LOCUS       NM_026312               2646 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus polysaccharide biosynthesis domain containing 1
            (Pbdc1), transcript variant 1, mRNA.
ACCESSION   NM_026312
VERSION     NM_026312.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2646)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2646)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671897.6, AK030507.1 and BY389180.1.
            
            On Aug 9, 2013 this sequence version replaced NM_026312.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030507.1, SRR1660815.20122.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AL671897.6         67500-67534
            36-2638             AK030507.1         18-2620
            2639-2646           BY389180.1         448-455
FEATURES             Location/Qualifiers
     source          1..2646
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 46.83 cM"
     gene            1..2646
                     /gene="Pbdc1"
                     /gene_synonym="2610029G23Rik"
                     /note="polysaccharide biosynthesis domain containing 1"
                     /db_xref="GeneID:67683"
                     /db_xref="MGI:MGI:1914933"
     exon            1..88
                     /gene="Pbdc1"
                     /gene_synonym="2610029G23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..655
                     /gene="Pbdc1"
                     /gene_synonym="2610029G23Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0368 protein Cxorf26 homolog; protein PBDC1"
                     /codon_start=1
                     /product="protein PBDC1 isoform 1"
                     /protein_id="NP_080588.1"
                     /db_xref="CCDS:CCDS30334.1"
                     /db_xref="GeneID:67683"
                     /db_xref="MGI:MGI:1914933"
                     /translation="MDAAGESEEPVSGEALSIAHALSHPPESYGNDPDIEMAWAIRAM
                     QHAEVYYKLISSVDPQFLKLTKVDDQIYSEFREIFETLRVDVLDPEELKSESAKEKWR
                     PFCLKFEGIVEDYNYGTLLRLDCSQGYTEENTIFAPRIQFFAIEIARNREGYNKAVSV
                     SIQDKEGEEGAGNKEEAAEKGADSGGEKEEGANREGEK"
     exon            89..154
                     /gene="Pbdc1"
                     /gene_synonym="2610029G23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            155..214
                     /gene="Pbdc1"
                     /gene_synonym="2610029G23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            215..355
                     /gene="Pbdc1"
                     /gene_synonym="2610029G23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            356..467
                     /gene="Pbdc1"
                     /gene_synonym="2610029G23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            468..2646
                     /gene="Pbdc1"
                     /gene_synonym="2610029G23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      915..920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pbdc1"
                     /gene_synonym="2610029G23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      939
                     /gene="Pbdc1"
                     /gene_synonym="2610029G23Rik"
                     /note="major polyA site"
     regulatory      1020..1025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pbdc1"
                     /gene_synonym="2610029G23Rik"
                     /note="hexamer: TATAAA"
     polyA_site      1043
                     /gene="Pbdc1"
                     /gene_synonym="2610029G23Rik"
     regulatory      1595..1600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pbdc1"
                     /gene_synonym="2610029G23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1625
                     /gene="Pbdc1"
                     /gene_synonym="2610029G23Rik"
ORIGIN      
        1 gcagcgcgcg caacaggtca cttccgggac gagaaagccg cacttaccta gcggcgacat
       61 ggatgctgcc ggcgaaagcg aagagccggt ctctggggaa gcgttgtcca tcgcccatgc
      121 gctctctcac cctccggagt catatggcaa cgaccctgat attgaaatgg cttgggccat
      181 tcgagcaatg cagcatgctg aagtctatta taaactgatt tcatcagttg acccacagtt
      241 tctgaaactc accaaagtag atgaccaaat ctactctgag ttccgtgaga tttttgagac
      301 actcagggta gatgtattgg acccagaaga actcaaatca gaatcagcta aagaaaagtg
      361 gagaccattc tgcttaaaat ttgaagggat cgtagaagat tataactacg ggactttact
      421 gcgactggat tgttcccagg gctacactga agagaacacc atctttgcac ccaggattca
      481 attttttgcc attgaaattg ctcggaaccg ggaaggctat aataaagcag tttccgtcag
      541 tattcaggac aaagaaggag aggaaggagc tggcaataaa gaagaagcag ctgagaaagg
      601 agctgatagt ggaggagaaa aagaggaagg agccaacaga gaaggagaaa agtaggaaac
      661 taacgaggga ggagaaaaag aaagccaaga aacccgtgac tcagctgaac tcacacgtgt
      721 ctgctgtaca cagccccctt tggttcagtg atgcccttgt gcaagtggag gactcaaacg
      781 gacatctttc tagctagcaa gagaagctac tctggccata atagcttaaa cacccttagt
      841 ggagtctctt aattcattat tgcttgatac cctgtttctt ggctttaact gttgttgaaa
      901 taaggcattt tgtaaataaa ttccttttgg tttattttac taatgactga tcttagaaag
      961 tatttacatt tatttgatac ttcacaatgt caggtatata atctcatcac agtatctcat
     1021 ataaaactct ctattaattc ttctccctgt tctcagtagt gaaattctct taacctgtta
     1081 gcttgtacct ggtatcagga ttaaaagtct atataagaat agactcttag ccagacttaa
     1141 gtgactcata cttgtaattc caatacctga gaggctgagg taagagagtt ccatgacttt
     1201 gaggttagtg tgacctacag agtgagaccc tgtctcaaaa atgaattgtt taaaaaaaaa
     1261 tggctttttc ctttgtggtg actatagctc tctgatttcc tttactgttt tggaaggata
     1321 tgtatacctg gaacagcagc ctgaacggtc aggttagaga gtgcagccca ttcattagag
     1381 aagagcaagg gcctttactt ccttttagag cattgttgtc atttgtttat tggttggttg
     1441 gttggttggt ttttctgaga tggagtctca ccttatagac cattctggcc cagtaccagt
     1501 actcactatg taggtcagac tagcttcata ctcacaatcc tgccttgttc atcctctcat
     1561 agctacgttg ttaacctgaa acttagccag tagcaataaa tgctaatata gtacttataa
     1621 tgtgatatat gactgagaaa gtggtttccc atatataatg ttatagacaa gagcatatat
     1681 ttatatttga catataaaca tttgttgatt tgaaatggga gggaggtgtt tccttctcag
     1741 gtgaagctgt tcagagtgaa gaaagacttc agttatctac tcaggttcgt gtgcatctac
     1801 aacagagttt gatcactgaa agttaaagga aaccacaacc cttgcggtgc atacagacaa
     1861 tactctctca agcggaacta taacattctt gtgtaagaaa ggatttattg ccaggtgggg
     1921 acctgggagg cagaggcagg tgaatatctg agtttgaggc taccctggtc tacatataga
     1981 gtgagtaagg gcttcacagc aaagccctgc ctcataaata tacagttcta tttgaggata
     2041 aatgtattga atactaggaa aataacactt tcaatgcttt tattggaaaa ttcttaagag
     2101 tatttcaaac atttattaaa actttccttt tataaaaatg tatagctttg aaagagttgg
     2161 agagtccctt gtatttcata ctagccaggc tgttaaaaaa aaatctatac tgtgtaattt
     2221 tctttagttg catgtcaata tatattatct tagaagttga ggaagaaaaa gtattgacca
     2281 catataattg cagttccatc acagagcctg aagcagcctg cacaggtctg caccaggtcc
     2341 tgtgtggatt tattatgatt tccaggttag gattttatgg gatttcttag tatgagacta
     2401 agtgggtctc gatttcttcc actttttttt gagctctttt tcttctcttt gttttgtcca
     2461 attccaatgt gttagttttt attttatcct ttttattttt attagtattc cttaaaagcc
     2521 tgttttctaa tgagagacag aaaaggggtg aatccacatg ggaggggagg tgggatgagg
     2581 gaaggggaac cataatcagg atgtattatg tgaaaaagaa tctattttca ataaaaggaa
     2641 aaaaat
//
