LOCUS       NM_020264               1001 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus prostate and testis expressed 4 (Pate4), mRNA.
ACCESSION   NM_020264
VERSION     NM_020264.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1001)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1001)
  AUTHORS   Noda,T., Fujihara,Y., Matsumura,T., Oura,S., Kobayashi,S. and
            Ikawa,M.
  TITLE     Seminal vesicle secretory protein 7, PATE4, is not required for
            sperm function but for copulatory plug formation to ensure
            fecunditydagger
  JOURNAL   Biol Reprod 100 (4), 1035-1045 (2019)
   PUBMED   30452524
  REMARK    GeneRIF: PATE4 is a novel factor in forming the copulatory plug
            that inhibits sequential matings and maintains spermatozoa in the
            uterus to ensure male fecundity.
REFERENCE   3  (bases 1 to 1001)
  AUTHORS   Loughner,C.L., Bruford,E.A., McAndrews,M.S., Delp,E.E.,
            Swamynathan,S. and Swamynathan,S.K.
  TITLE     Organization, evolution and functions of the human and mouse
            Ly6/uPAR family genes
  JOURNAL   Hum Genomics 10, 10 (2016)
   PUBMED   27098205
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1001)
  AUTHORS   Heckt,T., Keller,J., Reusch,R., Hartmann,K., Krasemann,S.,
            Hermans-Borgmeyer,I., Amling,M. and Schinke,T.
  TITLE     No obvious phenotypic abnormalities in mice lacking the Pate4 gene
  JOURNAL   Biochem Biophys Res Commun 469 (4), 1069-1074 (2016)
   PUBMED   26731031
  REMARK    GeneRIF: Taken together, our study was the first to generate and
            analyze a mouse model lacking Pate4, a gene with strong expression
            in prostate and seminal vesicles, yet without major function for
            fertility.
REFERENCE   5  (bases 1 to 1001)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1001)
  AUTHORS   Levitin,F., Weiss,M., Hahn,Y., Stern,O., Papke,R.L., Matusik,R.,
            Nandana,S.R., Ziv,R., Pichinuk,E., Salame,S., Bera,T., Vincent,J.,
            Lee,B., Pastan,I. and Wreschner,D.H.
  TITLE     PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR
            proteins that are expressed in reproductive and neuron-rich tissues
            and possess neuromodulatory activity
  JOURNAL   J Biol Chem 283 (24), 16928-16939 (2008)
   PUBMED   18387948
REFERENCE   7  (bases 1 to 1001)
  AUTHORS   Kaplan,N., Morpurgo,N. and Linial,M.
  TITLE     Novel families of toxin-like peptides in insects and mammals: a
            computational approach
  JOURNAL   J Mol Biol 369 (2), 553-566 (2007)
   PUBMED   17433819
REFERENCE   8  (bases 1 to 1001)
  AUTHORS   Luo,C.W., Lin,H.J. and Chen,Y.H.
  TITLE     A novel heat-labile phospholipid-binding protein, SVS VII, in mouse
            seminal vesicle as a sperm motility enhancer
  JOURNAL   J Biol Chem 276 (10), 6913-6921 (2001)
   PUBMED   11118436
REFERENCE   9  (bases 1 to 1001)
  AUTHORS   Coronel,C.E., Winnica,D.E., Novella,M.L. and Lardy,H.A.
  TITLE     Purification, structure, and characterization of caltrin proteins
            from seminal vesicle of the rat and mouse
  JOURNAL   J Biol Chem 267 (29), 20909-20915 (1992)
   PUBMED   1400406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118232.10.
            
            On Mar 8, 2022 this sequence version replaced NM_020264.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK020540.1, DV057901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AC118232.10        39959-40047
            90-200              AC118232.10        43502-43612
            201-1001            AC118232.10        43936-44736
FEATURES             Location/Qualifiers
     source          1..1001
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 20.34 cM"
     gene            1..1001
                     /gene="Pate4"
                     /gene_synonym="9530004K16Rik; Pate-B; Svs7"
                     /note="prostate and testis expressed 4"
                     /db_xref="GeneID:56872"
                     /db_xref="MGI:MGI:1930790"
     exon            1..89
                     /gene="Pate4"
                     /gene_synonym="9530004K16Rik; Pate-B; Svs7"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..322
                     /gene="Pate4"
                     /gene_synonym="9530004K16Rik; Pate-B; Svs7"
                     /note="seminal vesicle protein, secretion 7; caltrin;
                     prostate and testis expressed protein 4; PATE-like protein
                     B; seminal vesicle protein 7; calcium transport inhibitor;
                     seminal vesicle protein VII; seminal vesicle secretory
                     protein 7; SVS VII"
                     /codon_start=1
                     /product="prostate and testis expressed protein 4
                     precursor"
                     /protein_id="NP_064660.2"
                     /db_xref="CCDS:CCDS22967.1"
                     /db_xref="GeneID:56872"
                     /db_xref="MGI:MGI:1930790"
                     /translation="MNSVTKISTLLIVILSFLCFVEGLICNSCEKSRDSRCTMSQSRC
                     VAKPGESCSTVSHFVGTKHVYSKQMCSPQCKEKQLNTGKKLIYIMCCEKNLCNSF"
     exon            90..200
                     /gene="Pate4"
                     /gene_synonym="9530004K16Rik; Pate-B; Svs7"
                     /inference="alignment:Splign:2.1.0"
     exon            201..1001
                     /gene="Pate4"
                     /gene_synonym="9530004K16Rik; Pate-B; Svs7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      977..982
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pate4"
                     /gene_synonym="9530004K16Rik; Pate-B; Svs7"
                     /note="hexamer: AATAAA"
     polyA_site      1001
                     /gene="Pate4"
                     /gene_synonym="9530004K16Rik; Pate-B; Svs7"
                     /note="major polyA site"
ORIGIN      
        1 aagctgcctt ctaacatcca acatgaattc agtgacgaaa atcagcacac tgctcatcgt
       61 gattttatcc tttctctgtt ttgtggaggg tctgatctgt aattcatgtg aaaagtcacg
      121 agattcaaga tgtacaatgt cacaaagcag atgcgttgca aaacctggtg aatcatgcag
      181 taccgtatca cactttgttg gaacaaagca tgtgtactca aagcaaatgt gctcgcctca
      241 gtgcaaggaa aaacagctta acactggaaa gaagttgatt tacataatgt gctgcgaaaa
      301 aaacttgtgt aatagcttct agatggagaa gaatcacttg aagatcatct tctgttcaag
      361 atccaaactt acaaatgaat caagatgagg aacttgcttt cctactcgat ttccatgatg
      421 gcctgagatc cctgagatag caacagaggc tgtgtcctcg tttcagtgaa agacttcttg
      481 accacaccat tagagcactg caaaaaaaaa aaaaaaaaat ccatgcttac catgttattt
      541 tgcttttcca gtttgcaatg tctaagccct gtaatagtgt cccaaggatt tttattttaa
      601 tctcgagaat ctgtgaatgc tgcagtaagt ggcaaaagag acattggaga tgtgaataag
      661 gatctcagat ggaaagctat ttctggattg tcagggtggg tcctagttgt aagtacaaat
      721 gttcttataa aatgggggag gggaaggcat gaattgatta tagaagagga aatgattatg
      781 taatcgtgac tcacaaattg gagtgatgtc ccttgaagat ggatcaagtg gtcatgagcc
      841 aagagatata aaaggccact ggaagctgag aagagcaatg aatttaattt ttctcaatgc
      901 ctccagaaac ttgccatgct gatacttaat tatatcccca tgagatttat ttctgacttc
      961 agagttctac aaattgaata aatgtgtgtt gttttaagca a
//
