LOCUS       NM_172635               4221 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus protein associated with topoisomerase II homolog 1
            (yeast) (Patl1), mRNA.
ACCESSION   NM_172635
VERSION     NM_172635.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4221)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   2  (bases 1 to 4221)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 4221)
  AUTHORS   Marnef A, Maldonado M, Bugaut A, Balasubramanian S, Kress M, Weil D
            and Standart N.
  TITLE     Distinct functions of maternal and somatic Pat1 protein paralogs
  JOURNAL   RNA 16 (11), 2094-2107 (2010)
   PUBMED   20826699
REFERENCE   4  (bases 1 to 4221)
  AUTHORS   Thuret S, Bhatt L, O'Leary DD and Simon HH.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   5  (bases 1 to 4221)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 4221)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK150301.1, AC124464.3, AK161738.1 and AV316026.1.
            
            [WARNING] On Dec 8, 2023 this sequence was replaced by NM_172635.4.
            
            On Aug 6, 2009 this sequence version replaced NM_172635.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150301.1, AK170918.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2256              AK150301.1         2-2257
            2257-2257           AC124464.3         67801-67801
            2258-3414           AK150301.1         2259-3415
            3415-4220           AK161738.1         2377-3182
            4221-4221           AV316026.1         241-241
FEATURES             Location/Qualifiers
     source          1..4221
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 8.57 cM"
     gene            1..4221
                     /gene="Patl1"
                     /gene_synonym="Pat1b"
                     /note="protein associated with topoisomerase II homolog 1
                     (yeast)"
                     /db_xref="GeneID:225929"
                     /db_xref="MGI:MGI:2147679"
     exon            1..179
                     /gene="Patl1"
                     /gene_synonym="Pat1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..2477
                     /gene="Patl1"
                     /gene_synonym="Pat1b"
                     /note="PAT1-like protein 1; protein PAT1 homolog b"
                     /codon_start=1
                     /product="protein PAT1 homolog 1"
                     /protein_id="NP_766223.2"
                     /db_xref="CCDS:CCDS37924.1"
                     /db_xref="GeneID:225929"
                     /db_xref="MGI:MGI:2147679"
                     /translation="MFRYESLEDCPLDEDEDAFQGLGEEDEEIDQFNDDTFGSGAVDD
                     DWQEAHERLAELEEKLPVAADEQTGNGERDEMDLLGDHEENLAERLSKMVIENELEDP
                     AIMRAVQTRPVLQPQPGSLNSSIWDGSEVLRRIRGPLLAQEMPTVSVLEYALPQRPLQ
                     GPEDDRDLSERALPRRSTSPIIGSPPVRAVPIGTPPKQMAVPSFNQQILCPKPVHVRP
                     PMPPRYPAPYGERISPNQLCSVPNSSLLGHPFPPNVPPVLSPLQRAQLLGGAQLQPGR
                     MSPSQFARVPGFVGSPLAAMNPKLLQGRVGQMLPPAPSFRAFFSAPPPATPPPQQHPP
                     GPGPHLQNLRPQAPMFRADTTHLHPQHRRLLHQRQLQSRNQHRNLNGTGDRGGHQSSH
                     QDHLRKDPYANLMLQREKDWVSKIQMMQLQSTDPYLDDFYYQNYFEKLEKLSAAEEIQ
                     GDGPKKERTKLITPQVAKLEHAYQPVQFEGSLGKLTVSSVNNPRKMIDAVVTSRSEDD
                     ETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEERPALMDERKHKICSMY
                     DNLRGKLPGQERPSDDHFVQIMCIRKGKRMVARILPFLSTEQAADILMATARNLPFLI
                     KKDAQDEVLPCLLSPFSLLLYHLPSVTVTSLLQQLMNLPQSASAPAPSNSHLTAVLQN
                     KFGLSLLLILLSRGEDLQSSDPAIESTQNNQWTEVMFMATRELLRIPQAALAKPISIP
                     TNLVSLFSRYVDRQKLNLLETKLQLVQGIR"
     exon            180..291
                     /gene="Patl1"
                     /gene_synonym="Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            292..509
                     /gene="Patl1"
                     /gene_synonym="Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            510..590
                     /gene="Patl1"
                     /gene_synonym="Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            591..785
                     /gene="Patl1"
                     /gene_synonym="Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            786..887
                     /gene="Patl1"
                     /gene_synonym="Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            888..977
                     /gene="Patl1"
                     /gene_synonym="Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1195
                     /gene="Patl1"
                     /gene_synonym="Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1285
                     /gene="Patl1"
                     /gene_synonym="Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1466
                     /gene="Patl1"
                     /gene_synonym="Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1590
                     /gene="Patl1"
                     /gene_synonym="Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1688
                     /gene="Patl1"
                     /gene_synonym="Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1748
                     /gene="Patl1"
                     /gene_synonym="Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1897
                     /gene="Patl1"
                     /gene_synonym="Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2057
                     /gene="Patl1"
                     /gene_synonym="Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2213
                     /gene="Patl1"
                     /gene_synonym="Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2305
                     /gene="Patl1"
                     /gene_synonym="Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2455
                     /gene="Patl1"
                     /gene_synonym="Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..4221
                     /gene="Patl1"
                     /gene_synonym="Pat1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggcgcgcc tgcgcacgtc cccacgcacg ctccggcgta cggcggcggc caggggtcgc
       61 gagccggtgg gagacccgcg cgcgcggagc agcccgggga gtcggcgctt cttttccctc
      121 cctcccccca ctcccctccc cgctcccttc ccccctcccc aagaatgttc cgctacgagt
      181 ctttggagga ttgtcctcta gatgaagatg aagatgcatt tcaaggcctg ggagaagaag
      241 atgaagaaat tgatcaattt aatgatgata cctttgggtc aggtgcagtt gatgatgatt
      301 ggcaggaagc acatgagcgc ctggctgagt tggaagagaa gctacctgtg gcagctgatg
      361 aacaaacagg caatggagag agagatgaga tggatttgtt gggtgaccat gaggagaatc
      421 tagcagaaag gctcagtaag atggtgattg aaaatgagct agaagatcca gctatcatga
      481 gggcagtaca gaccaggcca gttttacaac ctcaaccagg aagtctgaat tccagcatct
      541 gggatggatc tgaagttctg aggcgaatcc gtggaccact acttgctcag gaaatgccta
      601 cagtgtctgt attagagtat gccttgcctc agaggcccct gcagggccca gaagatgatc
      661 gggacctttc tgagcgagct ttaccaaggc ggtcaacatc acctatcatt ggaagtcctc
      721 ctgttagagc cgttcctata ggcaccccac ctaagcagat ggctgttccc agcttcaacc
      781 aacagatcct gtgtccgaag cctgttcatg ttcggccccc aatgccgcca cgctatcctg
      841 ctccctatgg cgagaggata tctccaaacc agctctgcag tgtcccgaac tcctccctcc
      901 tgggccaccc ttttcctcct aatgttcctc ctgtacttag tcccctgcag agagcacagc
      961 ttcttggggg agcacagcta cagcctggac gaatgtctcc cagccagttt gcacgggtcc
     1021 ctgggtttgt tggtagccca ctggctgcca tgaatcctaa gttgctacaa gggcgcgttg
     1081 ggcagatgct tcccccagca ccaagcttcc gtgccttctt tagtgctcca ccccccgcta
     1141 cgccacctcc acagcagcat ccccctggcc caggacctca cctacaaaac ctcagacctc
     1201 aggccccaat gtttagagca gacacaactc accttcatcc acagcaccgg cgcctgttgc
     1261 atcagaggca gctgcagagc agaaatcagc atcggaatct caatggtact ggagatagag
     1321 gagggcacca gtccagtcat caagatcatc tccggaagga tccatatgct aatctaatgt
     1381 tgcagcggga gaaggattgg gtctctaaaa tacagatgat gcagctgcag agcactgatc
     1441 cctacctgga tgatttctat taccagaatt actttgaaaa actggagaaa ttgtcagctg
     1501 ctgaggaaat acaaggtgat ggccctaaga aggagcgtac caagctcatc acccctcagg
     1561 tggccaaact ggagcatgct tatcagcctg tgcagtttga gggctcgttg gggaagctta
     1621 ctgtctctag tgtgaataat cctcggaaga tgatagatgc tgttgtgaca tctcgaagtg
     1681 aggatgatga aacaaaagaa aaacaagttc gggataagag aagaaaaacc cttgttataa
     1741 ttgagaaaac ctatagttta ctccttgatg tggaggatta tgaaaggcgc tatctcctaa
     1801 gtctagaaga agagcggcct gccctgatgg atgaaagaaa gcacaaaata tgtagcatgt
     1861 atgacaacct gaggggcaaa ttgcctggac aagagaggcc aagtgatgac cactttgtac
     1921 agatcatgtg tatccgaaaa gggaagagaa tggttgcccg cattctccct ttcctctcca
     1981 cagagcaagc agctgacatt ctcatggcaa ctgccaggaa cctccctttc cttatcaaga
     2041 aggatgccca agatgaggtg ctgccatgct tactgagtcc cttctctctc ctcctctatc
     2101 atcttccttc agtgactgtc accagccttc tgcaacagct aatgaaccta cctcagagtg
     2161 caagtgcacc agcgccctcc aactctcacc tcactgctgt gctccagaac aagtttggct
     2221 tgtcactgct cctaatccta ctaagccgtg gagaagacct acagagttca gatcctgcta
     2281 tagaatcaac gcaaaataac cagtggacag aggtgatgtt catggcaacc cgagaacttc
     2341 tacggatccc ccaagctgcc ctggccaaac caatctctat ccctacaaat ctagtgtccc
     2401 ttttttctcg ctatgttgac cggcagaaac tgaacttgct ggaaacaaaa ctgcagctgg
     2461 ttcaggggat acggtaaaag atctccagag tatcctgtac ctcctgttgg ctgccacctg
     2521 cactgctgcc atcaccaatg gagtgttttt aatgagggag gggaggtagc ttatgaccca
     2581 aagcaaagtc ttgtgggatc cattcctgtt ttcagaagtt agctctgaat gccaggtatt
     2641 cccgctgctc tgatacttct gctgggtggt acttctgctg gtttctttta ccttctgcgt
     2701 tacacttttg catgtcctac ttttactcaa ttcttctcaa ttttgcattt tctttgccct
     2761 agagacacaa caaacgtccc tttatcccat caccactatt acaattcaaa gtaggttgta
     2821 gtataccaaa ggactccttc ccgctttgaa gtcttttttt catctcccct tattaatatg
     2881 attataggag agtcaaaatt aagtagaagt caagatatag gtaaatatat aaacacccta
     2941 cacaaacatt cgtatgatct ccagagggtc cttaaagaat aagtttgttt gaaaaatatt
     3001 tagttaacat atacctctaa aaataaacca gccgatatat ttttaatctg tttctgttcc
     3061 atcttgtcat ttggtggatt ctactttttt aatatataaa tacagggtat acagcatatt
     3121 acattaaatc aaacttgtta gttggctgat gcccagttct aggctgagag gacttttctt
     3181 tctcctaacc tgtatttcct ttgtttctga caaccataat agaaacagca cacacacggt
     3241 taagcctttt cctgtgatga ctacagcgtg cttgagagtc tgtccctcaa gtgcattcaa
     3301 gagtacccaa gatgagcctc acgtagagcc tgcttctgca gtgtagcttt tgtgcgcctg
     3361 cactgtcttc ctgacgtgac ttctgtaagc catgcttctg ctcctcttcc ccattttcat
     3421 ttagtgtctt gggtagaaac ctccaaatgt agccgtggct gctcagcttg ggctctgctc
     3481 ttcagtgtcc tctaccctgc agcagaactg ctgtcctggc tgctgagtct cacctgagcc
     3541 ccatccactg cagccagcag ggcctgggtg tgaatcttag ggacacttcc cttccactca
     3601 cttttcttcc cttcagcagt cagccaggat aagggactcg gctccctagt ggttacagtt
     3661 ctgaaaaaaa taaattgaat ttattttata ttcccttcct gatcctactt tctgctgttc
     3721 tcaccttttt gaatgtagtc gggggacagg ctatgatatt taaagagaat aaacgttttg
     3781 cacatacatg tattgtataa cagtaaagcc ctccgttaca accagctgtc tttgtactca
     3841 tctccatttc ttctcatttt gtggcctcgg gctccaccag ctgctcccca gtgacagtcc
     3901 ctagcttcct tctaccatct actgactgtc tccactgagc ctttcctacc ttcccttcac
     3961 acccgatcaa gtaaacactt gattattttt ttcttcctta ttgtgctttt tgttcagttc
     4021 taattaataa aataaaattt ctaaatttac atttttatag ggtattgtaa ataaaacaaa
     4081 ttgtatactt gaaaatgtgt gctttatacc tttctgtttc tgcatttgtt tttaatgttt
     4141 tccattatac ttggattcac tagcaaaact cttgatgttg gggaatacca ctttgctctg
     4201 aataaattca ctatttctag a
//
