LOCUS       NM_026251               2434 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus protein associated with topoisomerase II homolog 2
            (yeast) (Patl2), mRNA.
ACCESSION   NM_026251
VERSION     NM_026251.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2434)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2434)
  AUTHORS   Zhang,Z., Liu,R., Zhou,H., Li,Q., Qu,R., Wang,W., Zhou,Z., Yu,R.,
            Zeng,Y., Mu,J., Chen,B., Guo,X., Sang,Q. and Wang,L.
  TITLE     PATL2 regulates mRNA homeostasis in oocytes by interacting with
            EIF4E and CPEB1
  JOURNAL   Development 150 (12) (2023)
   PUBMED   37218508
  REMARK    GeneRIF: PATL2 regulates mRNA homeostasis in oocytes by interacting
            with EIF4E and CPEB1.
REFERENCE   3  (bases 1 to 2434)
  AUTHORS   Christou-Kent,M., Kherraf,Z.E., Amiri-Yekta,A., Le Blevec,E.,
            Karaouzene,T., Conne,B., Escoffier,J., Assou,S., Guttin,A.,
            Lambert,E., Martinez,G., Boguenet,M., Fourati Ben Mustapha,S.,
            Cedrin Durnerin,I., Halouani,L., Marrakchi,O., Makni,M.,
            Latrous,H., Kharouf,M., Coutton,C., Thierry-Mieg,N., Nef,S.,
            Bottari,S.P., Zouari,R., Issartel,J.P., Ray,P.F. and Arnoult,C.
  TITLE     PATL2 is a key actor of oocyte maturation whose invalidation causes
            infertility in women and mice
  JOURNAL   EMBO Mol Med 10 (5) (2018)
   PUBMED   29661911
REFERENCE   4  (bases 1 to 2434)
  AUTHORS   Marnef,A., Maldonado,M., Bugaut,A., Balasubramanian,S., Kress,M.,
            Weil,D. and Standart,N.
  TITLE     Distinct functions of maternal and somatic Pat1 protein paralogs
  JOURNAL   RNA 16 (11), 2094-2107 (2010)
   PUBMED   20826699
  REMARK    GeneRIF: hPat1b localizes to P-bodies, while mPat1a-GFP is either
            found weakly in P-bodies or disperses P-bodies in a
            dominant-negative fashion.
REFERENCE   5  (bases 1 to 2434)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY714747.1, DV658440.1, AK010811.1, DV660077.1 and AL845457.16.
            
            On Sep 8, 2006 this sequence version replaced NM_026251.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK015195.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849383,
                                           SAMN00849384 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-547               BY714747.1         2-548
            548-1156            DV658440.1         159-767
            1157-1391           AK010811.1         229-463
            1392-1701           DV660077.1         256-565
            1702-2315           AK010811.1         770-1383
            2316-2434           AL845457.16        165834-165952       c
FEATURES             Location/Qualifiers
     source          1..2434
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.53 cM"
     gene            1..2434
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /note="protein associated with topoisomerase II homolog 2
                     (yeast)"
                     /db_xref="GeneID:67578"
                     /db_xref="MGI:MGI:1914828"
     exon            1..59
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /inference="alignment:Splign:2.1.0"
     exon            60..213
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /inference="alignment:Splign:2.1.0"
     exon            214..407
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /inference="alignment:Splign:2.1.0"
     exon            408..494
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             479..2068
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /note="PAT1-like protein 2; protein PAT1 homolog a"
                     /codon_start=1
                     /product="protein PAT1 homolog 2"
                     /protein_id="NP_080527.2"
                     /db_xref="CCDS:CCDS16653.1"
                     /db_xref="GeneID:67578"
                     /db_xref="MGI:MGI:1914828"
                     /translation="MKCLEGLHLQQRPSKFSVSLAPEEGLVCAFQLEEEKENEDECVC
                     SDQAPEVKEEGCGLGDPAIVSAFQNTQVPQQRGLHSSHRVKVSGALGMSSASLHFMWQ
                     SVFPRASSPAHHFGPQQPSPDPFLFYSPLTPWPPKLSLPSHLTQLHPQHQQILQQQQR
                     WRRRRSPTARSVPAQKPWSREPAASDAYANLMTRKEKDWVIRVQMVQLQSENPRLDDY
                     YYQKYYQKLEKRQADKELLGQKTRAESLKLVTPYIQKPEVYESVVRIEGSLGQVAVST
                     CFSPRRAIDAVSHGTQEQDTGAASSQRLRVLSQIEKMFLQLLKIEEGQNDGLPQLYHT
                     REQSSQVEKLFQALKTQEQNNLEEAADNLLQVLSVRKGKVLVARLLPFLPPDQAVSLL
                     LYITYHLPLLIQRDMADQGLHMLFKPLGKYISHLTFHQLLHAMQGLMLLSPGSSERPV
                     SVVLQNQFGISLLYALLSHGEQLVSLDPSLRSSSDCATWTDLVILIAWEIAQLPAASL
                     AEPLAFPRNLLPCSAITWTSN"
     exon            495..703
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /inference="alignment:Splign:2.1.0"
     exon            704..784
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /inference="alignment:Splign:2.1.0"
     exon            785..894
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /inference="alignment:Splign:2.1.0"
     exon            895..987
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1141
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1262
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1360
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1414
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1548
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1708
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1849
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1944
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2093
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2434
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2410..2415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /note="hexamer: AATAAA"
     polyA_site      2429
                     /gene="Patl2"
                     /gene_synonym="4930424G05Rik; Pat1a"
                     /note="major polyA site"
ORIGIN      
        1 gggaaaggcc tcaggaagca ggcaaagaga cactgaaaga atagctgtgg aggacaaagg
       61 gttcccaagc atcacagact cgagtagttg cactttgctc cagaaacaag acatgaggac
      121 tatacccaga gtactctcgt gccttagaag accccagaga agcagaacgt tatcttgaat
      181 ggctccagca aaatctgtgt gggcaactga aatccttgtg acgtccaggc tggcctcaag
      241 tttcctaggt agctgaggct tcccttgaac tcctgagcct cctgtctcca tctctcaagt
      301 actggcatca ccggcctgtg cttccacacc tgactaagga ttttctttat tagagttctc
      361 atacttctac accacctcca tagtgaagca tcccagccct ttaacaggtt gcccccttca
      421 agaggtttct ctatcactgg aggacacagc tggcaaggaa gcccaccagg ctgccaacat
      481 gaaatgcctt gaaggtctgc acttacagca gagacccagc aagttctctg tctccttggc
      541 tcctgaagaa ggcttagtgt gtgccttcca actggaggaa gagaaggaga atgaagatga
      601 atgtgtgtgt tcagatcagg ctccagaagt gaaggaggaa gggtgtggtc tcggggatcc
      661 agccatagtg agcgccttcc aaaataccca agtaccacag cagagagggc tgcacagttc
      721 ccacagagtc aaggtctctg gtgccttggg gatgtcatca gcctccctgc attttatgtg
      781 gcagtctgtg tttccaagag ccagttctcc agcccatcat tttggaccgc aacagccttc
      841 accagatcct tttctgttct acagcccact gaccccgtgg ccccctaagc tcagccttcc
      901 cagtcatctg acccagctcc accctcagca ccagcagatc ctgcagcagc agcaacggtg
      961 gcgtaggagg cggagtccaa cagcaagaag tgtccccgcc cagaagcctt ggtctcgtga
     1021 gccagctgcc tcagatgcct atgctaacct catgacccga aaagagaagg actgggtgat
     1081 aagagtgcag atggttcaac tgcagagtga gaacccccgc ctggatgatt actactacca
     1141 gaaatactat cagaagctgg agaagagaca ggcagacaaa gagctgcttg gacaaaagac
     1201 cagggctgag tctctcaagt tggtcacgcc ttacatccag aagcctgaag tttatgagtc
     1261 agtggtgcgg attgagggtt ccctgggcca ggtagctgta tcaacatgtt ttagccctcg
     1321 ccgagctatt gacgctgtat ctcacggaac ccaagagcag gatacaggag ctgcgagcag
     1381 ccagaggctt cgggtattgt cccagattga gaagatgttc cttcagttac taaaaataga
     1441 ggagggccag aatgatgggc tcccacaact ctaccacact cgggaacaga gcagccaggt
     1501 tgagaagctc tttcaggcct taaaaaccca ggagcagaac aacctggagg aggcagcaga
     1561 taacctcctg caagtgctgt ctgtgaggaa agggaaagtt ttggtggctc ggctgctccc
     1621 cttcctgccc ccggatcaag ctgttagcct cctcctgtac atcacctacc atctgcccct
     1681 cctgatccag agggacatgg ctgaccaggg tctacacatg ctattcaaac ctctggggaa
     1741 atatatcagt catctgacct tccatcagct cctccatgca atgcaaggac taatgttgct
     1801 atcacctggc tcctcagagc ggccagtctc tgtggtactt cagaatcagt ttgggatatc
     1861 tctgctatat gccttgctga gtcatggaga gcagctggta tccctggatc cttccctccg
     1921 atccagcagt gactgtgcaa cctggacaga cttggtgatt ctgattgcct gggagatagc
     1981 tcagttgcct gcagcatcct tggcggagcc tctagccttc cccaggaatc tgcttccctg
     2041 ttctgccatc acatggacaa gcaattagtt cagcagctgg aagccagaat ggagcttgcc
     2101 tgtatctact gatgtattag ttaatgtgag aagctgaaat atcagaaacg gaactccatc
     2161 acctgtctac agtgacagtt gaggccattt cctatacttt gttatgttgg aggaccctgc
     2221 cacattgtca tatcctttct taaaatctag gtgacttgcc taaaattaag gcatgactac
     2281 tttaggtatg attaaagaaa tatcaaatga tatgttgaaa cttgtttgta agtttggaat
     2341 tacaacgaag gacatttttt tgaatatgtc aagaatatcc ttcctaataa ggggaaaggc
     2401 cttgtattta ataaaagtct aatctgggat gttg
//
