LOCUS       NM_018878               3724 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Mus musculus PAX interacting (with transcription-activation domain)
            protein 1 (Paxip1), mRNA.
ACCESSION   NM_018878
VERSION     NM_018878.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3724)
  AUTHORS   Nakata,Y., Nagasawa,S., Sera,Y., Yamasaki,N., Kanai,A.,
            Kobatake,K., Ueda,T., Koizumi,M., Manabe,I., Kaminuma,O. and
            Honda,H.
  TITLE     PTIP epigenetically regulates DNA damage-induced cell cycle arrest
            by upregulating PRDM1
  JOURNAL   Sci Rep 14 (1), 17987 (2024)
   PUBMED   39097652
  REMARK    GeneRIF: PTIP epigenetically regulates DNA damage-induced cell
            cycle arrest by upregulating PRDM1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3724)
  AUTHORS   Liang,J., Wang,J., Ye,C., Bai,Y., Tong,Y., Li,Y., Ji,Y. and
            Zhang,Y.
  TITLE     Ptip is essential for tooth development via regulating Wnt pathway
  JOURNAL   Oral Dis 30 (3), 1451-1461 (2024)
   PUBMED   36648392
  REMARK    GeneRIF: Ptip is essential for tooth development via regulating Wnt
            pathway.
REFERENCE   3  (bases 1 to 3724)
  AUTHORS   Zhang,T., Cui,M., Li,Y., Cheng,Y., Gao,Z., Wang,J., Zhang,T.,
            Han,G., Yin,R., Wang,P., Tian,W., Liu,W., Hu,J., Wang,Y., Liu,Z.
            and Zhang,H.
  TITLE     Pax transactivation domain-interacting protein is required for
            preserving hematopoietic stem cell quiescence via regulating
            lysosomal activity
  JOURNAL   Haematologica 108 (9), 2410-2421 (2023)
   PUBMED   36924252
  REMARK    GeneRIF: Pax transactivation domain-interacting protein is required
            for preserving hematopoietic stem cell quiescence via regulating
            lysosomal activity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3724)
  AUTHORS   Liu,J., Xu,Y., Chen,Y.Q. and Su,D.
  TITLE     PTIP Deficiency in B Lymphocytes Ameliorates Dextran Sulfate
            Sodium-Induced Ulcerative Colitis in Mice
  JOURNAL   Discov Med 35 (176), 343-352 (2023)
   PUBMED   37272101
  REMARK    GeneRIF: PTIP Deficiency in B Lymphocytes Ameliorates Dextran
            Sulfate Sodium-Induced Ulcerative Colitis in Mice.
REFERENCE   5  (bases 1 to 3724)
  AUTHORS   Munoz,I.M. and Rouse,J.
  TITLE     Control of histone methylation and genome stability by PTIP
  JOURNAL   EMBO Rep 10 (3), 239-245 (2009)
   PUBMED   19229280
  REMARK    Review article
REFERENCE   6  (bases 1 to 3724)
  AUTHORS   Cho,Y.W., Hong,T., Hong,S., Guo,H., Yu,H., Kim,D., Guszczynski,T.,
            Dressler,G.R., Copeland,T.D., Kalkum,M. and Ge,K.
  TITLE     PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4
            methyltransferase complex
  JOURNAL   J Biol Chem 282 (28), 20395-20406 (2007)
   PUBMED   17500065
  REMARK    GeneRIF: Without DNA damage agent treatment, endogenous PTIP
            associates with MLL3- and MLL4-containing histone H3 K4
            methyltransferase complex that also contains ASH2L, RBBP5, WDR5,
            hDPY-30, NCOA6, PA1 and JmjC domain-containing putative histone
            demethylase UTX.
REFERENCE   7  (bases 1 to 3724)
  AUTHORS   Kim,D., Wang,M., Cai,Q., Brooks,H. and Dressler,G.R.
  TITLE     Pax transactivation-domain interacting protein is required for
            urine concentration and osmotolerance in collecting duct epithelia
  JOURNAL   J Am Soc Nephrol 18 (5), 1458-1465 (2007)
   PUBMED   17429055
  REMARK    GeneRIF: Pax transactivation domain-interacting protein is required
            for the urine concentration mechanism by modulating arginine
            vasopressin receptor 2 and AQP2 expression in the inner medulla.
REFERENCE   8  (bases 1 to 3724)
  AUTHORS   Cho,E.A., Prindle,M.J. and Dressler,G.R.
  TITLE     BRCT domain-containing protein PTIP is essential for progression
            through mitosis
  JOURNAL   Mol Cell Biol 23 (5), 1666-1673 (2003)
   PUBMED   12588986
  REMARK    GeneRIF: PTIP is an essential element of the cell proliferation
            machinery, perhaps by functioning in the DNA repair pathways
REFERENCE   9  (bases 1 to 3724)
  AUTHORS   Hoffmeister,A., Ropolo,A., Vasseur,S., Mallo,G.V., Bodeker,H.,
            Ritz-Laser,B., Dressler,G.R., Vaccaro,M.I., Dagorn,J.C., Moreno,S.
            and Iovanna,J.L.
  TITLE     The HMG-I/Y-related protein p8 binds to p300 and Pax2
            trans-activation domain-interacting protein to regulate the
            trans-activation activity of the Pax2A and Pax2B transcription
            factors on the glucagon gene promoter
  JOURNAL   J Biol Chem 277 (25), 22314-22319 (2002)
   PUBMED   11940591
REFERENCE   10 (bases 1 to 3724)
  AUTHORS   Lechner,M.S., Levitan,I. and Dressler,G.R.
  TITLE     PTIP, a novel BRCT domain-containing protein interacts with Pax2
            and is associated with active chromatin
  JOURNAL   Nucleic Acids Res 28 (14), 2741-2751 (2000)
   PUBMED   10908331
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC146612.2.
            
            On Feb 17, 2022 this sequence version replaced NM_018878.3.
            
            Summary: This gene encodes a nuclear-localized protein that
            contains six BRCT1 (C-terminal of breast cancer susceptibility
            protein) domains. The encoded protein is involved in the repair of
            DNA double-strand breaks and is necessary for progression through
            cell division. The protein also functions in the regulation of
            transcription by recruiting histone methyltransferases to gene
            promoters bound by the sequence-specific transcription factor
            paired box protein 2 (Pax2). [provided by RefSeq, Mar 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066014.1, AK144606.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AC146612.2         19687-19881
            196-330             AC146612.2         22303-22437
            331-374             AC146612.2         27307-27350
            375-438             AC146612.2         29595-29658
            439-552             AC146612.2         35401-35514
            553-1173            AC146612.2         38456-39076
            1174-1873           AC146612.2         44790-45489
            1874-1968           AC146612.2         45848-45942
            1969-2064           AC146612.2         49408-49503
            2065-2202           AC146612.2         50970-51107
            2203-2324           AC146612.2         51589-51710
            2325-2509           AC146612.2         52465-52649
            2510-2553           AC146612.2         54084-54127
            2554-2624           AC146612.2         56525-56595
            2625-2727           AC146612.2         58234-58336
            2728-2896           AC146612.2         59949-60117
            2897-2997           AC146612.2         62166-62266
            2998-3132           AC146612.2         66525-66659
            3133-3208           AC146612.2         66748-66823
            3209-3269           AC146612.2         66905-66965
            3270-3724           AC146612.2         68577-69031
FEATURES             Location/Qualifiers
     source          1..3724
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 13.23 cM"
     gene            1..3724
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /note="PAX interacting (with transcription-activation
                     domain) protein 1"
                     /db_xref="GeneID:55982"
                     /db_xref="MGI:MGI:1890430"
     exon            1..195
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..3285
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /note="PAX transactivation activation domain-interacting
                     protein"
                     /codon_start=1
                     /product="PAX-interacting protein 1"
                     /protein_id="NP_061366.2"
                     /db_xref="CCDS:CCDS39039.1"
                     /db_xref="GeneID:55982"
                     /db_xref="MGI:MGI:1890430"
                     /translation="MSEPAPEVPEELFREVKYYAVGDIDPQVIQLLKAGKAKEVSYNA
                     LASHIISEDGDNPEVGEAREVFDLPVVKPSWVTLSVQCGALLPVNGFSPESCQIFFGL
                     TACLSQVSSEDRSALWALVTFHGGSCQLNLNKKCTHLIVPEPKGEKYERAVKRTSIKI
                     VTPDWVLDCVSEKRRKDEAFYHPRLIIYEEEEEEEEEGDNEEQDSQNEGSTEKSSVAS
                     SAVASPAEQPCSPKPRAEVSKGELMFDDSSDSSPEKQERSLNWAPAEAPPLNTAQRRL
                     PQGKGPGLINLCANVPPVPGDILPPDMRGNLMAPGQNLQNSERSEILGTWSPAVRTLR
                     NITNNADIQQINRPSNVAHILQSLSAPTKSLEQQVARGQQGHPNASAVLFGQAKGAPE
                     THVLQQHHPPQQPQQQHPALHLQPQIMQLQQQQQQQQQQQQQPQPYPQPPSHQFPQQV
                     HQHQFSQQQLQFPQQPLHPQQQLHRPQQQLQPFQQQHALQQQLHQLQQQQLQHHQLAQ
                     LQQQQQQQHNLLQQQQQQQQLQRLQQQQQMQNQAAHLSQASQALQHQVLPQQPLQLSL
                     QPPPQQQQQQQLFGHDPAVEIPEESFLLGCVFAIADYPEQMSDKQLLATWKRIIQAHG
                     GTVDPTFTSRCTHLLCASQVSSMYTQALRERKRCVTAHWLNTVLKKKKLMPPHRALHF
                     PVAFPPGGKPCSQHIISVTGFVDNDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPSG
                     LKYEKAKEWRIPCVNAQWLGDILLGNFEALRQVQYSRYTAFNMPDPFVPTPHLVLGLL
                     DAWRTPVKVTAELLMGVRLPPKLKPNEVANIQPSSKRARIEDLPPPTKKLTPELTPLV
                     LFTGFEPVQVQQYIKKLYILGGEVAECTKKCTHLIASKVTRTVKFLTAISVVKHIVTP
                     DWLEECFKRQTFIDEQNYILRDAEAEVLFSFSLEESLKRAHVSPLFKTKYFYITPGIC
                     PSLATMKAIVECAGGKVLAKQPSFRKLMEHKQNKSLSEIILISCENDLHLCREYFARG
                     IDVHNAEFVLTGVLTQTLDYESYKFN"
     exon            196..330
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            331..374
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            375..438
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            439..552
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            553..1173
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1873
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1968
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2064
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2202
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2324
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2509
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2553
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2624
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2727
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2896
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..2997
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..3132
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3133..3208
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..3269
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..3724
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3703..3708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /note="hexamer: AATAAA"
     polyA_site      3724
                     /gene="Paxip1"
                     /gene_synonym="D5Ertd149e; PTIP"
                     /note="major polyA site"
ORIGIN      
        1 gagtgcagct gcggctgcgg gccgggctgt gccgccgggc agtaggcaga gctacgacgc
       61 tgggcgcggc gggccgggtg acgcggggcc gggcgccgcc gcgccgccgc gatcatgtcg
      121 gagccggcgc ccgaagttcc agaggagcta ttccgcgagg tcaagtacta cgcggtgggc
      181 gacatcgacc cgcaggttat tcagctcctt aaagctggga aagccaagga agtctcctac
      241 aatgccctgg cctcacacat catttcagag gatggggaca acccagaggt gggagaagcc
      301 cgtgaggtct ttgacttgcc cgttgtaaag ccttcctggg tgactctgtc cgtgcaatgt
      361 ggcgctctcc tgccagtcaa tggtttctct ccagagtcct gtcagatttt ttttggactc
      421 actgcctgcc tttctcaggt gtcatctgaa gacagaagtg ccctgtgggc cttggttacg
      481 ttccacgggg gcagttgcca actaaacctt aacaagaagt gcacacactt gattgtccca
      541 gagccaaagg gggagaaata cgagcgtgct gtcaaaagaa caagtattaa gattgtcacc
      601 ccggactggg tcctggactg tgtgtctgag aagaggagga aggatgaagc gttttaccat
      661 ccacgcctga tcatctatga ggaggaggaa gaggaggagg aagagggaga caacgaggag
      721 caggactccc agaacgaggg cagcactgag aagtccagtg tcgccagctc tgcagtggcc
      781 tcccctgctg agcagccgtg ctctcccaag cccagggctg aggtgtccaa aggagagttg
      841 atgtttgatg actcttctga ctcatcccct gaaaagcagg agcgcagctt gaactgggcc
      901 cctgctgaag ccccaccact caacacagcc cagcgcaggc tgcctcaggg aaaagggcca
      961 ggactcatta acctgtgtgc caatgtccca cctgttccag gggacattct gcctcctgac
     1021 atgcggggta acttgatggc ccctggacaa aacctccaga attctgagcg gtcagaaata
     1081 ctagggacct ggagcccagc tgtccggacg ttgcgaaaca ttacaaacaa tgctgatatc
     1141 cagcagatca accggccatc caatgttgca catatcttac aatccctttc agcacccaca
     1201 aaaagcctag agcagcaggt ggcccgtggc cagcagggac accccaatgc cagtgctgtg
     1261 ctgtttggcc aggctaaagg tgctcccgag acacacgtgt tgcagcagca ccaccctccc
     1321 cagcagcctc agcagcagca cccagccctg cacctccagc cccagatcat gcagctccag
     1381 cagcagcagc agcagcagca acagcagcag cagcagcccc agccctaccc ccagcctcca
     1441 tcacatcagt tcccgcagca agtccatcag catcagttct ctcagcagca gctccagttt
     1501 ccacagcaac cattacaccc tcagcagcag ttgcatcgtc ctcaacagca gctgcagcca
     1561 tttcagcagc agcatgccct gcagcagcag cttcatcagt tgcagcagca gcagctccag
     1621 caccaccagt tagcacagct ccagcaacag cagcaacagc agcacaacct tctccagcag
     1681 cagcaacaac agcagcagct ccaacgcttg cagcagcagc agcagatgca gaatcaagca
     1741 gcacacttga gccaagcgtc ccaggcacta cagcaccagg ttctacccca gcagcccctg
     1801 cagctgtccc tgcagccccc acctcagcaa cagcagcagc agcagctttt tggacatgac
     1861 ccagcagtgg agattccaga agaaagcttc ttgctaggat gtgtgtttgc aattgcggac
     1921 tatcccgagc agatgtcgga taagcagctg ctggccacct ggaaaaggat aatccaggca
     1981 catggtggca ctgtggaccc cactttcaca agccgatgta cacacctcct ctgcgcaagt
     2041 caagtcagta gtatgtacac acaggcacta cgggagagaa agcggtgtgt cactgcacac
     2101 tggctcaaca cagtgctgaa gaagaagaag ctgatgcccc ctcatcgagc cctgcatttc
     2161 ccggtggcgt tcccacctgg gggcaaaccc tgttcacagc atattatctc tgtgactgga
     2221 tttgttgaca atgacagaga tgacctgaag ttaatggcat acctggcagg tgccaagtac
     2281 acagggtacc tgtgccgtag caacacagtc ctcatctgta aagaaccaag cggcttgaag
     2341 tatgaaaagg ccaaagagtg gaggatccca tgtgtgaatg cacagtggct gggggacatt
     2401 ctgctgggga actttgaggc cctgcggcaa gtgcagtaca gccggtacac cgccttcaac
     2461 atgccggacc ccttcgttcc cactccacac ttggtcttgg gtcttctaga tgcatggagg
     2521 accccagtga aggtgactgc agagctgttg atgggtgtaa gattacctcc taagctgaaa
     2581 ccaaatgagg tcgctaacat ccagccttct tctaaaagag ccagaattga agacttgcca
     2641 cctcccacta agaagctgac tccagagctg acgcctttag tgctcttcac tgggtttgag
     2701 cctgttcaag ttcagcagta cattaagaag ctgtacattc ttggtgggga agttgctgag
     2761 tgcacgaaga agtgtaccca cctcattgcc agcaaggtga cacgcacagt gaaattcttg
     2821 acggccatct ctgtagtaaa gcacattgtg actccggact ggctggagga gtgcttcaag
     2881 cgccagacat ttatcgatga gcagaactac atccttcgag atgctgaggc agaagtgctc
     2941 ttctctttca gtctggaaga gtccttaaag cgagcccatg tctctcccct ctttaagaca
     3001 aagtatttct atatcacccc tggcatctgc ccaagccttg caactatgaa ggcaattgta
     3061 gagtgtgcag ggggaaaggt gctagccaag cagccgtcct tccggaagct catggagcac
     3121 aagcagaata agagtctttc agagatcatt ttaatatcct gtgagaacga cctgcactta
     3181 tgtcgcgagt actttgccag gggaatagat gttcacaatg cggagtttgt cctgactgga
     3241 gtactcacac agacactgga ctatgaatca tataaattta actgatggcc tcttgctgct
     3301 gctagcctgg agcctggagc acaagggtag ctgctggcag catgaaccag gactccctcc
     3361 ccgcagaggg cttgttttcc agctctgcct tagggagaga cctcgaccag gaagacagat
     3421 gtaatactga ctgcatcgtg ttaagatgtg tgatcttatt ctaggaaaca taaattatgt
     3481 tttgtattat atgcctaaga gcccacatta agtcttctga ttaatttgcc aggtttttaa
     3541 tgtgttttca gaaagctgtg tgaaatttca tctacaaata aaaatgatgt aaataagact
     3601 ttgctgtcta aattatggct gttaaagata tgaaatgttt tgtactttga ttatttttat
     3661 ttcttacact tttcttttat attgataact tgctcacagt taaataaatg tacttttgaa
     3721 ctta
//
