LOCUS       NM_026110               3809 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus PAX3 and PAX7 binding protein 1 (Paxbp1), transcript
            variant 1, mRNA.
ACCESSION   NM_026110 XM_358888 XM_904433
VERSION     NM_026110.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3809)
  AUTHORS   Huang,C., Liu,S., Li,W., Zhao,S., Ren,X., Zhuo,F., Zhang,K., Li,X.,
            Wu,J., Zhu,Z., Chen,C., Zhang,W. and Yu,B.
  TITLE     Paxbp1 Is Indispensable for the Maintenance of Epidermal
            Homeostasis
  JOURNAL   J Invest Dermatol (2024) In press
   PUBMED   39236903
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 3809)
  AUTHORS   Li,W., Yang,Y., Zhuo,F., Liu,S., Zhang,K., Zhang,W., Huang,C. and
            Yu,B.
  TITLE     Paxbp1 is indispensable for the maintenance of peripheral CD4 T
            cell homeostasis
  JOURNAL   Immunology 172 (4), 641-652 (2024)
   PUBMED   38750609
  REMARK    GeneRIF: Paxbp1 is indispensable for the maintenance of peripheral
            CD4 T cell homeostasis.
REFERENCE   3  (bases 1 to 3809)
  AUTHORS   Li,W., Yang,Y., Liu,S., Zhang,D., Ren,X., Tang,M., Zhang,W.,
            Chen,X., Huang,C. and Yu,B.
  TITLE     Paxbp1 is indispensable for the survival of CD4 and CD8
            double-positive thymocytes
  JOURNAL   Front Immunol 14, 1183367 (2023)
   PUBMED   37404821
  REMARK    GeneRIF: Paxbp1 is indispensable for the survival of CD4 and CD8
            double-positive thymocytes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3809)
  AUTHORS   Zhou,S., Han,L., Weng,M., Zhu,H., Heng,Y., Wang,G., Shen,Z.,
            Chen,X., Fu,X., Zhang,M. and Wu,Z.
  TITLE     Paxbp1 controls a key checkpoint for cell growth and survival
            during early activation of quiescent muscle satellite cells
  JOURNAL   Proc Natl Acad Sci U S A 118 (13) (2021)
   PUBMED   33753492
  REMARK    GeneRIF: Paxbp1 controls a key checkpoint for cell growth and
            survival during early activation of quiescent muscle satellite
            cells.
REFERENCE   5  (bases 1 to 3809)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   6  (bases 1 to 3809)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3809)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   8  (bases 1 to 3809)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   9  (bases 1 to 3809)
  AUTHORS   Reymond,A., Friedli,M., Henrichsen,C.N., Chapot,F., Deutsch,S.,
            Ucla,C., Rossier,C., Lyle,R., Guipponi,M. and Antonarakis,S.E.
  TITLE     From PREDs and open reading frames to cDNA isolation: revisiting
            the human chromosome 21 transcription map
  JOURNAL   Genomics 78 (1-2), 46-54 (2001)
   PUBMED   11707072
REFERENCE   10 (bases 1 to 3809)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC141885.3.
            
            On or before Apr 9, 2009 this sequence version replaced
            XM_904433.2, XM_358888.5, NM_026110.1.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KY499709.1, SRR11927932.1961967.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-374               AC141885.3         35757-36130
            375-503             AC141885.3         37455-37583
            504-680             AC141885.3         42718-42894
            681-902             AC141885.3         43447-43668
            903-1006            AC141885.3         44114-44217
            1007-1224           AC141885.3         45119-45336
            1225-1414           AC141885.3         45849-46038
            1415-1538           AC141885.3         49580-49703
            1539-1638           AC141885.3         52807-52906
            1639-1754           AC141885.3         52991-53106
            1755-1954           AC141885.3         54441-54640
            1955-2099           AC141885.3         54845-54989
            2100-2221           AC141885.3         56677-56798
            2222-2298           AC141885.3         57391-57467
            2299-2365           AC141885.3         58019-58085
            2366-2512           AC141885.3         60827-60973
            2513-2667           AC141885.3         63136-63290
            2668-3809           AC141885.3         64958-66099
FEATURES             Location/Qualifiers
     source          1..3809
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 52.3 cM"
     gene            1..3809
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /note="PAX3 and PAX7 binding protein 1"
                     /db_xref="GeneID:67367"
                     /db_xref="MGI:MGI:1914617"
     exon            1..374
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2785
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /note="GC-rich sequence DNA-binding factor homolog;
                     GC-rich sequence DNA-binding factor 1"
                     /codon_start=1
                     /product="PAX3- and PAX7-binding protein 1"
                     /protein_id="NP_080386.3"
                     /db_xref="CCDS:CCDS49908.1"
                     /db_xref="GeneID:67367"
                     /db_xref="MGI:MGI:1914617"
                     /translation="MFRKARRVNVRKRNDSEEEERERDEEQEPPPLLPPPASGEEPGP
                     GGGDRAPAGESLLGPGPLPPPPSAHHPGLGAEAGGGISGGAEPGNGLKPRKRPRENKE
                     VPRASLLSFQDEEEENEEVFKVKKSSYSKKIVKLLKKEYKEDLEKSKIKTELNTAADS
                     DQPLDKTCHAKDTNPEDGVVISEHGEDEMDMESEKEEEKPKAGGAFSNALSSLNVLRP
                     GEIPDAAFIHAARKKRQLARELGDFTPHDSEPGKGRLVREDENDASDDEDDDEKRRIV
                     FSVKEKSQRQKIAEEIGIEGSDDDALVTGEQDEELSRWEQEQIRKGINIPQVQASQPS
                     EVNVYYQNTYQTMPYGASYGIPYSYTAYGSSDAKSQKTDNTVPFKTPSNEMAPVTIDL
                     VKRQLKDRLDSMKELHKTNQQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMR
                     GYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHSNKAL
                     MAPNLDSFGRDRALYQEHAKRRIAEREARRTRRRQAREQTGQMADHLEGLSSDDEETS
                     TDITNFNLEKDRILKESSKVFEDVLESFYSIDCIKAQFEAWRSKYYMSYKDAYIGLCL
                     PKLFNPLIRLQLLTWTPLEAKCRDFETMLWFESLLFYGCEDREQEKDEADVALLPTIV
                     EKVILPKLTVIAETMWDPFSTTQTSRMVGITMKLINGYPSVVNADNKNTQVYLKALLL
                     RMRRTLDDDVFMPLYPKNVLENKNSGPYLFFQRQFWSSVKLLGNFLQWYGIFSNKTLQ
                     ELSIDGLLNRYILMAFQNSEYGDDSIRKAQNVINCFPKQWFVNLKGERTISQLENFCR
                     YLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLLASVRALDHAISVASDHNVKEVKS
                     LIEGK"
     exon            375..503
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /inference="alignment:Splign:2.1.0"
     exon            504..680
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /inference="alignment:Splign:2.1.0"
     exon            681..902
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1006
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1224
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1414
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1538
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1638
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1754
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1954
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2099
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2221
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2298
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2365
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2512
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2667
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..3809
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2885..2890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /note="hexamer: AATACA"
     polyA_site      2905
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /note="major polyA site"
     regulatory      3024..3029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /note="hexamer: ATTAAA"
     polyA_site      3057
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
     regulatory      3787..3792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /note="hexamer: ATTAAA"
     polyA_site      3809
                     /gene="Paxbp1"
                     /gene_synonym="1810007M14Rik; C21orf66; Gcfc; Gcfc1;
                     Pax3/7bp"
                     /note="major polyA site"
ORIGIN      
        1 tgagagcgcg gtgacggcgg ctgggatgtt ccgaaaggcc cggcgggtga acgtgcgcaa
       61 gcggaacgac tcggaggagg aggagcggga gcgcgatgag gagcaggagc cgccaccgtt
      121 gctgcccccg ccggcctcgg gagaagagcc cggccctggc ggcggcgacc gggcccccgc
      181 gggggagtcg ctcctgggcc cggggccgct gccgccgccg ccctccgcgc accacccggg
      241 cctcggcgct gaggccgggg gcggcatctc cggcggcgcg gagcccggca atgggctgaa
      301 gccgcgcaag aggcctcgcg agaacaaaga ggtgcccagg gccagcctgc tcagcttcca
      361 agacgaggag gaagaaaatg aagaagtgtt caaagtaaag aaatcaagtt acagcaaaaa
      421 gatagttaaa ttgcttaaga aagaatataa agaagacctt gaaaaatcaa agatcaagac
      481 agaactcaac acagcagctg acagtgacca gcctctggac aaaacgtgtc atgctaagga
      541 cacaaaccca gaagatggag ttgtcatcag cgagcacggt gaggatgaaa tggacatgga
      601 gagcgagaag gaggaggaga agcccaaggc cgggggcgcc ttctccaatg ctctgtcttc
      661 cctgaacgtg ctccgcccag gagaaatccc agatgcagct ttcatacatg ctgcaagaaa
      721 gaagcgacaa ctggcccggg agctgggcga cttcacgcct cacgacagtg agcctggcaa
      781 aggccgcctc gtccgcgagg acgagaatga tgccagcgac gatgaggacg atgatgagaa
      841 gcgccggatc gttttttctg tgaaggaaaa gtcacaaaga caaaagatcg ctgaggagat
      901 aggtattgag gggagtgacg atgacgcgtt agtaactgga gagcaagacg aggagctcag
      961 ccgctgggag caggagcaga ttagaaaagg aattaacatc cctcaggttc aagcaagtca
     1021 gcccagtgaa gtgaatgtgt actaccagaa cacctaccag acaatgcctt acggtgcatc
     1081 ctatggcata ccgtatagtt acacagccta tggatcatca gatgccaagt ctcaaaaaac
     1141 agataataca gtccctttca aaactcccag taatgagatg gctcccgtta ctattgattt
     1201 ggtaaagaga cagcttaaag acaggttgga ctccatgaaa gaattgcaca aaaccaatca
     1261 acagcagcat gaaaaacatc tgcaaagccg agtggactcc accagggcta ttgagagatt
     1321 agaagggtct tctgggggta ttggtgaacg gtataaattt ttgcaagaaa tgcgagggta
     1381 tgtccaagac ttgcttgagt gtttcagtga aaaggtgcca ctgattaatg aacttgaatc
     1441 agcaatacat cagctgtaca aacagcgagc ttcccgcctt gtccaaagac gacaagatga
     1501 tattaaagat gaatcttcgg agttttcaag ccattcaaat aaagctttga tggcaccaaa
     1561 tcttgattcc tttggacgtg atcgggcact ttatcaagaa catgcaaaac gtcggattgc
     1621 agagcgggaa gccaggagga ctcgccgtag gcaagccaga gagcaaaccg gtcagatggc
     1681 agatcacctg gaaggcctgt ccagtgatga tgaagagacg tctacagata ttactaattt
     1741 caatctggag aaagatcgaa ttttgaaaga gtctagcaaa gtttttgaag atgtccttga
     1801 gagtttctat tcaattgact gcattaaagc acagtttgaa gcatggcgtt caaaatacta
     1861 catgtcctat aaggatgctt atattggtct ttgtctgccc aaactgttca accccctaat
     1921 cagacttcag cttctcacct ggactcctct tgaggcaaaa tgccgtgact ttgaaaccat
     1981 gctgtggttt gaatctctgc tgttctatgg ctgtgaagac cgagagcagg agaaggatga
     2041 ggctgacgtt gctctgctgc ccaccattgt ggagaaggtc attctcccca agctgacagt
     2101 gatagctgaa accatgtggg atcccttttc tacaacacag acttcaagga tggttggaat
     2161 cacaatgaaa ttaataaatg gctacccctc agtagtcaat gcagacaata aaaacacgca
     2221 ggtatacctt aaagctcttt tactgaggat gagaagaact ttagatgatg atgtatttat
     2281 gcccctatat cccaaaaatg tcttagaaaa taaaaattct gggccttact tattttttca
     2341 acgacagttt tggtcgtctg ttaagctatt gggaaatttt cttcagtggt atggcatttt
     2401 ctcaaacaaa actcttcagg agttatcaat agatggcttg ttaaacagat acatccttat
     2461 ggcttttcag aactcagaat acggagatga cagcatcaga aaagcccaaa atgtaatcaa
     2521 ctgtttccct aaacagtggt ttgtgaatct gaaaggagaa agaactattt ctcagttaga
     2581 aaatttttgc cgatatcttg tacatttagc agatacaatt tacaggaaca gtattgggtg
     2641 ctctgatgtg gaaaaaagaa atgcaaggga aaatataaaa cagatagtaa aacttcttgc
     2701 aagcgttcgg gctttggatc acgctatatc tgttgcaagt gaccacaatg tgaaggaagt
     2761 caagtctctg attgaaggaa aatagatctg cgaccaaaaa gtgtttgctt tgctgccatt
     2821 tccagtgtgt acattttgta tatatgtaaa gtttcttaaa ctgtaatata ctgattcttg
     2881 ttttaataca aaaacattat attaataccg tgtccttaaa tgtgatttct tgagaatgaa
     2941 aggaactcag attatttcta ggagtctatg gatgtttctt tactgcctgt catattttgt
     3001 ttatggaagt attttatatg gtcattaaat taacttcgtt tacgtatgct ctataaatga
     3061 tgagtgttta gtgtaagttg tataattttg cgtgtctgtg tgtgtgtgtg tgtgtgtgtg
     3121 tgtgtgtgtg tgcatgtata tttataccac catggatttt catgctggaa attttgcagt
     3181 gtttttctac agaggaggct ttttaacagc aggaacttac ccaatagcaa tcatcttagg
     3241 gaaatactgc actgcagcag ctgaagggct ggcaggtgat gaccttcacc ccccacagtg
     3301 actgctgtca ctgtagttgt gctgccttaa aatgaaaact gaaataagac tttgtcgttg
     3361 agtgagtgtg ggacttctgg gagtctgccc tggaggcagc tgtgggttta atacgagcct
     3421 gaggcgacat atgcagtagt gtggggtagg atgagccaca aactaactgc atggcctggg
     3481 ctgactgacc tttctcacta ttgtcttccc tgcccagcta tagatatgca tttctttagt
     3541 ctatcctgtt ttgaatccca catatgtgag ttatatatgc aataaagaac atgccttgct
     3601 gatcagacac acccaggcaa tttactatcc atggtattct gtaatgtttc taccacactg
     3661 taaatactca gagaaacttg ttttaaggtt gatgctttct gattctgtga ttttcagaag
     3721 agtaactttt cagaaattca ggactatcgt ttgaaaaata tatatgtaat taagctttag
     3781 ccaagcatta aattaatttt taaacacgc
//
