LOCUS       NM_001368749            3912 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus paired box 2 (Pax2), transcript variant 8, mRNA.
ACCESSION   NM_001368749
VERSION     NM_001368749.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3912)
  AUTHORS   Franks,N.E. and Allen,B.L.
  TITLE     Hedgehog-dependent and hedgehog-independent roles for growth arrest
            specific 1 in mammalian kidney morphogenesis
  JOURNAL   Development 151 (24) (2024)
   PUBMED   39629522
REFERENCE   2  (bases 1 to 3912)
  AUTHORS   Alvarez,S., Gupta,S., Mercado-Ayon,Y., Honeychurch,K.,
            Rodriguez,C., Kawaguchi,R. and Butler,S.J.
  TITLE     Netrin1 patterns the dorsal spinal cord through modulation of Bmp
            signaling
  JOURNAL   Cell Rep 43 (11), 114954 (2024)
   PUBMED   39547237
REFERENCE   3  (bases 1 to 3912)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   4  (bases 1 to 3912)
  AUTHORS   Baltar,J., Miranda,R.M., Cabral,M., Rebelo,S., Grahammer,F.,
            Huber,T.B., Reguenga,C. and Monteiro,F.A.
  TITLE     Neph1 is required for neurite branching and is negatively regulated
            by the PRRXL1 homeodomain factor in the developing spinal cord
            dorsal horn
  JOURNAL   Neural Dev 19 (1), 13 (2024)
   PUBMED   39049046
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3912)
  AUTHORS   Clark,J.F. and Soriano,P.
  TITLE     Diverse Fgfr1 signaling pathways and endocytic trafficking regulate
            mesoderm development
  JOURNAL   Genes Dev 38 (9-10), 393-414 (2024)
   PUBMED   38834239
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3912)
  AUTHORS   Hill,R.E. and Hanson,I.M.
  TITLE     Molecular genetics of the Pax gene family
  JOURNAL   Curr Opin Cell Biol 4 (6), 967-972 (1992)
   PUBMED   1485966
  REMARK    Review article
REFERENCE   7  (bases 1 to 3912)
  AUTHORS   Puschel,A.W., Westerfield,M. and Dressler,G.R.
  TITLE     Comparative analysis of Pax-2 protein distributions during
            neurulation in mice and zebrafish
  JOURNAL   Mech Dev 38 (3), 197-208 (1992)
   PUBMED   1457381
REFERENCE   8  (bases 1 to 3912)
  AUTHORS   Dressler,G.R. and Douglass,E.C.
  TITLE     Pax-2 is a DNA-binding protein expressed in embryonic kidney and
            Wilms tumor
  JOURNAL   Proc Natl Acad Sci U S A 89 (4), 1179-1183 (1992)
   PUBMED   1311084
REFERENCE   9  (bases 1 to 3912)
  AUTHORS   Yachou,A.K., Renaudie,F., Guenet,J.L., Simon-Chazottes,D.,
            Jones,R., Grandchamp,B. and Beaumont,C.
  TITLE     Mouse ferritin H multigene family is polymorphic and contains a
            single multiallelic functional gene located on chromosome 19
  JOURNAL   Genomics 10 (3), 531-538 (1991)
   PUBMED   1679743
REFERENCE   10 (bases 1 to 3912)
  AUTHORS   Dressler,G.R., Deutsch,U., Chowdhury,K., Nornes,H.O. and Gruss,P.
  TITLE     Pax2, a new murine paired-box-containing gene and its expression in
            the developing excretory system
  JOURNAL   Development 109 (4), 787-795 (1990)
   PUBMED   1977574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138457.3 and AC131105.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.681688.1,
                                           SRR7345558.211501.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-531               AC138457.3         24049-24579         c
            532-697             AC138457.3         20442-20607         c
            698-895             AC138457.3         19600-19797         c
            896-981             AC131105.4         159471-159556       c
            982-1101            AC131105.4         157531-157650       c
            1102-1277           AC131105.4         132250-132425       c
            1278-1404           AC131105.4         129781-129907       c
            1405-1506           AC131105.4         115066-115167       c
            1507-1593           AC131105.4         112856-112942       c
            1594-3912           AC131105.4         110064-112382       c
FEATURES             Location/Qualifiers
     source          1..3912
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.09 cM"
     gene            1..3912
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /note="paired box 2"
                     /db_xref="GeneID:18504"
                     /db_xref="MGI:MGI:97486"
     exon            1..531
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             489..1670
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /note="isoform 8 is encoded by transcript variant 8;
                     paired box protein Pax-2; optic disc coloboma; paired box
                     gene 2"
                     /codon_start=1
                     /product="paired box protein Pax-2 isoform 8"
                     /protein_id="NP_001355678.1"
                     /db_xref="GeneID:18504"
                     /db_xref="MGI:MGI:97486"
                     /translation="MDMHCKADPFSAMHRHGGVNQLGGVFVNGRPLPDVVRQRIVELA
                     HQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYK
                     RQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTAP
                     GHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRKREEDVSEGSVPNGDSQS
                     GVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSLPALTPGL
                     DEVKSSLSASANPELGSNVSGTQTYPVVTGRDMTSTTLPGYPPHVPPTGQGSYPTSTL
                     AGMVPGSEFSGNPYSHPQYTAYNEAWRFSNPALLSSPYYYSAAPRGSAPAAAAAAYDR
                     H"
     exon            532..697
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            698..895
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            896..981
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1101
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1277
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1404
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1506
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1593
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..3912
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3487..3492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /note="hexamer: AATAAA"
     polyA_site      3514
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /note="major polyA site"
ORIGIN      
        1 acttctctgc caacttcgcc aactcgccgg cacttggagc ggcccggctc ccctcctggc
       61 gccctcgggc cgcccccgcc ctgagctctc ttggttcaga gcctctcgga caaccgggtt
      121 ccaggggagc tgagtgagcc gtcttcccta cccggcctca gctctggccg cagctggcgc
      181 gcgagccatg cgccccaagt gccccttggt ccagccagtc gccccggggc tgcgttgctg
      241 actgcccagc cgcgtgcccc aacggtggca agttgcagcc tctgcggtcg caaaccccag
      301 cgggcccgga ggagtcccgg cgtggagcgc ggcgcggcgt cccccgccct cgcttgcccc
      361 ccagcagtcg ggcgcccgct cactctccct cccccaccgt cccttccttt tctcctcaag
      421 tcctgaagtt gagtttgaga ggcgacacgg cggcggcggc cgcgttgctc ccgctcctct
      481 gcctcccgat ggatatgcac tgcaaagcag accccttctc cgcgatgcac cggcacgggg
      541 gtgtgaacca gctcgggggg gtgtttgtga acggccggcc cctacccgac gtggtgaggc
      601 agcgcatcgt ggagctggcc caccagggtg tgcggccctg tgacatctcc cggcagctgc
      661 gggtcagcca tggctgtgtc agcaaaatcc tgggcaggta ctacgagact ggcagcatca
      721 agcccggagt gattggtggc tccaagccca aggtggcaac gcccaaagtg gtggacaaga
      781 ttgccgaata caagcgacag aacccgacta tgttcgcctg ggagatccgt gacaggctgc
      841 tagccgaggg catctgcgat aatgacacag ttcccagtgt ctcatccatc aacaggatca
      901 tccggaccaa agttcagcag cctttccacc caacgccgga tggggcaggg acaggagtga
      961 ctgcccccgg ccacaccatc gttcccagca cggcctcccc tcctgtttcc agcgcctcta
     1021 acgacccagt gggatcctac tccatcaacg ggatcctggg gattcctcgc tccaacggtg
     1081 agaagaggaa acgcgaggaa gatgtgtctg agggctctgt ccctaatgga gactcccaga
     1141 gtggtgtgga cagtttgcgg aagcacctgc gagccgacac cttcacccag cagcagctgg
     1201 aagctctgga tcgagtcttt gagcgtcctt cctatcccga tgtcttccag gcatcagagc
     1261 acatcaaatc agaacagggg aatgaatact ctctcccagc cctgacccct gggcttgatg
     1321 aagtcaagtc cagtctatct gcatcggcca accctgagct gggcagcaat gtgtcaggca
     1381 cacagacgta ccccgttgtg accggtcgtg atatgacgag caccactcta cctggttacc
     1441 cccctcatgt gccccccact ggccagggaa gctaccctac ctccaccctg gcaggaatgg
     1501 tgcctgggag cgagttctca ggcaacccat acagccatcc ccagtacacc gcctacaatg
     1561 aggcttggag attcagcaac cccgccttac taagttcccc ttattattat agtgccgccc
     1621 cccggggctc cgcccctgcc gctgctgccg ctgcctatga ccgccactag ttaccgcggg
     1681 gaccacatca agcttcaggc agacagcttc ggcctccaca tcgtccccgt ctgaccgccc
     1741 accccagagg gagggaggac cgaagcgacg cgctgcctct cggccaccgt ccctgtccca
     1801 cccccacctc gagacatcct cccccaagcc ccgcagccct tctcatcacc ctgtcgatgg
     1861 ccagacagga caggtggagc cgcgggtggg accctcaggc cccagccccg cccgtcgccc
     1921 ctccccgcct gcctggaccg cggcgccgtc cggaagcccg cccgcctctg gcccgcgcgc
     1981 cgtttctgtg acacacaatc agcgtggccc acccaggggc agcccacttc ggacgcccgg
     2041 gagtcgggag gcttcgctgg agaagctgag caagggaagc taaggaaagg actttgtgct
     2101 gaaggaggag ccgccgggga gaccctaggg gggaaatcct gccccatccc ccctgtgcct
     2161 gccaagctga ccccgccttc tgtctgcgcc ccgccccaga cggtggcact gggacgcaag
     2221 ggtcggactc gagggacagc gtttggggcg acagcgtttt ccaaggctgg tacccaaggc
     2281 gagcagacgc caactgagct catccacctg aactgcctag ttcccttggg cctgcgatct
     2341 ccttctgcag tgactctcct ctcggccccg ccttgccctt acgtcagcgc ctcttccacc
     2401 tgctggcctc tcacttttcc ctcctgtgct tcctcggctc atcccacgac accttgtgtt
     2461 tggtcccaag cacgcagcca cgtcggggcc accgcgggaa ccgtgtcctc aggctgcggc
     2521 tgcgagcatt gatcttttcc catcagtaat gcgctgccca cccccaccct cccatcccaa
     2581 actcccaacc tgcgggcgca aaaagcctgg aaggaactga cgaccgagcc gccccagatg
     2641 aaaatccggg tctccccgcc ccattccccc caagcacccc ctccccagcc ttcccttggg
     2701 caggagctga acagagcctc aaaaaaaaaa aaaagtctac acttatttaa tatgatgatg
     2761 gtctttgcaa aaatgaacaa acaaaaaccc aacaggctgc tttatagaaa gacggtgtgt
     2821 gctgtcgagg cgaacctctc tctgtacata gcccctccct ctctgccccg cccctccggg
     2881 taccatagag tccctgtcct cccgcccccc ccccgccccc ctgcctgtag atacaccctt
     2941 ctgtccgtgc tgtgagagtc gccgctcgct ggggggaggg aggggggaca cagctacatg
     3001 cccactaaag cacagcacgt cctgggggag gggggcattt ttttacgtta caaaaaaaaa
     3061 ttatgaaaga aatctctatg caaaatgacg aacatggtcc cgtggacacc tctcgcctgt
     3121 tttgttgact gtttctctgt aattccgtgt tcatcgccct gcatctctcc cacttcatct
     3181 cccttttctc tgctactctc gacccctctg tgtctctttc tcttcttcac ttgtctctgt
     3241 ctcggtccgt tctgccccag gcctccaagg ctacatctaa gatggcagaa ccaacctcgg
     3301 ggcttggccc cttgtggcca tgccccacgt gcccgaccag gccaccctgc cccaccccac
     3361 cctgtagttg ctctctcggt agcggcgatg ctccctgcat gtctcctcaa ccgtggatcg
     3421 tgacgacccg aaataacaga aacaaagtaa ataaaagtga aaaaaaaata agtaaataaa
     3481 taaataaata aaaatccttg aacaaatccg aaaaggcttg gagtcctagc ccagagtgcg
     3541 ctttccttcg agccatttta tttgaaaagg aaagcgagaa aagtgaacaa tctaagggaa
     3601 ctgccggcgc ccgaccgtgc tccagtggct ggagctggat ggcgagggca acgaggtccc
     3661 agcttcgagg cccagcctga cccagtcttg tgtggagctg gccgcgctcc aggagtgcgg
     3721 aatccaggag aaggcttagc cttccacaag tcccggctcc tccgccactt tcaacgtgtc
     3781 ggttcgtttt gattattttt cctttctttc tctctttcct tctttctttt ttctttcttt
     3841 ctcttttctt tctttttttg tgcacatgat aaataataat aaaaataata ataaaatttt
     3901 gtatgtcact cc
//
