LOCUS       NM_001405300            3282 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus poly (ADP-ribose) polymerase family, member 9 (Parp9),
            transcript variant 2, mRNA.
ACCESSION   NM_001405300 XM_030249336
VERSION     NM_001405300.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3282)
  AUTHORS   Thirunavukkarasu,S., Ahmed,M., Rosa,B.A., Boothby,M., Cho,S.H.,
            Rangel-Moreno,J., Mbandi,S.K., Schreiber,V., Gupta,A., Zuniga,J.,
            Mitreva,M., Kaushal,D., Scriba,T.J. and Khader,S.A.
  TITLE     Poly(ADP-ribose) polymerase 9 mediates early protection against
            Mycobacterium tuberculosis infection by regulating type I IFN
            production
  JOURNAL   J Clin Invest 133 (12), e158630 (2023)
   PUBMED   37200107
  REMARK    GeneRIF: Poly(ADP-ribose) polymerase 9 mediates early protection
            against Mycobacterium tuberculosis infection by regulating type I
            IFN production.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3282)
  AUTHORS   Xing,J., Zhang,A., Du,Y., Fang,M., Minze,L.J., Liu,Y.J., Li,X.C.
            and Zhang,Z.
  TITLE     Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a
            noncanonical sensor for RNA virus in dendritic cells
  JOURNAL   Nat Commun 12 (1), 2681 (2021)
   PUBMED   33976210
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3282)
  AUTHORS   Robert,I., Gaudot,L., Yelamos,J., Noll,A., Wong,H.K., Dantzer,F.,
            Schreiber,V. and Reina-San-Martin,B.
  TITLE     Robust immunoglobulin class switch recombination and end joining in
            Parp9-deficient mice
  JOURNAL   Eur J Immunol 47 (4), 665-676 (2017)
   PUBMED   28105679
  REMARK    GeneRIF: this study shows that Parp9-deficient mice are viable,
            fertile, and do not show any overt phenotype; Parp9 is dispensable
            for B-cell development, and that Parp9 is not essential for
            double-stranded DNA break repair, or that strong compensatory
            mechanisms exist
REFERENCE   4  (bases 1 to 3282)
  AUTHORS   Iwata,H., Goettsch,C., Sharma,A., Ricchiuto,P., Goh,W.W., Halu,A.,
            Yamada,I., Yoshida,H., Hara,T., Wei,M., Inoue,N., Fukuda,D.,
            Mojcher,A., Mattson,P.C., Barabasi,A.L., Boothby,M., Aikawa,E.,
            Singh,S.A. and Aikawa,M.
  TITLE     PARP9 and PARP14 cross-regulate macrophage activation via STAT1
            ADP-ribosylation
  JOURNAL   Nat Commun 7, 12849 (2016)
   PUBMED   27796300
  REMARK    GeneRIF: PARP9 and PARP14 regulate macrophage activation in
            macrophage cell lines treated with either IFNgamma or IL-4; PARP14
            silencing induces pro-inflammatory genes and STAT1 phosphorylation
            in M(IFNgamma) cells, whereas it suppresses anti-inflammatory gene
            expression and STAT6 phosphorylation in M(IL-4) cells
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3282)
  AUTHORS   Zhang,Y., Mao,D., Roswit,W.T., Jin,X., Patel,A.C., Patel,D.A.,
            Agapov,E., Wang,Z., Tidwell,R.M., Atkinson,J.J., Huang,G.,
            McCarthy,R., Yu,J., Yun,N.E., Paessler,S., Lawson,T.G.,
            Omattage,N.S., Brett,T.J. and Holtzman,M.J.
  TITLE     PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C
            protease to enhance interferon signaling and control viral
            infection
  JOURNAL   Nat Immunol 16 (12), 1215-1227 (2015)
   PUBMED   26479788
  REMARK    GeneRIF: Data indicate that PARP polymerase PARP9-E3 ligase DTX3L
            interacts with STAT1 transcription factor and enhances
            translocation of STAT1 to the nucleus.
REFERENCE   6  (bases 1 to 3282)
  AUTHORS   Hakme,A., Huber,A., Dolle,P. and Schreiber,V.
  TITLE     The macroPARP genes Parp-9 and Parp-14 are developmentally and
            differentially regulated in mouse tissues
  JOURNAL   Dev Dyn 237 (1), 209-215 (2008)
   PUBMED   18069692
  REMARK    GeneRIF: Data show that Parp-9 is developmentally regulated, and
            prominently expressed in the thymus and specific regions of the
            brain and gut.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133464.11.
            
            On Apr 21, 2022 this sequence version replaced XM_030249336.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.4223213.1,
                                           SRR13861890.158387.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AC133464.11        88407-88623         c
            218-320             AC133464.11        86478-86580         c
            321-462             AC133464.11        84103-84244         c
            463-1316            AC133464.11        79259-80112         c
            1317-1532           AC133464.11        73835-74050         c
            1533-1751           AC133464.11        70588-70806         c
            1752-1809           AC133464.11        67552-67609         c
            1810-2199           AC133464.11        63249-63638         c
            2200-2336           AC133464.11        59827-59963         c
            2337-2511           AC133464.11        57848-58022         c
            2512-3282           AC133464.11        55008-55778         c
FEATURES             Location/Qualifiers
     source          1..3282
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 25.43 cM"
     gene            1..3282
                     /gene="Parp9"
                     /gene_synonym="ARTD9; Bagl; Bal; PARP-9"
                     /note="poly (ADP-ribose) polymerase family, member 9"
                     /db_xref="GeneID:80285"
                     /db_xref="MGI:MGI:1933117"
     exon            1..217
                     /gene="Parp9"
                     /gene_synonym="ARTD9; Bagl; Bal; PARP-9"
                     /inference="alignment:Splign:2.1.0"
     exon            218..320
                     /gene="Parp9"
                     /gene_synonym="ARTD9; Bagl; Bal; PARP-9"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..2906
                     /gene="Parp9"
                     /gene_synonym="ARTD9; Bagl; Bal; PARP-9"
                     /EC_number="2.4.2.30"
                     /note="isoform a is encoded by transcript variant 2; poly
                     [ADP-ribose] polymerase 9; b aggressive lymphoma protein
                     homolog; ADP-ribosyltransferase diphtheria toxin-like 9;
                     protein mono-ADP-ribosyltransferase PARP9"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP9
                     isoform a"
                     /protein_id="NP_001392229.1"
                     /db_xref="GeneID:80285"
                     /db_xref="MGI:MGI:1933117"
                     /translation="MAYYMDTWAAAPAERPGMIASLSLSFKKAFAELFPQRRRGHSEG
                     DYPPLRGSANNSLEEHYRWQIPIKHNVFEILKSNESQLCEVLQNKFGCISTLSCPTLA
                     GSSSPAQRVFRRTLIPGIELSVWKDDLTRHVVDAVVNAANENLLHGSGLAGSLVKTGG
                     FEIQEESKRIIANVGKISVGGIAITGAGRLPCHLIIHAVGPRWTVTNSQTAIELLKFA
                     IRNILDYVTKYDLRIKTVAIPALSSGIFQFPLDLCTSIILETIRLYFQDKQMFGNLRE
                     IHLVSNEDPTVASFKSASESILGRDLSSWGGPETDPASTMTLRIGRGLTLQIVQGCIE
                     MQTTDVIVNSGYMQDFKSGRVAQSILRQAGVEMEKELDKVNLSTDYQEVWVTKGFKLS
                     CQYVFHVAWHSQINKYQILKDAMKSCLEKCLKPDINSISFPALGTGLMDLKKSTAAQI
                     MFEEVFAFAKEHKEKTLTVKIVIFPVDVETYKIFYAEMTKRSNELNLSGNSGALALQW
                     SSGEQRRGGLEAGSPAINLMGVKVGEMCEAQEWIERLLVSLDHHIIENNHILYLGKKE
                     HDVLSELQTSTRVSISETVSPRTATLEIKGPQADLIDAVMRIECMLCDVQEEVAGKRE
                     KNLWSLSGQGTNQQEKLDKMEESYTFQRYPASLTQELQDRKKQFEKCGLWVVQVEQID
                     NKVLLAAFQEKKKMMEERTPKGSGSQRLFQQVPHQFCNTVCRVGFHRMYSTSYNPVYG
                     AGIYFTKSLKNLADKVKKTSSTDKLIYVFEAEVLTGSFCQGNSSNIIPPPLSPGALDV
                     NDSVVDNVSSPETIVVFNGMQAMPLYLWTCTQDRTFSQHPMWSQGYSSGPGMVSSLQS
                     WEWVLNGSSV"
     exon            321..462
                     /gene="Parp9"
                     /gene_synonym="ARTD9; Bagl; Bal; PARP-9"
                     /inference="alignment:Splign:2.1.0"
     exon            463..1316
                     /gene="Parp9"
                     /gene_synonym="ARTD9; Bagl; Bal; PARP-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1532
                     /gene="Parp9"
                     /gene_synonym="ARTD9; Bagl; Bal; PARP-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1751
                     /gene="Parp9"
                     /gene_synonym="ARTD9; Bagl; Bal; PARP-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1809
                     /gene="Parp9"
                     /gene_synonym="ARTD9; Bagl; Bal; PARP-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..2199
                     /gene="Parp9"
                     /gene_synonym="ARTD9; Bagl; Bal; PARP-9"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2336
                     /gene="Parp9"
                     /gene_synonym="ARTD9; Bagl; Bal; PARP-9"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2511
                     /gene="Parp9"
                     /gene_synonym="ARTD9; Bagl; Bal; PARP-9"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..3282
                     /gene="Parp9"
                     /gene_synonym="ARTD9; Bagl; Bal; PARP-9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3259..3264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Parp9"
                     /gene_synonym="ARTD9; Bagl; Bal; PARP-9"
                     /note="hexamer: AATAAA"
     polyA_site      3282
                     /gene="Parp9"
                     /gene_synonym="ARTD9; Bagl; Bal; PARP-9"
                     /note="major polyA site"
ORIGIN      
        1 agaaggtccc tccttgttct ccgcagagcc gccgcctgtc ttgctctgcc atctctcaga
       61 gccatcaccc ggtgagtagt tcgcacgctc ggcggtgggc gctcagagga agtttcccta
      121 cggtggcagg tcgcccttct attcttgcag gatcggaagt ttggcgggaa cccggatccc
      181 aggttcaggc ctctcaaggg tggagcggaa tagagggaaa caggccacca tctcctcgat
      241 ctacagacta cacttggaaa cacaaacaaa tataaatatc tgaagaccca cgtgggacct
      301 gaagaatggc ctattacatg gatacatggg cggcagctcc cgccgaaaga ccaggtatga
      361 tcgcctctct ctccctctca tttaagaaag cctttgctga gctctttcct cagcgcagaa
      421 gagggcactc agaaggagac tatccccccc tcaggggttc agccaacaat tctcttgaag
      481 aacattatag atggcaaatt cccattaaac acaatgtctt cgaaatttta aagagcaatg
      541 agagtcagct atgtgaagtc ctccaaaata agtttggatg catctctacc ctgagctgtc
      601 caactctagc agggagcagc tctcctgctc agagagtctt cagaaggacc ctgatccctg
      661 ggatagagtt atctgtctgg aaggatgacc ttaccagaca cgttgttgat gctgtggtga
      721 acgcagccaa tgaaaacctt ttgcatggaa gtggcctggc cggaagcttg gtgaaaactg
      781 gtggctttga aatccaagaa gagagcaaaa gaatcattgc caacgttggt aaaatctcag
      841 ttggtggaat cgctatcacc ggtgcgggga gacttccttg ccatttgatt atccatgcgg
      901 ttggacctcg gtggacagtt acgaacagcc agacagctat cgaattactg aaatttgcca
      961 ttaggaacat tctagattat gtcaccaaat atgatctacg cattaagaca gtagcaattc
     1021 cagccctgag ctctggaatt ttccagttcc ctctggattt gtgtacaagc ataattttag
     1081 aaactatccg gctttatttc caagacaagc aaatgttcgg taatttgaga gagattcatc
     1141 tggtgagcaa tgaggacccc actgttgcgt cctttaaatc cgcctcagaa agcatcctag
     1201 ggagggacct gagctcttgg gggggtccag aaactgaccc tgcttccacc atgactcttc
     1261 gcatcggccg gggcctgact ctccagattg tccaaggctg tattgaaatg caaacaacag
     1321 atgtaattgt taattctgga tacatgcagg attttaaatc aggacgagtg gcacagtcga
     1381 ttcttagaca agcaggggtt gaaatggaaa aggaacttga caaggttaac ctgtccacag
     1441 attatcaaga ggtgtgggtc acaaaaggat ttaaattgtc ctgtcagtat gtcttccatg
     1501 tggcatggca ttcccaaatc aacaaatacc agatattgaa agatgcaatg aagtcctgtc
     1561 tagaaaaatg ccttaaacca gatataaatt ccatttcctt tcctgctctc gggacaggat
     1621 tgatggattt gaagaagagt acagcagctc agataatgtt tgaggaagtt tttgcatttg
     1681 ctaaagagca caaggaaaaa acgctaactg taaagattgt gatctttcca gtagatgtgg
     1741 agacgtacaa gattttttat gctgaaatga caaaaaggtc caacgagctg aatctcagcg
     1801 gtaatagtgg tgctttagcc ctgcagtggt ccagtgggga gcaaagaaga ggcggccttg
     1861 aagctggatc tcctgccatc aatctcatgg gtgtaaaagt gggagagatg tgtgaggccc
     1921 aggaatggat tgaaaggttg ctggtctccc tggaccacca catcattgag aataatcata
     1981 ttctctatct tgggaaaaaa gagcacgacg tgctgtctga gctccagacc agcacaagag
     2041 tctccatttc agagactgtc agtccaagaa cggccacttt ggagattaaa ggtccccagg
     2101 ctgacctcat tgacgcagtt atgaggattg aatgtatgct gtgtgacgtt caggaagaag
     2161 tggcaggaaa aagggagaaa aatctttgga gcttgtcagg acaggggacc aaccagcaag
     2221 aaaaactgga taaaatggaa gaatcgtaca catttcaacg atacccagca tcattaactc
     2281 aggaacttca ggaccgaaag aaacagtttg aaaagtgtgg cttgtgggtt gtgcaggtgg
     2341 agcagataga caataaggtg ctgctggctg ccttccaaga gaagaagaaa atgatggaag
     2401 agaggacgcc aaagggatct gggagccaaa ggttgtttca gcaggtccca catcagttct
     2461 gcaatacggt gtgcagagtc ggcttccaca gaatgtattc gacatcctat aacccagttt
     2521 atggagccgg catatatttc accaagagcc tcaaaaatct agcagacaag gtcaagaaaa
     2581 cctcaagcac agacaagcta atctatgtgt ttgaggcaga agtactcaca gggtccttct
     2641 gtcagggtaa ttcctcaaat atcatccctc caccattgag tcctggggcc ttagatgtca
     2701 atgacagcgt agttgacaat gtttccagcc ctgaaaccat tgttgttttt aatggcatgc
     2761 aggccatgcc cctgtacttg tggacttgca cacaggatag gacattctca cagcatccga
     2821 tgtggtcaca gggctactca tcaggaccag gaatggtctc ttcgctgcag tcctgggaat
     2881 gggtcttaaa tggcagctct gtttagtgtc tacatcagtt taacaagcag aaggggttga
     2941 gagaactgac aaaatgataa ataacaggtt acctgttcag aatgatgggg tcactaaagg
     3001 caccgaccac acactagcat catagtgcct ttgtctttac ctctgggctt gactgggcag
     3061 atgccagcta aaacttcctc actgtctttt ctatttgaca tctttcatct cctttcctat
     3121 aggtgacagc aagaatactt tatatagaac aaggatattt ttttcaagcc tgttattttc
     3181 taaaatgata gcacaaacta ggacaacagg atgatttcag gttttctata taattttata
     3241 aagtgctttg gatatccaaa taaatcacct ttgtctgagt aa
//
