LOCUS       NM_133167               3705 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus parvin, beta (Parvb), mRNA.
ACCESSION   NM_133167 XM_001002115
VERSION     NM_133167.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3705)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3705)
  AUTHORS   Honeycutt,S.E., N'Guetta,P.Y., Hardesty,D.M., Xiong,Y.,
            Cooper,S.L., Stevenson,M.J. and O'Brien,L.L.
  TITLE     Netrin 1 directs vascular patterning and maturity in the developing
            kidney
  JOURNAL   Development 150 (22) (2023)
   PUBMED   37818607
REFERENCE   3  (bases 1 to 3705)
  AUTHORS   Thievessen,I., Suhr,F., Vergarajauregui,S., Bottcher,R.T.,
            Brixius,K., Rosenberger,G., Dewald,O., Fleischmann,B.K., Ghanem,A.,
            Kruger,M., Engel,F.B., Fabry,B., Bloch,W. and Fassler,R.
  TITLE     The focal adhesion protein beta-parvin controls cardiomyocyte shape
            and sarcomere assembly in response to mechanical load
  JOURNAL   Curr Biol 32 (14), 3033-3047 (2022)
   PUBMED   35688156
REFERENCE   4  (bases 1 to 3705)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3705)
  AUTHORS   Pitter,B., Werner,A.C. and Montanez,E.
  TITLE     Parvins Are Required for Endothelial Cell-Cell Junctions and Cell
            Polarity During Embryonic Blood Vessel Formation
  JOURNAL   Arterioscler Thromb Vasc Biol 38 (5), 1147-1158 (2018)
   PUBMED   29567677
  REMARK    GeneRIF: Parvins are critical for the organization of endothelial
            cell-cell junctions, the establishment of endothelial apical-basal
            polarity, and the integrity of the basement membrane.
REFERENCE   6  (bases 1 to 3705)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3705)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3705)
  AUTHORS   Korenbaum,E., Olski,T.M. and Noegel,A.A.
  TITLE     Genomic organization and expression profile of the parvin family of
            focal adhesion proteins in mice and humans
  JOURNAL   Gene 279 (1), 69-79 (2001)
   PUBMED   11722847
REFERENCE   9  (bases 1 to 3705)
  AUTHORS   Olski,T.M., Noegel,A.A. and Korenbaum,E.
  TITLE     Parvin, a 42 kDa focal adhesion protein, related to the
            alpha-actinin superfamily
  JOURNAL   J Cell Sci 114 (Pt 3), 525-538 (2001)
   PUBMED   11171322
REFERENCE   10 (bases 1 to 3705)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL626769.18 and AK147758.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_001002115.1, NM_133167.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143614.1, AK147758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AL626769.18        107563-107584
            23-1428             AK147758.1         3-1408
            1429-3705           AL626769.18        188853-191129
FEATURES             Location/Qualifiers
     source          1..3705
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 39.78 cM"
     gene            1..3705
                     /gene="Parvb"
                     /gene_synonym="affixin; D15Gsk1"
                     /note="parvin, beta"
                     /db_xref="GeneID:170736"
                     /db_xref="MGI:MGI:2153063"
     exon            1..144
                     /gene="Parvb"
                     /gene_synonym="affixin; D15Gsk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1127
                     /gene="Parvb"
                     /gene_synonym="affixin; D15Gsk1"
                     /codon_start=1
                     /product="beta-parvin"
                     /protein_id="NP_573395.1"
                     /db_xref="CCDS:CCDS37167.1"
                     /db_xref="GeneID:170736"
                     /db_xref="MGI:MGI:2153063"
                     /translation="MSSAPPRSPTPRAPKMKKDESFLGKLGGTLARKKKTREVTDLQE
                     EGKSAINSPMAPALVDIHPEDTQLEENEERTMIDPTSREDPKFKELVKVLLDWINDVL
                     AEERIIVKQLEEDLYDGQVLQKLLEKLAHCKLNVAEVTQSEIGQKQKLQTVLEAVQDL
                     LRPHGWPLRWNVDSIHGKNLVAILHLLVSLAMHFRAPIHLPEHVTVQVVVVRKREGLL
                     HSSHISEELTTTTEIMMGRFERDAFDTLFDHAPDKLNLVKKSLITFVNKHLNKLNLEV
                     TDLETQFADGVYLVLLLGLLEDYFVPLHNFYLTPDSFDQKVHNVAFAFELMLDGGLKK
                     PKARPEDVVNLDLKSTLRVLYTLFTKYKDVE"
     exon            145..234
                     /gene="Parvb"
                     /gene_synonym="affixin; D15Gsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            235..305
                     /gene="Parvb"
                     /gene_synonym="affixin; D15Gsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..408
                     /gene="Parvb"
                     /gene_synonym="affixin; D15Gsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            409..549
                     /gene="Parvb"
                     /gene_synonym="affixin; D15Gsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            550..665
                     /gene="Parvb"
                     /gene_synonym="affixin; D15Gsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            666..724
                     /gene="Parvb"
                     /gene_synonym="affixin; D15Gsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..744
                     /gene="Parvb"
                     /gene_synonym="affixin; D15Gsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..806
                     /gene="Parvb"
                     /gene_synonym="affixin; D15Gsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..875
                     /gene="Parvb"
                     /gene_synonym="affixin; D15Gsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..977
                     /gene="Parvb"
                     /gene_synonym="affixin; D15Gsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1050
                     /gene="Parvb"
                     /gene_synonym="affixin; D15Gsk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..3705
                     /gene="Parvb"
                     /gene_synonym="affixin; D15Gsk1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1605..1610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Parvb"
                     /gene_synonym="affixin; D15Gsk1"
                     /note="hexamer: AGTAAA"
     polyA_site      1632
                     /gene="Parvb"
                     /gene_synonym="affixin; D15Gsk1"
                     /note="major polyA site"
     regulatory      2733..2738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Parvb"
                     /gene_synonym="affixin; D15Gsk1"
                     /note="hexamer: ATTAAA"
     polyA_site      2755
                     /gene="Parvb"
                     /gene_synonym="affixin; D15Gsk1"
ORIGIN      
        1 ggccggcggt gggtggcgcg cactcgctta tgtcctccgc gccaccacgg tcgcccaccc
       61 cgcgggcccc caagatgaag aaggacgagt ctttcttggg caagttgggc ggcacactgg
      121 caaggaagaa gaagaccagg gaggtgactg acttacagga agaaggcaag agcgccatca
      181 actctccaat ggccccggct ttggtggaca ttcaccctga agacacccag ctagaggaga
      241 atgaggagcg taccatgatc gatcccacct ctagagaaga ccccaagttc aaggagttgg
      301 tcaaggtact tctggactgg atcaacgatg tgctggcaga ggagcgcatc attgtgaagc
      361 agctggagga ggacctgtac gatggccagg tgctccagaa acttctggaa aagctggcgc
      421 actgcaagct gaatgtggca gaggtgacgc agtccgagat cgggcagaag cagaagttgc
      481 agacggttct ggaagccgtg caagacctgc ttcggcccca tggctggccg ctgcgttgga
      541 atgtggactc tatccatggg aagaacctag tggccattct gcatctcctc gtctccctgg
      601 ccatgcactt cagggccccc attcaccttc ctgagcatgt caccgtgcag gtggtggtcg
      661 ttcggaagcg agaaggcttg ctgcactcca gccacatctc agaggagctg accacgacca
      721 cagagatcat gatgggccgg tttgagcggg acgccttcga tactcttttc gaccacgccc
      781 cggacaagct caaccttgtg aagaagtctc tcatcacgtt tgtgaacaaa cacctgaata
      841 agctaaactt ggaggtgact gacctggaga cccagtttgc agatggtgtg tacctagttc
      901 tacttctggg ccttcttgaa gactactttg tcccccttca caacttctac ctgactcctg
      961 acagctttga ccagaaggtg cacaacgtgg cctttgcctt tgaactgatg ctggatggag
     1021 gcctcaagaa gcccaaggca cgccctgaag atgtggtgaa cttggacctc aagtccactc
     1081 tgcgggtcct ttacacgctg ttcaccaagt acaaggatgt ggagtgacgg agcaactgat
     1141 cctccaggga caagtgctag gccagaaaaa tgggtgtatc catccacaca gtccttgctt
     1201 tcccagaaaa cacctccctg gggaggcctc aggcttccct ggcctctgct ccctgtcccc
     1261 tgcctggttt ggttttaaca cccccccacc ccaccccctt ccgccgtgtg gttccctagc
     1321 tggttaggtc attgagaact tggtgcttca aataccctct cccgtttaag tttaaggcct
     1381 cacttcttct ttttctctgc ctcccctccc cctccccccc cccccccccc cccggagaaa
     1441 gatgaaaaag agcaaaggcc cagcctagcc ctcggctgga gagggctgtc cacctgtgct
     1501 ccagcccaca gagcaattac tgcaacagcc ctggctccag ggactccgcc ccatttgtcc
     1561 tcaggaatcc cctgggctgg cctctccttg gaagcaaggg tctcagtaaa aaaagatcct
     1621 ctcagttttt cactcctgag tctcagaaga tttagactcc tgatgtgtgt ctccacacac
     1681 cccatcccca tccgtcttgc ggtttgctgc ttttaacgga ccttttacat gaactctcag
     1741 gacccagaat gccttggggc cccggggtag tgtgtacggt gcatgtctgg gtctcttgct
     1801 ggctctgaat gtgcagcttc agagccggct tggagtagga acctcctgtc tcggaggccc
     1861 tgttagggaa tggacacatt tttagagact ttacaagaag gtagggatcc attacaaggg
     1921 ctgcctgacc acaggctacc agcgagcagc cagaattaca gaggccgtgt gtctgactgc
     1981 tctggaggct gagggtagaa ggtggaggtg ctggcaggct gcctttctct gccttcacac
     2041 cattcctcct cctcctcctc ctcctcctcc tcctctattt atctcctctt cattccacag
     2101 tggaaccatc ccctgcatga cctcgctgac cccatgatgt cagcaagcca cccctccctc
     2161 cccccgcccc ccagtcgcca aatgcagcct ccctccgacc agccaggaat tggtttgtgg
     2221 gctgtgtctc agctggcagt gggacctaag agatgtccac atccctccta gacactgctg
     2281 gtatccccta cagcatgacc tataagagaa aatcctgctg ctccctcaag cccttcacca
     2341 cccacttccc ttgactctgg aggtggtgcc atggccggct ggctccttgt ctcaggaatc
     2401 ctgcttctgt ggttcacccc cacccccacc cccttctcac gttcctcctg cctctcacct
     2461 gccttacagc actgttcatg gcagcttaca ggaaaccttc ctttcctgat tcccacctta
     2521 ccacaagacc cagggctgtg gggtgaggtg ttgctaccga gctgaacgcc agcaatgatg
     2581 ttccagaaaa cattttaata tcttcccttg gttccactgc tgctaagctg gggacgggtc
     2641 ttggaatagc cgctccggtg gaggaggctt cccagcaggg gagagagata attaaaatgg
     2701 cattaccgtg tctccctgtg ggatgcggtg acattaaaga gccacactga caaaataccc
     2761 gggactggaa ggttctgtgc tgccttcctc gcagacacag aaccacagca gtatctggga
     2821 gctgctggga ccgctttgct ctgctcacag gcggtctggg gcggggatcc tagatgcaaa
     2881 gacctaccgt gctgaaggga gggaaagaat tggtctggga cgggcggtgg cttcctgggg
     2941 ttccctatct ggagggcaca agtcctgctt ggaatgtaag caggctcctt tgcctgaggc
     3001 agaacttggg aagccagggt tctatgaagg tgtgacctcc cccattgact gagcgtggag
     3061 gtgtggttct cacacaccag tgaagggctg gccttaccgt cccttcactg cggagctgcc
     3121 attcatacca tagcctggac aaaggcacca ataactaaga tgtctaggcc aacttcaggg
     3181 ccacccgcgt aaggcaaggc tttcttcgta gaaaaaaaag agagaacccc cacccagatg
     3241 acctcaggtg accagtgccc acccccaaac tttcccacag ttctctgggt ggggggctgg
     3301 gatacaaata cttctctttg agctgttaat ttgagggcat tctggaacct tctactgctt
     3361 ggatcttcat tctctcctga tattgttgag aggtctggcc actaaaactc ttagaaatgt
     3421 catcatctgt cacttccatg gggtcttgag gaaggggcag gcaggtctgc accccctgcc
     3481 cccaggtctg caggccagga ctgggttcct cccttctgcc ctgccctgat tggcacatcc
     3541 cctccagctc tccagccttc tgtggacctg caggcagctc ttgtgccacc ttcacactca
     3601 gttgtgcaag tcctgagctc aggccccctg catccttcct cattggctga ccaaggggaa
     3661 tcttatatcc aagcagccga atccgttacg tcccctgtgc ggccg
//
