LOCUS       NM_011040               2569 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus paired box 8 (Pax8), mRNA.
ACCESSION   NM_011040
VERSION     NM_011040.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2569)
  AUTHORS   Yu,S.M., King,E., Fribourg,M., Hartzell,S., Tsou,L., Gee,L.,
            D'Agati,V.D., Thurman,J.M., He,J.C. and Cravedi,P.
  TITLE     A Newly Identified Protective Role of C5a Receptor 1 in Kidney
            Tubules against Toxin-Induced Acute Kidney Injury
  JOURNAL   Am J Pathol 195 (1), 126-142 (2025)
   PUBMED   39427763
REFERENCE   2  (bases 1 to 2569)
  AUTHORS   Kay,R.G.G., Reeves,R., Siggers,P., Greenaway,S., Mallon,A.M.,
            Wells,S., Koo,B.K., Mayere,C., Nef,S., Greenfield,A. and Simon,M.M.
  TITLE     Gonadal sex reversal at single-cell resolution in Znrf3-deficient
            mice
  JOURNAL   Development 151 (23) (2024)
   PUBMED   39629665
REFERENCE   3  (bases 1 to 2569)
  AUTHORS   Collier,J.B., Kang,H.S., Roh,Y.G., Srivastava,C., Grimm,S.A.,
            Jarmusch,A.K. and Jetten,A.M.
  TITLE     GLIS3: A novel transcriptional regulator of mitochondrial functions
            and metabolic reprogramming in postnatal kidney and polycystic
            kidney disease
  JOURNAL   Mol Metab 90, 102052 (2024)
   PUBMED   39505148
REFERENCE   4  (bases 1 to 2569)
  AUTHORS   Goode,D.K. and Elgar,G.
  TITLE     The PAX258 gene subfamily: a comparative perspective
  JOURNAL   Dev Dyn 238 (12), 2951-2974 (2009)
   PUBMED   19924770
  REMARK    Review article
REFERENCE   5  (bases 1 to 2569)
  AUTHORS   Okladnova,O., Poleev,A., Fantes,J., Lee,M., Plachov,D. and Horst,J.
  TITLE     The genomic organization of the murine Pax 8 gene and
            characterization of its basal promoter
  JOURNAL   Genomics 42 (3), 452-461 (1997)
   PUBMED   9205117
REFERENCE   6  (bases 1 to 2569)
  AUTHORS   Kozmik,Z., Kurzbauer,R., Dorfler,P. and Busslinger,M.
  TITLE     Alternative splicing of Pax-8 gene transcripts is developmentally
            regulated and generates isoforms with different transactivation
            properties
  JOURNAL   Mol Cell Biol 13 (10), 6024-6035 (1993)
   PUBMED   8413205
REFERENCE   7  (bases 1 to 2569)
  AUTHORS   Hill,R.E. and Hanson,I.M.
  TITLE     Molecular genetics of the Pax gene family
  JOURNAL   Curr Opin Cell Biol 4 (6), 967-972 (1992)
   PUBMED   1485966
  REMARK    Review article
REFERENCE   8  (bases 1 to 2569)
  AUTHORS   Poleev,A., Fickenscher,H., Mundlos,S., Winterpacht,A., Zabel,B.,
            Fidler,A., Gruss,P. and Plachov,D.
  TITLE     PAX8, a human paired box gene: isolation and expression in
            developing thyroid, kidney and Wilms' tumors
  JOURNAL   Development 116 (3), 611-623 (1992)
   PUBMED   1337742
REFERENCE   9  (bases 1 to 2569)
  AUTHORS   Asano,M. and Gruss,P.
  TITLE     Pax-5 is expressed at the midbrain-hindbrain boundary during mouse
            development
  JOURNAL   Mech Dev 39 (1-2), 29-39 (1992)
   PUBMED   1283313
REFERENCE   10 (bases 1 to 2569)
  AUTHORS   Plachov,D., Chowdhury,K., Walther,C., Simon,D., Guenet,J.L. and
            Gruss,P.
  TITLE     Pax8, a murine paired box gene expressed in the developing
            excretory system and thyroid gland
  JOURNAL   Development 110 (2), 643-651 (1990)
   PUBMED   1723950
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL732528.12, AK050717.1 and
            BY442465.1.
            
            On Mar 26, 2013 this sequence version replaced NM_011040.3.
            
            Summary: This gene encodes a member of a family of transcription
            factors that contain a characteristic N-terminal paired DNA-binding
            domain. The encoded protein is important for proper differentiation
            of the thyroid and the kidney. Alternatively spliced transcript
            variants of this gene have been described, but their full-length
            nature is not known. [provided by RefSeq, Mar 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020526.1, AK050717.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AL732528.12        155965-155989       c
            26-2499             AK050717.1         2-2475
            2500-2566           BY442465.1         341-407
            2567-2569           AL732528.12        100941-100943       c
FEATURES             Location/Qualifiers
     source          1..2569
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 16.43 cM"
     gene            1..2569
                     /gene="Pax8"
                     /gene_synonym="Pax-8"
                     /note="paired box 8"
                     /db_xref="GeneID:18510"
                     /db_xref="MGI:MGI:97492"
     exon            1..115
                     /gene="Pax8"
                     /gene_synonym="Pax-8"
                     /inference="alignment:Splign:2.1.0"
     exon            116..223
                     /gene="Pax8"
                     /gene_synonym="Pax-8"
                     /inference="alignment:Splign:2.1.0"
     exon            224..389
                     /gene="Pax8"
                     /gene_synonym="Pax-8"
                     /inference="alignment:Splign:2.1.0"
     exon            390..587
                     /gene="Pax8"
                     /gene_synonym="Pax-8"
                     /inference="alignment:Splign:2.1.0"
     exon            588..676
                     /gene="Pax8"
                     /gene_synonym="Pax-8"
                     /inference="alignment:Splign:2.1.0"
     exon            677..802
                     /gene="Pax8"
                     /gene_synonym="Pax-8"
                     /inference="alignment:Splign:2.1.0"
     exon            803..978
                     /gene="Pax8"
                     /gene_synonym="Pax-8"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1099
                     /gene="Pax8"
                     /gene_synonym="Pax-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1306
                     /gene="Pax8"
                     /gene_synonym="Pax-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1408
                     /gene="Pax8"
                     /gene_synonym="Pax-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1495
                     /gene="Pax8"
                     /gene_synonym="Pax-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..2569
                     /gene="Pax8"
                     /gene_synonym="Pax-8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2542..2547
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pax8"
                     /gene_synonym="Pax-8"
                     /note="hexamer: AATAAA"
     polyA_site      2565
                     /gene="Pax8"
                     /gene_synonym="Pax-8"
                     /note="major polyA site"
ORIGIN      
        1 aactggctgg cgatgccagg tggatgggag caaacttcag aaggaagaga cgcctgggcc
       61 ttgggcaccc tcaggggcag acccaggcag aaagggcctg aggccagccg gccagggtag
      121 ctgcgtggca gccagagctg ccaggacctg cgtaggaaag ctgcgagtgt ccctcagtct
      181 gtgagcgact ccccggcgat gcctcacaac tcgatcagat ccggccatgg agggctgaat
      241 caactaggag gggcctttgt gaatggcagg cctctgccag aagttgtacg tcaacgcatt
      301 gtggacttgg cccaccaggg cgtgaggccc tgtgatattt ctcgccagct ccgtgtcagc
      361 catggctgtg taagcaagat ccttggcagg tactacgaga ctggcagcat ccggcctgga
      421 gtgatagggg gctccaagcc caaggtggcc acccccaagg tggtggagaa gataggagac
      481 tacaagcggc agaaccctac catgtttgct tgggagatcc gggaccggct cctggcagaa
      541 ggcgtttgtg acaatgacac tgtccccagt gtcagctcca tcaacagaat catccggacc
      601 aaagtgcagc agccattcaa cctccccatg gatagctgtg tggccaccaa gtctctgagc
      661 ccaggacaca cactgatccc cagctcagct gtaacacccc cagagtcacc ccagtcggat
      721 tccttgggct ctacctactc tatcaacggg ctcctaggaa ttgctcagcc tggcaatgac
      781 aacaagagaa agatggatga tagtgaccag gacagctgtc ggctaagcat cgactcacag
      841 agcagcagca gtggtcctcg aaagcacctt cgtacggaca ccttcagcca gcaccatctc
      901 gaggcccttg agtgcccgtt tgagcggcag cattacccgg aggcctatgc ctcccccagc
      961 cacaccaaag gggagcaggg gctgtaccca ctgcccttac tcaacagtgc cctggatgat
     1021 gggaaggcca ccctgacatc ttccaataca cctctgggac gcaacctctc gactcaccag
     1081 acctaccctg tggtggcaga tcctcattca cccttcgcca taaagcagga aaccccagag
     1141 ctctccagtt ctagctccac cccttcctct ttatctagct ccgccttttt ggatctgcag
     1201 caagtcggct ctgggggccc agcaggtgcc tcggtcccac ccttcaatgc ctttccccat
     1261 gctgcctccg tgtatgggca gttcacgggc caggccctcc tctcagggcg agagatggtg
     1321 gggcccacgc tgcctggata cccaccccac atccccacca gtggacaggg cagctatgcc
     1381 tcttctgcta tcgcaggcat ggtggcagga agtgaatatt ctggcaatgc ctacagccac
     1441 accccgtatt cctcctacag tgaggcctgg cgcttcccca actccagcct gctgagttct
     1501 ccatattatt acagctctac atcaaggcca agcgcaccac ccacctctgc cacagccttt
     1561 gaccatctgt agttgtcatg gggacagtgg gaagaaccag gcaagaatca ggaggacttg
     1621 gcctgagaca ggccccagag agtcacacaa aggaatcttt atttattaca tgaaaaataa
     1681 ccacaattcc agcattgccg ctcactccct gtgtggtcaa ttaaatgaac catgaaagtc
     1741 aggatgacct tggagaaggc caaactgtcc tccaggattc attttgtgag tgacaggagt
     1801 tccaggaaac aagaaccacc catttcaaaa gagacacaga ggagaaatgt accgaagctg
     1861 gcacccacca aaggagagaa aaggggttca cgaagaactt agagggagat gagtctgagg
     1921 gtgtacaggg ccacctgttt ggtcttcatc tagacaactc cagcaattat gaacagtatg
     1981 caagtccttc tggcctacaa tcacagccta gggccaaggc tctacgtgtc agtcatccta
     2041 gcagttacca ccttgagcct ctactacctg catctttctg gggattcagc tgaccttcta
     2101 tttccagttg ctgtgcattt acaagcaccc cttagcctct caaccagtgg ctaccccttt
     2161 ggcagcagcg aacctgtccc ctggaaagtt cagtgaggct ctacgtagaa cataggaaga
     2221 cacaacagat gggaccagcc atgtcctctc ctcaacagcc ttgccaattc aagtgtgctt
     2281 tctgcagttc cagcccgcgc agccactgaa gagaccccca aggccagcaa caagattccc
     2341 tctctggctc ctcagctctt tccccacata caacctcact gtaaataccg taaatgaaac
     2401 tctgtttcgg tcaagctttc ctctttccat cccccagtct ttggtctctg aaatatctcc
     2461 ctactatgtt ggggttttct ccttcatact tttttttttt aaaaaaaaaa aaaaagacaa
     2521 cccaccatta ccacatgact caataaacca ttactcttgg tctcaggtt
//
