LOCUS       NM_022321               2655 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus parvin, gamma (Parvg), transcript variant 2, mRNA.
ACCESSION   NM_022321
VERSION     NM_022321.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2655)
  AUTHORS   Thievessen,I., Suhr,F., Vergarajauregui,S., Bottcher,R.T.,
            Brixius,K., Rosenberger,G., Dewald,O., Fleischmann,B.K., Ghanem,A.,
            Kruger,M., Engel,F.B., Fabry,B., Bloch,W. and Fassler,R.
  TITLE     The focal adhesion protein beta-parvin controls cardiomyocyte shape
            and sarcomere assembly in response to mechanical load
  JOURNAL   Curr Biol 32 (14), 3033-3047 (2022)
   PUBMED   35688156
REFERENCE   2  (bases 1 to 2655)
  AUTHORS   Chu,H., Thievessen,I., Sixt,M., Lammermann,T., Waisman,A.,
            Braun,A., Noegel,A.A. and Fassler,R.
  TITLE     gamma-Parvin is dispensable for hematopoiesis, leukocyte
            trafficking, and T-cell-dependent antibody response
  JOURNAL   Mol Cell Biol 26 (5), 1817-1825 (2006)
   PUBMED   16479001
  REMARK    GeneRIF: despite the high expression of gamma-parvin in
            hematopoietic cells it must play a more subtle role for blood cell
            homeostasis
REFERENCE   3  (bases 1 to 2655)
  AUTHORS   Korenbaum,E., Olski,T.M. and Noegel,A.A.
  TITLE     Genomic organization and expression profile of the parvin family of
            focal adhesion proteins in mice and humans
  JOURNAL   Gene 279 (1), 69-79 (2001)
   PUBMED   11722847
  REMARK    GeneRIF: Mammalian parvins are likely to have arisen late in
            evolution from gene duplication as they share a remarkably similar
            exon/intron organization.
REFERENCE   4  (bases 1 to 2655)
  AUTHORS   Olski,T.M., Noegel,A.A. and Korenbaum,E.
  TITLE     Parvin, a 42 kDa focal adhesion protein, related to the
            alpha-actinin superfamily
  JOURNAL   J Cell Sci 114 (Pt 3), 525-538 (2001)
   PUBMED   11171322
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028329.1, AK079881.1 and AL626769.18.
            
            On Jul 2, 2009 this sequence version replaced NM_022321.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. The encoded isoform
            (2) is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028329.1, BC011200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AK028329.1         2-76
            76-2616             AK079881.1         2-2542
            2617-2655           AL626769.18        218460-218498
FEATURES             Location/Qualifiers
     source          1..2655
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 39.78 cM"
     gene            1..2655
                     /gene="Parvg"
                     /note="parvin, gamma"
                     /db_xref="GeneID:64099"
                     /db_xref="MGI:MGI:2158329"
     exon            1..112
                     /gene="Parvg"
                     /inference="alignment:Splign:2.1.0"
     exon            113..208
                     /gene="Parvg"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1125
                     /gene="Parvg"
                     /note="isoform 2 is encoded by transcript variant 2;
                     gamma-parvin"
                     /codon_start=1
                     /product="gamma-parvin isoform 2"
                     /protein_id="NP_071716.3"
                     /db_xref="CCDS:CCDS27710.1"
                     /db_xref="GeneID:64099"
                     /db_xref="MGI:MGI:2158329"
                     /translation="MELEFLYDLLQLPKEVAQPTEEELPRGGKKKYLSPNSKRNPKFE
                     ELQKVLMEWINTTLLPEHIVVRSLEEDMFDGLILHHLFQKLASLKLEVEEISLTSASQ
                     RHKLGVILEAVNQNLQVEEKQAKWSVETIFNKDLLATLHLLVALAKRFQPDLPLPDNV
                     QVEVIHIESTKTGLKSDKQVEQLTECKSHKDQPLQDAFDELFKLAPEKVHAVQEAIVS
                     FVNQKLERLGLSVQSLDTQFADGVILLLLIGQLEGFFLHLKEFYLTPSSPTEMLHNVT
                     LALDLLKDEGLFSYPVNPEDIVNKDAKSTLRILYSLFQKHSLRAEGGGAHHATPN"
     exon            209..273
                     /gene="Parvg"
                     /inference="alignment:Splign:2.1.0"
     exon            274..376
                     /gene="Parvg"
                     /inference="alignment:Splign:2.1.0"
     exon            377..517
                     /gene="Parvg"
                     /inference="alignment:Splign:2.1.0"
     exon            518..633
                     /gene="Parvg"
                     /inference="alignment:Splign:2.1.0"
     exon            634..689
                     /gene="Parvg"
                     /inference="alignment:Splign:2.1.0"
     exon            690..712
                     /gene="Parvg"
                     /inference="alignment:Splign:2.1.0"
     exon            713..771
                     /gene="Parvg"
                     /inference="alignment:Splign:2.1.0"
     exon            772..840
                     /gene="Parvg"
                     /inference="alignment:Splign:2.1.0"
     exon            841..942
                     /gene="Parvg"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1015
                     /gene="Parvg"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..2655
                     /gene="Parvg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2595..2600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Parvg"
                     /note="hexamer: AATAAA"
     polyA_site      2619
                     /gene="Parvg"
                     /note="major polyA site"
ORIGIN      
        1 agaggaagtg aacagaagcc ctgccttcca cctccggaac ctgtctgcgt tgggaacctg
       61 gtcaccctct aagctagtgg gctccatttc ctgatttgaa aagaagcagc ggggaaggca
      121 aggaagaaga tggagttaga gttcctctat gacctgttgc agctcccaaa ggaggtagct
      181 cagcccacgg aggaagagct tccacgagga ggaaagaaga aatatctgtc acccaattcc
      241 aagaggaacc ccaagtttga agaactgcag aaggtgctga tggaatggat caacaccaca
      301 ctcctcccgg agcacatcgt ggtccgcagc ctggaggaag acatgtttga tggacttatt
      361 ctgcaccacc tgttccagaa gttggcatcg ctcaagctgg aagtggagga aatctctctg
      421 acctcggcca gccagaggca caagctgggg gtcatcctgg aggccgtcaa ccagaaccta
      481 caggtggaag agaagcaggc caagtggagc gtggagacca tcttcaacaa ggacctgctg
      541 gccaccttgc atctcctggt ggccctggcc aaacgcttcc agccggacct gcccctccca
      601 gacaacgtcc aggtggaagt catccacatt gagagcacca agaccggcct gaagtcggac
      661 aagcaggtgg agcagctcac agaatgcaag tcacacaagg accagccttt acaggacgcc
      721 tttgatgaat tatttaagct ggctccggag aaagtgcacg ccgtccaaga ggccattgtg
      781 agctttgtca accagaagct agagcgcctg ggcctgtctg tgcagagtct ggatacccag
      841 tttgcagatg gcgtcatcct gctcctgctg attggacaac tggaaggctt cttcttgcat
      901 ctgaaggaat tctatctcac tcccagctct cccacagaaa tgctgcacaa tgtcacccta
      961 gccctggatc tgctcaagga tgaaggcctg ttcagctacc ctgtcaaccc tgaagatatt
     1021 gtgaacaagg acgccaagag cacactgagg atactttaca gcctattcca gaagcattca
     1081 ctgagggcgg agggtggagg ggcacaccat gctaccccaa actagtcacc tccacctcct
     1141 ccagctgttt ctcgggagct gccacctctg aaggacccag cagtcagagc tcttcccatg
     1201 ccagccttgt tactgtggct tggtgacatg tttccctcct atacctttga cctctgctta
     1261 cctttgactc taccagatgg ggacctattt tgtgcccacc cctgctttgc tccgtgcatt
     1321 ttgacagtgt atgaattgcg tttaagtgga tgaggggccc tgcatgcctg tgaagtcctg
     1381 ggttagcctg tggtgaaaaa gagtttgatt cccaggcgag accagccctc atcagcatcc
     1441 agtctgtcta ctaaggctat accttggtag atagtggctg ctcagactcc acaaagctga
     1501 ccatccctag ccagaggctc tttggggtta aggctgatgg tctcaggcca tggtctctat
     1561 atacttagtt cctggccatc taccttccac ccctcactgg ggtgatgagg ccaggactat
     1621 cacccaaaga ccagagcccc atgtgggaga aaagagttca aaagaccctg gccaggctat
     1681 ccctacagct gctgtcctga gctcagccct gagcccctgg gaagagaacc tggagttggt
     1741 tcttgggttc aggttaaccc tggtctgcat tctgtcccgt gagacttggt gtcttctgaa
     1801 aagagagagg aacagctgaa taactgagct gggtccatgg aggaggagaa gttgtgggag
     1861 gagatgcaag tcatggggtt caggggcaca gagacatagg ggtgcaggga ctcaggggtg
     1921 cagggatgtg gggaggttag cctagctgtt ccggttctgg actttgccct gcttgcccag
     1981 ctctaggtcc ctgcgaggaa cgtcttttag gtttgggggt atatagccga acagctttgc
     2041 ctttggggaa ttttggagca gagtctggcc agggcaggcc acccctacaa ccacagtcgg
     2101 tggagctacg tgttctgggg ctctggtgtc tgatgtgagg aggtctgggg cttttctcta
     2161 cccagctcca ttccacttgt ccctttggcc ctaggcaggc cactcataag tgttagaggg
     2221 atatctcctg tcctgttacc tctgggacat gtccctcttc cgtatcaggg gcatccttat
     2281 tgtagctggg gtccggctat ctctttctgc ttaggtaatc ctttcataga gaccttcttc
     2341 tgtgccccat ctcttctctc tggagcatcc tgagccgtga tacaagcttg agcctctctg
     2401 cttcattact ggatgcttgg caggtcaaaa ccggagtcca cgctcaactc ctaggctctt
     2461 ggctctccct ccctctttct tccctgcttg cttgccctct tggcccctcc atgtcctcac
     2521 ctccacctcc tcacctcctg tctcatggga gatttgaatc ataaggagaa tcactttttg
     2581 taactttatt gaggaataaa taacatttcc cagtttaaat gcatgactta atgacagccg
     2641 acaaacatga cagcc
//
