LOCUS       NM_001024954            1427 bp    mRNA    linear   ROD 27-MAY-2024
DEFINITION  Mus musculus pre B cell leukemia homeobox 4 (Pbx4), transcript
            variant 1, mRNA.
ACCESSION   NM_001024954 XM_001052070 XM_001052071 XM_001052072
VERSION     NM_001024954.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1427)
  AUTHORS   Ning,Y., Duo,S., Lin,X., Zhang,H., Fei,J., Zhang,B., Zeng,Y.,
            Xie,D., Chen,J., Liu,X. and Han,C.
  TITLE     Transcription factor PBX4 regulates limb development and
            haematopoiesis in mice
  JOURNAL   Cell Prolif 57 (5), e13580 (2024)
   PUBMED   38230761
  REMARK    GeneRIF: Transcription factor PBX4 regulates limb development and
            haematopoiesis in mice.
REFERENCE   2  (bases 1 to 1427)
  AUTHORS   Rivera-Reyes,R., Kleppa,M.J. and Kispert,A.
  TITLE     Proteomic analysis identifies transcriptional cofactors and
            homeobox transcription factors as TBX18 binding proteins
  JOURNAL   PLoS One 13 (8), e0200964 (2018)
   PUBMED   30071041
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1427)
  AUTHORS   Hanley,O., Zewdu,R., Cohen,L.J., Jung,H., Lacombe,J.,
            Philippidou,P., Lee,D.H., Selleri,L. and Dasen,J.S.
  TITLE     Parallel Pbx-Dependent Pathways Govern the Coalescence and Fate of
            Motor Columns
  JOURNAL   Neuron 91 (5), 1005-1020 (2016)
   PUBMED   27568519
REFERENCE   4  (bases 1 to 1427)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 1427)
  AUTHORS   Ferretti,E., Villaescusa,J.C., Di Rosa,P., Fernandez-Diaz,L.C.,
            Longobardi,E., Mazzieri,R., Miccio,A., Micali,N., Selleri,L.,
            Ferrari,G. and Blasi,F.
  TITLE     Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major
            reduction of Pbx and Meis proteins and a pleiotropic embryonic
            phenotype
  JOURNAL   Mol Cell Biol 26 (15), 5650-5662 (2006)
   PUBMED   16847320
REFERENCE   6  (bases 1 to 1427)
  AUTHORS   Wagner,K., Mincheva,A., Korn,B., Lichter,P. and Popperl,H.
  TITLE     Pbx4, a new Pbx family member on mouse chromosome 8, is expressed
            during spermatogenesis
  JOURNAL   Mech Dev 103 (1-2), 127-131 (2001)
   PUBMED   11335119
REFERENCE   7  (bases 1 to 1427)
  AUTHORS   Vlachakis,N., Choe,S.K. and Sagerstrom,C.G.
  TITLE     Meis3 synergizes with Pbx4 and Hoxb1b in promoting hindbrain fates
            in the zebrafish
  JOURNAL   Development 128 (8), 1299-1312 (2001)
   PUBMED   11262231
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158564.7.
            
            On Oct 25, 2017 this sequence version replaced NM_001024954.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.838730.1,
                                           SRR7345562.854485.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               AC158564.7         26650-26877
            229-302             AC158564.7         53106-53179
            303-541             AC158564.7         58338-58576
            542-732             AC158564.7         58850-59040
            733-868             AC158564.7         60494-60629
            869-1022            AC158564.7         64055-64208
            1023-1129           AC158564.7         64604-64710
            1130-1427           AC158564.7         66021-66318
FEATURES             Location/Qualifiers
     source          1..1427
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 33.92 cM"
     gene            1..1427
                     /gene="Pbx4"
                     /gene_synonym="2410015M21Rik"
                     /note="pre B cell leukemia homeobox 4"
                     /db_xref="GeneID:80720"
                     /db_xref="MGI:MGI:1931321"
     exon            1..228
                     /gene="Pbx4"
                     /gene_synonym="2410015M21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1222
                     /gene="Pbx4"
                     /gene_synonym="2410015M21Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homeobox protein PBX4; pre-B-cell leukemia transcription
                     factor 4"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription factor 4
                     isoform 1"
                     /protein_id="NP_001020125.1"
                     /db_xref="CCDS:CCDS22352.1"
                     /db_xref="GeneID:80720"
                     /db_xref="MGI:MGI:1931321"
                     /translation="MAAPLRPVPPQPAPRRLPTTAPLGHDTSDVLQQIMAITDQSLDE
                     AQARKHALNCHRMKSALFSVLCEIKGKTAVSIQFQEEDPPDAQLLRLDNMLLAEGVSR
                     PEKRGRGAAAGSTATPGGCPNDNSIEHSDYRAKLSQIRQIYHSELEKYEQACREFTTH
                     VTNLLREQSRVRPVSCREMEHMVNTIQSKFSAIQRQLKQSTCEAVMTLRSRFLDARRK
                     RRNFSKQATDVLNEYFYSHLSNPYPSEETKEELARKGGITVSQVSNWFGNKRIRYKKN
                     TGKFQEEATMYTGKASTVTKARRPRGQSSCQSTPSPGPCGPLPLTNGSDVVLTLRTLA
                     FLQPPTGGVCLQPLVHSNWQRAAPQPASSPAGESGSFNWDAASN"
     exon            229..302
                     /gene="Pbx4"
                     /gene_synonym="2410015M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            303..541
                     /gene="Pbx4"
                     /gene_synonym="2410015M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            542..732
                     /gene="Pbx4"
                     /gene_synonym="2410015M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            733..868
                     /gene="Pbx4"
                     /gene_synonym="2410015M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1022
                     /gene="Pbx4"
                     /gene_synonym="2410015M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1129
                     /gene="Pbx4"
                     /gene_synonym="2410015M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1427
                     /gene="Pbx4"
                     /gene_synonym="2410015M21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1405..1410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pbx4"
                     /gene_synonym="2410015M21Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1427
                     /gene="Pbx4"
                     /gene_synonym="2410015M21Rik"
                     /note="major polyA site"
ORIGIN      
        1 ccctgggtct gcggcggttg gctgctgcgc aagcgcgaga gcccggcggg acctgtccct
       61 ctgcgctcgc tcgggactgt agcccatggc cgcccctctg cgtcccgtgc cgccacagcc
      121 cgccccgcgc cgcctgccga ccacagctcc actaggccat gacacgagcg acgtcctgca
      181 gcagatcatg gccatcaccg accagagcct ggacgaggct caggccagaa agcatgccct
      241 gaactgccat cggatgaagt ctgctctctt cagtgtgctc tgcgagatca aggggaagac
      301 tgccgtgagc atccagtttc aggaagagga ccctcccgat gcccagctgc tgaggttgga
      361 taacatgctg ctggctgagg gtgtgtccag gccagagaag agaggccgag gagcagcagc
      421 aggcagcaca gcaacaccag gtggctgtcc aaatgacaat agcattgagc actcagacta
      481 cagggccaag ctgtcccaga tccgacagat ttaccactct gagctagaga agtatgaaca
      541 ggcctgtcgt gagttcacca cacatgtcac caaccttctc cgggaacaga gtagggtgag
      601 gcctgtgtct tgcagggaga tggaacacat ggtgaacacc atccagagca agttcagtgc
      661 catccagagg cagctgaagc agagcacgtg tgaggctgtg atgactctac gctcacggtt
      721 cctggatgcc aggcgcaagc ggcggaattt cagcaagcag gccacagacg tgctgaatga
      781 atatttctat tcccatttga gcaaccctta ccccagtgaa gagaccaaag aagagctggc
      841 caggaagggt ggcatcacag tgtcccaggt ctctaactgg tttggcaaca aaagaatccg
      901 gtacaaaaag aatacaggga agtttcagga agaagccacc atgtacacag ggaaagcatc
      961 cacagtcacc aaggcccggc gtcccagggg tcagagcagc tgccagtcca cacccagccc
     1021 aggtccctgt ggccccttgc cactgaccaa tggaagtgac gtggttctca ctctgcggac
     1081 cctggccttc ctccagcccc ccactggggg agtctgccta cagcccctgg tccatagtaa
     1141 ctggcagagg gccgccccac agccagcctc atcacctgcg ggagagtctg gcagcttcaa
     1201 ttgggatgct gcatctaatt aagtttctgg cacctggctg agtgccatag gtgactggcc
     1261 ctgtgtcctg ctgatgacct cagaagtcct ggctgcggct ttgccctttt tcaggccact
     1321 tgcctcccca ccttggtgtg attttttttt ttaaagaaac atcagttaag tgactgacag
     1381 tggactgttc attctgagca cccgattaaa gttttgacct gtttgca
//
