-279 (2014)
   PUBMED   24390927
REFERENCE   5  (bases 1 to 822)
  AUTHORS   Ogaki,S., Harada,S., Shiraki,N., Kume,K. and Kume,S.
  TITLE     An expression profile analysis of ES cell-derived definitive
            endodermal cells and Pdx1-expressing cells
  JOURNAL   BMC Dev Biol 11, 13 (2011)
   PUBMED   21362171
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 822)
  AUTHORS   Rose,R.B., Pullen,K.E., Bayle,J.H., Crabtree,G.R. and Alber,T.
  TITLE     Biochemical and structural basis for partially redundant enzymatic
            and transcriptional functions of DCoH and DCoH2
  JOURNAL   Biochemistry 43 (23), 7345-7355 (2004)
   PUBMED   15182178
  REMARK    GeneRIF: HNF1alpha binding kinetics may distinguish regulation by
            DCoH2, under thermodynamic control, from regulation by DCoH, under
            kinetic control
REFERENCE   7  (bases 1 to 822)
  AUTHORS   Bayle,J.H., Randazzo,F., Johnen,G., Kaufman,S., Nagy,A., Rossant,J.
            and Crabtree,G.R.
  TITLE     Hyperphenylalaninemia and impaired glucose tolerance in mice
            lacking the bifunctional DCoH gene
  JOURNAL   J Biol Chem 277 (32), 28884-28891 (2002)
   PUBMED   12011081
  REMARK    GeneRIF: DCoH acts as a cofactor for HNF1 that stabilizes the
            dimeric HNF1 complex.
            GeneRIF: Mouse Pcbd1 is a moonlighting protein that has dehydratase
            activity in addition to functioning as a cofactor which regulates
            HNF1alpha.
REFERENCE   8  (bases 1 to 822)
  AUTHORS   Zobeley,E., Sufalko,D.K., Adkins,S. and Burmeister,M.
  TITLE     Fine genetic and comparative mapping of the deafness mutation Ames
            waltzer on mouse chromosome 10
  JOURNAL   Genomics 50 (2), 260-266 (1998)
   PUBMED   9653653
REFERENCE   9  (bases 1 to 822)
  AUTHORS   Milatovich,A., Mendel,D.B., Crabtree,G.R. and Francke,U.
  TITLE     Genes for the dimerization cofactor of hepatocyte nuclear factor-1
            alpha (DCOH) are on human and murine chromosomes 10
  JOURNAL   Genomics 16 (1), 292-295 (1993)
   PUBMED   8486378
REFERENCE   10 (bases 1 to 822)
  AUTHORS   Mendel,D.B., Khavari,P.A., Conley,P.B., Graves,M.K., Hansen,L.P.,
            Admon,A. and Crabtree,G.R.
  TITLE     Characterization of a cofactor that regulates dimerization of a
            mammalian homeodomain protein
  JOURNAL   Science 254 (5039), 1762-1767 (1991)
   PUBMED   1763325
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY116433.1, AK007401.1 and AC153515.8.
            
            On Jan 23, 2014 this sequence version replaced NM_025273.3.
            
            Summary: This gene encodes a member of the
            pterin-4-alpha-carbinolamine dehydratase family. The encoded
            protein has been identified as a moonlighting protein based on its
            ability to perform mechanistically distinct functions. The encoded
            protein functions as both a dehydratase involved in
            tetrahydrobiopterin biosynthesis, and as a cofactor for
            HNF1A-dependent transcription. [provided by RefSeq, Apr 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY707492.1, BC024354.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            multifunctional gene product(s) :: PMID: 12011081
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BY116433.1         1-30
            31-812              AK007401.1         3-784
            813-822             AC153515.8         185837-185846
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.14 cM"
     gene            1..822
                     /gene="Pcbd1"
                     /gene_synonym="Dcoh; Pcbd; Pcd; Phs"
                     /note="pterin 4 alpha carbinolamine
                     dehydratase/dimerization cofactor of hepatocyte nuclear
                     factor 1 alpha (TCF1) 1"
                     /db_xref="GeneID:13180"
                     /db_xref="MGI:MGI:94873"
     exon            1..86
                     /gene="Pcbd1"
                     /gene_synonym="Dcoh; Pcbd; Pcd; Phs"
                     /inference="alignment:Splign:2.1.0"
     exon            87..218
                     /gene="Pcbd1"
                     /gene_synonym="Dcoh; Pcbd; Pcd; Phs"
                     /inference="alignment:Splign:2.1.0"
     exon            219..299
                     /gene="Pcbd1"
                     /gene_synonym="Dcoh; Pcbd; Pcd; Phs"
                     /inference="alignment:Splign:2.1.0"
     exon            300..822
                     /gene="Pcbd1"
                     /gene_synonym="Dcoh; Pcbd; Pcd; Phs"
                     /inference="alignment:Splign:2.1.0"
     regulatory      796..801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcbd1"
                     /gene_synonym="Dcoh; Pcbd; Pcd; Phs"
                     /note="hexamer: AATAAA"
     polyA_site      817
                     /gene="Pcbd1"
                     /gene_synonym="Dcoh; Pcbd; Pcd; Phs"
                     /note="major polyA site"
ORIGIN      
        1 gatctctgcc ccgcccccgc ggtggcctgc tgcttgcccg ctgctctctc cctcgctgcc
       61 gccacctgct tcccgcactg gacatggccg gcaaggcaca caggctgagc gccgaggagc
      121 gagaccagct gctgccaaac ctgagggctg tggggtggaa tgaagtagaa ggccgagatg
      181 ctatcttcaa gcagttccat tttaaagact tcaacagggc ttttggcttc atgacaagag
      241 tagccctgca ggctgaaaag ctggaccacc atcccgagtg gtttaacgtg tacaacaagg
      301 tccatatcac cttgagcacc catgaatgtg ccggtctttc ggaacgggat ataaacctgg
      361 ccagcttcat cgaacaagtc gccgtgtcta tgacatagat ctaccctgac tcttatttgc
      421 ttgggggaag gagtgactgg aggaggaacc taggaaggga accaaggagg ctggcccttg
      481 ctccctgact ctttcagtga ccaccacctc cctatgcaga agggatgtca atgtcaacag
      541 cagggactga gacctttctc tgtgccactc tcctcactgg ggctctgcca tgttacacta
      601 atttgaataa gctctccctt tttctgtaga gttcccagcc tcagtaatgt tccaggctgc
      661 ttcttgttcc ttttctaccc tttctagttc attttccaag gtagctgtga taaagcatga
      721 cataaaagcc caattcagat cctactaata aaacaagctc caatgtatta tggaaacatg
      781 tgcttttacg cctccaataa aactatgtta tcgatgggct ca
//
