LOCUS       NM_011038               1378 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus paired box 4 (Pax4), transcript variant 1, mRNA.
ACCESSION   NM_011038 XM_133023
VERSION     NM_011038.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1378)
  AUTHORS   Gilda,J.E., Nahar,A., Kasiviswanathan,D., Tropp,N., Gilinski,T.,
            Lahav,T., Alexandrovich,D., Mandel-Gutfreund,Y., Park,S. and
            Shemer,S.
  TITLE     Proteasome gene expression is controlled by coordinated functions
            of multiple transcription factors
  JOURNAL   J Cell Biol 223 (8) (2024)
   PUBMED   38767572
  REMARK    GeneRIF: Proteasome gene expression is controlled by coordinated
            functions of multiple transcription factors.
REFERENCE   2  (bases 1 to 1378)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1378)
  AUTHORS   Dobosz,A.M., Janikiewicz,J., Krogulec,E., Dziewulska,A., Ajduk,A.,
            Szpila,M., Nieznanska,H., Szczepankiewicz,A.A., Wypych,D. and
            Dobrzyn,A.
  TITLE     Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs
            pancreatic islet morphogenesis and promotes loss of beta-cell
            identity and alpha-cell expansion in the mature pancreas
  JOURNAL   Mol Metab 67, 101659 (2023)
   PUBMED   36529318
REFERENCE   4  (bases 1 to 1378)
  AUTHORS   Zhou,H.M. and Conway,S.J.
  TITLE     Pax3 Hypomorphs Reveal Hidden Pax7 Functional Genetic Compensation
            in Utero
  JOURNAL   J Dev Biol 10 (2), 19 (2022)
   PUBMED   35645295
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1378)
  AUTHORS   Garrido-Utrilla,A., Ayachi,C., Friano,M.E., Atlija,J., Balaji,S.,
            Napolitano,T., Silvano,S., Druelle,N. and Collombat,P.
  TITLE     Conversion of Gastrointestinal Somatostatin-Expressing D Cells Into
            Insulin-Producing Beta-Like Cells Upon Pax4 Misexpression
  JOURNAL   Front Endocrinol (Lausanne) 13, 861922 (2022)
   PUBMED   35573999
  REMARK    GeneRIF: Conversion of Gastrointestinal Somatostatin-Expressing D
            Cells Into Insulin-Producing Beta-Like Cells Upon Pax4
            Misexpression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1378)
  AUTHORS   Zhang,Y., Proenca,R., Maffei,M., Barone,M., Leopold,L. and
            Friedman,J.M.
  TITLE     Positional cloning of the mouse obese gene and its human homologue
  JOURNAL   Nature 372 (6505), 425-432 (1994)
   PUBMED   7984236
  REMARK    Erratum:[Nature 1995 Mar 30;374(6521):479]
REFERENCE   7  (bases 1 to 1378)
  AUTHORS   Mansouri,A., Stoykova,A. and Gruss,P.
  TITLE     Pax genes in development
  JOURNAL   J Cell Sci Suppl 18, 35-42 (1994)
   PUBMED   7883790
  REMARK    Review article
REFERENCE   8  (bases 1 to 1378)
  AUTHORS   Stapleton,P., Weith,A., Urbanek,P., Kozmik,Z. and Busslinger,M.
  TITLE     Chromosomal localization of seven PAX genes and cloning of a novel
            family member, PAX-9
  JOURNAL   Nat Genet 3 (4), 292-298 (1993)
   PUBMED   7981748
REFERENCE   9  (bases 1 to 1378)
  AUTHORS   Le Roy,H., Simon-Chazottes,D., Montagutelli,X. and Guenet,J.L.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
REFERENCE   10 (bases 1 to 1378)
  AUTHORS   Walther,C., Guenet,J.L., Simon,D., Deutsch,U., Jostes,B.,
            Goulding,M.D., Plachov,D., Balling,R. and Gruss,P.
  TITLE     Pax: a murine multigene family of paired box-containing genes
  JOURNAL   Genomics 11 (2), 424-434 (1991)
   PUBMED   1685142
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF031150.2 and AF145233.1.
            
            On May 7, 2009 this sequence version replaced NM_011038.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF031150.2, AB008912.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN02415122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1346              AF031150.2         1-1346
            1347-1378           AF145233.1         1294-1325
FEATURES             Location/Qualifiers
     source          1..1378
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 11.99 cM"
     gene            1..1378
                     /gene="Pax4"
                     /gene_synonym="Pax-4"
                     /note="paired box 4"
                     /db_xref="GeneID:18506"
                     /db_xref="MGI:MGI:97488"
     exon            1..169
                     /gene="Pax4"
                     /gene_synonym="Pax-4"
                     /inference="alignment:Splign:2.1.0"
     exon            170..276
                     /gene="Pax4"
                     /gene_synonym="Pax-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..1313
                     /gene="Pax4"
                     /gene_synonym="Pax-4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     paired box protein Pax-4; paired box gene 4"
                     /codon_start=1
                     /product="paired box protein Pax-4 isoform 1"
                     /protein_id="NP_035168.1"
                     /db_xref="CCDS:CCDS39447.1"
                     /db_xref="GeneID:18506"
                     /db_xref="MGI:MGI:97488"
                     /translation="MQQDGLSSVNQLGGLFVNGRPLPLDTRQQIVQLAIRGMRPCDIS
                     RSLKVSNGCVSKILGRYYRTGVLEPKCIGGSKPRLATPAVVARIAQLKDEYPALFAWE
                     IQHQLCTEGLCTQDKAPSVSSINRVLRALQEDQSLHWTQLRSPAVLAPVLPSPHSNCG
                     APRGPHPGTSHRNRTIFSPGQAEALEKEFQRGQYPDSVARGKLAAATSLPEDTVRVWF
                     SNRRAKWRRQEKLKWEAQLPGASQDLTVPKNSPGIISAQQSPGSVPSAALPVLEPLSP
                     SFCQLCCGTAPGRCSSDTSSQAYLQPYWDCQSLLPVASSSYVEFAWPCLTTHPVHHLI
                     GGPGQVPSTHCSNWP"
     exon            277..407
                     /gene="Pax4"
                     /gene_synonym="Pax-4"
                     /inference="alignment:Splign:2.1.0"
     exon            408..623
                     /gene="Pax4"
                     /gene_synonym="Pax-4"
                     /inference="alignment:Splign:2.1.0"
     exon            624..699
                     /gene="Pax4"
                     /gene_synonym="Pax-4"
                     /inference="alignment:Splign:2.1.0"
     exon            700..825
                     /gene="Pax4"
                     /gene_synonym="Pax-4"
                     /inference="alignment:Splign:2.1.0"
     exon            826..908
                     /gene="Pax4"
                     /gene_synonym="Pax-4"
                     /inference="alignment:Splign:2.1.0"
     exon            909..978
                     /gene="Pax4"
                     /gene_synonym="Pax-4"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1034
                     /gene="Pax4"
                     /gene_synonym="Pax-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1176
                     /gene="Pax4"
                     /gene_synonym="Pax-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1357
                     /gene="Pax4"
                     /gene_synonym="Pax-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1333..1338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pax4"
                     /gene_synonym="Pax-4"
                     /note="hexamer: AATAAA"
     polyA_site      1352
                     /gene="Pax4"
                     /gene_synonym="Pax-4"
                     /note="major polyA site"
ORIGIN      
        1 cagaaggctg ccctctgctc ctgagtgaag gctctgtgaa gctctggacc ccctggcagg
       61 actgaagcag ctggaggctg ttacaagacc agaccaccag caaaccctgg agcctgcaca
      121 ggaccctgag acctcttcct ggaattccca ccttttttcc tccatccaga accagtccca
      181 aagagaaact tccagaagga gctctccgtt ttcagtttgc cagttggctt cctgtccttc
      241 tgtgaggagt accagtgtga agcatgcagc aggacggact cagcagtgtg aatcagctag
      301 ggggactctt tgtgaatggc cggccccttc ctctggacac caggcagcag attgtgcagc
      361 tagcaataag agggatgcga ccctgtgaca tttcacggag ccttaaggta tctaatggct
      421 gtgtgagcaa gatcctagga cgctactacc gcacaggtgt cttggaaccc aagtgtattg
      481 ggggaagcaa accacgtctg gccacacctg ctgtggtggc tcgaattgcc cagctaaagg
      541 atgagtaccc tgctcttttt gcctgggaga tccaacacca gctttgcact gaagggcttt
      601 gtacccagga caaggctccc agtgtgtcct ctatcaatcg agtacttcgg gcacttcagg
      661 aagaccagag cttgcactgg actcaactca gatcaccagc tgtgttggct ccagttcttc
      721 ccagtcccca cagtaactgt ggggctcccc gaggtcccca cccaggaacc agccacagga
      781 atcggactat cttctccccg ggacaagccg aggcactgga gaaagagttt cagcgtgggc
      841 agtatccaga ttcagtggcc cgtgggaagc tggctgctgc cacctctctg cctgaagaca
      901 cggtgagggt ttggttttct aacagaagag ccaaatggcg caggcaagag aagctgaaat
      961 gggaagcaca gctgccaggt gcttcccagg acctgacagt accaaaaaat tctccaggga
     1021 tcatctctgc acagcagtcc cccggcagtg taccctcagc tgccttgcct gtgctggaac
     1081 cattgagtcc ttccttctgt cagctatgct gtgggacagc accaggcaga tgttccagtg
     1141 acacctcatc ccaggcctat ctccaaccct actgggactg ccaatccctc cttcctgtgg
     1201 cttcctcctc atatgtggaa tttgcctggc cctgcctcac cacccatcct gtgcatcatc
     1261 tgattggagg cccaggacaa gtgccatcaa cccattgctc aaactggcca taagaggcct
     1321 ctatttgaca gtaataaaaa ccttttctta gatgttaaaa aaaaaaaaaa aaaaaaaa
//
