LOCUS       NM_001081251            8117 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus polybromo 1 (Pbrm1), transcript variant 1, mRNA.
ACCESSION   NM_001081251 XM_619217
VERSION     NM_001081251.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8117)
  AUTHORS   Pang,Y., Ruan,X., Liu,W., Hou,L., Yin,B., Shu,P. and Peng,X.
  TITLE     MicroRNA-495 Modulates Neuronal Layer Fate Determination by
            Targeting Tcf4
  JOURNAL   Int J Biol Sci 20 (15), 6207-6221 (2024)
   PUBMED   39664574
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8117)
  AUTHORS   Xin,Q., Feng,I., Yu,G. and Dean,J.
  TITLE     Stromal Pbrm1 mediates chromatin remodeling necessary for embryo
            implantation in the mouse uterus
  JOURNAL   J Clin Invest 134 (5), e174194 (2024)
   PUBMED   38426493
  REMARK    GeneRIF: Stromal Pbrm1 mediates chromatin remodeling necessary for
            embryo implantation in the mouse uterus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8117)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 8117)
  AUTHORS   Li,B.E., Li,G.Y., Cai,W., Zhu,Q., Seruggia,D., Fujiwara,Y.,
            Vakoc,C.R. and Orkin,S.H.
  TITLE     In vivo CRISPR/Cas9 screening identifies Pbrm1 as a regulator of
            myeloid leukemia development in mice
  JOURNAL   Blood Adv 7 (18), 5281-5293 (2023)
   PUBMED   37428871
  REMARK    GeneRIF: In vivo CRISPR/Cas9 screening identifies Pbrm1 as a
            regulator of myeloid leukemia development in mice.
REFERENCE   5  (bases 1 to 8117)
  AUTHORS   Xin,Q., Yu,G., Feng,I. and Dean,J.
  TITLE     Chromatin remodeling of prostaglandin signaling in smooth muscle
            enables mouse embryo passage through the female reproductive tract
  JOURNAL   Dev Cell 58 (18), 1716-1732 (2023)
   PUBMED   37714160
REFERENCE   6  (bases 1 to 8117)
  AUTHORS   Xue,Y., Canman,J.C., Lee,C.S., Nie,Z., Yang,D., Moreno,G.T.,
            Young,M.K., Salmon,E.D. and Wang,W.
  TITLE     The human SWI/SNF-B chromatin-remodeling complex is related to
            yeast rsc and localizes at kinetochores of mitotic chromosomes
  JOURNAL   Proc Natl Acad Sci U S A 97 (24), 13015-13020 (2000)
   PUBMED   11078522
REFERENCE   7  (bases 1 to 8117)
  AUTHORS   Zhang,H.S., Gavin,M., Dahiya,A., Postigo,A.A., Ma,D., Luo,R.X.,
            Harbour,J.W. and Dean,D.C.
  TITLE     Exit from G1 and S phase of the cell cycle is regulated by
            repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF
  JOURNAL   Cell 101 (1), 79-89 (2000)
   PUBMED   10778858
REFERENCE   8  (bases 1 to 8117)
  AUTHORS   Phelan,M.L., Sif,S., Narlikar,G.J. and Kingston,R.E.
  TITLE     Reconstitution of a core chromatin remodeling complex from SWI/SNF
            subunits
  JOURNAL   Mol Cell 3 (2), 247-253 (1999)
   PUBMED   10078207
REFERENCE   9  (bases 1 to 8117)
  AUTHORS   Reyes,J.C., Muchardt,C. and Yaniv,M.
  TITLE     Components of the human SWI/SNF complex are enriched in active
            chromatin and are associated with the nuclear matrix
  JOURNAL   J Cell Biol 137 (2), 263-274 (1997)
   PUBMED   9128241
REFERENCE   10 (bases 1 to 8117)
  AUTHORS   Wang,W., Xue,Y., Zhou,S., Kuo,A., Cairns,B.R. and Crabtree,G.R.
  TITLE     Diversity and specialization of mammalian SWI/SNF complexes
  JOURNAL   Genes Dev 10 (17), 2117-2130 (1996)
   PUBMED   8804307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154727.2 and AC154446.2.
            
            On Feb 6, 2007 this sequence version replaced XM_619217.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849382,
                              SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AC154727.2         129852-130007
            157-296             AC154727.2         133434-133573
            297-449             AC154727.2         136212-136364
            450-547             AC154727.2         138162-138259
            548-695             AC154727.2         141558-141705
            696-839             AC154727.2         143123-143266
            840-956             AC154727.2         146657-146773
            957-1025            AC154727.2         149647-149715
            1026-1124           AC154727.2         151147-151245
            1125-1210           AC154727.2         155338-155423
            1211-1306           AC154727.2         156044-156139
            1307-1398           AC154727.2         157046-157137
            1399-1612           AC154727.2         160752-160965
            1613-1754           AC154727.2         162894-163035
            1755-1852           AC154727.2         164872-164969
            1853-1897           AC154727.2         166950-166994
            1898-2174           AC154727.2         172183-172459
            2175-2280           AC154727.2         175460-175565
            2281-2923           AC154727.2         178036-178678
            2924-3135           AC154727.2         185485-185696
            3136-3321           AC154446.2         47343-47528
            3322-3479           AC154446.2         48867-49024
            3480-3743           AC154446.2         49579-49842
            3744-3889           AC154446.2         52309-52454
            3890-4047           AC154446.2         54258-54415
            4048-4231           AC154446.2         70140-70323
            4232-4442           AC154446.2         70931-71141
            4443-4644           AC154446.2         71902-72103
            4645-4809           AC154446.2         75208-75372
            4810-4965           AC154446.2         78642-78797
            4966-5036           AC154446.2         81806-81876
            5037-5253           AC154446.2         81993-82209
            5254-8117           AC154446.2         83522-86385
FEATURES             Location/Qualifiers
     source          1..8117
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.09 cM"
     gene            1..8117
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /note="polybromo 1"
                     /db_xref="GeneID:66923"
                     /db_xref="MGI:MGI:1923998"
     exon            1..156
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            157..296
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..449
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..5426
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein polybromo-1; BRG1-associated factor 180;
                     2310032M22Rik"
                     /codon_start=1
                     /product="protein polybromo-1 isoform 1"
                     /protein_id="NP_001074720.1"
                     /db_xref="CCDS:CCDS36851.1"
                     /db_xref="GeneID:66923"
                     /db_xref="MGI:MGI:1923998"
                     /translation="MGSKRRRATSPSSSVSGDFDDGHHSVPTPGPSRKRRRLSNLPTV
                     DPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQPIDLMKIQQKLK
                     MEEYDDVNLLTADFQLLFNNAKAYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDE
                     DDDEDGQDNQGTLADGSSPGYLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYP
                     DYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDANSI
                     KKIFYMKKAEIEHHEMTKSSLRIRTASNLAAARLTGPSHNKSSLGEERNPTSKYYRNK
                     RAVQGGRLSAITMALQYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFHQLYDT
                     VRSCRNHQGQLIAEPFFHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
                     DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTG
                     SAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPS
                     KKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMMEDMKLMFRNARHYNEEGSQVYN
                     DAHILEKLLKDKRKELGPLPDDDDMASPKLKLSRKSGVSPKKSKYMTPMQQKLNEVYE
                     AVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMV
                     EDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIH
                     NLFVSVMSHQDDEGRCYSDSLAEIPAVDPNSPNKPPLTFDIIRKNVESNRYRRLDLFQ
                     EHMFEVLERARRMNRTDSEIYEDAVELQQFFIRIRDELCKNGEILLSPALSYTTKHLH
                     NDVEKEKKEKLPKEIEEDKLKREEEKREAEKSEDSSGTTGLSGLHRTYSQDCSFKNSM
                     YHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEK
                     EVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKI
                     KLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSDDNRAEDNFNLEKEK
                     EDVPVEMSNGEPGCHYFEQLRYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAA
                     YFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMSCILGKCAVLSFKDFLSCRPT
                     EIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIIPQKEPSPLL
                     EKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEAPSLPQLQTPLANELDLMPYTPPQS
                     TPKSAKGSAKKESSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLE
                     TAKKAEYEERAAKVAEQQERERAAQQQQPSASPRAGTPVGALMGVVPPPTPMGMLNQQ
                     LTPVAGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPG
                     VMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFV
                     APPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWL
                     KSKGAHTTMADALWRLRDLMLRDTLNIRQAYNLENV"
     exon            450..547
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            548..695
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..839
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            840..956
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1025
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1124
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1210
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1306
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1398
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1612
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1754
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1852
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1897
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2174
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2280
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2923
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..3135
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3321
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..3479
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3480..3743
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3744..3889
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3890..4047
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4048..4231
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4232..4442
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4443..4644
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4645..4809
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4810..4965
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4966..5036
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5037..5253
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5254..8117
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8092..8097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /note="hexamer: AATAAA"
     polyA_site      8117
                     /gene="Pbrm1"
                     /gene_synonym="2610016F04Rik; BAF180; Pb1"
                     /note="major polyA site"
ORIGIN      
        1 ggatttacgg cagcactggg aggggtgagg gcggtgaggg cggcgggtgc cggagagacg
       61 gccgcggcca gaggagcgct agcagccgtg gcggccacgg ggcggggctc ggcggtcggg
      121 gaccgcagcc ggggctgcag gcggcggagc ggcgggcttg ccaacacttg gtgtcacatg
      181 tgagcctccc acatgtgtgc actctccatt ccagctctgt gattgaactc tgctcttatt
      241 gactaggggg cacttgggca ggcatgcttc attcctggag ttgacagtca tttcataaga
      301 agttggattc catgggttcc aagagaagaa gagccacctc tccttccagc agtgtcagtg
      361 gagactttga tgacgggcac cattctgtgc ctacaccagg cccaagcagg aaaaggagaa
      421 gactgtccaa tcttccaact gtagatccta ttgctgtgtg ccatgaactc tataacacca
      481 tccgagacta taaggatgaa cagggcagac tcctctgtga gctgttcatt agggctccaa
      541 agcggagaaa tcaaccagac tattatgaag tggtttctca gcccattgac ttgatgaaaa
      601 tccaacagaa acttaaaatg gaagagtatg atgatgttaa tctactgact gctgacttcc
      661 agctgctttt taacaatgca aaggcctact ataagccaga ttcccctgag tataaagctg
      721 cttgtaaact ctgggatttg taccttcgaa caagaaatga gtttgttcag aaaggagaag
      781 cagacgatga agatgatgac gaagatgggc aagacaatca aggcacactg gctgacggct
      841 cttctccagg ttatctgaag gagatcctgg agcagcttct tgaagccata gttgtagcca
      901 caaatccatc aggacggctc atcagtgaac tttttcagaa actgccttcc aaagtgcaat
      961 atccagacta ttatgcaata attaaggaac ctatagatct caagaccatt gctcagagga
     1021 tacagaatgg aagctacaaa agtatacacg caatggccaa agatatagat cttctagcaa
     1081 aaaatgccaa aacatacaat gagcctgggt ctcaagtatt caaggatgcc aattcgatta
     1141 aaaaaatatt ttatatgaaa aaggcagaaa ttgaacatca tgaaatgact aaatcaagtc
     1201 ttcgaataag gactgcatca aatttggctg cagccaggct gacaggtcct tcgcacaata
     1261 aaagcagcct tggtgaagaa agaaacccca ctagcaagta ttaccgtaat aaaagagcag
     1321 tccaaggggg tcgcttgtca gcaattacca tggcacttca gtatggatca gagagtgaag
     1381 aggacgctgc tttagctgct gcacgctatg aagaagggga atctgaagca gagagcatca
     1441 cttccttcat ggacgtttcc aacccctttc atcagcttta cgacacagtt aggagctgta
     1501 ggaatcacca agggcagctc atagctgaac ctttcttcca tttgccttca aagaaaaaat
     1561 acccagatta ttatcagcaa attaaaatgc ccatatcact tcaacagatc agaacaaagc
     1621 taaagaacca agaatatgaa actttagatc atttggagtg tgatctgaat ttaatgtttg
     1681 aaaatgccaa acgttataac gttcccaatt cagccatcta taagcgagtt ctaaaactgc
     1741 agcaagtcat gcaggcaaag aagaaggagc ttgcgaggag agatgacatt gaggacggag
     1801 acagcatgat ctcctcagcc acttctgaca ctggtagtgc caaaaggaaa aggaatactc
     1861 atgacagtga gatgttgggt ctcaggaggc tatccagtaa aaagaacata agaaaacagc
     1921 gaatgaaaat tttattcaat gttgttcttg aagctcgaga gccaggttca ggcagaagac
     1981 tttgcgatct atttatggtt aagccatcca agaaggacta tcctgattat tataaaatca
     2041 tcttagagcc aatggacctg aaaataattg agcataacat ccgaaatgac aaatatgcag
     2101 gtgaagaagg aatgatggaa gacatgaaac tcatgttccg caatgccagg cactacaatg
     2161 aggagggctc ccaggtatac aatgatgccc atatcctgga gaagttactc aaagataaaa
     2221 ggaaagagct gggccctctg cctgatgatg atgacatggc ttctcccaaa cttaaattga
     2281 gtaggaagag tggtgtttct cctaagaaat caaagtacat gactccaatg cagcagaaac
     2341 tgaatgaagt gtatgaagct gtaaagaact atactgataa gaggggtcgc cgccttagtg
     2401 ctatatttct aagactcccc tctagatcag agctgcctga ctactacctg accattaaaa
     2461 agcccatgga catggaaaaa attcgaagtc acatgatggc aaacaagtac caagacatag
     2521 attctatggt agaggacttt gtcatgatgt ttaataatgc ctgtacctac aatgaaccag
     2581 agtctttgat ctacaaagat gcccttgtac tgcataaagt cctccttgag actcggagag
     2641 acctggaggg agatgaggat tctcatgtcc ctaatgtgac gttgctgatt caagagctca
     2701 tccataacct ttttgtgtca gtcatgagtc atcaggatga cgaagggagg tgttacagcg
     2761 actccttagc agaaattcct gctgtggatc ccaactctcc caataaacct ccccttacat
     2821 ttgacattat caggaaaaat gttgaaagta atcggtatcg gcgacttgat ttatttcagg
     2881 agcatatgtt tgaagtattg gaacgggcaa gaaggatgaa ccggacagat tccgaaatat
     2941 atgaggatgc tgtagaactt cagcagtttt ttattagaat tcgtgatgaa ctctgcaaaa
     3001 atggagagat ccttctttct ccagcactca gctataccac aaaacacttg cataacgatg
     3061 tggaaaaaga aaaaaaggaa aaattgccta aagaaataga ggaagataaa ctaaaacgcg
     3121 aagaagaaaa aagagaagct gaaaaaagtg aagattcctc aggtactaca ggcctctcag
     3181 gcttacatcg tacatacagc caggactgca gctttaagaa cagcatgtat catgtcggag
     3241 attatgtcta tgttgaacct gcggaggcca atctacaacc acatatagtg tgtattgaga
     3301 gactgtggga ggattcagct ggtgaaaaat ggttgtacgg ctgttggttt tatcggccaa
     3361 atgaaacatt ccatttggct acacgaaaat ttctagaaaa agaagttttt aagagtgact
     3421 actacaataa agtacctgtt agtaaaattc taggcaaatg tgtagtcatg tttgtcaagg
     3481 aatactttaa attatgtcca gaaaactttc gcgatgagga tgtttttgtc tgtgaatcga
     3541 ggtattctgc caaaaccaaa tcttttaaga aaattaaact gtggaccatg cccatcagtt
     3601 cagttagatt tgtccctcgg gatgtgcctt tgcctgtggt ccgagtggcc tctgtgtttg
     3661 caaatgcaga taaaggggat gatgagaaga atacagacaa ctcagatgac aatagagctg
     3721 aagacaattt taacttggaa aaggaaaaag aagatgttcc tgtggagatg tccaatggtg
     3781 agccaggttg ccactacttt gagcagcttc ggtacaatga catgtggctg aaggttggtg
     3841 attgtgtctt catcaaatcc cacggcttgg tgcgccctcg tgtgggcaga attgagaaag
     3901 tatgggtccg agatggagct gcatattttt atggccctat cttcattcat ccagaagaaa
     3961 cagaacatga gcccacaaaa atgttctaca aaaaagaagt gtttctgagt aatctggaag
     4021 agacctgccc tatgagttgt attctgggga aatgtgcagt gctgtcattc aaggacttcc
     4081 tctcctgcag gccaactgaa ataccagaaa atgacattct gctttgtgag agccgctata
     4141 atgagagtga caagcagatg aagaagttca agggtttgaa gaggttttca ctctctgcta
     4201 aagttgtaga tgatgaaatc tactacttca gaaaaccaat cattcctcag aaggaaccct
     4261 cacctttgtt agaaaagaag atacaattgc tagaagctaa atttgcagag ttagaaggag
     4321 gagatgatga tattgaggag atgggagaag aggatagtga agtcattgaa gctccatctc
     4381 tacctcaact gcagacaccc ctggccaatg agttggacct catgccctat acacccccac
     4441 agtctacccc aaagtctgcc aaaggcagtg caaagaagga aagttctaaa cgaaaaatca
     4501 acatgagtgg ctacattttg ttcagcagtg aaatgagagc tgtgattaaa gcccagcacc
     4561 cagactactc ttttggggag ctcagcagac tggtggggac agaatggaga aaccttgaaa
     4621 cagccaagaa agcagaatat gaagagcggg cagctaaagt tgctgagcag caggagagag
     4681 agcgagcagc acagcaacag cagccgagtg cttctccccg agcaggcacc cctgtggggg
     4741 ctctcatggg ggtggtgcca ccaccaacac caatggggat gctcaatcag cagttgacac
     4801 ctgttgcagg catgatgggt ggctatccgc caggccttcc acctttgcag ggcccagttg
     4861 atggccttgt tagcatgggc agcatgcagc cacttcaccc tggggggcct ccacctcacc
     4921 atcttccgcc aggtgtgcct ggcctcccag gcatcccacc accgggtgtg atgaatcaag
     4981 gagtagcccc catggtaggg actccagcac caggtggaag tccgtatgga caacaggtag
     5041 gagttttggg acctccaggg cagcaggcac cacctccata tcctggtcct catccagctg
     5101 gcccccctgt catacagcag ccaacaacgc ccatgtttgt ggctccccca ccaaagaccc
     5161 aaaggcttct ccactcagag gcctacctga aatacattga aggactcagt gctgaatcca
     5221 acagcattag caagtgggac caaactttgg cagctcgaag acgggatgtc catttgtcca
     5281 aagaacagga gagccgccta ccttctcact ggctcaaaag taaaggggca cacaccacca
     5341 tggcagatgc cctctggcgc ctacgggatt taatgcttcg agacactctc aacatccgac
     5401 aggcatacaa cctagaaaat gtttaatcac atcactgttt cttctgtgga agcaaagagt
     5461 tgtggagcgg tagccatttt agttactggg gtgggaggga ggaacaaagg atgataattt
     5521 ttattgcatt ttattgtaca tcacacagcc atttttatat aaggacactt ttaataagct
     5581 atttcaaatt tggttttgtt acattaagtt gactatcaaa tacacaaaag attttttttg
     5641 catatgtttc ctttgtttaa aaccagtttc ataattggtt atatatagta atagttttat
     5701 ctttacttgt taaaggactt aaatcatcaa aggttttggc ttggcttagg gttttcgttt
     5761 tcttttttat aaatatatat tatatatata tacacatata aaagaaaaaa tgaaaaaaaa
     5821 gtttacaaat ttaagttgac aatgaaatgt gaagttggtc ctagtttaca tcttagagga
     5881 atgtatatgt atgttttaca tgcctaaata tctgcaggtt ttcttacagg taaagcgaag
     5941 tgctttgaaa agtttagatt atacatgtgt gacagatgcg gcatatttgc tctattaaca
     6001 cagaggctta ctatagaaat ctaaagtcaa tgctgtacat ccatccagtt agtgtaactg
     6061 aagggaaatg taactttgtg ctgagttaga catctgtatt gtcagtgatt cttgtagaat
     6121 atgtgctcag atctgagtta tatttagttt tggaaggtaa gttgaagagt acttttgatc
     6181 agtttatgat tcagtttatg attttagttt ttgccttcat gttatacatt tatgatttga
     6241 aactgtacat ctgttacctt gaaaaacatt gaagaaagta ctgaagtgtg catggaggtg
     6301 gtttaagcat aatacttaac ccaagaaaga gtgtaagtgg acacaagctg tgcctgcaca
     6361 tagctgtgca gggtagactg cctacataca catggccggg attctttatt tccttgttat
     6421 caattatagt gctttgtttg tttcagggtt ggaattctca accagaaata atactttcta
     6481 aaatatttta aaattcagct tgtgctttgg attatagaag gaaattatac tttaagaaaa
     6541 tgttcacaaa aaaaaaaaaa aaaaaaggac tattacagat cccaatactt ggatttggtg
     6601 accttgtctt tctttctttt cttgagacat ggtcctacta ccaaccctgg ctggactgga
     6661 gctcagtgta tagaccaggc tagtctcaaa ctctgcctct tcctcccaag tgctgggatt
     6721 aagggcaggt accatagtgc tcagcaacca caaccctgtc tttccaacac ggccctagcg
     6781 taagcactga ggcagtgtgc agtgctcagg cagcagcaaa catttcccgg gggtggtttt
     6841 gaacctgctt gggtggttgt gtggtgctga cgctgccact gccctgttgt tcattgagaa
     6901 tgattgttaa atgacactct tcctttagaa tataacggat cagtactcat gtttaattgc
     6961 catgcttaat aaatcatgag aacaaaagag tatagaatgg aaagcattcc ctggtagcta
     7021 ctttaaatac aggagccctg taacttaata ccagtagtca accactggat ctcagttttc
     7081 atcaagtatt ttaaataaat aatcttaaat tttaaaatac gtactgcaga gtatgccagt
     7141 atcttattgt taaaactgaa tcaaataaat cttcgattcc tggttatttg gaccattgac
     7201 tcatcatgga ctatataatg taataagatt cttttctctt aaggtatcct tgaattacac
     7261 caaagaacca gaaacttaat tttggttaaa ttatttattt atttcatgca ttaattttct
     7321 ttttcttttt aaaggtttag atgaggctcc ttagggagtc tctaaaaccg cttcactatc
     7381 agcaaccagg agtactagaa gccagagcac tcttcctcct ggctcctccc cagtgctcta
     7441 gtgctgtagg aaccaagagc cagccccagg ttccccgagg cagtaaaaat ccagcacagg
     7501 gggctgtgtc cctaaggcaa gccctgatta cctttaaaaa aaaccaaaaa aacaaacaaa
     7561 aaaaaaaaac ctaattaact aaagcattta aggcactatt tattttagaa tcatgctttt
     7621 gaagagcatc agtgattact tagggtgtaa tatgtaaaga tcagacatct ccaaaaacag
     7681 aaaaagtaca agtaaacaac acactttctc atgactttta agaactgtag taatgtggct
     7741 taggaaatat aatggcctaa ttgttttcaa aatgtaagtt cctgtgaaga attttgttta
     7801 tattgggttg gggacctata ggtttaaaat agaatgtcag tcagctgact taaaaaacat
     7861 tggttttact aagtctgcct tccccttcta aggaagaact gagtgggtaa gggacaggtg
     7921 tgtaaaatct ccaaatggat gttacagctt tcagcttgaa cgtttgtttc cagacctgat
     7981 taaaatttgg tttattctaa tttctgtact atatcatctg aggttttaag tggtaactgg
     8041 ttctatacca tgtatgtatc atatgtttgt tcatcaaagc tttttaatcc aaataaaaac
     8101 aacagtttgc aaagtga
//
