LOCUS       NP_035169                503 aa            linear   ROD 25-FEB-2025
DEFINITION  paired box protein Pax-7 [Mus musculus].
ACCESSION   NP_035169
VERSION     NP_035169.1
DBSOURCE    REFSEQ: accession NM_011039.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 503)
  AUTHORS   Pryce,B.R., Oles,A., Talbert,E.E., Romeo,M.J., Vaena,S., Sharma,S.,
            Spadafora,V., Tolliver,L., Mahvi,D.A., Morgan,K.A., Lancaster,W.P.,
            Beal,E., Koren,N., Watts,B., Overstreet,M., Berto,S.,
            Subramanian,S., Calisir,K., Crawford,A., Neelon,B., Ostrowski,M.C.,
            Zimmers,T.A., Tidball,J.G., Wang,D.J. and Guttridge,D.C.
  TITLE     Muscle inflammation is regulated by NF-kappaB from multiple cells
            to control distinct states of wasting in cancer cachexia
  JOURNAL   Cell Rep 43 (11), 114925 (2024)
   PUBMED   39475511
REFERENCE   2  (residues 1 to 503)
  AUTHORS   Lu,Y., Walji,T., Ravaux,B., Pandey,P., Yang,C., Li,B.,
            Luvsanjav,D., Lam,K.H., Zhang,R., Luo,Z., Zhou,C., Habela,C.W.,
            Snapper,S.B., Li,R., Goldhamer,D.J., Schmidtke,D.W., Pan,D.,
            Svitkina,T.M. and Chen,E.H.
  TITLE     Spatiotemporal coordination of actin regulators generates invasive
            protrusions in cell-cell fusion
  JOURNAL   Nat Cell Biol 26 (11), 1860-1877 (2024)
   PUBMED   39487253
REFERENCE   3  (residues 1 to 503)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 503)
  AUTHORS   Cai,S. and Yin,N.
  TITLE     Single-cell transcriptome and chromatin accessibility mapping of
            upper lip and primary palate fusion
  JOURNAL   J Cell Mol Med 28 (19), e70128 (2024)
   PUBMED   39392189
REFERENCE   5  (residues 1 to 503)
  AUTHORS   Zhou,D., Shi,Y., Zhang,D., Zuo,J., Zeng,C., Mamtawla,G., Huang,L.,
            Gao,X., Zhang,L. and Wang,X.
  TITLE     Liver-secreted FGF21 induces sarcopenia by inhibiting satellite
            cell myogenesis via klotho beta in decompensated cirrhosis
  JOURNAL   Redox Biol 76, 103333 (2024)
   PUBMED   39226764
REFERENCE   6  (residues 1 to 503)
  AUTHORS   Hill,R.E. and Hanson,I.M.
  TITLE     Molecular genetics of the Pax gene family
  JOURNAL   Curr Opin Cell Biol 4 (6), 967-972 (1992)
   PUBMED   1485966
  REMARK    Review article
REFERENCE   7  (residues 1 to 503)
  AUTHORS   Weydert,A., Cloez-Tayarani,I., Fillion,M.P., Simon-Chazottes,D.,
            Guenet,J.L. and Fillion,G.
  TITLE     Molecular cloning of two partial serotonin 5-HT1D receptor
            sequences in mouse and one in guinea pig
  JOURNAL   C R Acad Sci III 314 (10), 429-435 (1992)
   PUBMED   1521164
REFERENCE   8  (residues 1 to 503)
  AUTHORS   Le Roy,H., Simon-Chazottes,D., Montagutelli,X. and Guenet,J.L.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
REFERENCE   9  (residues 1 to 503)
  AUTHORS   Walther,C., Guenet,J.L., Simon,D., Deutsch,U., Jostes,B.,
            Goulding,M.D., Plachov,D., Balling,R. and Gruss,P.
  TITLE     Pax: a murine multigene family of paired box-containing genes
  JOURNAL   Genomics 11 (2), 424-434 (1991)
   PUBMED   1685142
REFERENCE   10 (residues 1 to 503)
  AUTHORS   Jostes,B., Walther,C. and Gruss,P.
  TITLE     The murine paired box gene, Pax7, is expressed specifically during
            the development of the nervous and muscular system
  JOURNAL   Mech Dev 33 (1), 27-37 (1990)
   PUBMED   1982921
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844480.29 and AL831790.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.4795858.1,
                                           SRR7345562.3222161.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.83 cM"
     Protein         1..503
                     /product="paired box protein Pax-7"
                     /note="paired box transcription factor PAX7; paired box
                     gene 7"
                     /calculated_mol_wt=54808
     Region          27..208
                     /region_name="Sufficient to mediate interaction with
                     PAXBP1. /evidence=ECO:0000269|PubMed:22862948"
                     /note="propagated from UniProtKB/Swiss-Prot (P47239.2)"
     Region          34..159
                     /region_name="PAX"
                     /note="Paired Box domain; smart00351"
                     /db_xref="CDD:128645"
     Region          37..93
                     /region_name="PAI subdomain.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00381"
                     /note="propagated from UniProtKB/Swiss-Prot (P47239.2)"
     Site            order(39..40,45,47..49,51,56,68,70,79,82,84..85,89,
                     98..104,106..107,109..110,129..131,150,152..153,156,159)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238076"
     Site            105
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:34059674; propagated from
                     UniProtKB/Swiss-Prot (P47239.2)"
     Region          113..161
                     /region_name="RED subdomain.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00381"
                     /note="propagated from UniProtKB/Swiss-Prot (P47239.2)"
     Site            139
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:34059674; propagated from
                     UniProtKB/Swiss-Prot (P47239.2)"
     Region          165..221
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P47239.2)"
     Region          216..272
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          345..383
                     /region_name="Pax7"
                     /note="Paired box protein 7; pfam12360"
                     /db_xref="CDD:403540"
     Region          477..489
                     /region_name="OAR.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00138"
                     /note="propagated from UniProtKB/Swiss-Prot (P47239.2)"
     CDS             1..503
                     /gene="Pax7"
                     /gene_synonym="Pax-7"
                     /coded_by="NM_011039.3:36..1547"
                     /db_xref="CCDS:CCDS18850.1"
                     /db_xref="GeneID:18509"
                     /db_xref="MGI:MGI:97491"
ORIGIN      
        1 maalpgavpr mmrpgpgqny prtgfplevs tplgqgrvnq lggvfingrp lpnhirhkiv
       61 emahhgirpc visrqlrvsh gcvskilcry qetgsirpga iggskprqva tpdvekkiee
      121 ykrenpgmfs weirdrllkd ghcdrstvps vssisrvlri kfgkkeddee gdkkeedgek
      181 kakhsidgil gdkgnrldeg sdvesepdlp lkrkqrrsrt tftaeqleel ekaferthyp
      241 diytreelaq rtkltearvq vwfsnrrarw rkqaganqla afnhllpggf pptgmptlpp
      301 yqlpdstypt ttisqdggst vhrpqplpps tmhqgglaaa aaaadtssay garhsfssys
      361 dsfmnpgaps nhmnpvsngl spqvmsilsn psavppqpqa dfsisplhgg ldsassisas
      421 csqradsikp gdslptsqsy cpptysttgy svdpvagyqy sqygqtavdy laknvslstq
      481 rrmklgehsa vlgllpvetg qay
//
