LOCUS       NM_001145978            6391 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus poly (ADP-ribose) polymerase family, member 4 (Parp4),
            mRNA.
ACCESSION   NM_001145978 XM_978866 XM_994286
VERSION     NM_001145978.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6391)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6391)
  AUTHORS   Vezzali,R., Weise,S.C., Hellbach,N., Machado,V., Heidrich,S. and
            Vogel,T.
  TITLE     The FOXG1/FOXO/SMAD network balances proliferation and
            differentiation of cortical progenitors and activates Kcnh3
            expression in mature neurons
  JOURNAL   Oncotarget 7 (25), 37436-37455 (2016)
   PUBMED   27224923
REFERENCE   3  (bases 1 to 6391)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   4  (bases 1 to 6391)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6391)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   6  (bases 1 to 6391)
  AUTHORS   Raval-Fernandes,S., Kickhoefer,V.A., Kitchen,C. and Rome,L.H.
  TITLE     Increased susceptibility of vault poly(ADP-ribose)
            polymerase-deficient mice to carcinogen-induced tumorigenesis
  JOURNAL   Cancer Res 65 (19), 8846-8852 (2005)
   PUBMED   16204055
REFERENCE   7  (bases 1 to 6391)
  AUTHORS   Liu,Y., Snow,B.E., Kickhoefer,V.A., Erdmann,N., Zhou,W.,
            Wakeham,A., Gomez,M., Rome,L.H. and Harrington,L.
  TITLE     Vault poly(ADP-ribose) polymerase is associated with mammalian
            telomerase and is dispensable for telomerase function and vault
            structure in vivo
  JOURNAL   Mol Cell Biol 24 (12), 5314-5323 (2004)
   PUBMED   15169895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK164513.1, AK172907.1, AC154731.2 and AK053992.1.
            
            On Dec 23, 2009 this sequence version replaced NM_001145978.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849377,
                              SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1583              AK164513.1         1-1583
            1584-2633           AK164513.1         1585-2634
            2634-3821           AK172907.1         2566-3753
            3822-5597           AC154731.2         104851-106626       c
            5598-6391           AK053992.1         234-1027
FEATURES             Location/Qualifiers
     source          1..6391
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.31 cM"
     gene            1..6391
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /note="poly (ADP-ribose) polymerase family, member 4"
                     /db_xref="GeneID:328417"
                     /db_xref="MGI:MGI:2685589"
     exon            1..112
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            113..245
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..6023
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /EC_number="2.4.2.30"
                     /note="ADP-ribosyltransferase (NAD+; poly (ADP-ribose)
                     polymerase)-like 1; mVparp; poly [ADP-ribose] polymerase
                     4; vault poly(ADP-ribose) polymerase;
                     ADP-ribosyltransferase diphtheria toxin-like 4"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP4"
                     /protein_id="NP_001139450.2"
                     /db_xref="CCDS:CCDS49503.1"
                     /db_xref="GeneID:328417"
                     /db_xref="MGI:MGI:2685589"
                     /translation="MTLGIFANCIFCLKVKYLPRQQKKKLQTDIKENGGKFSFLLNPQ
                     CTHVIVDSADVLSRCHLNSIQKNDVQIANPAFIQDSVRQRRLLDVRNYDPLSPAPAAP
                     PAERSRSEVQSEYLPSDNTPEKENTEVTEVSAENVEIPPFLQDFEVVKYNILEKVGGP
                     ETVVVELQSSQDPESCPFVITAHFLLADQKTRRESTGKQTSEGAIEYYESYVEDLKRQ
                     GFLLQEHFTAEATQLASEKLQALLLEEVISSGALSQEVSDLLEVIWTEALGHLENTLL
                     KPVNSMSLNDVSKAEGILLLVKTALKNGDSPGQLQKTMAEFYRLLPHRHPASEEVNLR
                     LLAQKEDLCQLVRDMVNVCETNLSKPNPPSLAKYRALRCKIEHVDQNTEEFSRVRKEV
                     LQNNRSEQPVDILQIFRVGRVNEATEFLSKLGNVRLLFHGSPVRNILGILSRGLLLPK
                     VAEDRGVQRTDVGNLGSGIYFSDSLSTSIKYAHAGETDGSRLLVVCDVALGKCVNLFK
                     KDFSLTEAPPGYDSVHGVSETTSVPTDFQDDEFVVYKTNQVKMKYIVKFCTPGDQIKE
                     FHPHENTEVEEQRAEPSSVPEAGDFQLPDIKPFTNIKAGLQDASANPVPLDSVHIKGR
                     VIDFVAQVIVFQTYTNQSHVPIEAKYIFPLDDKAAVCGFEAFINGKHIVGEIKEKEEA
                     RQEYREAVSQGHGAYLMDQDTPDVFTVSVGNLPPRAKVLIKITYITELSIQSPVAIFF
                     IPGTVAPWQQDKALNENLQDTVETIRIKEIGAEQSFSLAMSIEMPYMIEFISSDTHEL
                     RQKSTDCKAVVSTVEGSSLDSGGFSLHIGLRDAYLPRMWVEKHPEKESEACMLVFQPE
                     LADVLPDLRGKNEVIICLDCSSSMEGVTFTQAKQVALYALSLLGEEQKVNIMQFGTGY
                     KELFSYPKCITDSKMATEFIMSAAPSMGNTDFWKVLRYLSLLYPSEGFRNILLISDGH
                     LQSESLTLQLVKRNIQHTRVFTCAVGSTANRHILRTLSQCGAGVFEYFNSKSKHSWKK
                     QIEAQMTRIRSPSCHSVSVKWQQLSRDAPEPLQAPAWVPSLFHNDRLLVYGFIPHCTQ
                     ATLQAFIQEKEFCTMVSTTELQKTTGTMIHKLAARALIRDYEDGILHDDETNHEMKKN
                     IMKSLIIELSKENSLITQFTSFVAVEKRDVNEIPFANVPNISELVAKEDVDFLPYVSW
                     QEKQPEASISQTEIDSSRLKHNKLSDGHGVLQPVSVSSEVNEKPSLLLAAKKRKIKTI
                     KKCSLDISEDFEDRTAVAQSPATAQSLNFHLPLSVRPQLKAVEQQLHGNRLEPKQRGG
                     FRKLLMAKKCRNVPDSLVSSAPAVTAEFSYLSACSSSSAFLSPLCDIPSSLPPHPLGG
                     THPPPPLPLPDGTHLPSPLFGSTHPPPPLFGGTLIPPPSSLFGGTHLPPPPPLPGGTH
                     IPPPPPIPGGTLIPPSSSLFGGTHLPPPPLLSAGTHIPPPPLLSAGTHLPPPPLLPAG
                     THIPPPPPITGSTHPPPPSSLFGGTHLPPPPPLPGGTHIPPPPPIPGGTLIPSPSSLF
                     GGTHLPPPPLLPAGTHIPPPPPITGSTHPPPPSSLFGGTHLPPPPPAGTQFSLSPIGF
                     IPPKLGPPKLSHSHKLVGDTNIHDSEPPLLGFKDLCSRDMGFSCGTAFSGSFASSKDF
                     DPGKFSQGPNNISFSPKAPEMGVLHQSPFCSPPKPPSAPPLVTNVLCSEAPQSYFLNL
                     QSAAVHQSPNNRVSEIIMESVESSLPSDYSSRDASSYLALEGAEDSLLGGSSFETDTD
                     EAAAFIANDLLTSIETSSDEECAFCDEDQESPVPWASLFALQTENGFWKLTPELGLIL
                     NLNVNALLTSLEEKGIRSLGTKGRERLLDLIATLLVLQFLYTKLEQEGMVAKSLIKMD
                     DAFISRNIPWAFENIKKAREWARKTEGQYPSICQRLELGKDWESATKQLLGIQPQANT
                     SLHRILYYSQG"
     exon            246..441
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            442..505
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            506..581
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            582..683
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            684..833
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            834..971
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1145
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1306
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1444
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1540
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1724
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1881
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2006
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2138
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2225
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2390
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2437
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2516
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2654
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2850
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..2918
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3106
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3206
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            3207..3377
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            3378..3458
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            3459..3539
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..3635
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            3636..3758
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            3759..3821
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            3822..5597
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            5598..5697
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            5698..5830
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
     exon            5831..6391
                     /gene="Parp4"
                     /gene_synonym="Adprtl1; ARTD4; C030027K23Rik;
                     E230037B21Rik; Gm743; p193; PARP-4; PARPL; PH5P; VAULT3;
                     VPARP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acctaacccg gctgcgcctg gagcggaagc accaaggctg gaacgctggc tgcggagcac
       61 ggaggagggg accatccgac accaggaagg gccaggcggg atctccgagc aggatgactt
      121 taggaatctt tgcaaattgt atattctgct tgaaggtcaa gtacttacct cgtcagcaga
      181 agaaaaagct gcaaactgat attaaggaaa atggcggaaa gttttccttt ttattaaacc
      241 ctcagtgcac acatgtcatc gtagacagtg ctgacgtcct gagtcggtgt catctgaact
      301 ccatccaaaa gaacgatgtg cagattgcca acccagcatt catccaggac tctgtgagac
      361 agaggagact cctggatgtg aggaattatg atcctctgtc gccggctcca gcagcaccac
      421 cagctgaaag gagcaggtct gaagtgcaat cagaatatct gccttcagac aacaccccag
      481 agaaggaaaa caccgaagtc actgaggttt ctgcagagaa tgttgaaatt cccccctttc
      541 ttcaagactt tgaagttgtg aaatataaca tcttggaaaa ggtaggaggc cccgagactg
      601 tggtggtaga gctgcagagc tcccaggacc cagagagctg cccctttgtg ataacagcac
      661 acttcctcct ggctgatcaa aagaccagga gagagagcac tggaaagcaa acttctgaag
      721 gtgcaattga atattatgaa agttatgtgg aagacctgaa gagacaagga tttctgctcc
      781 aagaacactt tacggccgaa gcaacacagt tagcgtctga gaaactgcag gcgttgcttt
      841 tggaggaggt cattagttca ggcgccctga gccaggaggt gagcgatttg ctggaggtga
      901 tctggacaga agctctgggc cacctggaga acacgctcct caagccagtg aacagcatga
      961 gcctgaatga cgtgagtaaa gcagagggaa ttctccttct ggtgaagaca gccctgaaga
     1021 atggagactc gcccggacaa ctgcagaaga caatggccga gttctaccgc ttgctgcctc
     1081 acaggcatcc agcctcagag gaagttaacc tgaggctgtt ggctcaaaaa gaggaccttt
     1141 gtcagctggt aagagacatg gtgaatgttt gtgaaactaa tttatccaaa cccaacccac
     1201 catctcttgc caaataccgt gctttgcgat gcaaaatcga acatgttgac cagaacactg
     1261 aagaattttc cagggttaga aaagaagtgt tgcagaataa tcgaagtgaa caaccagtag
     1321 atatcttgca gatatttaga gttggcagag tgaatgaagc tacggagttt ttaagcaaac
     1381 tgggcaacgt gcgactctta tttcatggat ctcctgtgcg gaacattctt ggaatcttgt
     1441 cccgagggct gctcttacct aaggtagctg aagaccgcgg tgtacagaga acagatgttg
     1501 gaaatctcgg gagcgggatc tacttcagcg actcactcag tacaagcatt aagtatgcac
     1561 acgcaggaga gacagatggg tccagactcc tggtcgtctg tgacgttgcc ctgggaaagt
     1621 gtgtgaactt attcaagaag gacttttctt taactgaggc gccaccaggc tatgacagtg
     1681 tgcatggagt ttcggaaacc acctctgtcc ccacagactt tcaggacgat gaatttgttg
     1741 tatataaaac caaccaagtt aaaatgaaat acattgttaa attttgcact cctggagatc
     1801 aaataaagga attccatcct catgaaaata ccgaagtaga ggagcaaagg gctgagccct
     1861 ccagtgttcc agaggctgga gatttccagt taccagacat caagcccttc acaaacatca
     1921 aagccggcct tcaggatgca tctgcgaatc ctgttcctct tgacagtgtt cacattaagg
     1981 gaagagtaat agacttcgta gcccaggtca ttgtttttca gacatacacg aatcaaagcc
     2041 acgtgcctat tgaggcaaaa tatatcttcc cattggatga caaagcagct gtgtgtggct
     2101 tcgaggcatt catcaatggg aagcacattg tgggagagat aaaggaaaag gaagaggccc
     2161 ggcaggagta ccgagaggct gtcagccaag gccatggtgc ttacttgatg gaccaggaca
     2221 ctccggatgt tttcactgta agtgttggaa acttaccccc tcgggctaaa gtcctcatca
     2281 aaatcaccta catcacggaa ctcagcatcc agagtcctgt ggccatcttc ttcatccctg
     2341 gcactgtagc accctggcaa caggacaagg cgttgaatga gaaccttcag gatacagtgg
     2401 agacaattcg tataaaggaa attggagcag agcaaagctt ctccctggct atgtccattg
     2461 agatgcccta catgattgaa ttcatttcca gtgacacaca tgaactgaga caaaagagca
     2521 cagactgtaa agctgtggtt agcactgtgg aaggcagctc cttggacagc ggtggatttt
     2581 ctctccacat tggtttgcgt gatgcatacc tcccaagaat gtgggttgaa aaacatccag
     2641 aaaaagaaag cgaggcctgc atgcttgtct ttcaaccgga gcttgcggac gtcctccctg
     2701 acctccgtgg aaagaacgaa gtgattattt gtcttgactg ttccagttcc atggagggtg
     2761 tgacattcac acaagccaag caggttgccc tgtatgctct gtctttgctg ggtgaagagc
     2821 agaaagtcaa cattatgcaa tttggcacag gttacaagga actgttttca tatcctaagt
     2881 gcatcacgga cagtaaaatg gccacagagt tcattatgtc tgcagcacct tccatgggga
     2941 acacagactt ctggaaagtt ctccgctatt taagtctcct gtacccttca gaagggttcc
     3001 ggaacattct cctcatatct gatgggcacc tccagagtga gagtctgaca ctgcagcttg
     3061 tgaaaagaaa tatccagcac accagagtgt tcacctgtgc tgttggttcc acagcaaatc
     3121 gtcacatctt aaggaccttg tctcagtgtg gcgctggagt atttgaatat tttaactcaa
     3181 aatctaagca cagttggaaa aaacagatag aagctcaaat gaccaggata cgttccccaa
     3241 gttgccactc tgtctctgtc aaatggcagc agcttagcag agatgccccc gagcctctgc
     3301 aggccccggc atgggtgccc tctttgttcc acaatgatcg actcctggtc tacggcttca
     3361 ttcctcattg tacacaagca actctgcaag cattcatcca agagaaagaa ttttgcacaa
     3421 tggtgtcaac tacagagctt cagaagacaa ctgggactat gattcacaag ctggcagccc
     3481 gggcactaat cagagattat gaagacggca ttctccacga cgatgaaacc aaccacgaga
     3541 tgaagaaaaa catcatgaaa tctctgatta tcgaactcag taaagaaaat tctcttatta
     3601 cacaatttac aagctttgtg gcagttgaga aaagggacgt aaatgagatt ccttttgcta
     3661 atgtcccaaa tatttcggaa cttgttgcca aagaagatgt tgactttcta ccatacgtga
     3721 gttggcagga aaagcaacca gaggcctcca tatcacagac agagattgat tcttcgagac
     3781 taaagcacaa taaactctct gatggccatg gagtgctaca gcccgtttcc gtctcctctg
     3841 aagtgaatga gaaaccatca ctgctactcg ctgctaaaaa aaggaaaata aagactataa
     3901 agaagtgcag tctagacatt tctgaagatt ttgaagacag gactgcagta gcacagtcac
     3961 ctgcaacagc gcagtctctt aatttccacc tgcctctcag tgtccgccca caactgaaag
     4021 ctgtggagca gcagctgcat gggaaccggc tggagccaaa gcaaagggga ggatttcgaa
     4081 aactgctcat ggcaaagaag tgtcgaaatg tgcctgattc cctggtttcc tctgctcctg
     4141 cagtcacagc tgagttttct tacctttctg cctgcagctc tagttctgcc ttcctgtctc
     4201 ctctctgcga catcccttct tctcttcctc cccatcccct tggtggtacc caccctcctc
     4261 cccctcttcc tctccctgat ggcacccatc ttccttcccc tctctttggt agcacccacc
     4321 ctcctccccc tctctttggt ggcaccctta ttcctccccc ttcttctctt tttggtggca
     4381 cccatcttcc tccccctccc cctctccctg gtggcaccca tattcctccc cctccaccta
     4441 tccctggtgg cacccttatt cctccctctt cttctctctt tggtggcacc catcttcctc
     4501 cccctcccct tctctctgct ggcacccata ttcctccccc tccccttctc tctgctggca
     4561 cccatcttcc tccccctccc cttctccctg ctggcaccca tattcctccc cctcccccta
     4621 tcactggcag cacccaccct cctccccctt cctctctctt tggtggcacc catcttcctc
     4681 cccctccccc tctccctggt ggcacccata ttcctccccc tccacctatc cctggtggca
     4741 cccttattcc ttccccttct tctctctttg gtggcaccca tcttcctccc cctccccttc
     4801 tccctgctgg cacccatatt cctccccctc cccctattac tggcagcacc caccctcctc
     4861 ccccttcctc tctctttggt ggcacccatc ttcctccccc tccccctgct ggcacccaat
     4921 tttctctttc tcctatagga ttcataccac ctaagttggg tccacctaag cttagccaca
     4981 gccataaact tgtcggagat accaacatcc atgactcaga gccacctctc ctgggcttta
     5041 aggatttgtg ctctagagat atgggcttta gttgtggtac cgctttctca ggtagctttg
     5101 ctagttcaaa ggattttgat ccaggtaaat tttcccaagg ccccaacaac atcagcttct
     5161 ctcccaaagc ccctgagatg ggcgttcttc accagtcacc tttttgcagt cctcctaagc
     5221 caccttctgc ccctcctctt gtcaccaacg tactttgctc tgaggctcct cagagctatt
     5281 ttcttaattt gcaaagtgcc gcagtgcatc agagccctaa taacagagtg tcagagatca
     5341 tcatggagtc agttgagtca tctctcccat cagattactc ttccagagat gcgtcatcat
     5401 acttggctct agaaggggca gaagactcct tgctgggtgg aagttctttt gaaaccgata
     5461 cagatgaagc agcagcattt atagccaatg atcttttaac aagtattgag acttcctcag
     5521 atgaggaatg tgccttctgt gatgaagacc aggagagtcc tgtgccgtgg gcttcactct
     5581 ttgctctaca gactgagaat ggtttttgga agctgacacc agaactagga cttatattaa
     5641 accttaatgt aaatgctctg ctcacttctc ttgaagaaaa gggcattcga tctctaggta
     5701 caaaagggcg agagcgtctc ctggatctga ttgccacttt gctcgtactg cagtttcttt
     5761 ataccaagtt ggaacaagaa ggaatggttg ccaagtctct gataaagatg gatgacgcct
     5821 tcatttctag gaatattcca tgggcttttg agaacataaa gaaagcaaga gaatgggcca
     5881 gaaagacaga aggacagtat ccatctatct gccaacggct tgagctgggt aaagactggg
     5941 agtcagccac aaagcaacta ctgggaattc agccccaagc caacacttct cttcaccgaa
     6001 ttctatacta cagccaaggc tgaagccaat gaaattgcat tttaaaactt tcttttattt
     6061 cttttgttat tgttttgttt ttgttttttt ttttttcaag acagggtttc tctgtgtagt
     6121 cctggccatc ctggaactca ctctgtagag caggctggtc tcacactcaa gggatctgcc
     6181 tgcctctgca ttccaagtgc tgagattaaa ggcatccacc actgctctga tgcctttctc
     6241 atatttctat gtagaaaata atcaaatagt aaaatgtacc aataatgacg tgtaatacgt
     6301 gttaaatgta gctacagccc ctttaaaata aaattaatgg aaagaattga ttaatcattt
     6361 aacaacaata aaagctgtaa gaactaatac t
//
