LOCUS       NM_172696               7305 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus PATJ, crumbs cell polarity complex component (Patj),
            transcript variant 1, mRNA.
ACCESSION   NM_172696
VERSION     NM_172696.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7305)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7305)
  AUTHORS   Baliova,M., Jahodova,I. and Jursky,F.
  TITLE     A Significant Difference in Core PDZ Interactivity of SARS-CoV,
            SARS-CoV2 and MERS-CoV Protein E Peptide PDZ Motifs In Vitro
  JOURNAL   Protein J 42 (4), 253-262 (2023)
   PUBMED   36932261
REFERENCE   3  (bases 1 to 7305)
  AUTHORS   Yu,M., Jiang,X., Cai,W., Yang,X., An,W., Zhang,M., Xu,Y., Zhang,B.
            and Tang,S.
  TITLE     PATJ and MPDZ are required for trophectoderm lineage specification
            in early mouse embryos
  JOURNAL   Reproduction 166 (2), 175-185 (2023)
   PUBMED   37318097
  REMARK    GeneRIF: PATJ and MPDZ are required for trophectoderm lineage
            specification in early mouse embryos.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7305)
  AUTHORS   Jiang,X., An,W., Yang,X., Lin,J., Ma,S., Wang,D. and Tang,S.
  TITLE     Asymmetric distribution of CRUMBS polarity complex proteins from
            compacted 8-cell to blastocyst stage during mouse preimplantation
            development
  JOURNAL   Gene Expr Patterns 27, 93-98 (2018)
   PUBMED   29155075
REFERENCE   5  (bases 1 to 7305)
  AUTHORS   Ramkumar,N., Omelchenko,T., Silva-Gagliardi,N.F., McGlade,C.J.,
            Wijnholds,J. and Anderson,K.V.
  TITLE     Crumbs2 promotes cell ingression during the
            epithelial-to-mesenchymal transition at gastrulation
  JOURNAL   Nat Cell Biol 18 (12), 1281-1291 (2016)
   PUBMED   27870829
REFERENCE   6  (bases 1 to 7305)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 7305)
  AUTHORS   Poliak,S., Matlis,S., Ullmer,C., Scherer,S.S. and Peles,E.
  TITLE     Distinct claudins and associated PDZ proteins form different
            autotypic tight junctions in myelinating Schwann cells
  JOURNAL   J Cell Biol 159 (2), 361-372 (2002)
   PUBMED   12403818
REFERENCE   8  (bases 1 to 7305)
  AUTHORS   Anzai,N., Deval,E., Schaefer,L., Friend,V., Lazdunski,M. and
            Lingueglia,E.
  TITLE     The multivalent PDZ domain-containing protein CIPP is a partner of
            acid-sensing ion channel 3 in sensory neurons
  JOURNAL   J Biol Chem 277 (19), 16655-16661 (2002)
   PUBMED   11872753
REFERENCE   9  (bases 1 to 7305)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 7305)
  AUTHORS   Kurschner,C., Mermelstein,P.G., Holden,W.T. and Surmeier,D.J.
  TITLE     CIPP, a novel multivalent PDZ domain protein, selectively interacts
            with Kir4.0 family members, NMDA receptor subunits, neurexins, and
            neuroligins
  JOURNAL   Mol Cell Neurosci 11 (3), 161-172 (1998)
   PUBMED   9647694
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CK340630.1, AK050545.1,
            AK077268.1, BB617492.1, AK044043.1 and AL670941.11.
            
            On Nov 15, 2004 this sequence version replaced NM_172696.1.
            
            Summary: This gene encodes a multivalent PDZ domain protein, which
            is expressed exclusively in brain and kidney. This protein
            selectively interacts with inward rectifier K+ (Kir) family
            members, N-methyl-D-aspartate receptor subunits, neurexins and
            neuroligins, as well as cell surface molecules enriched in synaptic
            membranes. Thus, this protein may serve as a scaffold that brings
            structurally diverse but functionally connected proteins into close
            proximity at the synapse. Multiple alternatively spliced transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141404.1, SRR10223969.4671.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                CK340630.1         1-29
            30-1822             AK050545.1         2-1794
            1823-2350           AK077268.1         105-632
            2351-2370           BB617492.1         630-649
            2371-3090           AK077268.1         653-1372
            3091-3107           AK044043.1         599-615
            3108-3501           AK050545.1         2084-2477
            3502-6060           AK077268.1         1784-4342
            6061-7305           AL670941.11        45674-46918
FEATURES             Location/Qualifiers
     source          1..7305
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 45.6 cM"
     gene            1..7305
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /note="PATJ, crumbs cell polarity complex component"
                     /db_xref="GeneID:12695"
                     /db_xref="MGI:MGI:1277960"
     exon            1..99
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            100..155
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..5638
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /note="isoform 1 is encoded by transcript variant 1;
                     channel-interacting PDZ domain protein; PALS1-associated
                     tight junction protein; inactivation no after-potential
                     D-like protein; inaD-like protein; novel ankyrin-repeat
                     protein; protein associated to tight junctions;
                     channel-interacting PDZ domain-containing protein"
                     /codon_start=1
                     /product="inaD-like protein isoform 1"
                     /protein_id="NP_766284.2"
                     /db_xref="CCDS:CCDS18375.1"
                     /db_xref="GeneID:12695"
                     /db_xref="MGI:MGI:1277960"
                     /translation="MPENPAAEKMQVLQVLDRLRGKLQEKGDTTQNEKLSAFYETLKS
                     PLFNQILTLQQSIKQLKGQLSHIPSDCSANFDFSRKGLLVFTDGSITNGNAQRPCSNV
                     TASELLPWTQKSASEDFNSVIQQMAQGRHVEYIDIERPSTGGLGFSVVALRSQSLGLI
                     DIFVKEVHPGSVADRDHRLKENDQILAINDTPLDQNISHQQAIALLQQATGSLRLVVA
                     REVGHTQGRASTSSADTTLPETVCWGHTEEVELINDGSGLGFGIVGGKSSGVVVRTIV
                     PGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPVGEIAV
                     TPPTPVSLPVALPAVATRTLDSDRSPFETYSVELVKKDGQSLGIRIVGYVGTAHPGEA
                     SGIYVKSIIPGSAAYHNGQIQVNDKIVAVDGVNIQGFANQDVVEVLRNAGQVVHLTLV
                     RRKTSLSASPFEHSSSRETVAEPPKVPERAGSPKPEANLSVEAEEIGERLDNLKNNTV
                     QALEKPDVYPEKVPGSPENELKSRWENLLGPDYEVMVATLDAQIADDEELQKYSKLLP
                     IHTLRLGMEVDSFDGHHYISSVAPGGPVDTLNLLQPEDELLEVNGMQLYGKSRREAVS
                     FLKEVPPPFTLVCCRRLFDDEASVDEPRTMEPALLEAEVDHSVDVNIEDDDDGELALW
                     SPEVKTVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGELLPGDRLV
                     SVNEFSLDNATLAEAVEVLKAVPPGVVHLGICKPLVEDEKEERFSLHSNNNGDSSEPA
                     DAVHEIHSSLILEAPQGFRDEPYLEELVDEPFLDLGKSLQFQQKDVDSSSEAWEMHEF
                     LSPPLDGRGEEREMLVDEEYELYQDHLRAMESNPPPPHIREAAPASPVLELQAGTQWL
                     HANLSGGERLECHDAESMMSAYPQEMQQYSYSTADMMEETFGLDSRAPIPSSEGNGQH
                     GRFDDMGHLHSLTSSSLDLGMMIPSDLQGPGVLVDLPAVAQRREQEDLPLYRLPSARV
                     VTKPSSHMGLVSSRHANAACELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGIS
                     IVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHAE
                     AVEAIKSAGNPVVFVVQSLSSTPRVIPTVNNKGKTPAPNQDQNTQERKAKRHGTAPPP
                     MKLPPPYRAPSADMEGSEEDCALTDKKIRQRYADLPGELHIIELEKDKNGLGLSLAGN
                     KDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPTRV
                     KLVFIRNEDAVSQMAVAPFPELSHSPSPVEDLGGTELVSSEEESSVDAKHLPEPESSK
                     PEDLSQVVDDNMVAEQQKESESPDSAACQIKQQTYSTQVSSSSQDSPSSPAPLCQSAH
                     ADVTGSGNFQAPLPVDPAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPL
                     DAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRSSSHEEAITALRQTPQKVRLVVY
                     RDEAQYRDEENLEVFLVDLQKKTGRGLGLSIVGKRSGSGVFISDIVKGGAADLDGRLI
                     RGDQILSVNGEDMRHASQETVATILKCVQGLVQLEIGRLRAGSWAASRKTSQNSQGDQ
                     HSAHSSCRPSFAPVITSLQNLVGTKRSSDPPQKCTEEEPRTVEIIRELSDALGISIAG
                     GKGSPLGDIPIFIAMIQANGVAARTQKLKVGDRIVSINGQPLDGLSHTDAVNLLKNAF
                     GRIILQVVADTNISAIATQLEIMSAGSQLGSPTADRHPEDTEEQMQRTAD"
     exon            156..322
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            323..517
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            518..657
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            658..853
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            854..982
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1201
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1301
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1393
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1535
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1676
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1765
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1822
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1957
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2119
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2251
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2461
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2575
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2983
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3107
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3282
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3354
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            3355..3532
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            3533..3643
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            3644..3721
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            3722..3821
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            3822..4018
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            4019..4110
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            4111..4183
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            4184..4270
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            4271..4342
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            4343..4460
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            4461..4615
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            4616..4699
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            4700..4893
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            4894..5041
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            5042..5128
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            5129..5237
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            5238..5275
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            5276..5398
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            5399..5503
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            5504..5610
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     exon            5611..7305
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7287..7292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /note="hexamer: AATACA"
     polyA_site      7305
                     /gene="Patj"
                     /gene_synonym="Cipp; Inadl"
                     /note="major polyA site"
ORIGIN      
        1 acttccgtcc aggtgagggc agcagctgta cttccgccag gtgaggaggc cgtccgtgcc
       61 cgcagccccg gggctcccac cccgccgtcg cccgatcaga ctttttggaa gtgattgaaa
      121 agaatatccc aaaatgcctg aaaaccctgc tgcagagaag atgcaggtcc tgcaggtcct
      181 ggatcgcctt cgagggaagc tgcaggagaa gggagacacg acgcagaacg agaagctgtc
      241 tgcgttctac gagacgctga agagccctct cttcaaccag atccttacac tgcagcagtc
      301 catcaagcag ctgaagggac agcttagcca catcccctca gattgctcag ccaactttga
      361 cttttctcgc aagggcttgc tagtgttcac ggatggttcc attacaaacg ggaatgccca
      421 aaggccttgt agtaatgtga ctgcatctga actgttgccc tggactcaaa agtcagcaag
      481 tgaagacttt aactcagtca ttcagcagat ggctcagggc cggcacgttg agtatataga
      541 tattgaacgt ccttcaactg gaggccttgg attcagtgtg gtggctctga gaagccaaag
      601 cctgggatta attgatatct ttgtgaagga agtccatccc gggagtgtag cagacaggga
      661 tcacagattg aaggaaaatg accagatttt ggccattaat gacaccccat tggatcagaa
      721 tatttcccat cagcaggcga ttgcattact acaacaagcc actggatctc tgcggctggt
      781 tgtggccagg gaagtgggcc acacacaggg ccgagcatcc accagctcag ctgatacaac
      841 tctgccagaa acggtgtgtt ggggccacac ggaagaggtt gagctcatta acgatggctc
      901 tggattaggt tttgggatag ttggagggaa atccagcggc gtggtcgtga ggactattgt
      961 tcctggagga ctggcagacc gagatggaag actgcagaca ggggatcaca tcttgaagat
     1021 tggtggtaca aatgttcaag ggatgaccag tgaacaagtt gctcaagtgc taaggaactg
     1081 tgggaattca gtgaggatgc tggtggccag agaccctgtt ggtgaaattg cagtaacacc
     1141 tcctacccct gtatccttac ctgttgccct acctgctgta gccacaagga cccttgattc
     1201 tgacaggtct ccttttgaaa cttacagtgt tgaacttgtt aagaaagatg ggcagagtct
     1261 tgggattaga attgttggct atgttggaac agctcatcca ggggaagctt ccgggattta
     1321 tgtgaaaagt ataattccag gcagcgctgc ataccacaat ggccaaattc aagtgaatga
     1381 taaaatcgtg gctgtggatg gtgtgaatat tcaaggtttt gctaatcagg atgttgtcga
     1441 agtattgcgg aatgctgggc aggtggtaca cctgaccctt gttcgaagga aaacatcttt
     1501 atctgcttct ccgtttgagc actcttcaag cagagaaact gttgcagaac cacctaaagt
     1561 accagaacga gcaggatccc cgaaaccaga agctaatttg agtgtggaag cagaggaaat
     1621 tggagaaaga ctggataatc taaaaaacaa cactgtacaa gccttagaaa aaccagatgt
     1681 atatccagag aaagttccag gctctccaga aaatgagctg aaatccagat gggaaaacct
     1741 actgggccca gattatgaag taatggtagc cactttggat gctcagattg cagacgatga
     1801 ggagctacag aaatactcga agctgctgcc tatccacacg ctcaggcttg ggatggaagt
     1861 cgactccttc gatgggcacc actatatctc ctcagttgct cctgggggtc ctgtggatac
     1921 cctgaacctc cttcagccag aggatgaact tcttgaggtc aacggcatgc agctttatgg
     1981 gaagtctcgc cgagaagcag tctccttcct taaagaagtg cccccaccat ttaccttggt
     2041 ctgctgccgc cggctgtttg atgatgaggc ctcagttgat gagccaagaa ccatggagcc
     2101 tgctcttctt gaggccgagg ttgaccacag tgtagatgtc aacattgaag atgatgatga
     2161 tggagaatta gccctgtggt ctcctgaagt caagactgtg gagctggtga aagactgcaa
     2221 aggcttagga ttcagtattt tggattatca ggaccccctg gatcccacgc ggtcagtgat
     2281 tgtgattcgc tccttggtgg cagatggtgt agcggaaaga agtggagaac ttttacctgg
     2341 agatcgccta gtctccgtca atgagttctc cttggacaat gccactcttg ctgaggctgt
     2401 ggaagtgttg aaggctgtac ccccaggtgt ggtgcatctt ggcatctgta agcctttggt
     2461 ggaagatgag aaggaagagc gttttagttt acattcaaac aacaatggtg acagcagcga
     2521 gcctgcagac gctgttcatg agatccactc atctttaatc cttgaggcac cccagggatt
     2581 tagagatgag ccatatcttg aagaactcgt ggatgaacct tttctagatt tgggaaagtc
     2641 tttgcagttc caacaaaaag acgtggacag cagctcggaa gcttgggaaa tgcatgagtt
     2701 cctgagtcct ccgctggacg gcaggggtga ggagagagag atgcttgtcg atgaggagta
     2761 tgaactttat caagatcacc tccgggccat ggagtcaaac ccaccaccac cacacattcg
     2821 ggaggccgct cctgcatctc ccgtgctgga actccaggct ggtacacagt ggctgcatgc
     2881 taacctctca ggaggcgaaa ggctggagtg tcacgatgca gagtccatga tgagtgccta
     2941 tccccaggag atgcagcagt atagctacag cactgcagac atgatggaag aaacgtttgg
     3001 ccttgattcc cgggccccca taccgtcctc tgaaggaaat ggtcaacacg gcagatttga
     3061 tgacatggga caccttcatt cactaacgag cagcagcctg gatttaggca tgatgattcc
     3121 aagtgatctg caaggtcctg gcgtgcttgt cgatcttcca gctgttgctc aaagaagaga
     3181 acaggaagat ttgcctctgt accgactccc cagcgcccgc gttgtcacca agccgtcatc
     3241 acacatggga ctggtgtctt cacggcatgc aaatgctgca tgtgaattac cggagagaga
     3301 ggaaggtgaa ggagaggaga caccgaactt cagccactgg ggtccaccaa gaatagttga
     3361 aatttttaga gaacctaatg tgtctcttgg catcagcatc gttggtggac aaacagttat
     3421 aaaacgcctc aagaatggag aggaactcaa ggggatattc atcaaacaag tgttagagga
     3481 cagtcctgcc gggaagacca atgcgctgaa aaccggagat aaaattcttg aggtgtctgg
     3541 tgtagacctg cagaatgcct cccatgcaga agccgtggag gcaatcaaga gtgcgggaaa
     3601 ccctgtggta ttcgtggtac agagcctgtc atccacccca agggtcatcc caactgtgaa
     3661 taacaaaggc aaaacacctg ccccgaacca ggatcaaaac actcaagaaa ggaaagctaa
     3721 gaggcacgga acagctccac ctccaatgaa gctgcccccg ccctacagag ctccatctgc
     3781 agacatggag ggaagtgaag aagactgtgc gctgaccgac aaaaagatca ggcaaagata
     3841 tgcagacctg ccgggagaac tacacattat cgaactggaa aaggacaaga atggactggg
     3901 gctcagtctc gctggcaata aggacaggtc acggatgagc atcttcgtgg tggggattaa
     3961 tccggaggga cctgctgctg cagacggacg gatgcggatt ggagacgagc tgctagagat
     4021 aaacaatcag attctttatg gaagaagtca tcagaacgca tctgccatta ttaagactgc
     4081 cccaaccagg gtcaaactgg ttttcattag aaacgaagat gcagtcagtc agatggccgt
     4141 cgctcccttc ccggagctat cacattctcc atcgcctgtt gaggatctgg gtggcactga
     4201 acttgtcagt agtgaagagg agagcagtgt ggatgctaaa cacctgcctg aaccagaaag
     4261 ctccaaaccg gaagacctgt cccaggtggt tgatgacaac atggtggcag agcagcagaa
     4321 ggaatcggag tcacctgaca gtgctgcctg ccagataaaa cagcagacat attcaacaca
     4381 agtctcctcc agctcgcaag atagcccatc gtcaccggct ccattgtgtc agtcagcaca
     4441 tgcagacgtc acaggctctg gtaacttcca ggctcctctc ccagtggacc ctgctccact
     4501 ctcggtggac cctgcaacat gtcccatcgt ccctggccag gaaatgatca tagaaatatc
     4561 caagggacgc tccgggctcg ggctcagcat tgttggagga aaagacacac ctttggatgc
     4621 tatagttatc catgaagtct atgaagaagg tgcagctgcc agagatggaa gattatgggc
     4681 tggagaccag atattagagg ttaatggggt tgatctgcgg agctccagcc atgaagaagc
     4741 catcacagcc ctgaggcaga ccccccagaa ggtgcggctg gtggtataca gagatgaagc
     4801 acagtacaga gacgaggaga acttggaggt gttccttgtg gacctgcaga agaagactgg
     4861 ccgaggacta ggcctgagca ttgttgggaa acggagtgga agtggagtgt ttatttctga
     4921 cattgtgaaa ggcggggccg cagacctcga tgggaggtta attcgaggag accagatctt
     4981 gtctgtgaat ggagaggaca tgagacacgc ctcacaggag acagtggcca ccatcctgaa
     5041 gtgtgtccag ggccttgtcc agctggagat tgggagactc cgcgccggtt cctgggccgc
     5101 ctctcggaag acctcgcaga acagccaggg ggatcagcac agtgcgcaca gcagctgtcg
     5161 gccttccttt gccccagtca tcaccagcct acaaaacctg gttggcacaa aaagatcttc
     5221 agatcctcca cagaaatgca cagaggagga accaaggact gtagagataa tcagagagct
     5281 cagcgatgcc cttgggatca gtatcgctgg aggaaaaggg agtcctttag gagatatccc
     5341 catatttatt gccatgattc aggccaacgg agtggccgca cggacccaga agcttaaggt
     5401 tggagatcgg attgtgagca ttaatggaca acctctggat ggactgtctc acacagatgc
     5461 cgttaatcta ctgaagaatg ccttcgggcg cattatcctg caggttgtgg cagataccaa
     5521 cataagtgcc atagcgaccc agctggaaat catgtctgca ggctcccagc ttggctctcc
     5581 gactgctgac cgacatccgg aagacacaga ggagcagatg cagaggacgg ctgattaaag
     5641 tgaagtgacc agatcttagc tgaaatggcg agaccctgga aggcattacc atgagcaagc
     5701 tgcctccatt ctaaagcagc agagagggac tgtggccttg actgtgctgc cgtgagctgc
     5761 gggtcctgat catgacacac tttttcacga gactgctgca gaattctgcg gcttctggtt
     5821 gggatgaaca gttgcctcgg ctaaagccca gcatcatcac tggctctgac tctgtttgca
     5881 gaaacagagc tgctgtctct gcttcctgct catatccctc atccccacag aggcttagct
     5941 gcaagctcct gtggtctcat ctaatgagta gaaacaaagg tttagcttgt catcttaact
     6001 cgtgatttac ttatgctaat ttgcctcttc aaataaacca gaaaacatta gcagtgtaat
     6061 taacttcctc gcaatgaact attcatactc tgccgctggg aattactgcg ttctgttctg
     6121 tgtgactcag tcaagtagac ctcgcatccc tgcctctaga ttgatctgct gttagtcctt
     6181 ggtgattcgg aggagtccat ttacagactt tgtaatctac ttggagtcct aacaggcgtt
     6241 gattctgagt ttgacaagcg cacactgctc agcaagtatg ccttggtctc cacaggaaca
     6301 agtaaccctc gagtttgagt tccacccatg ctagctcaca ttactgggac gctaactggg
     6361 agtggtgggc atctcagcag atcggaatca cccgttccct acccccctag actgcaggtg
     6421 aggaggtgga aaccctagac cacactgtag actgtagaga tgagcaagtt cgatcggcct
     6481 cagccttatc agaagcaagt tacaagtttg gttagccttt ctctcacctt cgtaccaacc
     6541 tgcacagtgg ctcagcctgc agcggctgtg tgcagctcgg gaacttaaag caaatgacct
     6601 gggaatcaga cacagaagtg cttagcttga gtttcccagc ctctacctcc tattggctga
     6661 agttctgtag ctaagaaagc agctgtggct gagagcatca agagtcctca gagcatgcaa
     6721 tgggctggga agggagatgg atggtcatca ccaagcaccg tagagtcgtc tgttgaaagc
     6781 aaaggaaact accacgaagg gtcagcaata gacatagctt agcattctag gactataact
     6841 cgatgcagca gaatgttcag taattaccca gaatttaatg ggccctaatt taaaatgtta
     6901 tttaattagt gaggatttta actgatattc cttttgagta gatgcaatcc caaagtgcat
     6961 taactcttgt ggctattcta aagtgcagaa tgcctcaatt ttatgttgat ggtgtattcc
     7021 aatgactggt attaagcttt ttgagattct gtagggtttt tagaatttat aatgtatcca
     7081 aaatacatgg ttttggtagg ctctcatctc ccagttcatg agaagccacc aacctcagtg
     7141 tcctctgtga atggtaccca aaagaaggtc tcaagcagca aaaaccaaat gaagcccaaa
     7201 tgaaagtgca ccttagaaga caaagataac agcattaatg ctctccaagt gcgatcttgc
     7261 ttacttttga tggaatggcg gcgttaaata cacattttga aatga
//
