LOCUS       NM_016768               2870 bp    mRNA    linear   ROD 23-DEC-2022
DEFINITION  Mus musculus pre B cell leukemia homeobox 3 (Pbx3), transcript
            variant a, mRNA.
ACCESSION   NM_016768 XM_917583 XM_925017 XM_925020 XM_925023 XM_925025
VERSION     NM_016768.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2870)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   2  (bases 1 to 2870)
  AUTHORS   Lopez-Gonzalez L, Alonso A, Garcia-Calero E, de Puelles E and
            Puelles L.
  TITLE     Tangential Intrahypothalamic Migration of the Mouse Ventral
            Premamillary Nucleus and Fgf8 Signaling
  JOURNAL   Front Cell Dev Biol 9, 676121 (2021)
   PUBMED   34095148
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2870)
  AUTHORS   Huisman C, Kim YA, Jeon S, Shin B, Choi J, Lim SJ, Youn SM, Park Y,
            K C M, Kim S, Lee SK, Lee S and Lee JW.
  TITLE     The histone H3-lysine 4-methyltransferase Mll4 regulates the
            development of growth hormone-releasing hormone-producing neurons
            in the mouse hypothalamus
  JOURNAL   Nat Commun 12 (1), 256 (2021)
   PUBMED   33431871
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2870)
  AUTHORS   Younes ST and Herrington B.
  TITLE     In silico analysis identifies a putative cell-of-origin for BRAF
            fusion-positive cerebellar pilocytic astrocytoma
  JOURNAL   PLoS One 15 (11), e0242521 (2020)
   PUBMED   33206716
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2870)
  AUTHORS   Alankarage D, Szot JO, Pachter N, Slavotinek A, Selleri L, Shieh
            JT, Winlaw D, Giannoulatou E, Chapman G and Dunwoodie SL.
  TITLE     Functional characterization of a novel PBX1 de novo missense
            variant identified in a patient with syndromic congenital heart
            disease
  JOURNAL   Hum Mol Genet 29 (7), 1068-1082 (2020)
   PUBMED   31625560
REFERENCE   6  (bases 1 to 2870)
  AUTHORS   Kasahara M, Hayashi M, Tanaka K, Inoko H, Sugaya K, Ikemura T and
            Ishibashi T.
  TITLE     Chromosomal localization of the proteasome Z subunit gene reveals
            an ancient chromosomal duplication involving the major
            histocompatibility complex
  JOURNAL   Proc Natl Acad Sci U S A 93 (17), 9096-9101 (1996)
   PUBMED   8799160
REFERENCE   7  (bases 1 to 2870)
  AUTHORS   Pilz A, Woodward K, Povey S and Abbott C.
  TITLE     Comparative mapping of 50 human chromosome 9 loci in the laboratory
            mouse
  JOURNAL   Genomics 25 (1), 139-149 (1995)
   PUBMED   7774911
REFERENCE   8  (bases 1 to 2870)
  AUTHORS   Pilz A, Prohaska R, Peters J and Abbott C.
  TITLE     Genetic linkage analysis of the Ak1, Col5a1, Epb7.2, Fpgs, Grp78,
            Pbx3, and Notch1 genes in the region of mouse chromosome 2
            homologous to human chromosome 9q
  JOURNAL   Genomics 21 (1), 104-109 (1994)
   PUBMED   8088777
REFERENCE   9  (bases 1 to 2870)
  AUTHORS   Rowe LB, Nadeau JH, Turner R, Frankel WN, Letts VA, Eppig JT, Ko
            MS, Thurston SJ and Birkenmeier EH.
  TITLE     Maps from two interspecific backcross DNA panels available as a
            community genetic mapping resource
  JOURNAL   Mamm Genome 5 (5), 253-274 (1994)
   PUBMED   8075499
  REMARK    Erratum:[Mamm Genome 1994 Jul;5(7):463]
REFERENCE   10 (bases 1 to 2870)
  AUTHORS   Monica K, Galili N, Nourse J, Saltman D and Cleary ML.
  TITLE     PBX2 and PBX3, new homeobox genes with extensive homology to the
            human proto-oncogene PBX1
  JOURNAL   Mol Cell Biol 11 (12), 6149-6157 (1991)
   PUBMED   1682799
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF463864.1, AF020199.1, AF020200.1 and AW123376.1.
            
            [WARNING] On May 3, 2023 this sequence was replaced by NM_016768.3.
            
            On Mar 14, 2014 this sequence version replaced NM_016768.1.
            
            Transcript Variant: This variant (a) represents the longer
            transcript and encodes the longer isoform (PBX3a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057879.1, AF020199.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BF463864.1         1-9
            10-2402             AF020199.1         1-2393
            2403-2575           AF020200.1         2283-2455
            2576-2870           AW123376.1         1-295               c
FEATURES             Location/Qualifiers
     source          1..2870
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.84 cM"
     gene            1..2870
                     /gene="Pbx3"
                     /note="pre B cell leukemia homeobox 3"
                     /db_xref="GeneID:18516"
                     /db_xref="MGI:MGI:97496"
     exon            1..325
                     /gene="Pbx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1430
                     /gene="Pbx3"
                     /note="isoform PBX3a is encoded by transcript variant a;
                     pre-B-cell leukemia transcription factor 3; homeobox
                     protein PBX3"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription factor 3
                     isoform PBX3a"
                     /protein_id="NP_058048.1"
                     /db_xref="CCDS:CCDS15947.1"
                     /db_xref="GeneID:18516"
                     /db_xref="MGI:MGI:97496"
                     /translation="MDDQSRMLQTLAGVNLAGHSVQGGMALPPPPHGHEGADGDGRKQ
                     DIGDILHQIMTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRGAQEED
                     PPDPQLMRLDNMLLAEGVSGPEKGGGSAAAAAAAAASGGSSDNSIEHSDYRAKLTQIR
                     QIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLK
                     QSTCEAVMILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCS
                     ITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTP
                     NSGSSGSFNLPNSGDMFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGL
                     GANSLYSPHNLNANGGWQDATTPSSVTSPTEGPGSVHSDTSN"
     exon            326..399
                     /gene="Pbx3"
                     /inference="alignment:Splign:2.1.0"
     exon            400..641
                     /gene="Pbx3"
                     /inference="alignment:Splign:2.1.0"
     exon            642..832
                     /gene="Pbx3"
                     /inference="alignment:Splign:2.1.0"
     exon            833..968
                     /gene="Pbx3"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1134
                     /gene="Pbx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1247
                     /gene="Pbx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1337
                     /gene="Pbx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..2854
                     /gene="Pbx3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccgcct ccccctcccc ctccccctct ttcttctcct ccctcgccgc cgccgccgct
       61 gccgccgccg ccgcctcagc cttcgcctcc gccgccgccg cccgctcccg cccgcgcgcg
      121 gcgggatgga cgatcaatcc aggatgctgc agactctggc cggggtgaac ctggccggcc
      181 actcggtcca ggggggtatg gctctgccgc ctccccctca cggccacgaa ggggcggacg
      241 gcgacggcag gaagcaggac atcggcgaca tcctccacca gatcatgacc atcaccgacc
      301 agagcttgga cgaggcgcaa gcaaagaaac atgctctgaa ctgtcacaga atgaaaccgg
      361 cgctcttcag cgtcttgtgt gagatcaaag agaaaacagg tctcagcatc agaggagccc
      421 aggaggaaga ccctcccgac ccccagctaa tgagactgga caatatgctt ttggcagaag
      481 gggtttcagg tcctgagaaa ggtgggggat cggcggcagc agctgcagcc gcggcagcct
      541 ctggaggttc ttcagataac tctattgaac actcagatta cagagccaaa ttgacccaga
      601 tcagacaaat ctatcacaca gaactggaga aatatgaaca ggcatgtaat gaattcacaa
      661 cacatgtgat gaaccttctc cgagaacaga gtagaacgcg tcccatttcc ccgaaagaga
      721 tcgaaaggat ggtgggcatc atccatcgga aatttagttc cattcagatg cagctcaagc
      781 aaagcacgtg tgaagcagtt atgattttga gatcaaggtt ccttgatgcc agacggaaaa
      841 ggcgtaactt cagtaaacag gctacggaaa tcttgaatga atatttttac tcacacctca
      901 gcaaccccta ccccagtgaa gaagccaaag aggagctggc caagaaatgc agcatcacag
      961 tatcacaggt atccaactgg tttggcaaca aacgaatcag gtacaagaag aacatcggca
     1021 aatttcaaga ggaggccaat ctctatgctg caaaaacagc cgtgacagcc gcacatgcag
     1081 tggctgcagc cgtgcagaac aaccagacca actcacccac cacgccaaac tctggttctt
     1141 ctggttcttt taacctccca aattctgggg acatgttcat gaacatgcag agtctgaatg
     1201 gggattctta ccaagggtcc caagtcggag ccaatgtgca gtcacaggtg gataccctcc
     1261 gtcatgttat caatcagacg ggaggctaca gtgacggcct tggagcaaac tcactgtaca
     1321 gtccacataa cttaaacgct aatggaggct ggcaggacgc aacaactcca tcttctgtga
     1381 cttctcctac ggaaggcccg ggcagtgtgc actcggatac ctctaactaa tccccggcgc
     1441 tttcccagct gacatgcctt gataagcgca tttggagcac taggagaagg aaagcgtttg
     1501 taacccacca cctacagctt tactgtaacc ctgtcttctt agagaactcg ggaaacctgt
     1561 tttttaagga atcataatca tttgtattta aacttaagac acacgtttaa aaagaaagca
     1621 ctttatccaa ttaggccaag atgtaacatt gttgacactt ctttaactgt ttcatcctaa
     1681 tttattatgg gtcttttaca ttaatggttc cacagttgcc agttccttgg ccttaagggt
     1741 aagaagtacc atctatgcta gaccccaatt atagagcagg caaggttcac cctgcctaag
     1801 ctgaaccctt gcggatttcc atgcaggctc tcatcatcgt tctcatatca cggatgggct
     1861 tggagggaag gcgatgtctg cctgtcttct taaggaaggc atttcaggac ttcccttgcc
     1921 atgtttgtgt tgccatctct tatgttgtaa ttaggtcaaa gactggtggc ctcctttctc
     1981 cctctgaagt accagagcct ggagtctgcg ctaatgagac catggatcca gattgcccta
     2041 agatgaagat cttgctgcta cagaggtgaa aacaagacct gtctggggtt tgaccgtgtg
     2101 cgctaggtgc tgcacagact tgtcaaggtg tgctcttcct ctgggcagcc tggaaaggcc
     2161 ctgctctctg gagtgctgta tatagtgtag caaaagagta tttatacatc ccaccaatca
     2221 aaacacagct ttattacctc atgcgaactc atacaaacca atagaatccc aacatgttct
     2281 gtagcttaga gcgctcactt actacctctg aacaatactc acgctgtagt ttgtctcttt
     2341 cttatctttt ttgcatcttg taattaactc tttgtttccc ttcacaaaat gtaatgtaca
     2401 ttgtaatctt ttaaaagaaa actcagggtt gcatttgcaa cccttaaaaa gccaagattg
     2461 gcaacattgg gtctgactct taacacagga tcatccaagc tgttgtaaat actgagaagc
     2521 gttttgaatg ttcttcatct tgttactaat ccatacagaa gaaaaaggaa aaaaagaaaa
     2581 aaaaaaaaaa ggcgggttct tgtgatgcgt tcagattcag tattcagcac tgtacatttc
     2641 accctgtgtg gcgggccctc tccttctctt tttgtattgt atgcgattct gaaactgact
     2701 gggtcgtgac aataatttgt ggcggtgatt ctgatgtatt aaaagcgttc cgtgttcctt
     2761 tctactggct cacaccctgg attgaaaagt cttccttgtg gtagttatat gtagtttcaa
     2821 acatgaataa actttgcttt cctgattaaa cttaaaaaaa aaaaaaaaaa
//
