LOCUS       NM_008780               2639 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus paired box 1 (Pax1), mRNA.
ACCESSION   NM_008780
VERSION     NM_008780.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2639)
  AUTHORS   Ushiki,A., Sheng,R.R., Zhang,Y., Zhao,J., Nobuhara,M., Murray,E.,
            Ruan,X., Rios,J.J., Wise,C.A. and Ahituv,N.
  TITLE     Deletion of Pax1 scoliosis-associated regulatory elements leads to
            a female-biased tail abnormality
  JOURNAL   Cell Rep 43 (3), 113907 (2024)
   PUBMED   38461417
  REMARK    GeneRIF: Deletion of Pax1 scoliosis-associated regulatory elements
            leads to a female-biased tail abnormality.
REFERENCE   2  (bases 1 to 2639)
  AUTHORS   Zbasnik,N. and Fish,J.L.
  TITLE     Fgf8 regulates first pharyngeal arch segmentation through
            pouch-cleft interactions
  JOURNAL   Front Cell Dev Biol 11, 1186526 (2023)
   PUBMED   37287454
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2639)
  AUTHORS   Cai,S., Si,N., Wang,Y. and Yin,N.
  TITLE     Transcriptomic analysis of the upper lip and primary palate
            development in mice
  JOURNAL   Front Genet 13, 1039850 (2023)
   PUBMED   36685938
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2639)
  AUTHORS   Ramachandran,J., Zhou,W., Bardenhagen,A.E., Nasr,T., Yates,E.R.,
            Zorn,A.M., Ji,H. and Vokes,S.A.
  TITLE     Hedgehog regulation of epithelial cell state and morphogenesis in
            the larynx
  JOURNAL   Elife 11, e77055 (2022)
   PUBMED   36398878
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2639)
  AUTHORS   Arostegui,M., Scott,R.W., Bose,K. and Underhill,T.M.
  TITLE     Cellular taxonomy of Hic1+ mesenchymal progenitor derivatives in
            the limb: from embryo to adult
  JOURNAL   Nat Commun 13 (1), 4989 (2022)
   PUBMED   36008423
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2639)
  AUTHORS   Hill,R.E. and Hanson,I.M.
  TITLE     Molecular genetics of the Pax gene family
  JOURNAL   Curr Opin Cell Biol 4 (6), 967-972 (1992)
   PUBMED   1485966
  REMARK    Review article
REFERENCE   7  (bases 1 to 2639)
  AUTHORS   Schnittger,S., Rao,V.V., Deutsch,U., Gruss,P., Balling,R. and
            Hansmann,I.
  TITLE     Pax1, a member of the paired box-containing class of developmental
            control genes, is mapped to human chromosome 20p11.2 by in situ
            hybridization (ISH and FISH)
  JOURNAL   Genomics 14 (3), 740-744 (1992)
   PUBMED   1358810
REFERENCE   8  (bases 1 to 2639)
  AUTHORS   Copeland,N.G., Gilbert,D.J., Chretien,M., Seidah,N.G. and
            Jenkins,N.A.
  TITLE     Regional localization of three convertases, PC1 (Nec-1), PC2
            (Nec-2), and furin (Fur), on mouse chromosomes
  JOURNAL   Genomics 13 (4), 1356-1358 (1992)
   PUBMED   1354647
REFERENCE   9  (bases 1 to 2639)
  AUTHORS   Johnson,D.R.
  TITLE     The interfrontal bone and mutant genes in the mouse
  JOURNAL   J Anat 121 (Pt 3), 507-513 (1976)
   PUBMED   1018005
REFERENCE   10 (bases 1 to 2639)
  AUTHORS   Wallace,M.E.
  TITLE     Mapping an invisible lethal in the mouse
  JOURNAL   Genet Res 27 (1), 3-10 (1976)
   PUBMED   1278673
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL805918.5.
            
            On Aug 26, 2008 this sequence version replaced NM_008780.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M69222.1, AK134066.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-313               AL805918.5         58718-59030         c
            314-943             AL805918.5         57662-58291         c
            944-1086            AL805918.5         56005-56147         c
            1087-1303           AL805918.5         55429-55645         c
            1304-2639           AL805918.5         48975-50310         c
FEATURES             Location/Qualifiers
     source          1..2639
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 72.63 cM"
     gene            1..2639
                     /gene="Pax1"
                     /gene_synonym="hbs; hunchback; Pax-1; un; undulated; wt"
                     /note="paired box 1"
                     /db_xref="GeneID:18503"
                     /db_xref="MGI:MGI:97485"
     exon            1..313
                     /gene="Pax1"
                     /gene_synonym="hbs; hunchback; Pax-1; un; undulated; wt"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1395
                     /gene="Pax1"
                     /gene_synonym="hbs; hunchback; Pax-1; un; undulated; wt"
                     /note="wavy tail; paired box gene 1"
                     /codon_start=1
                     /product="paired box protein Pax-1"
                     /protein_id="NP_032806.2"
                     /db_xref="CCDS:CCDS16835.2"
                     /db_xref="GeneID:18503"
                     /db_xref="MGI:MGI:97485"
                     /translation="MKFTLGLGSRAWRVSWERAAAAAAGPGAGGALGSGSLRVSSRRG
                     PRLARALPLCLSGGGGARALPDCAGPSPRRSGARQLAGPRAMEQTYGEVNQLGGVFVN
                     GRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSK
                     PRVTTPNVVKHIRDYKQGDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGS
                     LAQPGPYEASKQPPPQPALPYNHIYQYPYPSPVSPTGTKMGTHPGVPGSAGHVSIPRS
                     WPSAHSVSNILGIRTFMEQTGALAGSEGAAYSPKMEDWAGVNRAAFPTSPAVNGLEKP
                     ALEADIKYTQSASSLSAVGGFLPACAYPASNQHGVYSAPAAGYLSPGPPWPPAQAPPL
                     TPHGAGVAVHGGELAAAMTFKHREGTDRKPPSPGGKATDALGSLHGLPIPASTS"
     exon            314..943
                     /gene="Pax1"
                     /gene_synonym="hbs; hunchback; Pax-1; un; undulated; wt"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1086
                     /gene="Pax1"
                     /gene_synonym="hbs; hunchback; Pax-1; un; undulated; wt"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1303
                     /gene="Pax1"
                     /gene_synonym="hbs; hunchback; Pax-1; un; undulated; wt"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..2639
                     /gene="Pax1"
                     /gene_synonym="hbs; hunchback; Pax-1; un; undulated; wt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2597..2602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pax1"
                     /gene_synonym="hbs; hunchback; Pax-1; un; undulated; wt"
                     /note="hexamer: AATAAA"
     polyA_site      2639
                     /gene="Pax1"
                     /gene_synonym="hbs; hunchback; Pax-1; un; undulated; wt"
                     /note="major polyA site"
ORIGIN      
        1 aaattgattc tcgcaccctg cagcttcccg gtcagacgaa tttctcccaa tcggatgaag
       61 ttcaccttgg gcctggggtc gcgggcctgg agagtgtcct gggagcgggc ggcggcggct
      121 gcggcaggcc ctggggcggg cggcgcgctg ggcagcggct cactgcgcgt ctccagccgc
      181 cgcggcccac ggctcgcgcg cgccctccct ctatgcctct ccggcggtgg cggcgcccga
      241 gctctcccgg actgcgccgg gcccagcccc cgccgctccg gcgccaggca gctggccggc
      301 ccgcgcgcga tggagcagac gtacggcgaa gtgaaccaac ttggtggcgt gttcgtcaac
      361 ggccgtcccc tgcccaatgc catccgccta cgaatcgtgg agctagcaca gctgggtatc
      421 cgaccctgtg acatcagtag gcaactgcgg gtctctcatg gctgcgtgag caaaatcctg
      481 gcgcgctaca acgagaccgg ctccatcctg cccggggcca tcgggggcag caaacctcga
      541 gttaccaccc ccaatgtagt gaagcacatc cgggactaca aacaggggga tcctggcatc
      601 tttgcctggg agatccgtga ccggctactg gctgatggcg tttgtgacaa gtacaacgtg
      661 ccctctgtga gctccatcag tcgcatcctg cgaaataaga ttggcagcct ggcgcagcca
      721 gggccatacg aagcaagtaa gcagccgcct ccgcagcctg cactgcccta caatcatatc
      781 taccagtacc cctaccccag cccagtgtca cccacgggca ctaagatggg cactcatccc
      841 ggggtccccg gctcggcggg ccacgtcagt atcccgcgtt catggccctc cgcacattca
      901 gtcagcaaca tcctgggcat ccggacgttt atggagcaaa caggggccct ggctgggagc
      961 gaaggcgctg cctactcccc caagatggaa gactgggcgg gtgtgaaccg tgcggccttc
     1021 cccacctcgc cagcagtgaa tggactcgag aaacctgcct tggaggcaga cattaaatat
     1081 actcagtcgg cttccagcct ctccgcagtg ggaggcttcc ttcctgcctg cgcctacccg
     1141 gcttccaacc agcacggagt atacagcgct ccagcagccg gctacctatc tcccggcccg
     1201 ccctggccac cagcccaggc acccccactg acgccccacg gagctggtgt ggcggtgcac
     1261 ggcggggagc ttgcagcggc aatgaccttc aaacaccgag aagggaccga ccggaagccc
     1321 cccagcccgg gaggcaaggc cacggatgca ctcggtagct tacacggact gcccatccca
     1381 gcctcgacct cctaggggct gtcctctcac agagccacag cccggttcag aggagccggc
     1441 cgggagtgca gctcagctca ttcgacctct gcacctctgc gctagcagca tcctggagtt
     1501 ggggccccgg cattgctttg gtctcaacag ttccgccggt gcttccttca ggaaaccctg
     1561 gaatttttta ggtctttccg agtcttggtt ttagatggct gcgttctcct aaccttccta
     1621 gttcggagag agactcctgc atccacctca atttattttt gttttgtctt ttcccatcca
     1681 tatccttcct ctctcttctt cttcctcttc cactccctcc ctccgcctgt tctctctctc
     1741 tcttccctcc tttatattct catctcaatc ctttctcttt ctgcattctc tctctctctc
     1801 tctctctctc tctctctctc tctctctctc tctctctctc tctctctcct cacacacact
     1861 tttctcacaa tcaaaggtct ttacagcttc cctaggctcg acttcttcaa tccgcgggtg
     1921 gggaaaactt cagtgcattc ttcaaggacc caaccttcct ttatacccct ccccccactc
     1981 ccctgagcag ccacagtccc aagggagtgg ggcttgaacc taggagcaaa gccaaagccc
     2041 ttaatcatat atttttatag taacaaacaa gagtacaact tccttggatt gctgccccta
     2101 ccccaagaat attgtttgga aaccttttgt ttttctgtgc ccagtgacta ggctggcttt
     2161 gtttctacgt taatgtcacc caaaagaaga caggacagga gaaagagatg ctgggactgg
     2221 tgttgggact ggtggtgttt ttagtaatta aagactaggc ttatctctca gccagatatg
     2281 cccaacactc cttaatgtac ctccagagcc atcagcatgg tttcgggtgt ttggggctca
     2341 gtacatttgt taattttgaa gaacaaactg cttcagggtg gtgaggttca ttttggtttc
     2401 tggtttgcaa agaattgggg tgggcaaaaa cccaggaacc cagaaggctt cttctggagc
     2461 taggcaagag ggctattaaa tgatttcaag ttaaggcgca ctggtggtgg ggactctgag
     2521 cataattcaa ttgttgtagt cataaacata ttactggtga gagtctgact tcacctgtta
     2581 aacatggctg cctttgaata aaggaaagtc tgaaactcgc cagcttggtg agggagaaa
//
