LOCUS       NM_020606               4265 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus parvin, alpha (Parva), mRNA.
ACCESSION   NM_020606
VERSION     NM_020606.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4265)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4265)
  AUTHORS   Yuan,J., Guo,L., Wang,J., Zhou,Z. and Wu,C.
  TITLE     alpha-parvin controls chondrocyte column formation and regulates
            long bone development
  JOURNAL   Bone Res 11 (1), 46 (2023)
   PUBMED   37607905
  REMARK    GeneRIF: alpha-parvin controls chondrocyte column formation and
            regulates long bone development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4265)
  AUTHORS   Thievessen,I., Suhr,F., Vergarajauregui,S., Bottcher,R.T.,
            Brixius,K., Rosenberger,G., Dewald,O., Fleischmann,B.K., Ghanem,A.,
            Kruger,M., Engel,F.B., Fabry,B., Bloch,W. and Fassler,R.
  TITLE     The focal adhesion protein beta-parvin controls cardiomyocyte shape
            and sarcomere assembly in response to mechanical load
  JOURNAL   Curr Biol 32 (14), 3033-3047 (2022)
   PUBMED   35688156
REFERENCE   4  (bases 1 to 4265)
  AUTHORS   Rogg,M., Maier,J.I., Van Wymersch,C., Helmstadter,M., Sammarco,A.,
            Lindenmeyer,M., Zareba,P., Montanez,E., Walz,G., Werner,M.,
            Endlich,N., Benzing,T., Huber,T.B. and Schell,C.
  TITLE     alpha-Parvin Defines a Specific Integrin Adhesome to Maintain the
            Glomerular Filtration Barrier
  JOURNAL   J Am Soc Nephrol 33 (4), 786-808 (2022)
   PUBMED   35260418
  REMARK    GeneRIF: alpha-Parvin Defines a Specific Integrin Adhesome to
            Maintain the Glomerular Filtration Barrier.
REFERENCE   5  (bases 1 to 4265)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4265)
  AUTHORS   Zhang,Y., Chen,K., Tu,Y., Velyvis,A., Yang,Y., Qin,J. and Wu,C.
  TITLE     Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is
            essential for localization of each component to cell-matrix
            adhesion sites
  JOURNAL   J Cell Sci 115 (Pt 24), 4777-4786 (2002)
   PUBMED   12432066
REFERENCE   7  (bases 1 to 4265)
  AUTHORS   Korenbaum,E., Olski,T.M. and Noegel,A.A.
  TITLE     Genomic organization and expression profile of the parvin family of
            focal adhesion proteins in mice and humans
  JOURNAL   Gene 279 (1), 69-79 (2001)
   PUBMED   11722847
  REMARK    GeneRIF: Mammalian parvins are likely to have arisen late in
            evolution from gene duplication as they share a remarkably similar
            exon/intron organization.
REFERENCE   8  (bases 1 to 4265)
  AUTHORS   Tu,Y., Huang,Y., Zhang,Y., Hua,Y. and Wu,C.
  TITLE     A new focal adhesion protein that interacts with integrin-linked
            kinase and regulates cell adhesion and spreading
  JOURNAL   J Cell Biol 153 (3), 585-598 (2001)
   PUBMED   11331308
REFERENCE   9  (bases 1 to 4265)
  AUTHORS   Olski,T.M., Noegel,A.A. and Korenbaum,E.
  TITLE     Parvin, a 42 kDa focal adhesion protein, related to the
            alpha-actinin superfamily
  JOURNAL   J Cell Sci 114 (Pt 3), 525-538 (2001)
   PUBMED   11171322
REFERENCE   10 (bases 1 to 4265)
  AUTHORS   Nikolopoulos,S.N. and Turner,C.E.
  TITLE     Actopaxin, a new focal adhesion protein that binds paxillin LD
            motifs and actin and regulates cell adhesion
  JOURNAL   J Cell Biol 151 (7), 1435-1448 (2000)
   PUBMED   11134073
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132392.3 and AC127694.3.
            
            On Jan 23, 2023 this sequence version replaced NM_020606.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF237774.1, AB045321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               AC132392.3         25086-25291         c
            207-296             AC127694.3         91403-91492         c
            297-367             AC127694.3         90866-90936         c
            368-470             AC127694.3         88056-88158         c
            471-611             AC127694.3         75600-75740         c
            612-727             AC127694.3         67791-67906         c
            728-786             AC127694.3         62740-62798         c
            787-806             AC127694.3         60295-60314         c
            807-868             AC127694.3         59208-59269         c
            869-937             AC127694.3         58665-58733         c
            938-1039            AC127694.3         55912-56013         c
            1040-1112           AC127694.3         54647-54719         c
            1113-4265           AC127694.3         43977-47129         c
FEATURES             Location/Qualifiers
     source          1..4265
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 58.76 cM"
     gene            1..4265
                     /gene="Parva"
                     /gene_synonym="2010012A22Rik; 5430400F08Rik; Actp;
                     CH-ILKBP; Parvin"
                     /note="parvin, alpha"
                     /db_xref="GeneID:57342"
                     /db_xref="MGI:MGI:1931144"
     exon            1..206
                     /gene="Parva"
                     /gene_synonym="2010012A22Rik; 5430400F08Rik; Actp;
                     CH-ILKBP; Parvin"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1189
                     /gene="Parva"
                     /gene_synonym="2010012A22Rik; 5430400F08Rik; Actp;
                     CH-ILKBP; Parvin"
                     /note="actopaxin"
                     /codon_start=1
                     /product="alpha-parvin"
                     /protein_id="NP_065631.3"
                     /db_xref="CCDS:CCDS40091.1"
                     /db_xref="GeneID:57342"
                     /db_xref="MGI:MGI:1931144"
                     /translation="MATSPQKSPLVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAK
                     EVSEFQEEGMNAINLPLSPISFELDPEDTLLEENEVRTMVDPNSRNDPKLQELMKVLI
                     DWINDVLVGERIIVKDLAEDLYDGQVLQKLFEKLESEKLNVAEVTQSEIAQKQKLQTV
                     LEKINETLKLPPRSIKWNVDSVHAKNLVAILHLLVALSQYFRAPIRLPDHVSIQVVVV
                     QKREGILQSRQIQEEITGNTEALSGRHERDAFDTLFDHAPDKLNVVKKTLITFVNKHL
                     NKLNLEVTELETQFADGVYLVLLMGLLEGYFVPLHSFFLTPDSFEQKVLNVSFAFELM
                     QDGGLEKPKPRPEDIVNCDLKSTLRVLYNLFTKYRNVE"
     exon            207..296
                     /gene="Parva"
                     /gene_synonym="2010012A22Rik; 5430400F08Rik; Actp;
                     CH-ILKBP; Parvin"
                     /inference="alignment:Splign:2.1.0"
     exon            297..367
                     /gene="Parva"
                     /gene_synonym="2010012A22Rik; 5430400F08Rik; Actp;
                     CH-ILKBP; Parvin"
                     /inference="alignment:Splign:2.1.0"
     exon            368..470
                     /gene="Parva"
                     /gene_synonym="2010012A22Rik; 5430400F08Rik; Actp;
                     CH-ILKBP; Parvin"
                     /inference="alignment:Splign:2.1.0"
     exon            471..611
                     /gene="Parva"
                     /gene_synonym="2010012A22Rik; 5430400F08Rik; Actp;
                     CH-ILKBP; Parvin"
                     /inference="alignment:Splign:2.1.0"
     exon            612..727
                     /gene="Parva"
                     /gene_synonym="2010012A22Rik; 5430400F08Rik; Actp;
                     CH-ILKBP; Parvin"
                     /inference="alignment:Splign:2.1.0"
     exon            728..786
                     /gene="Parva"
                     /gene_synonym="2010012A22Rik; 5430400F08Rik; Actp;
                     CH-ILKBP; Parvin"
                     /inference="alignment:Splign:2.1.0"
     exon            787..806
                     /gene="Parva"
                     /gene_synonym="2010012A22Rik; 5430400F08Rik; Actp;
                     CH-ILKBP; Parvin"
                     /inference="alignment:Splign:2.1.0"
     exon            807..868
                     /gene="Parva"
                     /gene_synonym="2010012A22Rik; 5430400F08Rik; Actp;
                     CH-ILKBP; Parvin"
                     /inference="alignment:Splign:2.1.0"
     exon            869..937
                     /gene="Parva"
                     /gene_synonym="2010012A22Rik; 5430400F08Rik; Actp;
                     CH-ILKBP; Parvin"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1039
                     /gene="Parva"
                     /gene_synonym="2010012A22Rik; 5430400F08Rik; Actp;
                     CH-ILKBP; Parvin"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1112
                     /gene="Parva"
                     /gene_synonym="2010012A22Rik; 5430400F08Rik; Actp;
                     CH-ILKBP; Parvin"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..4265
                     /gene="Parva"
                     /gene_synonym="2010012A22Rik; 5430400F08Rik; Actp;
                     CH-ILKBP; Parvin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4237..4242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Parva"
                     /gene_synonym="2010012A22Rik; 5430400F08Rik; Actp;
                     CH-ILKBP; Parvin"
                     /note="hexamer: AATAAA"
     regulatory      4248..4253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Parva"
                     /gene_synonym="2010012A22Rik; 5430400F08Rik; Actp;
                     CH-ILKBP; Parvin"
                     /note="hexamer: AATGAA"
     polyA_site      4257
                     /gene="Parva"
                     /gene_synonym="2010012A22Rik; 5430400F08Rik; Actp;
                     CH-ILKBP; Parvin"
                     /note="major polyA site"
     polyA_site      4265
                     /gene="Parva"
                     /gene_synonym="2010012A22Rik; 5430400F08Rik; Actp;
                     CH-ILKBP; Parvin"
ORIGIN      
        1 ggaaagccgc agcctcagtc ccgccgccgc ccgccgcggc cgcccagctc cagctccgcg
       61 tccagccgcc atggccacat ccccacagaa gtcgcccttg gtccccaaat cacccactcc
      121 caagtcgcct ccgtcccgca agaaggatga ctcgttcttg gggaaactcg gagggacgct
      181 ggcccggagg aagaaagcca aagaagtatc cgagttccag gaggaaggaa tgaacgccat
      241 caacctgcct cttagcccca tctccttcga gctggacccc gaggacactc tgctggagga
      301 gaatgaggtc cggacaatgg tcgatccaaa ctcacgcaat gaccccaaac ttcaagagct
      361 gatgaaggtg ctcatcgact ggatcaatga cgtattggtg ggagaaagaa tcatcgtgaa
      421 ggacctcgct gaagatctct atgatggcca agtcctacag aagctcttcg agaaactgga
      481 gagtgagaag ctcaacgtgg ccgaggttac gcagtcggag atcgcccaga aacagaagct
      541 acagactgtg ctggagaaga tcaatgagac cctgaagctt cctcccagga gcatcaagtg
      601 gaacgtggac tctgttcatg ccaagaacct ggttgccatc ctccacctgc tggttgctct
      661 gtctcaatat ttccgggcac ccatccgact cccagaccat gtttccatcc aagtggttgt
      721 ggtccagaaa cgagaaggga tcctccagtc tcgacaaatc caagaggaaa taactggtaa
      781 cacagaggcc ctttccggaa ggcatgaacg tgatgccttt gacacgctgt ttgaccatgc
      841 accagacaaa ctcaatgtgg tgaagaagac cctcatcacg ttcgtgaaca agcatctgaa
      901 taaactgaac ttggaggtca cagaactgga gacacagttt gcagatgggg tttacctggt
      961 gttgctcatg gggctcctgg aaggctactt tgtacccctg cacagcttct tcctgacccc
     1021 agacagcttt gaacagaagg tcctgaatgt ctcctttgcc tttgagctca tgcaagatgg
     1081 agggctggaa aagcctaaac cgcggccaga agacattgtc aactgtgacc tgaagtccac
     1141 gctgagagtg ctatacaacc tcttcaccaa gtaccggaat gtggagtgag accctgggct
     1201 gcctcctgct gcccagccac tcttcgtgaa ggccatctgg accagcttcc caacagcctt
     1261 gccctgcttg ctcctgtctc ttgttccacc ctctcccaca agcccagcaa ccacccagag
     1321 atagtggaca ttaaaatcag taaggaagtg accactaacc cagtgaacta ataacatctg
     1381 taggctctgg ggactgaacc agcaatgtct tgggaaattg tctccatcca aattcaggcc
     1441 ctagaggttc ctacatgtgc tgtggggatc aacacagccc agagacagtc cccctgaaca
     1501 taggaataaa gatcagaatt agtccccaca ataaggggga gtctctaccg tgctcaagtt
     1561 cattaggttt atgtcttatt aaaggagatc attcctccct gttgtagatg aagaaactga
     1621 ggcccagaga tgcgaaggtt tgctatccat tagcatgtat tctctgggtg acttactggt
     1681 ttatgactgg tcaactgcat tccattctgt gtgtgtccta aaatgtgtgc atgcttgttc
     1741 agaccagcct tacctgcata tacctgtgtc ctctagcaga caagacactc tgatctcacc
     1801 ctagggcagg ccaggtcagg gctgggtgat tctcactaaa attgccaaat tgaatttaac
     1861 tctattaata ctgtgtgtgg caggagcctc atccctcaaa tcctttgtac aaatgaaaat
     1921 tacccttaat tccttcagat tggtaataag cccacgctcc ggttgcaaga tgacatttgg
     1981 gaagcgttct gtttggaatt aatagagtgc ccatttcgca gcctttttgc ttgattgcat
     2041 gtaatggatg tgccctatat tttcctgcaa aataagtact caattcatta tcgttaggca
     2101 aatgtagggt atgcttgcac atggcaaaga gctgggtgca gacccactgg agcatcgcct
     2161 gagaagtagg gctcgtcaac agagaccctt gaactttgag ggaaaaagaa aaagaacctc
     2221 ctttttgcct tctaattggt catttaggcc gttctggcta agtctgccca catgcaatta
     2281 ctggctaatt ccaggcgtgg agaatgtcag tcatttaagc tgaagctcag cagctagctt
     2341 cctcactcca gtgactcaag ggctgctgct cacgcatctc ctcatacaaa cctggctctg
     2401 aaggatagag ctctgcctct ccagtctgcc ccgaggccct acagagaaag cagagaggct
     2461 aatgggaaaa ggagggtcag acctaaggga acaagaaatg ggggtgagag agctggatac
     2521 taattgctta acatgtaggg tatgccatca gagacaaagc agcaggtaca gtacttaacc
     2581 cttgtgctct tctattgaga agctaatggg atatcttggg ataatgaccc gtgctactgc
     2641 tgtcttcaca gaactcatga cagggagatg ccagcttggg ttgcctcctc cagaagtgtg
     2701 taactatgta atctatcttt gtcttagtta tgtttctcaa tggaacataa gaaccagacg
     2761 agaacaattt acaagaagga gaacttattt gggctcatga tctaaagccc atcatggagg
     2821 gcaggttaag gcagccatgg cgagaagagc atacagccag gacccctcac ttcacatgtc
     2881 agaacaagga gaggagagac aaggagtgtg gctgagctgt aaaccccaag gcttgacagc
     2941 tcctcccgtg aggctccacc tcctaaagga ttcataattt ctcaaaacag tgtcaccagc
     3001 tgagagccaa gtgttcaaaa tgagcccgtg gggggggggg ggagactttc cacatgcaaa
     3061 cagacatcaa gtaaagcctt ctctggtttg aggattcgct aagatggctt gctagactca
     3121 ggccttgcag tcgttcacag cattccctgc ccattcttgc ttctctttgt actgatcatc
     3181 cagggcagct caaaacccag ctcccttaga tccactgtgc atctccccag ctgttctgtt
     3241 ctaggaatca ttattcggca cagtgagcat ctaagacgtg aaggcgatgc actgtctccc
     3301 attgatctgt gtataagaac ggaattcttt tttgcataat taatgaagga tcatagtttt
     3361 tcattaggat tcatgttggt ctcatgctct tttaaattcc tgttagtaaa atgagattaa
     3421 taacggtttg gtctctgtga gcagcactga agtagaataa gaaaccttca tctacttgaa
     3481 gtctgcatcc gggtcctgcc ttgccgctcc ctgatactca agccattcat acacactaca
     3541 cttcctaagg gccctccatc ggagttttgt attctccaca gtaggaggta actttctcaa
     3601 cagcacatca gtgtacccaa cagctgagta ttggggctac ggtctttacc tcagcccagc
     3661 atcccaaagc ttgagtctgg ctttataaag ctgttgttgg agatggatgt ttccgtttag
     3721 attctaggat ggaatactta acatacgatt gtggttttga agaagaaaga gaccttgcca
     3781 ttataagtaa tcaaacagcc ttcatctcct gaaaaaaaaa ggagaggaaa gaagaaactg
     3841 agacaagaat cattctggct cactgtttga gggtacaggg aaggggacag gagagacaag
     3901 gccacaggag tgtgacagag gcagctggtc acattgtgtc tgcaggcagg aagcagagaa
     3961 agttgaatgc tgtgctcagc ctactgattt ttatctagtc tgggacccca gcctatgaaa
     4021 cggtaccacc acagttaggg tgggtctttc ccccgaagtt aatcatcact gtttttagta
     4081 gttgatacgt aagtaacaca gaattcaaaa agcaaaagga tgtctgatta aaaaccctaa
     4141 ttatctgcct cccctcttcc ccatcagtct ctactctcca tggagatgac tgtcttgatc
     4201 catttcttct gcatgattcc agaaatactc tgtgcaaata aagcctgaat gaacgaacat
     4261 acaaa
//
