LOCUS       NP_758476                475 aa            linear   ROD 02-JUN-2024
DEFINITION  probable proline--tRNA ligase, mitochondrial isoform 1 [Mus
            musculus].
ACCESSION   NP_758476
VERSION     NP_758476.2
DBSOURCE    REFSEQ: accession NM_172272.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 475)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929585.11 and BY768753.1.
            
            On Apr 4, 2007 this sequence version replaced NP_758476.1.
            
            Transcript Variant: This variant (1) differs in the 5' UTR and the
            5' coding region and initiates translation at an alternate start
            codon, compared to variant 3. Variants 1 and 4 encode the same
            isoform (1), which is shorter at the N-terminus compared to isoform
            2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038817.1, SRR7345562.937397.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 49.67 cM"
     Protein         1..475
                     /product="probable proline--tRNA ligase, mitochondrial
                     isoform 1"
                     /EC_number="6.1.1.15"
                     /note="class II tRNA synthetase; probable prolyl-tRNA
                     synthetase, mitochondrial; proRS; proline--tRNA ligase;
                     probable proline--tRNA ligase, mitochondrial"
                     /calculated_mol_wt=50216
     transit_peptide 1..29
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q8CFI5.2)"
                     /calculated_mol_wt=3320
     mat_peptide     30..475
                     /product="Probable proline--tRNA ligase, mitochondrial.
                     /id=PRO_0000035819"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CFI5.2)"
                     /calculated_mol_wt=50216
     Region          42..470
                     /region_name="PRK09194"
                     /note="prolyl-tRNA synthetase; Provisional"
                     /db_xref="CDD:236405"
     CDS             1..475
                     /gene="Pars2"
                     /coded_by="NM_172272.2:77..1504"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS18423.1"
                     /db_xref="GeneID:230577"
                     /db_xref="MGI:MGI:2386296"
ORIGIN      
        1 meglltrcrt lsalaacslr hcryiihkcy hrapgrgqrl vlsrmfqpqn lredqvlsle
       61 grasdltcks qrlmlqvgli lpaspgcyhl mpytvravek lvrvidqemq aiggqkinmp
      121 slspaelwra tsrwdlmgre llrlrdrhgk eyclgpthee avtalvasqk klsykqlpll
      181 lyqvtrkfrd eprprfgllr grefymkdmy tfdssseaaq etyglvcday crlfdrlglq
      241 wmkaradvgs iggtmshefq lpvdigedrl vvcpschfsa nteildlsqk icpdcqgplt
      301 etkgievght fylstkyssi fnalftnahg esllaemgcy glgvtrilaa aievlstedc
      361 irwprllapy qvcvippkkg sketaateiv eklyddimea vpqlrgevll ddrthltign
      421 rlkdanklgy pfviiagkra ledpahfevw sqntgevvfl tkegvmellt gvhvv
//
