LOCUS       NM_017463               3072 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus pre B cell leukemia homeobox 2 (Pbx2), mRNA.
ACCESSION   NM_017463 XM_994405
VERSION     NM_017463.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3072)
  AUTHORS   Ning,Y., Duo,S., Lin,X., Zhang,H., Fei,J., Zhang,B., Zeng,Y.,
            Xie,D., Chen,J., Liu,X. and Han,C.
  TITLE     Transcription factor PBX4 regulates limb development and
            haematopoiesis in mice
  JOURNAL   Cell Prolif 57 (5), e13580 (2024)
   PUBMED   38230761
REFERENCE   2  (bases 1 to 3072)
  AUTHORS   Losa,M., Barozzi,I., Osterwalder,M., Hermosilla-Aguayo,V.,
            Morabito,A., Chacon,B.H., Zarrineh,P., Girdziusaite,A.,
            Benazet,J.D., Zhu,J., Mackem,S., Capellini,T.D., Dickel,D.,
            Bobola,N., Zuniga,A., Visel,A., Zeller,R. and Selleri,L.
  TITLE     A spatio-temporally constrained gene regulatory network directed by
            PBX1/2 acquires limb patterning specificity via HAND2
  JOURNAL   Nat Commun 14 (1), 3993 (2023)
   PUBMED   37414772
  REMARK    GeneRIF: A spatio-temporally constrained gene regulatory network
            directed by PBX1/2 acquires limb patterning specificity via HAND2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3072)
  AUTHORS   Mariani,L., Guo,X., Menezes,N.A., Drozd,A.M., Cakal,S.D., Wang,Q.
            and Ferretti,E.
  TITLE     A TALE/HOX code unlocks WNT signalling response towards paraxial
            mesoderm
  JOURNAL   Nat Commun 12 (1), 5136 (2021)
   PUBMED   34446717
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3072)
  AUTHORS   Cozzitorto,C., Mueller,L., Ruzittu,S., Mah,N., Willnow,D.,
            Darrigrand,J.F., Wilson,H., Khosravinia,D., Mahmoud,A.A.,
            Risolino,M., Selleri,L. and Spagnoli,F.M.
  TITLE     A Specialized Niche in the Pancreatic Microenvironment Promotes
            Endocrine Differentiation
  JOURNAL   Dev Cell 55 (2), 150-162 (2020)
   PUBMED   32857951
REFERENCE   5  (bases 1 to 3072)
  AUTHORS   Remesal,L., Roger-Baynat,I., Chirivella,L., Maicas,M.,
            Brocal-Ruiz,R., Perez-Villalba,A., Cucarella,C., Casado,M. and
            Flames,N.
  TITLE     PBX1 acts as terminal selector for olfactory bulb dopaminergic
            neurons
  JOURNAL   Development 147 (8) (2020)
   PUBMED   32156753
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3072)
  AUTHORS   Toresson,H., Parmar,M. and Campbell,K.
  TITLE     Expression of Meis and Pbx genes and their protein products in the
            developing telencephalon: implications for regional differentiation
  JOURNAL   Mech Dev 94 (1-2), 183-187 (2000)
   PUBMED   10842069
REFERENCE   7  (bases 1 to 3072)
  AUTHORS   Vlachakis,N., Ellstrom,D.R. and Sagerstrom,C.G.
  TITLE     A novel pbx family member expressed during early zebrafish
            embryogenesis forms trimeric complexes with Meis3 and Hoxb1b
  JOURNAL   Dev Dyn 217 (1), 109-119 (2000)
   PUBMED   10679934
REFERENCE   8  (bases 1 to 3072)
  AUTHORS   Ferretti,E., Schulz,H., Talarico,D., Blasi,F. and Berthelsen,J.
  TITLE     The PBX-regulating protein PREP1 is present in different
            PBX-complexed forms in mouse
  JOURNAL   Mech Dev 83 (1-2), 53-64 (1999)
   PUBMED   10381567
REFERENCE   9  (bases 1 to 3072)
  AUTHORS   Shen,W.F., Rozenfeld,S., Kwong,A., Kom ves,L.G., Lawrence,H.J. and
            Largman,C.
  TITLE     HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells
  JOURNAL   Mol Cell Biol 19 (4), 3051-3061 (1999)
   PUBMED   10082572
REFERENCE   10 (bases 1 to 3072)
  AUTHORS   Monica,K., Galili,N., Nourse,J., Saltman,D. and Cleary,M.L.
  TITLE     PBX2 and PBX3, new homeobox genes with extensive homology to the
            human proto-oncogene PBX1
  JOURNAL   Mol Cell Biol 11 (12), 6149-6157 (1991)
   PUBMED   1682799
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT009767.6 and AK159623.1.
            
            On Feb 7, 2019 this sequence version replaced NM_017463.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159623.1, AF020198.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 CT009767.6         149686-149689
            5-1505              AK159623.1         2-1502
            1506-1506           CT009767.6         153261-153261
            1507-2080           AK159623.1         1504-2077
            2081-2081           CT009767.6         153836-153836
            2082-3072           AK159623.1         2079-3069
FEATURES             Location/Qualifiers
     source          1..3072
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.17 cM"
     gene            1..3072
                     /gene="Pbx2"
                     /gene_synonym="G17"
                     /note="pre B cell leukemia homeobox 2"
                     /db_xref="GeneID:18515"
                     /db_xref="MGI:MGI:1341793"
     exon            1..516
                     /gene="Pbx2"
                     /gene_synonym="G17"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..1588
                     /gene="Pbx2"
                     /gene_synonym="G17"
                     /note="homeobox protein PBX2"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription factor 2"
                     /protein_id="NP_059491.1"
                     /db_xref="CCDS:CCDS28648.1"
                     /db_xref="GeneID:18515"
                     /db_xref="MGI:MGI:1341793"
                     /translation="MDERLLGPPPPGGGRGGLGLVGAEPGGPGEPPGGGDPGGGSGGV
                     PGGRGKQDIGDILQQIMTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSI
                     RSSQEEEPVDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGGVSPDNSIEHSD
                     YRSKLAQIRHIYHSELEKYEQACNEFTTHVMNLLREQSRTRPVAPKEMERMVSIIHRK
                     FSAIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEVLNEYFYSHLSNPYPSEEA
                     KEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAVKTAVSVAQGGHSRTSS
                     PTPPSSAGSGGSFNLSGSGDMFLGMPGLNGDSYPASQVESLRHSMGPGSYGDNIGGGQ
                     IYSPREIRANGGWQEAVTPSSVTSPTEGPGSVHSDTSN"
     exon            517..590
                     /gene="Pbx2"
                     /gene_synonym="G17"
                     /inference="alignment:Splign:2.1.0"
     exon            591..838
                     /gene="Pbx2"
                     /gene_synonym="G17"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1029
                     /gene="Pbx2"
                     /gene_synonym="G17"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1165
                     /gene="Pbx2"
                     /gene_synonym="G17"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1319
                     /gene="Pbx2"
                     /gene_synonym="G17"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1408
                     /gene="Pbx2"
                     /gene_synonym="G17"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1495
                     /gene="Pbx2"
                     /gene_synonym="G17"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..3072
                     /gene="Pbx2"
                     /gene_synonym="G17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2198..2203
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pbx2"
                     /gene_synonym="G17"
                     /note="hexamer: AAGAAA"
     polyA_site      2216
                     /gene="Pbx2"
                     /gene_synonym="G17"
                     /note="major polyA site"
     regulatory      2319..2324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pbx2"
                     /gene_synonym="G17"
                     /note="hexamer: AATAAA"
     polyA_site      2346
                     /gene="Pbx2"
                     /gene_synonym="G17"
                     /note="major polyA site"
ORIGIN      
        1 cttctccctc ctccctcctc tcgcacacac acccccgctt gggcctcctc tctctctctc
       61 tctctctccg gctccatttt ctccgccgcc gggggccggg gtctcctgtg ggggtgccca
      121 ggcggcaccc cgggtctccc cttcagtgcc ggggtgaacc cccgagggga gccgggaggc
      181 gggttgccgg gcggggttgg ggcggaggga gcagcggccc cagcgagttt gggggggaag
      241 tcacccggcg gggggagggg cgagcaggga gggggcctca ggcccccccc cagctatgga
      301 cgagcggctg ctggggccgc ctcctccggg cgggggccgt gggggtctgg ggctggtagg
      361 tgcggagccc gggggccctg gcgagcctcc cggtggcgga gaccccggtg ggggaagtgg
      421 gggggtcccg ggaggccgag ggaagcaaga catcggggac attctgcaac agataatgac
      481 catcacggac cagagcctgg acgaggccca ggccaagaaa catgccctaa actgtcaccg
      541 aatgaaacct gccctgttta gtgtcctgtg tgaaatcaag gagaaaactg gccttagcat
      601 tcggagctcc caagaggagg agcccgtgga cccacagctg atgcgcctgg acaacatgct
      661 tctggcagaa ggtgtggctg gacccgagaa agggggcggc tccgcagcag ctgctgcagc
      721 tgccgcagcc tccggtggtg gcgtatcccc ggacaactcc atcgaacact cagactatcg
      781 cagcaagctt gcccagatcc gccacatcta ccactcagag ctggagaagt atgagcaggc
      841 atgcaatgag ttcacaactc acgtcatgaa cctgctgagg gagcagagcc gcactcgccc
      901 ggtcgccccc aaggagatgg agcgcatggt tagcatcatc catcgaaagt tcagcgccat
      961 tcagatgcag ctgaagcaaa gcacctgtga ggccgtcatg atcctgcgtt ctcgcttcct
     1021 ggatgccaga cggaaacgcc ggaacttcag caaacaggcc actgaggtcc tgaatgagta
     1081 tttctactcc cacctgagca acccttaccc tagtgaggag gccaaagagg agcttgccaa
     1141 gaagtgtggc atcaccgtct ctcaggtttc caactggttc ggtaacaagc gaattcgcta
     1201 caagaagaat attgggaagt tccaagagga ggcgaacatc tatgctgtga agacagccgt
     1261 gtcagttgcc caggggggcc acagccgcac cagctctcca acgccccctt cctctgcagg
     1321 ctctggcggc tctttcaatc tctcaggatc cggagacatg tttctgggga tgcccgggct
     1381 caatggcgat tcctaccctg cttcccaggt ggaatcactc cgacactcga tggggccggg
     1441 gagctacggg gataacattg ggggaggtca gatatacagt cctcgagaaa ttcgggccaa
     1501 tggtggctgg caggaggctg tgaccccgtc ctcggtgaca tccccgacag agggaccagg
     1561 aagtgttcac tctgacacct ccaactgacc ttgcccctca aggtcgcggg gctaggggct
     1621 tccaccaggc aactcttaag gactctgggc atctagagga caaaccccac agaagcacaa
     1681 aacagagggc gattggggtt gtgccctccc cgaccagacg cttggtgctg gggtgctgac
     1741 aacatggcag ggagagtggg gtgtccccat ttcttctttc tttttttcgt ctcacctctc
     1801 accaaaacca gatacctatt tctcagatgt ctctcttaaa tctacaacct aacaccagtt
     1861 gtgtttgtct tggactcctc ctacttctgt tccccacccc acttatatac tctggaatct
     1921 ggagatgtca gccctgcccg acccagagat gccaaaaatg gggactcttg gacagaggcc
     1981 ctgggccaac accccctccc ccatgcaccc ccacctcctg cccctccaga cggctttatt
     2041 acctcatacg cagctcatct taaaccaata gaaccgctcg gtggacaaga gtgtctgact
     2101 cggatatcta cctcggaggg agtttctgct actttagaaa actgttgact aggctttgga
     2161 gttggacttt ttgttttgtt tgtttgtttt ttaagaaaag aaaccctgaa tctgtatttc
     2221 tttttaattg tttctgttgg tagtggtgat ccttaagttt taatatagtt tgaagaagta
     2281 gggttttggg tgtgtgtggg gtgtgtgtgt gtgtcttaaa taaacatgct gatttatttt
     2341 tgtttaccca cttgagaagt aagagccaaa ggggcctagt aagagacaag acagatctgg
     2401 tggtggctac ttgacccagc cccccagtgg ggaatcggat tttgtaggac accaggtcct
     2461 cagcctggac acgtgggttt cttagcctgc gcaggcagat ctctgctgta tttcctatgg
     2521 agcatgaagc cctgtagcct cctgcctccc ccacctcccc agtaaccttt gggcaagact
     2581 agactgaact cagtgatttt gaaaaagtca aaaggctttt gttttgtttt ttaaactatt
     2641 tgcagagtgg aaaagattga tcggggaggg gagttcttgc caaatacgct aaatatgggc
     2701 tgggtgcttc tatatgtgtc tcccccagtt tcccagaagt acatgtttct gttcagttct
     2761 taatctcatg ccaaaatcaa gggggtgggg agaagagggc ggtcacagaa agccaggtat
     2821 gagggaaggc taaaaaagtc tcagccctga acccttctat ctgaccccct cagacatcct
     2881 caggatcttc aagactgtca ccatggggaa cccctcccat caaaggccca ggctggactg
     2941 agggagtgaa gagggtggtg ggaggcaggg gccaggggca gtttctctcc tcacttgtaa
     3001 acatagattc acagaaaaaa aaaaaaaaga aagaagtggc agttttaaat aaagatattt
     3061 ctttttcccc tg
//
