LOCUS       NM_001368747            3896 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus paired box 2 (Pax2), transcript variant 5, mRNA.
ACCESSION   NM_001368747
VERSION     NM_001368747.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3896)
  AUTHORS   Franks,N.E. and Allen,B.L.
  TITLE     Hedgehog-dependent and hedgehog-independent roles for growth arrest
            specific 1 in mammalian kidney morphogenesis
  JOURNAL   Development 151 (24) (2024)
   PUBMED   39629522
REFERENCE   2  (bases 1 to 3896)
  AUTHORS   Alvarez,S., Gupta,S., Mercado-Ayon,Y., Honeychurch,K.,
            Rodriguez,C., Kawaguchi,R. and Butler,S.J.
  TITLE     Netrin1 patterns the dorsal spinal cord through modulation of Bmp
            signaling
  JOURNAL   Cell Rep 43 (11), 114954 (2024)
   PUBMED   39547237
REFERENCE   3  (bases 1 to 3896)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   4  (bases 1 to 3896)
  AUTHORS   Baltar,J., Miranda,R.M., Cabral,M., Rebelo,S., Grahammer,F.,
            Huber,T.B., Reguenga,C. and Monteiro,F.A.
  TITLE     Neph1 is required for neurite branching and is negatively regulated
            by the PRRXL1 homeodomain factor in the developing spinal cord
            dorsal horn
  JOURNAL   Neural Dev 19 (1), 13 (2024)
   PUBMED   39049046
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3896)
  AUTHORS   Clark,J.F. and Soriano,P.
  TITLE     Diverse Fgfr1 signaling pathways and endocytic trafficking regulate
            mesoderm development
  JOURNAL   Genes Dev 38 (9-10), 393-414 (2024)
   PUBMED   38834239
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3896)
  AUTHORS   Hill,R.E. and Hanson,I.M.
  TITLE     Molecular genetics of the Pax gene family
  JOURNAL   Curr Opin Cell Biol 4 (6), 967-972 (1992)
   PUBMED   1485966
  REMARK    Review article
REFERENCE   7  (bases 1 to 3896)
  AUTHORS   Puschel,A.W., Westerfield,M. and Dressler,G.R.
  TITLE     Comparative analysis of Pax-2 protein distributions during
            neurulation in mice and zebrafish
  JOURNAL   Mech Dev 38 (3), 197-208 (1992)
   PUBMED   1457381
REFERENCE   8  (bases 1 to 3896)
  AUTHORS   Dressler,G.R. and Douglass,E.C.
  TITLE     Pax-2 is a DNA-binding protein expressed in embryonic kidney and
            Wilms tumor
  JOURNAL   Proc Natl Acad Sci U S A 89 (4), 1179-1183 (1992)
   PUBMED   1311084
REFERENCE   9  (bases 1 to 3896)
  AUTHORS   Yachou,A.K., Renaudie,F., Guenet,J.L., Simon-Chazottes,D.,
            Jones,R., Grandchamp,B. and Beaumont,C.
  TITLE     Mouse ferritin H multigene family is polymorphic and contains a
            single multiallelic functional gene located on chromosome 19
  JOURNAL   Genomics 10 (3), 531-538 (1991)
   PUBMED   1679743
REFERENCE   10 (bases 1 to 3896)
  AUTHORS   Dressler,G.R., Deutsch,U., Chowdhury,K., Nornes,H.O. and Gruss,P.
  TITLE     Pax2, a new murine paired-box-containing gene and its expression in
            the developing excretory system
  JOURNAL   Development 109 (4), 787-795 (1990)
   PUBMED   1977574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138457.3 and AC131105.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2299577.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-531               AC138457.3         24049-24579         c
            532-700             AC138457.3         20442-20610         c
            701-898             AC138457.3         19600-19797         c
            899-984             AC131105.4         159471-159556       c
            985-1104            AC131105.4         157531-157650       c
            1105-1280           AC131105.4         132250-132425       c
            1281-1407           AC131105.4         129781-129907       c
            1408-1509           AC131105.4         115066-115167       c
            1510-1596           AC131105.4         112856-112942       c
            1597-3896           AC131105.4         110064-112363       c
FEATURES             Location/Qualifiers
     source          1..3896
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.09 cM"
     gene            1..3896
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /note="paired box 2"
                     /db_xref="GeneID:18504"
                     /db_xref="MGI:MGI:97486"
     exon            1..531
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             489..1718
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /note="isoform 5 is encoded by transcript variant 5;
                     paired box protein Pax-2; optic disc coloboma; paired box
                     gene 2"
                     /codon_start=1
                     /product="paired box protein Pax-2 isoform 5"
                     /protein_id="NP_001355676.1"
                     /db_xref="GeneID:18504"
                     /db_xref="MGI:MGI:97486"
                     /translation="MDMHCKADPFSAMHPGHGGVNQLGGVFVNGRPLPDVVRQRIVEL
                     AHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEY
                     KRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTA
                     PGHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRKREEDVSEGSVPNGDSQ
                     SGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSLPALTPG
                     LDEVKSSLSASANPELGSNVSGTQTYPVVTGRDMTSTTLPGYPPHVPPTGQGSYPTST
                     LAGMVPGSEFSGNPYSHPQYTAYNEAWRFSNPALLMPPPGAPPLPLLPLPMTATSYRG
                     DHIKLQADSFGLHIVPV"
     exon            532..700
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            701..898
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            899..984
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1104
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1280
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1407
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1509
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1596
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..3896
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3471..3476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /note="hexamer: AATAAA"
     polyA_site      3498
                     /gene="Pax2"
                     /gene_synonym="Opdc; Pax-2"
                     /note="major polyA site"
ORIGIN      
        1 acttctctgc caacttcgcc aactcgccgg cacttggagc ggcccggctc ccctcctggc
       61 gccctcgggc cgcccccgcc ctgagctctc ttggttcaga gcctctcgga caaccgggtt
      121 ccaggggagc tgagtgagcc gtcttcccta cccggcctca gctctggccg cagctggcgc
      181 gcgagccatg cgccccaagt gccccttggt ccagccagtc gccccggggc tgcgttgctg
      241 actgcccagc cgcgtgcccc aacggtggca agttgcagcc tctgcggtcg caaaccccag
      301 cgggcccgga ggagtcccgg cgtggagcgc ggcgcggcgt cccccgccct cgcttgcccc
      361 ccagcagtcg ggcgcccgct cactctccct cccccaccgt cccttccttt tctcctcaag
      421 tcctgaagtt gagtttgaga ggcgacacgg cggcggcggc cgcgttgctc ccgctcctct
      481 gcctcccgat ggatatgcac tgcaaagcag accccttctc cgcgatgcac ccagggcacg
      541 ggggtgtgaa ccagctcggg ggggtgtttg tgaacggccg gcccctaccc gacgtggtga
      601 ggcagcgcat cgtggagctg gcccaccagg gtgtgcggcc ctgtgacatc tcccggcagc
      661 tgcgggtcag ccatggctgt gtcagcaaaa tcctgggcag gtactacgag actggcagca
      721 tcaagcccgg agtgattggt ggctccaagc ccaaggtggc aacgcccaaa gtggtggaca
      781 agattgccga atacaagcga cagaacccga ctatgttcgc ctgggagatc cgtgacaggc
      841 tgctagccga gggcatctgc gataatgaca cagttcccag tgtctcatcc atcaacagga
      901 tcatccggac caaagttcag cagcctttcc acccaacgcc ggatggggca gggacaggag
      961 tgactgcccc cggccacacc atcgttccca gcacggcctc ccctcctgtt tccagcgcct
     1021 ctaacgaccc agtgggatcc tactccatca acgggatcct ggggattcct cgctccaacg
     1081 gtgagaagag gaaacgcgag gaagatgtgt ctgagggctc tgtccctaat ggagactccc
     1141 agagtggtgt ggacagtttg cggaagcacc tgcgagccga caccttcacc cagcagcagc
     1201 tggaagctct ggatcgagtc tttgagcgtc cttcctatcc cgatgtcttc caggcatcag
     1261 agcacatcaa atcagaacag gggaatgaat actctctccc agccctgacc cctgggcttg
     1321 atgaagtcaa gtccagtcta tctgcatcgg ccaaccctga gctgggcagc aatgtgtcag
     1381 gcacacagac gtaccccgtt gtgaccggtc gtgatatgac gagcaccact ctacctggtt
     1441 acccccctca tgtgcccccc actggccagg gaagctaccc tacctccacc ctggcaggaa
     1501 tggtgcctgg gagcgagttc tcaggcaacc catacagcca tccccagtac accgcctaca
     1561 atgaggcttg gagattcagc aaccccgcct tactaatgcc gccccccggg gctccgcccc
     1621 tgccgctgct gccgctgcct atgaccgcca ctagttaccg cggggaccac atcaagcttc
     1681 aggcagacag cttcggcctc cacatcgtcc ccgtctgacc gcccacccca gagggaggga
     1741 ggaccgaagc gacgcgctgc ctctcggcca ccgtccctgt cccaccccca cctcgagaca
     1801 tcctccccca agccccgcag cccttctcat caccctgtcg atggccagac aggacaggtg
     1861 gagccgcggg tgggaccctc aggccccagc cccgcccgtc gcccctcccc gcctgcctgg
     1921 accgcggcgc cgtccggaag cccgcccgcc tctggcccgc gcgccgtttc tgtgacacac
     1981 aatcagcgtg gcccacccag gggcagccca cttcggacgc ccgggagtcg ggaggcttcg
     2041 ctggagaagc tgagcaaggg aagctaagga aaggactttg tgctgaagga ggagccgccg
     2101 gggagaccct aggggggaaa tcctgcccca tcccccctgt gcctgccaag ctgaccccgc
     2161 cttctgtctg cgccccgccc cagacggtgg cactgggacg caagggtcgg actcgaggga
     2221 cagcgtttgg ggcgacagcg ttttccaagg ctggtaccca aggcgagcag acgccaactg
     2281 agctcatcca cctgaactgc ctagttccct tgggcctgcg atctccttct gcagtgactc
     2341 tcctctcggc cccgccttgc ccttacgtca gcgcctcttc cacctgctgg cctctcactt
     2401 ttccctcctg tgcttcctcg gctcatccca cgacaccttg tgtttggtcc caagcacgca
     2461 gccacgtcgg ggccaccgcg ggaaccgtgt cctcaggctg cggctgcgag cattgatctt
     2521 ttcccatcag taatgcgctg cccaccccca ccctcccatc ccaaactccc aacctgcggg
     2581 cgcaaaaagc ctggaaggaa ctgacgaccg agccgcccca gatgaaaatc cgggtctccc
     2641 cgccccattc cccccaagca ccccctcccc agccttccct tgggcaggag ctgaacagag
     2701 cctcaaaaaa aaaaaaaagt ctacacttat ttaatatgat gatggtcttt gcaaaaatga
     2761 acaaacaaaa acccaacagg ctgctttata gaaagacggt gtgtgctgtc gaggcgaacc
     2821 tctctctgta catagcccct ccctctctgc cccgcccctc cgggtaccat agagtccctg
     2881 tcctcccgcc ccccccccgc ccccctgcct gtagatacac ccttctgtcc gtgctgtgag
     2941 agtcgccgct cgctgggggg agggaggggg gacacagcta catgcccact aaagcacagc
     3001 acgtcctggg ggaggggggc atttttttac gttacaaaaa aaaattatga aagaaatctc
     3061 tatgcaaaat gacgaacatg gtcccgtgga cacctctcgc ctgttttgtt gactgtttct
     3121 ctgtaattcc gtgttcatcg ccctgcatct ctcccacttc atctcccttt tctctgctac
     3181 tctcgacccc tctgtgtctc tttctcttct tcacttgtct ctgtctcggt ccgttctgcc
     3241 ccaggcctcc aaggctacat ctaagatggc agaaccaacc tcggggcttg gccccttgtg
     3301 gccatgcccc acgtgcccga ccaggccacc ctgccccacc ccaccctgta gttgctctct
     3361 cggtagcggc gatgctccct gcatgtctcc tcaaccgtgg atcgtgacga cccgaaataa
     3421 cagaaacaaa gtaaataaaa gtgaaaaaaa aataagtaaa taaataaata aataaaaatc
     3481 cttgaacaaa tccgaaaagg cttggagtcc tagcccagag tgcgctttcc ttcgagccat
     3541 tttatttgaa aaggaaagcg agaaaagtga acaatctaag ggaactgccg gcgcccgacc
     3601 gtgctccagt ggctggagct ggatggcgag ggcaacgagg tcccagcttc gaggcccagc
     3661 ctgacccagt cttgtgtgga gctggccgcg ctccaggagt gcggaatcca ggagaaggct
     3721 tagccttcca caagtcccgg ctcctccgcc actttcaacg tgtcggttcg ttttgattat
     3781 ttttcctttc tttctctctt tccttctttc ttttttcttt ctttctcttt tctttctttt
     3841 tttgtgcaca tgataaataa taataaaaat aataataaaa ttttgtatgt cactcc
//
