LOCUS       NM_054056               1828 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus PRKC, apoptosis, WT1, regulator (Pawr), mRNA.
ACCESSION   NM_054056 XM_125814 XM_915592
VERSION     NM_054056.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1828)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1828)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1828)
  AUTHORS   McKenna,M.K., Noothi,S.K., Alhakeem,S.S., Oben,K.Z., Greene,J.T.,
            Mani,R., Perry,K.L., Collard,J.P., Rivas,J.R., Hildebrandt,G.C.,
            Fleischman,R.A., Durbin,E.B., Byrd,J.C., Wang,C., Muthusamy,N.,
            Rangnekar,V.M. and Bondada,S.
  TITLE     Novel role of prostate apoptosis response-4 tumor suppressor in
            B-cell chronic lymphocytic leukemia
  JOURNAL   Blood 131 (26), 2943-2954 (2018)
   PUBMED   29695515
  REMARK    GeneRIF: Lack of Par-4 increased the expression of p21 and delayed
            chronic lymphocytic leukemia (CLL) growth in Emu-Tcl1 mice.
REFERENCE   4  (bases 1 to 1828)
  AUTHORS   Burikhanov,R., Hebbar,N., Noothi,S.K., Shukla,N., Sledziona,J.,
            Araujo,N., Kudrimoti,M., Wang,Q.J., Watt,D.S., Welch,D.R.,
            Maranchie,J., Harada,A. and Rangnekar,V.M.
  TITLE     Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell
            Apoptosis and Inhibition of Metastasis
  JOURNAL   Cell Rep 18 (2), 508-519 (2017)
   PUBMED   28076793
REFERENCE   5  (bases 1 to 1828)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 1828)
  AUTHORS   Garcia-Cao,I., Lafuente,M.J., Criado,L.M., Diaz-Meco,M.T.,
            Serrano,M. and Moscat,J.
  TITLE     Genetic inactivation of Par4 results in hyperactivation of
            NF-kappaB and impairment of JNK and p38
  JOURNAL   EMBO Rep 4 (3), 307-312 (2003)
   PUBMED   12634851
  REMARK    GeneRIF: loss of PAR4 leads to a reduction in the ability of tumour
            necrosis factor-alpha to induce apoptosis by increased activation
            of NF-kappaB
REFERENCE   7  (bases 1 to 1828)
  AUTHORS   D'Andrea,M.R., Saban,M.R., Nguyen,N.B., Andrade-Gordon,P. and
            Saban,R.
  TITLE     Expression of protease-activated receptor-1, -2, -3, and -4 in
            control and experimentally inflamed mouse bladder
  JOURNAL   Am J Pathol 162 (3), 907-923 (2003)
   PUBMED   12598324
REFERENCE   8  (bases 1 to 1828)
  AUTHORS   El-Guendy,N. and Rangnekar,V.M.
  TITLE     Apoptosis by Par-4 in cancer and neurodegenerative diseases
  JOURNAL   Exp Cell Res 283 (1), 51-66 (2003)
   PUBMED   12565819
  REMARK    Review article
REFERENCE   9  (bases 1 to 1828)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 1828)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ363525.1, AW123400.1 and DV057979.1.
            
            On Dec 14, 2006 this sequence version replaced NM_054056.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ363525.1, SRR7652917.976963.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-710               DQ363525.1         1-710
            711-711             AW123400.1         314-314
            712-1190            DQ363525.1         712-1190
            1191-1828           DV057979.1         174-811
FEATURES             Location/Qualifiers
     source          1..1828
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 56.43 cM"
     gene            1..1828
                     /gene="Pawr"
                     /gene_synonym="2310001G03Rik; Par-4; PAR4"
                     /note="PRKC, apoptosis, WT1, regulator"
                     /db_xref="GeneID:114774"
                     /db_xref="MGI:MGI:2149961"
     exon            1..60
                     /gene="Pawr"
                     /gene_synonym="2310001G03Rik; Par-4; PAR4"
                     /inference="alignment:Splign:2.1.0"
     exon            61..684
                     /gene="Pawr"
                     /gene_synonym="2310001G03Rik; Par-4; PAR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..1191
                     /gene="Pawr"
                     /gene_synonym="2310001G03Rik; Par-4; PAR4"
                     /note="prostate apoptosis response 4 protein"
                     /codon_start=1
                     /product="PRKC apoptosis WT1 regulator protein"
                     /protein_id="NP_473397.1"
                     /db_xref="CCDS:CCDS36053.1"
                     /db_xref="GeneID:114774"
                     /db_xref="MGI:MGI:2149961"
                     /translation="MATGGYRSGGSTTTDFLEEWKAKREKMRAKQNPAGPGSSGGDPA
                     AKSPAGSLTPTAVAGTSELNHGPAGAAAPAAPAPGALNCAHGSSTLPRAAPGSRRAED
                     ECPSAAAASGAPGSRGDEEEPDSAREKGRSSGPSARKGKGQIEKRKLREKRRSTGVVN
                     IPAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAATLPDPGTSYLPQDPSRTVPGR
                     YKSTTSAPEDEISNRYPRTDRSGFSRHNRDANAPASFSSSSTLEKRIEDLEKEVVRER
                     QENLRLVRLMQDKEEMIGKLKEEIDLLNRDLDDMEDENEQLKQENKTLLKVVGQLTR"
     exon            685..816
                     /gene="Pawr"
                     /gene_synonym="2310001G03Rik; Par-4; PAR4"
                     /inference="alignment:Splign:2.1.0"
     exon            817..851
                     /gene="Pawr"
                     /gene_synonym="2310001G03Rik; Par-4; PAR4"
                     /inference="alignment:Splign:2.1.0"
     exon            852..999
                     /gene="Pawr"
                     /gene_synonym="2310001G03Rik; Par-4; PAR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1104
                     /gene="Pawr"
                     /gene_synonym="2310001G03Rik; Par-4; PAR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1828
                     /gene="Pawr"
                     /gene_synonym="2310001G03Rik; Par-4; PAR4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1415..1420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pawr"
                     /gene_synonym="2310001G03Rik; Par-4; PAR4"
                     /note="hexamer: ATTAAA"
     polyA_site      1435
                     /gene="Pawr"
                     /gene_synonym="2310001G03Rik; Par-4; PAR4"
                     /note="major polyA site"
     regulatory      1461..1466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pawr"
                     /gene_synonym="2310001G03Rik; Par-4; PAR4"
                     /note="hexamer: AATATA"
     polyA_site      1479
                     /gene="Pawr"
                     /gene_synonym="2310001G03Rik; Par-4; PAR4"
ORIGIN      
        1 ctcacctgga caaccctcat ccccgccacg ctccttgtcc cacctaaaaa cttctcggag
       61 agcgtcggtc cggcagcgcg ctcaccccgc gcagtcccca gcgcattctc gcttcccggg
      121 caggcggcgg cgccggcggg agacaggagt cgcggcgtga ggggcgcccc cgccggcccc
      181 tctgggaaca tggcgaccgg cggctaccgg agcggcggca gcaccaccac ggacttcctg
      241 gaggagtgga aggcgaagcg cgagaagatg cgcgccaagc agaaccccgc gggcccgggg
      301 tcgagcggcg gggatccagc cgccaagtcc cccgcgggat cgctgacccc gaccgcggtc
      361 gcgggaacct cggagctcaa ccacggcccc gcgggcgcgg ccgcacctgc cgcccccgcg
      421 cccggcgccc tgaactgcgc tcacggctcg tccacgctgc cccgcgcggc tcccggctcc
      481 cggcgggcgg aggacgagtg ccctagcgcc gctgcggcct cgggagcgcc tgggtcccgg
      541 ggcgatgagg aggagccgga tagcgcccgg gagaagggcc gcagctcggg acccagcgcc
      601 aggaaaggca aggggcagat cgagaagagg aagctgcggg agaagcgccg ctccaccggc
      661 gtggtcaaca tccccgcggc ggagtgctta gatgagtacg aagatgatga agcaggacag
      721 aaggaacgga agcgagagga tgccatcacc cagcaaaaca ccatccagaa tgaagctgcg
      781 accctcccag atccaggcac atcctacctg ccccaggacc cgtcgagaac agttccaggc
      841 agatacaaaa gcacaaccag tgccccagaa gatgaaatct caaatagata tccccgaaca
      901 gacagaagtg gtttcagtag acacaacaga gatgcaaatg cgccggctag tttctcctca
      961 agtagcacct tggaaaagag aattgaagat cttgaaaagg aagttgtaag agaaaggcaa
     1021 gaaaaccttc gacttgtgag gctgatgcaa gataaagaag aaatgattgg gaaactcaag
     1081 gaagagatcg atttgttaaa tagagaccta gatgacatgg aagatgagaa cgagcaacta
     1141 aaacaggaaa ataaaactct tttgaaggtt gttgggcagc tgacaaggta gaagctgcac
     1201 gggcggcttc ggtgtggaaa gcctgctttt acactactga tgaatgtcat ggctaaggct
     1261 gagctgagac gcctgtgatt cactgcgttg ttgagaggac tgtatattta tttctagaaa
     1321 acacgtggat ttttttttca agattcactc tttcattgct agtttctaaa aagtattaag
     1381 ccctgtattt cacatagaag taacgttttt agttattaaa gtcataggta atgcctcttg
     1441 gttttgtgtg atatccagat aatatatggt tcaaagtaac agccatttgc atatatttta
     1501 tctacgttag cccatattct ccctaaagga atatgcatag tctttgttta catgaattca
     1561 catccttggg ggagttggcc tacaatgcct tattactaat gcgtgcggcc ttctgtgtgt
     1621 taacacttag acggaaagac tcatctgctg tcgtctcctc tttccacatg ctgtaatggt
     1681 tcccagtagt aatagataca ctattttgta tagcagtaat cattcaaagg aaagctattt
     1741 tacagagtta cttcatatgt tctagttggc taattataaa cttaagagaa tacttgaact
     1801 gtgttatagt aagtgaaaaa ttactatt
//
