LOCUS       NM_001081009            7083 bp    mRNA    linear   ROD 26-SEP-2023
DEFINITION  Mus musculus poly (ADP-ribose) polymerase family, member 8 (Parp8),
            mRNA.
ACCESSION   NM_001081009 XM_001000670
VERSION     NM_001081009.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7083)
  AUTHORS   Anania C, Acemel RD, Jedamzick J, Bolondi A, Cova G, Brieske N,
            Kuhn R, Wittler L, Real FM and Lupianez DG.
  TITLE     In vivo dissection of a clustered-CTCF domain boundary reveals
            developmental principles of regulatory insulation
  JOURNAL   Nat Genet 54 (7), 1026-1036 (2022)
   PUBMED   35817979
REFERENCE   2  (bases 1 to 7083)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7083)
  AUTHORS   Sundberg JP, Dadras SS, Silva KA, Kennedy VE, Garland G, Murray SA,
            Sundberg BA, Schofield PN and Pratt CH.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7083)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   5  (bases 1 to 7083)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 7083)
  AUTHORS   Akagi K, Li J, Stephens RM, Volfovsky N and Symer DE.
  TITLE     Extensive variation between inbred mouse strains due to endogenous
            L1 retrotransposition
  JOURNAL   Genome Res 18 (6), 869-880 (2008)
   PUBMED   18381897
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154224.1 and CT025610.7.
            
            [WARNING] On Jan 10, 2024 this sequence was replaced by
            NM_001081009.3.
            
            On Feb 16, 2019 this sequence version replaced NM_001081009.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR6116558.54262.1,
                                           SRR7345562.2331492.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AC154224.1         44613-44779
            168-269             AC154224.1         44867-44968
            270-324             AC154224.1         45915-45969
            325-362             CT025610.7         161253-161290       c
            363-452             CT025610.7         149811-149900       c
            453-523             CT025610.7         149026-149096       c
            524-601             CT025610.7         147475-147552       c
            602-696             CT025610.7         145079-145173       c
            697-757             CT025610.7         133893-133953       c
            758-848             CT025610.7         133374-133464       c
            849-915             CT025610.7         125299-125365       c
            916-1041            CT025610.7         118165-118290       c
            1042-1600           CT025610.7         117145-117703       c
            1601-1651           CT025610.7         115706-115756       c
            1652-1747           CT025610.7         115509-115604       c
            1748-1840           CT025610.7         101504-101596       c
            1841-1966           CT025610.7         100000-100125       c
            1967-2032           CT025610.7         99040-99105         c
            2033-2100           CT025610.7         94152-94219         c
            2101-2149           CT025610.7         91932-91980         c
            2150-2262           CT025610.7         90949-91061         c
            2263-2335           CT025610.7         90635-90707         c
            2336-2405           CT025610.7         89545-89614         c
            2406-2479           CT025610.7         86695-86768         c
            2480-2549           CT025610.7         85584-85653         c
            2550-2634           CT025610.7         84719-84803         c
            2635-7083           CT025610.7         73353-77801         c
FEATURES             Location/Qualifiers
     source          1..7083
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 65.32 cM"
     gene            1..7083
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /note="poly (ADP-ribose) polymerase family, member 8"
                     /db_xref="GeneID:52552"
                     /db_xref="MGI:MGI:1098713"
     exon            1..167
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            168..269
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..2737
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /EC_number="2.4.2.30"
                     /note="poly [ADP-ribose] polymerase 8; PARP-8;
                     ADP-ribosyltransferase diphtheria toxin-like 16"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP8"
                     /protein_id="NP_001074478.2"
                     /db_xref="CCDS:CCDS36790.2"
                     /db_xref="GeneID:52552"
                     /db_xref="MGI:MGI:1098713"
                     /translation="MGMCSRQERIQKDIDVVIQKSRAEKDCLFADFRYSDSTFTFTYV
                     GGPKSVSYSVHVSEDYPDNTYVSSSENDEDVLVTTDPIPVIFHRIATELRKTNDINCC
                     LSIRSKLQKENGEESRQNSTVEEDSEGDNDSEEFYYGGQVNYDGELHKHPQLEADLSA
                     VRELYGPHAVSLREYGAIDDVDIDLHIDVSFLDEEIAVAWEVIRTEPIIVRLHCSLTQ
                     YLNGPVPTVDVFQISTKERFGLGHQLKKIMQTFVSQQWKQSKDKSNCPHGKKLSEKKV
                     KSPLHLFSTLRRSPSYPPPGCGKSKSKLKPEQDGISKTHKLLRRTCSSTVKADDMCAK
                     SHRTFGRSLSSDPRAEQAMSTIKSHKLLGRPCPSAGKQEDCLTLKSHKLLTRSCSGDP
                     RCEHNTNLKPHKLLSRSYSSNLRMEELYGLKNHKLLSKSYSSAPKTSKMEHFKEPNAE
                     GRRLSLTSGLIGILTPSSSSSQPPTNGAKSIPIRDRGFLVQTIEFAEQRIPVLNEYCV
                     VCDEPHVFQNGPMLRPTVCERELCVFAFQTLGVMNEAADEIATGAQVVDLLVSMCRSA
                     LESPRKVVIFEPYPSVVDPNDPQMLAFNPRKKNYDRVMKALDSITSIREMTQAPYLEI
                     KKQMDKQDPLAHPLLQWVISSNRSHIVKLPVNRQLKFMHTPHQFLLLSSPPAKESNFR
                     AAKKLFGSTFAFHGSHIENWHSILRNGLVVASNTRLQLHGAMYGSGIYLSPMSSISFG
                     YSGMNKKQKVSSKDEPASSSKSSNASQSQKKGQQSQFLQSRNLKCIALCEVITSPDLH
                     KHGEIWVVPNTDHVCTRFFFVYEDGQVGDANINTQEGGIHKEILRVIGNQTATG"
     exon            270..324
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            325..362
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            363..452
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            453..523
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            524..601
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            602..696
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            697..757
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            758..848
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            849..915
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1041
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1600
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1651
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1747
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1840
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1966
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2032
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2100
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2149
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2262
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2335
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2405
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2479
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2549
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2634
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..7083
                     /gene="Parp8"
                     /gene_synonym="2810430O08Rik; ARTD16; D13Ertd275e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaacaggag gaaattggaa tccagcagcg gcgagcagca gctgggcggt cacatctggg
       61 aatgcaaagc cgacctcctc ctcctcctcc tcctccacct cctcctcctc tctcacccgg
      121 gatcacttcc gaaaccactt cgccttcagc ccctgcctcg gccagaggga tttatttaat
      181 ggggatgtgt tcaaggcaag agagaattca gaaggatatc gacgtcgtga tccagaagtc
      241 aagagccgag aaagactgcc tgtttgcaga tttcagatac tcagactcca cctttacttt
      301 cacctacgtt ggcggcccca aaagtgtatc ctactccgtc cacgtctcag aagactaccc
      361 agacaacacg tatgtgtcaa gttcagaaaa tgatgaggat gtcctagtca ctacagaccc
      421 aattcctgtc attttccata gaatagcaac agaattaagg aaaacaaatg atattaactg
      481 ttgtttgtcc ataagatcta agttacaaaa ggaaaatggg gaggagtcaa ggcaaaatag
      541 tacggtggaa gaagactcag agggtgacaa cgactctgaa gaattttatt atggaggaca
      601 ggtgaactat gatggggaac tacacaagca ccctcagcta gaagctgatc tgtctgcggt
      661 gagagagctc tatggaccac atgcagtttc tctcagggaa tatggggcta tcgatgatgt
      721 agatattgat ctgcacattg atgtcagctt tctggatgag gagattgctg tggcctggga
      781 agtgattaga acagaaccta ttattgtccg actacactgc tctcttacac agtatttaaa
      841 cggcccagtg cccacggttg atgtctttca gatttcgaca aaagagcggt ttggattggg
      901 acatcaactg aaaaaaatca tgcagacgtt tgtttctcag cagtggaaac agagcaaaga
      961 caagtccaat tgcccgcacg gtaagaagct gtcagagaag aaggtgaagt cacctctgca
     1021 tttgttttct accctgcgca ggtcgcccag ctatcctccc cctggttgtg gcaaaagcaa
     1081 atccaaactg aaacccgaac aagacggcat ctccaaaaca cacaagctgc tgcggaggac
     1141 ttgctccagt actgtcaaag ccgatgatat gtgtgccaag tcgcacagga ccttcgggcg
     1201 ctcgctgtcc agcgacccca gggccgagca ggcgatgtcc accattaaat cgcacaaact
     1261 tttgggccgg ccctgcccct cagccggcaa gcaagaggac tgcctcacac tgaagtccca
     1321 taagttattg actcgatctt gttctggaga cccacgatgt gagcacaaca ccaacttgaa
     1381 gccccacaaa ctgctaagca gatcttactc cagtaatctc agaatggaag agttatatgg
     1441 cctgaaaaat cacaaattgc tcagcaagtc ttactccagt gcccccaaga catcgaaaat
     1501 ggagcatttc aaggaaccca acgcagaggg caggaggctc tcgcttacct cagggcttat
     1561 cggtatttta acaccatcat cgtcttcttc ccagcctcct acaaatggtg caaaaagcat
     1621 tccaatccga gaccgcggct tcctggtgca gaccattgag tttgctgagc agcggatccc
     1681 tgtactgaat gaatattgtg tggtgtgtga tgaaccacac gtgtttcaaa atggccccat
     1741 gcttaggccc acagtatgtg agcgagagct gtgtgtgttt gcttttcaaa ccctgggagt
     1801 gatgaatgaa gctgccgacg agatcgctac cggagctcag gtggtagatc tgcttgtgtc
     1861 catgtgtaga tctgcgttgg aatctcctag aaaagttgtc atttttgagc catatccttc
     1921 tgtggtagat cctaatgacc ctcagatgtt agccttcaat cccaggaaga agaactatga
     1981 tcgtgtaatg aaagctctgg acagcataac ttccatcaga gaaatgacac aggcacccta
     2041 tctggaaatc aagaagcaga tggataaaca ggaccccctt gctcatccac ttctgcaatg
     2101 ggtcatctca agtaataggt cacatattgt gaaactgcca gtcaacaggc aactgaagtt
     2161 catgcacacg ccacaccagt tcctcctcct cagcagccca ccagccaaag agtccaactt
     2221 cagagccgcc aagaagctct tcgggagcac cttcgcattt catggctctc acattgaaaa
     2281 ctggcactct atcctgagga atggtctggt cgttgcctct aacacgcgtc tgcagctcca
     2341 cggtgcaatg tacggaagtg ggatctatct tagcccgatg tccagcatat catttggtta
     2401 ctcagggatg aacaagaagc agaaggtgtc aagcaaggac gagccagctt ccagtagtaa
     2461 aagcagcaat gcatcacagt ctcagaaaaa aggacagcaa tcccagttcc tgcaaagccg
     2521 taacttgaaa tgcatagcct tatgtgaagt gatcacgtca cctgacctgc acaaacatgg
     2581 cgagatatgg gttgtcccga acacggatca tgtctgtaca agattctttt ttgtttatga
     2641 agatggccag gtgggagatg ccaatatcaa cacacaagaa ggaggtattc acaaagagat
     2701 actccgtgtg attggtaatc agactgcgac tggttaaagg aagaccacgt aacaggatct
     2761 gaaaagcctt cctcgggttc aaagctggat tttgaactga agaagatgac aaaataattt
     2821 attgttatta taaacaaaat taaccctttg aatactgatt tttttttctt ttcttagtat
     2881 ttctaaatat ttcattaaat gcctaaaatg gtataagatt taccgattgt agggttatgg
     2941 aatctagtaa ataaacatta aacagcactt aaactgaagt ttgggttgcg tacacaataa
     3001 acagattgaa aaaacagttt tgtgctgata tttttatatg aaatccttta attggacatt
     3061 cggtatcata tactgctatt ataggatact gaagtagaat tgaggtcgtt ctataatggc
     3121 ttctaaatct gccagacagt ctgcaataag tacaatgtct gcacgtggcg gtgtgctcag
     3181 tcagtgtgag tcacaccaac atttgaatgc cataggaggg atattcctat tctcatgtct
     3241 tttcttataa aacggcagtt aggtccagag gcagtgcaat gccagaaggc ttggagcaca
     3301 cccatctgta gatgtcatgt ttcaggatgt gcgattgagc acatgtgtgc atgttcatgc
     3361 tgcatgtatt ttgacagcag agatggatag cttcttcatt ctgtcattta gtgaacagaa
     3421 aatcacaatc aataggcagt aagtctggac ataaactgaa aaatgagcca aatttactgt
     3481 agttcattca catacacaaa aaaatactta tacgctcatt ttttttcccg atagtttgat
     3541 gaaatttttc actggttaat ataactaatt taaaatgtta cctgaaagtc aactagggga
     3601 aaagtaatgt ccctggtggc tcacatctgt atttaaatac ttagttgatt tttaaaaagg
     3661 accatagaag taaccgaaag tgcacatttc ttatttcttc cagtggagtt tacttgtacc
     3721 atacctgtat ttttgtattt tcatctgcta cctctgatta tttttttcat attgagaaag
     3781 aaggtcaact ctgaagctcc ttttacatta aaagaacaca agcttacaga gaacgctcac
     3841 ctccctgtca gcactttgtc gagagtcatg cgctcatcca atcctttctg ttcttttgtt
     3901 tcttagattc ataggccttt caagttttaa ctgacattgt ttattttgct atatgaacga
     3961 tacctttgga atcagaccat tcatgggagc agtttaatta gtgagtttgc cactctattt
     4021 agtccctgaa tcaaggctcc tatctgattt tgtgtaaaca gaaaaaaact acaaacatgt
     4081 catcatttgc agttgtggtg taataatttt cctctttatt ccctttggca taaaaggtga
     4141 gaggcgggtc atgcttgttg tcaggggttg cagtttagaa agattttact ggtcatttgt
     4201 tttccttata ctataaataa ttgaaatgcc accacttatg aaaaaaaaac agaattgaag
     4261 aggctgggat acaagtagtt taatagtgtc tgctcagagg agcatcgatt tgttgtgact
     4321 tctccctctg atctagggag taatatcagc atattagatc ctctattgag cgttcagtga
     4381 tcagttattt gaagacttgt gtggcatgag aatatcattt acttctttct accagacatc
     4441 ctaagtcatt gcaacaatat tttgagatat tttctaggca acaaaaaagg aagtgatttt
     4501 atgggacgtt ctacatgaga taataatata aagatgtaat tcctaaattt aaaatgggtg
     4561 cttgtcttag gatcctccta tcaagatacc agtgaggaac ctccgaaaag tctgtagaat
     4621 gcctcctagc ttaattgaaa ccccctgacc tgtcaattat ggtttcattt aatagttagt
     4681 atgctgtact cgaatatgaa ccagaagggt aacctgtatt tgcattcaag ggaaataatt
     4741 aagaggaggg aaaactgaca tcaaaaactt ctactgccaa tttaagagta caagaaaatt
     4801 tgcctattca agtagaaaag taattggtag tttaataccc atttaataca acacagcaat
     4861 gggcatttta tgataattaa atgagatatc ttaaaatgat catcgagttg tattaccttc
     4921 ccagaattag tttcccacaa ttgcatcaga acttttataa gcaaatattc taaaaagaga
     4981 aaaactttta ttgaactttt gaaattggaa ctcttatgat atattaatga aaatgcttat
     5041 atttctaaag gatgtaattt ctactaatac cattagctgg tgaataccct acttctaaaa
     5101 ctcaaggtct ctaaaaaatt cagaaacaac tatcatccta tgacccagtt gccctattag
     5161 ggtgatttta cttgatgact ctagaaattt tagatggtat tgcagtttaa ttatcgttgg
     5221 aaatctatcc attgtctttt ataacagtaa tattagctct ttagtcattg ctactcagta
     5281 ctacccacaa agcaaacctc attcgtcata tagagtaggg tccattcttt ctcatgttgc
     5341 taattttatg gaacatttca ttaggaaaca ttcttcctct tttgctacaa aatagagatg
     5401 aaatgactgg aaattgaagc agagaaaaat gtaatgagat ataaataatg aagtactaca
     5461 gagttgagtg tgtcacagtg aagcactttg atgtgcccag gagtatgata ggctgggagt
     5521 taatctcagt cagatgttgg gttcaaaggt tttttattta aacttgaatt ttaaaagtgc
     5581 catatcctta gagttgctgt gaaactctgt agaaataaga gatgaaccca agttgatgtg
     5641 attgttcctc cttggaaatt ttaagaatat ggcatagtag ccactcagtt tccactcctc
     5701 tactgattaa aagtgagcat taaatatgga agtctataat ctttaatacc ccttgagact
     5761 tttaccaatg tttgccaaat tggtaaaagt ttcattaatc ataacttgtt tcaggacatg
     5821 cagtttcaga aagcattcag gacaaactca tccacaactt tcatcacaca gtaatttaat
     5881 atcacgaagg gccactcaat cttggatcat ctctcatcca aatgaataga gatatcatgg
     5941 tcacatttga agcacattaa agaaacacac tatcctattg gcctgctgaa ttcttcgttc
     6001 taacactacc tcagcactaa agagtgactg cttataaaag caaattggtt tccagagtaa
     6061 ggaacaaata caattttaca gactgaagtc gtcaaatcaa tcaacagttg agaccatact
     6121 agacacagac attgccggct ccttcccaag ggcagtagcc taggcatctt agtcacagca
     6181 atcaatgaca tagttaatga gttattgcaa aggatttaag tggcataatt ataagtcaat
     6241 tagttcactg ttaggctcat tttctacatg ggccactttc atgtccaatc acttaagagc
     6301 cacagttacg cacacgaaag ggttaaagag tttaaagagc aaaacaaaat aaccccagtt
     6361 gctgggctag aacgacaaac tgaatattca aatactgttg gcaactattg cctatgaaat
     6421 ttttgtcagc tcatctatgg atttgatgta tattattacc cagtaaattt ttcttgggga
     6481 ctttgtacac accatgaaat atagactaag tttttgtcag tcaaaagtat ttcaagtagc
     6541 ttttagacaa aacatatcca tgagtgtgaa aacgctgtct tgaggaatag attacgttac
     6601 ccatttacca gcaagtccac aaaaaataaa ataaaaaata aaataaaaaa taaaaataaa
     6661 taaatagtac ttacttacat agtcaacgtc atttaatgtt ctaaaacagt ttcttcaaat
     6721 ctgcccaata tttaatgtat catttgagat ttttaaaact gcagccacat ctttatgtaa
     6781 acattaaggt atgcctatgt ttctttgaca accttcttta caagaaattt cttgactttt
     6841 gtgcacagaa tagtattgca acctgctatt tagcctttgg tgccttagag ttattctaac
     6901 tatttaacaa tatgtacata atgtaaatac tgccaagaga tcactaaggc caaatatttt
     6961 ctctattcac tttttattgc acttgctttc tattgctccc tcagcctctt ttatccagct
     7021 ttgtaatagt tctaccattg tagccgatgt acatgtttac tttcaataaa tctggatttg
     7081 ttc
//
