LOCUS       NM_001205239            2714 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus poly (ADP-ribose) polymerase family, member 6 (Parp6),
            transcript variant 1, mRNA.
ACCESSION   NM_001205239
VERSION     NM_001205239.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2714)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2714)
  AUTHORS   Vermehren-Schmaedick,A., Huang,J.Y., Levinson,M., Pomaville,M.B.,
            Reed,S., Bellus,G.A., Gilbert,F., Keren,B., Heron,D., Haye,D.,
            Janello,C., Makowski,C., Danhauser,K., Fedorov,L.M., Haack,T.B.,
            Wright,K.M. and Cohen,M.S.
  TITLE     Characterization of PARP6 Function in Knockout Mice and Patients
            with Developmental Delay
  JOURNAL   Cells 10 (6), 1289 (2021)
   PUBMED   34067418
  REMARK    GeneRIF: Characterization of PARP6 Function in Knockout Mice and
            Patients with Developmental Delay.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2714)
  AUTHORS   Nakano,Y., Wiechert,S., Fritzsch,B. and Banfi,B.
  TITLE     Inhibition of a transcriptional repressor rescues hearing in a
            splicing factor-deficient mouse
  JOURNAL   Life Sci Alliance 3 (12), e202000841 (2020)
   PUBMED   33087486
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2714)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   5  (bases 1 to 2714)
  AUTHORS   Kasowitz,S.D., Ma,J., Anderson,S.J., Leu,N.A., Xu,Y., Gregory,B.D.,
            Schultz,R.M. and Wang,P.J.
  TITLE     Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and
            splicing during mouse oocyte development
  JOURNAL   PLoS Genet 14 (5), e1007412 (2018)
   PUBMED   29799838
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2714)
  AUTHORS   Zhang,M., Chen,D., Xia,J., Han,W., Cui,X., Neuenkirchen,N.,
            Hermes,G., Sestan,N. and Lin,H.
  TITLE     Post-transcriptional regulation of mouse neurogenesis by Pumilio
            proteins
  JOURNAL   Genes Dev 31 (13), 1354-1369 (2017)
   PUBMED   28794184
REFERENCE   7  (bases 1 to 2714)
  AUTHORS   Huang,J.Y., Wang,K., Vermehren-Schmaedick,A., Adelman,J.P. and
            Cohen,M.S.
  TITLE     PARP6 is a Regulator of Hippocampal Dendritic Morphogenesis
  JOURNAL   Sci Rep 6, 18512 (2016)
   PUBMED   26725726
  REMARK    GeneRIF: PARP6 is a regulator of dendrite morphogenesis, supporting
            a role for mono-ADP-ribosylation in neurons during development.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2714)
  AUTHORS   Nakano,Y., Jahan,I., Bonde,G., Sun,X., Hildebrand,M.S.,
            Engelhardt,J.F., Smith,R.J., Cornell,R.A., Fritzsch,B. and Banfi,B.
  TITLE     A mutation in the Srrm4 gene causes alternative splicing defects
            and deafness in the Bronx waltzer mouse
  JOURNAL   PLoS Genet 8 (10), e1002966 (2012)
   PUBMED   23055939
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ442721.1, BC062096.1 and AC160637.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.183822.1,
                                           SRR7974084.6221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-350               BQ442721.1         1-350
            351-1569            BC062096.1         208-1426
            1570-1570           AC160637.2         130427-130427       c
            1571-2709           BC062096.1         1428-2566
            2710-2714           AC160637.2         115006-115010       c
FEATURES             Location/Qualifiers
     source          1..2714
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 32.02 cM"
     gene            1..2714
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /note="poly (ADP-ribose) polymerase family, member 6"
                     /db_xref="GeneID:67287"
                     /db_xref="MGI:MGI:1914537"
     exon            1..125
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            126..365
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            366..560
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             558..2450
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /EC_number="2.4.2.30"
                     /note="isoform 1 is encoded by transcript variant 1; poly
                     [ADP-ribose] polymerase 6; ADP-ribosyltransferase
                     diphtheria toxin-like 17; protein
                     mono-ADP-ribosyltransferase PARP6"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP6
                     isoform 1"
                     /protein_id="NP_001192168.1"
                     /db_xref="CCDS:CCDS57680.1"
                     /db_xref="GeneID:67287"
                     /db_xref="MGI:MGI:1914537"
                     /translation="MDIKGQFWNDDDSEGDNESEEFLYGVQGSCAADLYRHPQLDADI
                     EAVKEIYSENSVSIREYGTIDDVDLDLHINISFLDEEVSTAWKVLRTEPIVLRLRFSL
                     SQYLDGPEPSIEVFQPSNKEGFGLGLQLKKILCMFTSQQWKHLSNDFLKTQQEKRHSW
                     FKASGTIKKFRAGLSIFSPIPKSPSFPIIQDSMLKGKLGVPELRVGRLMNRSISCTMK
                     NPKVEVFGYPPSPQAGLLCPQHVGLPPPARTSPLVSGHCKNIPTLEYGFLVQIMKYAE
                     QRIPTLNEYCVVCDEQHVFQNGSMLKPAVCTRELCVFSFYTLGVMSGAAEEVATGAEV
                     VDLLVAMCRAALESPRKSIIFEPYPSVVDPTDPKTLAFNPKKKNYERLQKALDSVMSI
                     REMTQGSYLEIKKQMDKLDPLAHPLLQWIISSNRSHIVKLPLSRLKFMHTSHQFLLLS
                     SPPAKEARFRTAKKLYGSTFAFHGSHIENWHSILRNGLVNASYTKLQLHGAAYGKGIY
                     LSPISSISFGYSGMGKGQHRMPSKDELVQRYNRMNTIPQTRSIQSRFLQSRNLNCIAL
                     CEVITSKDLQKHGNIWVCPVSDHVCTRFFFVYEDGQVGDANINTQDPKIQKEIMRVIG
                     TQVYTN"
     exon            561..638
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            639..733
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            734..794
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            795..885
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            886..952
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1102
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1313
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1367
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1463
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1556
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1682
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1748
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1816
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1865
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1975
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2048
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2118
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2198
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2262
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2347
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2714
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2674..2679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /note="hexamer: AATAAA"
     polyA_site      2709
                     /gene="Parp6"
                     /gene_synonym="1700119G14Rik; 2310028P13Rik;
                     3110038K10Rik; ARTD17; C030013N01Rik; PARP-6"
                     /note="major polyA site"
ORIGIN      
        1 ggcgtgtggt gcgcgacctc acccgcccgc ctcggtcccc gccccttggc ctgccgctcc
       61 gcccccgcgg ggcgtcccgg gccgctcgtc ccctccgcgg cggccgcgcg cggcccgggg
      121 tcgcccatca gaaaccaagc agcaaaccct gaggagatgc tcagttttcc ttgacttcta
      181 cagtgaaaga ccttgagaaa gttggcactt ctagcctaag ctgccctcat tctactgctc
      241 accccaagac aacccaggct ggactgtagt gcttccctct tcgtccagag cagcatttga
      301 ctgttttcaa tctaaaagaa ccctggtccc aaacttcata attggcacct cagctgctct
      361 tgaaggacag tgacttatta ctatcacagc agaacctgcc atccccagca gattgccagc
      421 acctatgaca tcatcccctt cttcgtctca ttctgtggtc tcctaaatgc tcatctcgtt
      481 ggcctgggtt cagttggtgg tatggagggg tgctgcttag cactgacctg agagtgtgtg
      541 tgaaacccac tgacccaatg gacatcaaag gccagttctg gaatgatgat gattcagaag
      601 gagataatga atcagaggaa tttctgtatg gagttcaggg gagctgtgca gctgacctgt
      661 atagacaccc acagcttgat gcagacattg aagcagtgaa agagatctac agtgagaact
      721 ccgtgtccat cagagaatat ggaactatcg atgacgtgga ccttgacctc cacatcaaca
      781 tcagcttcct cgatgaggaa gtatctacag cttggaaggt ccttcgaaca gaacctattg
      841 tgttgaggct acggttttct ctctctcagt accttgatgg accagagcca tcaattgagg
      901 ttttccagcc atcgaataag gaagggtttg ggctaggtct tcagttgaaa aaaatcctgt
      961 gtatgtttac atcccaacaa tggaagcatc tgagcaatga tttcttgaag acccagcagg
     1021 agaagaggca cagttggttc aaggcaagtg gtaccatcaa gaagttccga gctggcctca
     1081 gcatcttctc acccattccc aagtctccca gttttcctat catacaggac tctatgctga
     1141 aaggcaaact gggtgtacca gagctccgag ttggacgcct tatgaatcgt tccatttctt
     1201 gcaccatgaa gaacccaaaa gtagaggtgt ttggctatcc ccccagcccc caggcaggtc
     1261 tcctgtgccc ccagcacgtg ggcctccctc ccccagcacg gacttctcct ttggtcagtg
     1321 gtcactgcaa gaacatcccc actctggagt atggattcct tgtccagatt atgaagtatg
     1381 cagagcagag gattccaacg ttaaatgagt actgtgtggt ttgtgatgag cagcatgtct
     1441 tccagaatgg gtccatgctc aagccagctg tctgtactcg tgagttatgc gtcttctcct
     1501 tctacacact gggagtcatg tctggagctg cagaagaagt ggctacagga gcagaggtgg
     1561 tagatctgct ggtggccatg tgtagagcag ctttggaatc ccctagaaaa agcatcatct
     1621 tcgagcctta tccctctgtg gtggacccca ctgatcccaa gactctggcc tttaacccta
     1681 agaagaagaa ttatgagcgg cttcagaaag ctctggatag tgtgatgtcc atccgggaga
     1741 tgacccaggg ctcatatttg gaaatcaaga aacagatgga caagctggat cccttggccc
     1801 atcctcttct gcagtggata atttctagca acaggtcaca cattgtcaaa ctacctctca
     1861 gcaggctgaa gttcatgcac acctcacacc aattcctcct gctgagcagc cctcctgcca
     1921 aggaggctcg gttccggaca gccaagaagc tctacggaag cacctttgct ttccatgggt
     1981 cccacattga gaattggcat tcaatcctgc gcaatgggct ggtcaatgca tcctacacca
     2041 aactgcagct gcatggagca gcctatggca aaggcatcta cctgagcccc atctccagta
     2101 tttcctttgg atactcagga atgggcaaag gacagcacag gatgccttcc aaggatgagc
     2161 tggtccagag atacaacagg atgaacacca tcccccagac ccgatccatt cagtcaaggt
     2221 tcctgcagag tcggaatcta aactgtatag cactttgtga agtgattacg tctaaggacc
     2281 tccagaagca tgggaacatt tgggtgtgcc ctgtgtctga ccatgtctgc acaaggttct
     2341 tctttgtata tgaggatggg caggtgggcg atgccaacat taatactcag gaccccaaga
     2401 ttcagaagga aatcatgcgt gtgatcggaa ctcaggttta cacaaactga gggggcccca
     2461 gccctcgtac caccctgtta ccccaggatc catctgccct tgtaaaagga ctcaggagca
     2521 gcaagtgagg ctgtcctgag aaactcaagg ggcaaaaaaa gtatagaaga ggtggccttc
     2581 atggtggaga ttgatccagg aactactcca catttggatg gccctgactg actcccaccc
     2641 ctgatttgcc caattgactt caccctgttt gtaaataaaa caataaaatg gaaggtgctg
     2701 tggactggat atga
//
