LOCUS       NM_080850               5119 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus PAS domain containing serine/threonine kinase (Pask),
            mRNA.
ACCESSION   NM_080850
VERSION     NM_080850.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5119)
  AUTHORS   Hinds TD Jr, Kipp ZA, Xu M, Yiannikouris FB, Morris AJ, Stec DF,
            Wahli W and Stec DE.
  TITLE     Adipose-Specific PPARalpha Knockout Mice Have Increased Lipogenesis
            by PASK-SREBP1 Signaling and a Polarity Shift to Inflammatory
            Macrophages in White Adipose Tissue
  JOURNAL   Cells 11 (1), 4 (2021)
   PUBMED   35011564
  REMARK    GeneRIF: Adipose-Specific PPARalpha Knockout Mice Have Increased
            Lipogenesis by PASK-SREBP1 Signaling and a Polarity Shift to
            Inflammatory Macrophages in White Adipose Tissue.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5119)
  AUTHORS   Perez-Garcia A, Hurtado-Carneiro V, Herrero-De-Dios C, Dongil P,
            Garcia-Maurino JE, Sanchez MD, Sanz C and Alvarez E.
  TITLE     Storage and Utilization of Glycogen by Mouse Liver during
            Adaptation to Nutritional Changes Are GLP-1 and PASK Dependent
  JOURNAL   Nutrients 13 (8), 2552 (2021)
   PUBMED   34444712
  REMARK    GeneRIF: Storage and Utilization of Glycogen by Mouse Liver during
            Adaptation to Nutritional Changes Are GLP-1 and PASK Dependent.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5119)
  AUTHORS   Dongil P, Perez-Garcia A, Hurtado-Carneiro V, Herrero-de-Dios C,
            Alvarez E and Sanz C.
  TITLE     PAS kinase deficiency reduces aging effects in mice
  JOURNAL   Aging (Albany NY) 12 (3), 2275-2301 (2020)
   PUBMED   31974316
  REMARK    GeneRIF: PAS kinase deficiency reduces aging effects in mice.
REFERENCE   4  (bases 1 to 5119)
  AUTHORS   Yang Y, Liu S, Lei Z, Chen G, Huang L, Yang F, Lei Y, Liu Y, Yang
            L, Liu W, Lai L and Guo J.
  TITLE     Circular RNA profile in liver tissue of EpCAM knockout mice
  JOURNAL   Int J Mol Med 44 (3), 1063-1077 (2019)
   PUBMED   31524221
REFERENCE   5  (bases 1 to 5119)
  AUTHORS   Dongil P, Perez-Garcia A, Hurtado-Carneiro V, Herrero-de-Dios C,
            Blazquez E, Alvarez E and Sanz C.
  TITLE     Pas Kinase Deficiency Triggers Antioxidant Mechanisms in the Liver
  JOURNAL   Sci Rep 8 (1), 13810 (2018)
   PUBMED   30217996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5119)
  AUTHORS   Borter E, Niessen M, Zuellig R, Spinas GA, Spielmann P, Camenisch G
            and Wenger RH.
  TITLE     Glucose-stimulated insulin production in mice deficient for the PAS
            kinase PASKIN
  JOURNAL   Diabetes 56 (1), 113-117 (2007)
   PUBMED   17192472
  REMARK    GeneRIF: Paskin gene expression is not induced by glucose in
            pancreatic beta-cells and glucose-stimulated insulin production is
            independent of PASKIN.
REFERENCE   7  (bases 1 to 5119)
  AUTHORS   Katschinski DM, Marti HH, Wagner KF, Shibata J, Eckhardt K, Martin
            F, Depping R, Paasch U, Gassmann M, Ledermann B, Desbaillets I and
            Wenger RH.
  TITLE     Targeted disruption of the mouse PAS domain serine/threonine kinase
            PASKIN
  JOURNAL   Mol Cell Biol 23 (19), 6780-6789 (2003)
   PUBMED   12972598
  REMARK    GeneRIF: Targeted disruption of the PAS domain serine/threonine
            kinase was studied.
REFERENCE   8  (bases 1 to 5119)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S, Saga
            Y, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (bases 1 to 5119)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 5119)
  AUTHORS   Hofer T, Spielmann P, Stengel P, Stier B, Katschinski DM,
            Desbaillets I, Gassmann M and Wenger RH.
  TITLE     Mammalian PASKIN, a PAS-serine/threonine kinase related to
            bacterial oxygen sensors
  JOURNAL   Biochem Biophys Res Commun 288 (4), 757-764 (2001)
   PUBMED   11688972
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY058767.1, AK028435.1, AK129063.1 and AK141220.1.
            
            [WARNING] On May 10, 2023 this sequence was replaced by
            NM_080850.3.
            
            On Jul 19, 2008 this sequence version replaced NM_080850.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083590.1, AK083528.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-298               BY058767.1         1-298
            299-2071            AK028435.1         301-2073
            2072-2806           AK129063.1         1962-2696
            2807-3868           AK028435.1         2809-3870
            3869-5119           AK141220.1         506-1756
FEATURES             Location/Qualifiers
     source          1..5119
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..5119
                     /gene="Pask"
                     /gene_synonym="mKIAA0135"
                     /note="PAS domain containing serine/threonine kinase"
                     /db_xref="GeneID:269224"
                     /db_xref="MGI:MGI:2155936"
     exon            1..263
                     /gene="Pask"
                     /gene_synonym="mKIAA0135"
                     /inference="alignment:Splign:2.1.0"
     exon            264..499
                     /gene="Pask"
                     /gene_synonym="mKIAA0135"
                     /inference="alignment:Splign:2.1.0"
     exon            500..735
                     /gene="Pask"
                     /gene_synonym="mKIAA0135"
                     /inference="alignment:Splign:2.1.0"
     exon            736..906
                     /gene="Pask"
                     /gene_synonym="mKIAA0135"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1047
                     /gene="Pask"
                     /gene_synonym="mKIAA0135"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1182
                     /gene="Pask"
                     /gene_synonym="mKIAA0135"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1443
                     /gene="Pask"
                     /gene_synonym="mKIAA0135"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1612
                     /gene="Pask"
                     /gene_synonym="mKIAA0135"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1766
                     /gene="Pask"
                     /gene_synonym="mKIAA0135"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..3214
                     /gene="Pask"
                     /gene_synonym="mKIAA0135"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3396
                     /gene="Pask"
                     /gene_synonym="mKIAA0135"
                     /inference="alignment:Splign:2.1.0"
     exon            3397..3564
                     /gene="Pask"
                     /gene_synonym="mKIAA0135"
                     /inference="alignment:Splign:2.1.0"
     exon            3565..3690
                     /gene="Pask"
                     /gene_synonym="mKIAA0135"
                     /inference="alignment:Splign:2.1.0"
     exon            3691..3825
                     /gene="Pask"
                     /gene_synonym="mKIAA0135"
                     /inference="alignment:Splign:2.1.0"
     exon            3826..4025
                     /gene="Pask"
                     /gene_synonym="mKIAA0135"
                     /inference="alignment:Splign:2.1.0"
     exon            4026..4159
                     /gene="Pask"
                     /gene_synonym="mKIAA0135"
                     /inference="alignment:Splign:2.1.0"
     exon            4160..4306
                     /gene="Pask"
                     /gene_synonym="mKIAA0135"
                     /inference="alignment:Splign:2.1.0"
     exon            4307..5119
                     /gene="Pask"
                     /gene_synonym="mKIAA0135"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagcgcgcg gatcttcacg ttgtgaatcc gactgagact tgcgccagcc tggggtgaga
       61 caccagcctt cgaaaaacct ccgggtggcg gcgagtgtta gttacgcatt gtcgtggagt
      121 ggctctggcc ctttcctcgc gcgcccgcac tccctccgcc cagccccggc cccagagtgg
      181 tggcgggttc tggccgtttg acccgcgctc aagagccgcc agcgcccgaa agcctctgat
      241 tgaactggaa gctttgcttt aaggtgaggg ctgttggagg caggagctcg gtgacctgtt
      301 gctctgctct tcatggagga cagaggtcca ccagtttttg ctgaggactg gaaatgtttg
      361 tctgagagtc ctcctgtcca agaaggccca gcggcccagg ctacctttga gcccagcaag
      421 ccactctcca tagcccacaa acacctgagc aggaagaatg ggctttctag actctgccag
      481 agccgaatgg cgctctctga ggacaggtgg agctcttact gtctttcatc attggctgcc
      541 caaaacatct gcacaagcaa actgcactgc gctgctgcac ctgagtatgc tgaccctaca
      601 gctgggccac tgggcagtac ttcctgctgc tccttgctgc gtggcctggc ttcaggatgc
      661 tctgggtccc tgctttcgac ccctgtgtgc aaccccaaca aggctgtctt taccgtggat
      721 gccaagacca cagagattct ggttgccaac gacaaagcct gcagcctcct agggtatagc
      781 agtcatgacc tgattggcca aaagctcgcc caattcttcc tcaaatctga ttccgaggtg
      841 gtggaagccc tcagcgagga acatgtggag gctgatggcc acgctgcagt ggtgttcggc
      901 acagtggtgg acatcgtcag ccgaattggg gagaagattc cagtctctgt gtggataaag
      961 agattgcagc aagatcgtgg cttgtgctgt gtagtggttc tggagcctgt ggagagagtg
     1021 tcagcctggg tcgccttcca gagtgatgga actatcacat catgcgacag tctctttgct
     1081 catctccatg ggttcacatc tccaaaggat gtagttgggc agtgtgtcat agacttgatt
     1141 ccatccatgc agctccctcc tcctggccaa catatcccaa agagtctcaa gattcaaagg
     1201 tctgttggga gagccagaga cggcaccacc ttccctctca gtttgaagct gaaatccaag
     1261 cccagtggaa gggctgtagc tgacagtgag gcggcctctg aaccaggtta ccaggcttct
     1321 gtgtgggtgt tctgcaccat cagtggcctc atcactctgc tgccagatgg cacaatttat
     1381 ggagtcaacc acagctttgc actaatgctg tttggttatg gaaagacaga gctcctgggc
     1441 aagaatatca ctttcctgat tcctggtttc taccactaca tggacctcac atatgatagt
     1501 tcggtacagc tgccagatct ggtcaattgc ctcgacattg gcagaaagag tgggcctggg
     1561 gagatgaact ctgatgccca acacaactgg gaactggcca gtggggccca gggtccaaga
     1621 attgacgtgg tgttggcacg ggaccacatg ccatcacaag atgagaccct gaagctggtg
     1681 ggaggacaag tctcctctag gactcagaca cgattggaaa ctggatacaa gatacttcct
     1741 tcttctgcat gtcagccctc actgggggtg gacagcaacc cagaggatgg tgagcagtca
     1801 ttgctcacag accagcaaag cattccaaag agaaacctgc cagcccatgg tggtcagaac
     1861 cagctagaca cctcagaaat atccctacca gtccttaaag aacatttatt gtctgaaatt
     1921 cagaaaaata tctcagaaga aagcccacta acccacagga aatggttatc caaggtgcaa
     1981 caaaacccca caaaaggaag cctgcccatc cacgaggagc agctattgtt tgcaggccag
     2041 catatccatg tcttgggaaa ggaggatcct tcagcagcag agagctacag ggagagtctt
     2101 ttagaagaaa gcaagtccaa accagtggat gcaaaactgt ttgcttcatg tgaagattct
     2161 gagcctctag tttcagttaa ggacaggggc agcagtgtgg acacgtgtaa tctgcatcag
     2221 gaagctcagt tggagctgat gggtgtcagc agtcctaacc cctgggctga tgccaccatg
     2281 cctgagcccc acaccacagg gcagatagca ggcgggagcc ttacatattg cccacagtac
     2341 agaagcgagt gggcctcaca gcagcgaggc caggactcgg ctcccagccc ctctggaatg
     2401 gcgtgtgtct tgcttgggac acccactctg gatgaaccat ggccaggagt gagaaatgac
     2461 agagaagagc tgcagacttg cttgattaag gaacagttat ccaagtcaag ctgtgaggga
     2521 aatctgggca tctcccgtgt ggaactcgtt cctgaagaac atcctccttt caccgccccc
     2581 gtgtctttct gtgatctggg aggccgagat ctacacgcta gccgctcagg cagctcctca
     2641 gcctgctatg ctttggccac cgacctccct ggtgtcctgg aggcagtgga agctcaggag
     2701 gctgatgtga attcttattc ctggaacctc aaggagctct ttctcaagga ccagacagac
     2761 agaactccat cacattgttc ctgtaccaca tctgaactca gcgaggcgcc atctctttca
     2821 gtggtggggt cagatttaga tgtgggtatt ctgcataggc agacttcaga tattttagtt
     2881 gaccgagaga tgttgctcct tactgggacc tattttgacc ttagtgaagg ccaacggttc
     2941 caggagatgg gagcaggaca tgatcgagca gaactgtcta acatttcttt ggtatcctct
     3001 gaacactatg aaactagtga catagaaagc ccaggttgtg accctccctt accagatcct
     3061 ggtcccaacg atatgtgcct atcagcagag aagcccaggc cgagtgccca gatcacttcc
     3121 actcctgtgg cacgtggggc caccagcctg cagcaggaga tccaagaggg catctactct
     3181 ggaagctgct accaccggga tggcttacaa ctgagtatac agtttgaagt caagcgtgtg
     3241 gagctccagg gctctgcgac cctgttctgc tgctggctgg tgaaggacct cttccatagc
     3301 caccgggact cagccacacg aacccgcctg ttccttgcca gtctgcctag ctctacccac
     3361 tccatgcctg agctgtctgg atccagcttt ggagaggtgc tcagagccaa gccttggttt
     3421 gaggaatccc caacacctgc agagctagag gggctggcgg cctgtgaggg cgagtacgac
     3481 tataagtata acaccatcag cccacttggc agtggggcct ttggctttgt gtggactgca
     3541 gtggagaagg aatgcaacaa agaggtggtg gtgaagttta ttaagaagga gaaggtttta
     3601 gaggattgct ggattgagga tcccaaactt ggaagagtta ctttagagat tgcaattctg
     3661 tccaaggtgg accatgccaa cataatcaag gttctggata tattcgaaaa ccaagagttc
     3721 ttccagctgg tgatggaaaa gcacggctct ggcatggacc tctttgcttt cattgaccac
     3781 catccctgct tggatgagcc cctggcgagt ttcatctttc gacaactagt gtctgctgta
     3841 ggatacctgc actcccaagg catcatccat agagacatca aggatgagaa cattgtgatt
     3901 gctgaggact tcacaattaa gctgatagat tttggctcag ctgcctactt agagaggggc
     3961 aaactatttt ataccttttg tggaacaatc gaatactgtg cacctgaggt tctcattgga
     4021 aatccctaca gagggccaga gctggagatg tggtctctgg gggtcaccct gtacacgctc
     4081 atcttcgagg agaatccctt ctgtgaggtg gaggagacca tggaggcagt tattcatccc
     4141 ccattcctgg tttcccaaga acttatgagt cttctgtctg gactgctgca gccttgccct
     4201 gagcagcgga ccactttgga gaagctgatc agggacccct gggtgacaca gcctgtgaac
     4261 cttgctagct atacttggga agaggtgtgt aggaccaacc agccagaaag tggcctgctg
     4321 tcagctgcaa gtctggagat tgggagtagg agtccaagtg aaatggctca gagagagggt
     4381 ctctgtgggc ctcctgctcc cagggagact cgtggtgacc agcactgctt gcatcttaag
     4441 gacccctctt tgccagtcag ctgagcaagc tctcctgctc tttggtttgg gcagttgtat
     4501 ggatttcagg gctttctacc tggagaaagg aagttgtgaa ggattgggat gacttctgct
     4561 tctagattcc tatgcaaatg ctacaagagc ctgcgatgct agttttctta ggtttatgat
     4621 atagacttgt aattcatgtt tttttataac cttgaaaatc attctaatgt tcagttatac
     4681 tgtactatta aagggcttta agttgtaagc ctcagaaaga cacaaggagt gtttaagttc
     4741 tctatttttg ttgtttgttt ttgcttgtaa gtttttgaga caggatctca ccatgtaact
     4801 ttggctggcc tggaactcaa ctatgtagac caggtagacc ttaaactgac agatctgcct
     4861 gcgcttgcct cccaagcatt aggactgatg gtgtgtgtca ccatgcccag ttcttcctgg
     4921 ttttgtgtgt aggtttcttt cccactgact tggtacatgt gacatgtgac agatgtatgg
     4981 agtctataga agtggccaga caaaaatggc cagaatattt atttattttc ttaaaaattt
     5041 tccaaattaa agctacttag ttaacagtta aactggccag gactatatga gataaacttg
     5101 gttttctatt tctttttgt
//
