LOCUS       NM_146131               4481 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus pre B cell leukemia transcription factor interacting
            protein 1 (Pbxip1), mRNA.
ACCESSION   NM_146131 XM_910108
VERSION     NM_146131.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4481)
  AUTHORS   Dwivedi,A., Padala,C., Kumari,A., Khumukcham,S.S., Penugurti,V.,
            Ghosh,S., Mazumder,A., Goffin,V. and Manavathi,B.
  TITLE     Hematopoietic PBX-interacting protein is a novel regulator of
            mammary epithelial cell differentiation
  JOURNAL   FEBS J 289 (6), 1575-1590 (2022)
   PUBMED   34668648
  REMARK    GeneRIF: Hematopoietic PBX-interacting protein is a novel regulator
            of mammary epithelial cell differentiation.
REFERENCE   2  (bases 1 to 4481)
  AUTHORS   Ji,Q., Xu,X., Kang,L., Xu,Y., Xiao,J., Goodman,S.B., Zhu,X., Li,W.,
            Liu,J., Gao,X., Yan,Z., Zheng,Y., Wang,Z., Maloney,W.J., Ye,Q. and
            Wang,Y.
  TITLE     Hematopoietic PBX-interacting protein mediates cartilage
            degeneration during the pathogenesis of osteoarthritis
  JOURNAL   Nat Commun 10 (1), 313 (2019)
   PUBMED   30659184
  REMARK    GeneRIF: HPIP promotes the transcription of Wnt targets by
            interacting with lymphoid enhancer binding factor 1 (LEF1). HPIP
            potentiates the transcriptional activity of LEF1 and acetylates
            histone H3 lysine 56 in the promoters of Wnt targets, suggesting
            that HPIP is an attractive target in OA regulatory network.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4481)
  AUTHORS   Yu,Y.H., Siao,F.P., Hsu,L.C. and Yen,P.H.
  TITLE     TEX11 modulates germ cell proliferation by competing with estrogen
            receptor beta for the binding to HPIP
  JOURNAL   Mol Endocrinol 26 (4), 630-642 (2012)
   PUBMED   22383461
  REMARK    GeneRIF: mouse spermatogonial stem cells expressed Tex11, Hpip, and
            Esr2 but not Esr1, and in cultured cells, TEX11 competed with Esr2
            for binding to HPIP.
REFERENCE   4  (bases 1 to 4481)
  AUTHORS   Ogaki,S., Harada,S., Shiraki,N., Kume,K. and Kume,S.
  TITLE     An expression profile analysis of ES cell-derived definitive
            endodermal cells and Pdx1-expressing cells
  JOURNAL   BMC Dev Biol 11, 13 (2011)
   PUBMED   21362171
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4481)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171273.1, AK028858.1, AK047898.1 and CD742482.1.
            
            On Aug 25, 2009 this sequence version replaced NM_146131.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028858.1, BC027771.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC171273.1         105468-105469       c
            3-2474              AK028858.1         1-2472
            2475-3958           AK047898.1         320-1803
            3959-4474           CD742482.1         15-530              c
            4475-4481           AC171273.1         91221-91227         c
FEATURES             Location/Qualifiers
     source          1..4481
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.12 cM"
     gene            1..4481
                     /gene="Pbxip1"
                     /gene_synonym="4732463H20Rik"
                     /note="pre B cell leukemia transcription factor
                     interacting protein 1"
                     /db_xref="GeneID:229534"
                     /db_xref="MGI:MGI:2441670"
     exon            1..77
                     /gene="Pbxip1"
                     /gene_synonym="4732463H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            78..162
                     /gene="Pbxip1"
                     /gene_synonym="4732463H20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..2295
                     /gene="Pbxip1"
                     /gene_synonym="4732463H20Rik"
                     /note="hematopoietic PBX-interacting protein"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription
                     factor-interacting protein 1"
                     /protein_id="NP_666243.1"
                     /db_xref="CCDS:CCDS17510.1"
                     /db_xref="GeneID:229534"
                     /db_xref="MGI:MGI:2441670"
                     /translation="MASCPDSDNSWVLAGSENLPVETLGPEPRMDPESEGASQALRDS
                     SKADGKELAGTLDGEEKLFQTESSQRETAVLTESAAKGTLGADGHGTEAPGDTVVQED
                     SQETPVATSLGPDTQDLESEIHPQNLPSSPRAVWKEHRCSSSDDDTDVDVEGLRRRRG
                     REPSSSQPVVPVDVEDQAKGEGIGGELGISLNMCFLGALVLLGLGILLFSGTLLEPET
                     GPMEEAELQVFPETGPETELVETLGNRQDEIEHLQASSVPPDSVPSLQSMGFLLDKLA
                     KENQDIRLLQAQLQAQKEELQSLLHQPKGLEEENARLREALQQGKTSHQALESELQQL
                     RARLQGLEANCVRGVDGVCLNWGGDPQDGKATKEQGHKGQEPDPSLLEQHKQLEAEAK
                     ALRQELQRQWQLLGSVHWDLQRGLRDAGRGAPAHPGLAELGHMLAQTLQDLENQGINT
                     GRSPNDSEAWHQKKPHTQSPREWGGKEKWRGGQRDQKAEHWKPRKEESGQERQRSWRD
                     EGREHTGRWREDRLRADESGSRKDSKRQDPKVHPRKDGNSHSVERQKHSWGKDNSPDA
                     LSSWEELLRRKYRPPQGCSGVADCARQEGLALFGVELAPVRQQELASVLREYLSRLPW
                     AGQLTKQLPLSPAYFGEDGIFRHDRLRFRDFVDALEDSLEEVALKQTGDDDEVDDFED
                     FVFGHFFGDKALKKRSRKKEKHSWNPRVVGPREEHSRHPHHYHQG"
     exon            163..289
                     /gene="Pbxip1"
                     /gene_synonym="4732463H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            290..354
                     /gene="Pbxip1"
                     /gene_synonym="4732463H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            355..514
                     /gene="Pbxip1"
                     /gene_synonym="4732463H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            515..742
                     /gene="Pbxip1"
                     /gene_synonym="4732463H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            743..766
                     /gene="Pbxip1"
                     /gene_synonym="4732463H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            767..849
                     /gene="Pbxip1"
                     /gene_synonym="4732463H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            850..981
                     /gene="Pbxip1"
                     /gene_synonym="4732463H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            982..2201
                     /gene="Pbxip1"
                     /gene_synonym="4732463H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..4481
                     /gene="Pbxip1"
                     /gene_synonym="4732463H20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4453..4458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pbxip1"
                     /gene_synonym="4732463H20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4473
                     /gene="Pbxip1"
                     /gene_synonym="4732463H20Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtgactcccc tcttgtcttc ctgggctggg aggttgcaac aagttaagct gaagactgaa
       61 gcgaggagct gggtcaggtg gccactctag ctgcactgga cctccacaac tatggcctcc
      121 tgcccagact cagataatag ctgggtgctc gctggttctg agaatctgcc tgtggagact
      181 ctgggcccag aacccaggat ggacccagaa tctgagggag cctcccaggc ccttcgggac
      241 tcctccaagg cagatggcaa agaattagct gggaccttgg atggagaaga gaagcttttc
      301 cagacggaaa gttcccagag agaaactgct gttctgacag agtctgcggc caagggcact
      361 ctgggagccg atggtcatgg gacggaggcc cctggagaca cagtggtcca ggaagattcg
      421 caggagactc ctgtggcgac gagcctcgga ccagacacac aggacctgga gagtgagatc
      481 catccacaga acttaccctc cagtcccaga gcagtttgga aagagcatcg ctgctccagc
      541 agtgacgacg acactgatgt agatgtggag ggtctgcgga gacggagggg ccgggagccc
      601 agctcatccc agcccgtggt acccgtagat gtggaggacc aggccaaggg cgagggtata
      661 ggtggagagc tgggcatctc cctcaacatg tgtttcctgg gggccctggt tcttctgggc
      721 ctggggatcc tcctgttctc tggtacactg ctggagcccg agactgggcc catggaggaa
      781 gccgagttgc aggtctttcc agaaaccggg ccggagactg aactggtaga gactctgggg
      841 aacaggcagg atgagataga gcacctgcag gcttcaagtg tcccaccaga cagtgtcccc
      901 agcctgcaga gcatggggtt tctgctggac aagctggcca aggagaacca ggatatccgg
      961 ctgctgcagg ctcagctaca ggctcagaaa gaagaacttc agagcctgtt gcaccagccc
     1021 aaagggctgg aggaggagaa tgcccggctc cgggaagccc tgcagcaggg caagacctcc
     1081 caccaggccc tagaatcaga actgcagcag ctaagggccc gactccaagg gctagaggct
     1141 aactgtgtcc ggggtgtaga tggggtgtgt ctcaactggg gtggagatcc acaggatggc
     1201 aaggccacta aagaacaagg ccacaagggg caggagccag accccagctt attggagcag
     1261 cataagcagc ttgaggcgga ggccaaggcc ctaaggcagg agctgcagag acagtggcag
     1321 ctgctggggt ctgtgcactg ggacctgcag aggggcttgc gggatgctgg ccggggagcc
     1381 ccagctcacc ctggcctggc tgaactcggt cacatgttgg cccagacact gcaggacctc
     1441 gagaatcagg gtatcaacac tggcaggtcc cccaatgact cggaggcctg gcaccagaag
     1501 aagcctcaca cccagagtcc cagggagtgg ggtgggaagg agaagtggcg cggtgggcag
     1561 agggatcaga aggctgagca ctggaagccg aggaaggagg agtctggcca ggagaggcaa
     1621 aggagctgga gggatgaggg ccgggagcac actgggcgct ggagggagga cagactgcgg
     1681 gcggacgaat ctgggagcag aaaggacagc aagcgacagg accccaaggt acaccctagg
     1741 aaagatggga actcccattc tgtagaaagg cagaagcatt cttgggggaa agacaacagc
     1801 cctgacgccc tgtcctcctg ggaggagctg ctgaggcgca agtaccgacc ccctcagggc
     1861 tgttcaggtg tggccgactg tgcccggcag gagggcctgg ccctctttgg tgtggagctg
     1921 gcccctgtgc ggcagcagga gctggcctct gtgctgagag aatacttgtc tcggctgccc
     1981 tgggccgggc agctgaccaa acagctgccc ctctcacctg cttactttgg agaagatggc
     2041 atcttcaggc atgaccggct tcgcttcaga gattttgtgg atgccttgga ggacagcctg
     2101 gaggaggtgg cactgaaaca gacaggcgac gatgatgaag tggatgactt tgaggacttt
     2161 gtcttcggcc acttctttgg ggacaaggcc ctgaagaaga ggtcacgaaa gaaggagaag
     2221 cactcctgga accccagagt tgtggggccc agggaagagc acagccgcca tccgcaccac
     2281 taccaccaag gctgagccct gtcctgctgc aacagccggc cttggcatgc acccagctca
     2341 agatgcctgg agttatgtga ccctagcagc tatgctccca ctgtccagcg ggcccctcct
     2401 ggctcgttgg tgcccttgaa tgaccttcac agaagagagc aacgcacttg gccctgcact
     2461 ggtaccactt ttgctaaaaa aaaaaaaaaa aaagaagaag aagaaaaaaa aaaaggccat
     2521 agttggcgct gctgaactgt ctaagcagac atatgcaaag ataaaggccc tgggtactaa
     2581 gtgacatgta ggggcctgct gggagcctgc tggggaggac tcttattctg aagtcagaga
     2641 gctgtcattt ttttgtggct atcctgggtc cacagcagag cctatcaccc tgtgctagag
     2701 ctgctggtta gagacttagc tccagacttg ccttggggtt tagctagctg tggagacagc
     2761 tatccctaag cctgaggagt cctcaccatg cctcttgcgg ctttcacctc cccacctgag
     2821 ctgtcccacc atggcggggc tctgtcactt gaggtggtcc ctaaatgcaa ggaacacctt
     2881 gcagtcacca cgctggtgtt taggcacaat ctaggcactg cactcggcct tcccatccat
     2941 tccccatgtg cgcccacctt ccccaaggag cctagccttg agtccagcca ccaattgtct
     3001 cacagtccag gtggggtggc ctcaagccag gtcattctcc gcagtgtggt gtggtgttct
     3061 tatcctcaga aagagagctg aagggaatgg agtcagtgaa gcaaggaagc agacattctg
     3121 tttctgccac acaagaatcg atcccttttt tggagcgtgc tgtggaggac agggaacacg
     3181 ctaacctggg tctgcagagg tgagggagcc actaggtggc gctctggctt cacatttctc
     3241 tagacttctc cctcctgccc ctggtcacca ccccacaccc cagacaccct acccattgac
     3301 tagctctcaa gaattcccag aatccccctg gttattcttc aggaacgccc cgccccctca
     3361 gttcaaacct ctacgccatt ggtagcacac tgggcttcta gctctggaac tctcccaggg
     3421 actctagggg gcagtgacca cacaggtcag gtcaattaag gaggggatta aggactgtaa
     3481 gcttactggg caatggtgat gcacgccttt aatcccagcc cttgggaggc agaggcaggc
     3541 tgatttctga gtttgaggcc agcctgatct acaaagtgag ttccaggata gccagggaaa
     3601 caaaacagga ctgtaggctc tagaaagtgc tggaatcgat tttgaattat ttagcaatgc
     3661 ttttatgtca ctgttaaaag gcttttaagt gcagtggctt gtttaatttc cgtgctagac
     3721 aagacaggta gaaagggtgg ctcattccac aaatgtttaa acagtctgct gtgtggtgct
     3781 ggagggatgg ctcagccgct gagggcacag gctgctcttc cagaagcccc aggtttgatt
     3841 cccagcaccc acatggtagc tcacaaatgt ctgcaacttc agtctccagg gatctgatgt
     3901 tctcttctgg ccctgtaggc accaggcaca cacacacacg gtacacaaac atacacgcaa
     3961 aaacaaaaaa agatcaccca tcaccacatt tcttgaaaat aaaagtctat tgtgtatgag
     4021 aaccaggtag tgaggcccta ggcctgtaga ccctttaata tgcatggaat ctgcagcagc
     4081 aggagctctg gttagactta aggcacatta ccttacacag gtcagtgttg taggctgggg
     4141 gctccaggaa ggagccgtct ggtttagaaa gacaattata ttccctgtct ctctggacca
     4201 gtgtccctca gaaggaaggc aggtttaacc ctgcttttgc tgctcactca agggtcctca
     4261 gagatcgatc tgtttataca gatgtggtga ccttggtggc tgggtgaaag ctcaaggccg
     4321 gaggcaggta ggctggcatg ttggggtgct gggtctggag atggggattc acaggcctgc
     4381 cttggtttcc tagatggtgt tggtacaggg ctctctggcc tctggtttcc atgtcaagag
     4441 ctcatgttgg ataataaatt ttggagtctc agagttcctc t
//
