LOCUS       NM_001417501            1837 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus PDZ binding kinase (Pbk), transcript variant 2, mRNA.
ACCESSION   NM_001417501 XM_006519257
VERSION     NM_001417501.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1837)
  AUTHORS   Zeng,F., Du,S., Wu,M., Dai,C., Li,J., Wang,J., Hu,G., Cai,P. and
            Wang,L.
  TITLE     The oncogenic kinase TOPK upregulates in psoriatic keratinocytes
            and contributes to psoriasis progression by regulating neutrophils
            infiltration
  JOURNAL   Cell Commun Signal 22 (1), 386 (2024)
   PUBMED   39090602
  REMARK    GeneRIF: The oncogenic kinase TOPK upregulates in psoriatic
            keratinocytes and contributes to psoriasis progression by
            regulating neutrophils infiltration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1837)
  AUTHORS   Cao,Y., Feng,Z., He,X., Zhang,X., Xing,B., Wu,Y., Hojnacki,T.,
            Katona,B.W., Ma,J., Zhan,X. and Hua,X.
  TITLE     Prolactin-regulated Pbk is involved in pregnancy-induced beta-cell
            proliferation in mice
  JOURNAL   J Endocrinol 252 (2), 107-123 (2021)
   PUBMED   34788229
  REMARK    GeneRIF: Prolactin-regulated Pbk is involved in pregnancy-induced
            beta-cell proliferation in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1837)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1837)
  AUTHORS   Ma,J., Xing,B., Cao,Y., He,X., Bennett,K.E., Tong,C., An,C.,
            Hojnacki,T., Feng,Z., Deng,S., Ling,S., Xie,G., Wu,Y., Ren,Y.,
            Yu,M., Katona,B.W., Li,H., Naji,A. and Hua,X.
  TITLE     Menin-regulated Pbk controls high fat diet-induced compensatory
            beta cell proliferation
  JOURNAL   EMBO Mol Med 13 (5), e13524 (2021)
   PUBMED   33821572
  REMARK    GeneRIF: Menin-regulated Pbk controls high fat diet-induced
            compensatory beta cell proliferation.
REFERENCE   5  (bases 1 to 1837)
  AUTHORS   Miki,Y., Devi,L., Imai,Y., Minami,N., Koide,T. and Goel,S.
  TITLE     Deletion of the PDZ-binding kinase (Pbk) gene does not affect male
            fertility in mice
  JOURNAL   Reprod Fertil Dev 32 (10), 893-902 (2020)
   PUBMED   32586419
REFERENCE   6  (bases 1 to 1837)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 1837)
  AUTHORS   Easterday,M.C., Dougherty,J.D., Jackson,R.L., Ou,J., Nakano,I.,
            Paucar,A.A., Roobini,B., Dianati,M., Irvin,D.K., Weissman,I.L.,
            Terskikh,A.V., Geschwind,D.H. and Kornblum,H.I.
  TITLE     Neural progenitor genes. Germinal zone expression and analysis of
            genetic overlap in stem cell populations
  JOURNAL   Dev Biol 264 (2), 309-322 (2003)
   PUBMED   14651920
REFERENCE   8  (bases 1 to 1837)
  AUTHORS   Geschwind,D.H., Ou,J., Easterday,M.C., Dougherty,J.D.,
            Jackson,R.L., Chen,Z., Antoine,H., Terskikh,A., Weissman,I.L.,
            Nelson,S.F. and Kornblum,H.I.
  TITLE     A genetic analysis of neural progenitor differentiation
  JOURNAL   Neuron 29 (2), 325-339 (2001)
   PUBMED   11239426
REFERENCE   9  (bases 1 to 1837)
  AUTHORS   Abe,Y., Matsumoto,S., Kito,K. and Ueda,N.
  TITLE     Cloning and expression of a novel MAPKK-like protein kinase,
            lymphokine-activated killer T-cell-originated protein kinase,
            specifically expressed in the testis and activated lymphoid cells
  JOURNAL   J Biol Chem 275 (28), 21525-21531 (2000)
   PUBMED   10781613
REFERENCE   10 (bases 1 to 1837)
  AUTHORS   Gaudet,S., Branton,D. and Lue,R.A.
  TITLE     Characterization of PDZ-binding kinase, a mitotic kinase
  JOURNAL   Proc Natl Acad Sci U S A 97 (10), 5167-5172 (2000)
   PUBMED   10779557
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125058.4.
            
            On Mar 6, 2023 this sequence version replaced XM_006519257.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422590.517901.1,
                                           SRR13422601.1625535.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-415               AC125058.4         121269-121683       c
            416-490             AC125058.4         118282-118356       c
            491-584             AC125058.4         115547-115640       c
            585-727             AC125058.4         114463-114605       c
            728-897             AC125058.4         113595-113764       c
            898-1027            AC125058.4         112270-112399       c
            1028-1204           AC125058.4         110795-110971       c
            1205-1837           AC125058.4         109749-110381       c
FEATURES             Location/Qualifiers
     source          1..1837
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.36 cM"
     gene            1..1837
                     /gene="Pbk"
                     /gene_synonym="2810434B10Rik; D14Ertd732e; TOPK"
                     /note="PDZ binding kinase"
                     /db_xref="GeneID:52033"
                     /db_xref="MGI:MGI:1289156"
     exon            1..415
                     /gene="Pbk"
                     /gene_synonym="2810434B10Rik; D14Ertd732e; TOPK"
                     /inference="alignment:Splign:2.1.0"
     exon            416..490
                     /gene="Pbk"
                     /gene_synonym="2810434B10Rik; D14Ertd732e; TOPK"
                     /inference="alignment:Splign:2.1.0"
     exon            491..584
                     /gene="Pbk"
                     /gene_synonym="2810434B10Rik; D14Ertd732e; TOPK"
                     /inference="alignment:Splign:2.1.0"
     exon            585..727
                     /gene="Pbk"
                     /gene_synonym="2810434B10Rik; D14Ertd732e; TOPK"
                     /inference="alignment:Splign:2.1.0"
     exon            728..897
                     /gene="Pbk"
                     /gene_synonym="2810434B10Rik; D14Ertd732e; TOPK"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1027
                     /gene="Pbk"
                     /gene_synonym="2810434B10Rik; D14Ertd732e; TOPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1204
                     /gene="Pbk"
                     /gene_synonym="2810434B10Rik; D14Ertd732e; TOPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1837
                     /gene="Pbk"
                     /gene_synonym="2810434B10Rik; D14Ertd732e; TOPK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1804..1809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pbk"
                     /gene_synonym="2810434B10Rik; D14Ertd732e; TOPK"
                     /note="hexamer: AATAAA"
     polyA_site      1837
                     /gene="Pbk"
                     /gene_synonym="2810434B10Rik; D14Ertd732e; TOPK"
                     /note="major polyA site"
ORIGIN      
        1 ggttactgcg agtgttggcg ggagggagct gttcctgcat tttctggagc gagtcttctg
       61 actgctttta gttagaactc cagtgcccct cggcgggccg cggcctttga aaatgcgcgc
      121 gccctaaacg ctgcggcggt tacgctgttg gcgggaggga gctgagcctg cactttccgg
      181 actaggtgtc cagacagctt tgagccagcc cgtcactttc acctttttac ccgagcgtgc
      241 gagcgtggta agggaaagcc tggccgactc gaaggtggtt ggcagactgg gggtcagggg
      301 tggagcatcg aggacctgag gggagggtcg cggacgggag ggacggggac gagagggagg
      361 ctgcctccac tggaggacct ggaggagatc tgcggggaag aacagcaaac tgagggacct
      421 aacgtgattg ctacaatgga aggaattaat aatttcaaga cgccaaacaa atctgaaaaa
      481 aggaaatctg tattatgttc cactccatgt gtaaatatcc ctgcctctcc atttatgcag
      541 aagcttggct ttgggactgg ggtcagcgtt tacctaatga aaagatctcc aagagggttg
      601 tctcattctc cttgggccgt gaaaaagata agtcttttat gcgatgatca ttatcgaact
      661 gtgtatcaga agagactaac tgatgaagct aagattttaa aaaaccttaa tcacccaaac
      721 attataggat atcgtgcttt tactgaagcc agtgatggta gtctgtgcct tgctatggag
      781 tatggaggtg aaaagtctct gaatgactta atagaagagc ggaacaaaga cagtggaagt
      841 ccttttccag cagctgtaat tctcagagtt gctttgcaca tggccagagg gctaaagtac
      901 ctgcaccaag aaaagaagct gcttcatgga gacataaagt cttcaaatgt tgtaattaaa
      961 ggtgattttg aaacaattaa aatctgtgat gtaggagtct ctctgccatt ggatgaaaat
     1021 atgactgtga ctgatcctga ggcctgttat attggtactg agccatggaa acccaaggaa
     1081 gcgttggaag aaaatggcat cattactgac aaggcagatg tgtttgcttt tggccttact
     1141 ctgtgggaaa tgatgacttt atgtattcca cacgtcaatc ttccagatga tgatgttgat
     1201 gaagatgcaa cctttgatga gagtgacttc gatgatgaag catattatgc agctctgggg
     1261 acaaggccat ccatcaacat ggaagagctg gatgactcct accagaaggc cattgaactc
     1321 ttctgtgtgt gcactaatga ggatcctaaa gatcgcccgt ctgctgcaca catcgttgaa
     1381 gctttggaac tagatggcca atgttgtggt ctaagctcaa agcattaact tgtatgggaa
     1441 ctgttaacta gatatatgta gttaatataa cttatggtag ctagattcta gaagtagctt
     1501 taacactagt gacccctgtc taagatgact taagaatcaa gggaccattg ctttgttaca
     1561 gatcttttta gatattcttg cttctttagt gggttactaa aaatttcact acgtacatgt
     1621 ggtacagata tctgtctgct catagtgtca gtccttcagc tggcctgtca gcccatgcgc
     1681 cctgggactt gagaagagtt cataaacgta gctcctaggg tgtcttgcct ctctacactt
     1741 agcttctaat ttattacttt gtttctactg attgtgtctt aagtctttta aaataaatgt
     1801 aagaataaac aataaaagac agttttagta ccaggca
//
