LOCUS       NM_145619               2962 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus poly (ADP-ribose) polymerase family, member 3 (Parp3),
            transcript variant 2, mRNA.
ACCESSION   NM_145619
VERSION     NM_145619.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2962)
  AUTHORS   Zhou,Z., Yin,H., Suye,S., Ren,Z., Yan,L., Shi,L. and Fu,C.
  TITLE     Fance deficiency inhibits primordial germ cell proliferation
            associated with transcription-replication conflicts accumulate and
            DNA repair defects
  JOURNAL   J Ovarian Res 16 (1), 160 (2023)
   PUBMED   37563658
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2962)
  AUTHORS   Peng,X., Liu,H., Wang,J., Jiang,J., Chen,H., Tao,J. and Wu,B.
  TITLE     Fall of PARP3 restrains Lgr5+ intestinal stem cells proliferation
            and mucosal renovation in intestinal aging
  JOURNAL   Mech Ageing Dev 211, 111796 (2023)
   PUBMED   36870456
  REMARK    GeneRIF: Fall of PARP3 restrains Lgr5[+] intestinal stem cells
            proliferation and mucosal renovation in intestinal aging.
REFERENCE   3  (bases 1 to 2962)
  AUTHORS   Layer,J.V., Cleary,J.P., Brown,A.J., Stevenson,K.E., Morrow,S.N.,
            Van Scoyk,A., Blasco,R.B., Karaca,E., Meng,F.L., Frock,R.L.,
            Tivey,T., Kim,S., Fuchs,H., Chiarle,R., Alt,F.W., Roberts,S.A.,
            Weinstock,D.M. and Day,T.A.
  TITLE     Parp3 promotes long-range end joining in murine cells
  JOURNAL   Proc Natl Acad Sci U S A 115 (40), 10076-10081 (2018)
   PUBMED   30213852
  REMARK    GeneRIF: these data indicate that Parp3 and Parp1 promote
            rearrangements with distinct phenotypes.
REFERENCE   4  (bases 1 to 2962)
  AUTHORS   Robert,I., Gaudot,L., Rogier,M., Heyer,V., Noll,A., Dantzer,F. and
            Reina-San-Martin,B.
  TITLE     Parp3 negatively regulates immunoglobulin class switch
            recombination
  JOURNAL   PLoS Genet 11 (5), e1005240 (2015)
   PUBMED   26000965
  REMARK    GeneRIF: We show that Poly(ADP)ribose polymerase 3 (Parp3), an
            enzyme recently implicated in DNA repair, contributes to antibody
            diversification by negatively regulating class switch recombination
            without affecting somatic hypermutation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2962)
  AUTHORS   Boehler,C., Gauthier,L.R., Mortusewicz,O., Biard,D.S., Saliou,J.M.,
            Bresson,A., Sanglier-Cianferani,S., Smith,S., Schreiber,V.,
            Boussin,F. and Dantzer,F.
  TITLE     Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular
            response to DNA damage and mitotic progression
  JOURNAL   Proc Natl Acad Sci U S A 108 (7), 2783-2788 (2011)
   PUBMED   21270334
REFERENCE   6  (bases 1 to 2962)
  AUTHORS   Rulten,S.L., Fisher,A.E., Robert,I., Zuma,M.C., Rouleau,M., Ju,L.,
            Poirier,G., Reina-San-Martin,B. and Caldecott,K.W.
  TITLE     PARP-3 and APLF function together to accelerate nonhomologous
            end-joining
  JOURNAL   Mol Cell 41 (1), 33-45 (2011)
   PUBMED   21211721
  REMARK    GeneRIF: PARP-3 has a role in chromosomal DNA double-strand break
            repair.
REFERENCE   7  (bases 1 to 2962)
  AUTHORS   Urbanek,P., Paces,J., Kralova,J., Dvorak,M. and Paces,V.
  TITLE     Cloning and expression of PARP-3 (Adprt3) and U3-55k, two genes
            closely linked on mouse chromosome 9
  JOURNAL   Folia Biol (Praha) 48 (5), 182-191 (2002)
   PUBMED   12448766
  REMARK    GeneRIF: We cloned and sequenced the cDNAs of the mouse PARP-3
            (Adprt3) gene encoding poly(ADP-ribose) polymerase 3 and of the
            closely linked U3-55k gene coding for the U3 small nucleolar
            ribonucleoprotein complex-associated 55-kilodalton protein.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147868.1 and AF368233.1.
            
            On Jul 25, 2015 this sequence version replaced NM_145619.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region compared to variant 1. It
            encodes isoform 2, which is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147868.1, AF368233.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-298               AK147868.1         2-299
            299-2931            AF368233.1         1-2633
            2932-2962           AK147868.1         2933-2963
FEATURES             Location/Qualifiers
     source          1..2962
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 57.58 cM"
     gene            1..2962
                     /gene="Parp3"
                     /gene_synonym="A930002C11Rik; ADPRT-3; Adprt3; Adprtl3;
                     ARTD3; pADPRT-3; PARP-3"
                     /note="poly (ADP-ribose) polymerase family, member 3"
                     /db_xref="GeneID:235587"
                     /db_xref="MGI:MGI:1891258"
     exon            1..457
                     /gene="Parp3"
                     /gene_synonym="A930002C11Rik; ADPRT-3; Adprt3; Adprtl3;
                     ARTD3; pADPRT-3; PARP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            458..641
                     /gene="Parp3"
                     /gene_synonym="A930002C11Rik; ADPRT-3; Adprt3; Adprtl3;
                     ARTD3; pADPRT-3; PARP-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             465..2051
                     /gene="Parp3"
                     /gene_synonym="A930002C11Rik; ADPRT-3; Adprt3; Adprtl3;
                     ARTD3; pADPRT-3; PARP-3"
                     /EC_number="2.4.2.30"
                     /note="isoform 2 is encoded by transcript variant 2; A
                     DP-ribosyltransferase (NAD+; poly (ADP-ribose
                     polymerase)-like 3; ADP-ribosyltransferase (NAD+, poly
                     (ADP-ribose polymerase)-like 3; NAD+
                     ADP-ribosyltransferase 3; Poly[ADP-ribose] synthetase-3;
                     poly[ADP-ribose] synthase 3; poly [ADP-ribose] polymerase
                     3; NAD(+) ADP-ribosyltransferase 3; DNA
                     ADP-ribosyltransferase PARP3; ADP-ribosyltransferase
                     diphtheria toxin-like 3; protein
                     mono-ADP-ribosyltransferase PARP3"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP3
                     isoform 2"
                     /protein_id="NP_663594.2"
                     /db_xref="CCDS:CCDS23480.1"
                     /db_xref="GeneID:235587"
                     /db_xref="MGI:MGI:1891258"
                     /translation="MAPKRKASVQTEGSKKRRQGTEEEDSFRSTAEALRAAPADNRVI
                     RVDPSCPFSRNPGIQVHEDYDCTLNQTNIGNNNNKFYIIQLLEEGSRFFCWNRWGRVG
                     EVGQSKMNHFTCLEDAKKDFKKKFWEKTKNKWEERDRFVAQPNKYTLIEVQGEAESQE
                     AVVKVYSGPVRTVVKPCSLDPATQNLITNIFSKEMFKNAMTLMNLDVKKMPLGKLTKQ
                     QIARGFEALEALEEAMKNPTGDGQSLEELSSCFYTVIPHNFGRSRPPPINSPDVLQAK
                     KDMLLVLADIELAQTLQAAPGEEEEKVEEVPHPLDRDYQLLRCQLQLLDSGESEYKAI
                     QTYLKQTGNSYRCPDLRHVWKVNREGEGDRFQAHSKLGNRRLLWHGTNVAVVAAILTS
                     GLRIMPHSGGRVGKGIYFASENSKSAGYVTTMHCGGHQVGYMFLGEVALGKEHHITID
                     DPSLKSPPSGFDSVIARGQTEPDPAQDIELELDGQPVVVPQGPPVQCPSFKSSSFSQS
                     EYLIYKESQCRLRYLLEIHL"
     exon            642..767
                     /gene="Parp3"
                     /gene_synonym="A930002C11Rik; ADPRT-3; Adprt3; Adprtl3;
                     ARTD3; pADPRT-3; PARP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            768..956
                     /gene="Parp3"
                     /gene_synonym="A930002C11Rik; ADPRT-3; Adprt3; Adprtl3;
                     ARTD3; pADPRT-3; PARP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1080
                     /gene="Parp3"
                     /gene_synonym="A930002C11Rik; ADPRT-3; Adprt3; Adprtl3;
                     ARTD3; pADPRT-3; PARP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1307
                     /gene="Parp3"
                     /gene_synonym="A930002C11Rik; ADPRT-3; Adprt3; Adprtl3;
                     ARTD3; pADPRT-3; PARP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1460
                     /gene="Parp3"
                     /gene_synonym="A930002C11Rik; ADPRT-3; Adprt3; Adprtl3;
                     ARTD3; pADPRT-3; PARP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1547
                     /gene="Parp3"
                     /gene_synonym="A930002C11Rik; ADPRT-3; Adprt3; Adprtl3;
                     ARTD3; pADPRT-3; PARP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1725
                     /gene="Parp3"
                     /gene_synonym="A930002C11Rik; ADPRT-3; Adprt3; Adprtl3;
                     ARTD3; pADPRT-3; PARP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1881
                     /gene="Parp3"
                     /gene_synonym="A930002C11Rik; ADPRT-3; Adprt3; Adprtl3;
                     ARTD3; pADPRT-3; PARP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2962
                     /gene="Parp3"
                     /gene_synonym="A930002C11Rik; ADPRT-3; Adprt3; Adprtl3;
                     ARTD3; pADPRT-3; PARP-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2639..2644
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Parp3"
                     /gene_synonym="A930002C11Rik; ADPRT-3; Adprt3; Adprtl3;
                     ARTD3; pADPRT-3; PARP-3"
                     /note="hexamer: AATAGA"
     polyA_site      2657
                     /gene="Parp3"
                     /gene_synonym="A930002C11Rik; ADPRT-3; Adprt3; Adprtl3;
                     ARTD3; pADPRT-3; PARP-3"
                     /note="major polyA site"
ORIGIN      
        1 gaagctaata caaccagact ctaaaactta aggaatggaa ttcaggcagc tctggagagg
       61 agacagcatc cgaacccaga gccaaaatca ccgggcaaat aatggatata tgctgtatgt
      121 gcctagtcaa agctgcatga ggggccagtc agtccgagcg gctttggata cgtctacatt
      181 actgtcattt catctctggg actggccacc aacctcagcc tacccagcct ctgactcacc
      241 ccactagcgg ccaaaagctg gaattctaca ccacccccaa gctctttccc ctcctcacgt
      301 gattgctggg aaatccctac caaaaactag ctgaaggctc acgaagggtc gctagatggg
      361 atcccagact tggaacttgt ttcttaggag gcacattcag cattcctgat accgggctgg
      421 ataacagcca cctcttccag ggtcctgttt catttgggag aaccatggct ccaaaacgaa
      481 aggcctctgt gcagactgag ggctccaaga agcggcgaca agggacagag gaggaggaca
      541 gcttccggtc cactgccgag gctctcagag cagcacctgc tgataatcgg gtcatccgtg
      601 tggacccctc atgtccattc agccggaacc ccgggataca ggtccacgag gactatgact
      661 gtaccctgaa ccagaccaac atcggcaaca acaacaacaa gttctatatt atccaactgc
      721 tggaggaggg tagtcgcttc ttctgctgga atcgctgggg ccgcgtggga gaggtgggcc
      781 agagcaagat gaaccacttc acctgcctgg aagatgcaaa gaaggacttt aagaagaaat
      841 tttgggagaa gactaaaaac aaatgggagg agcgggaccg ttttgtggcc cagcccaaca
      901 agtacacact tatagaagtc cagggagaag cagagagcca agaggctgta gtgaaggtgt
      961 acagcggccc tgtgaggacc gtggtcaagc cctgctccct agaccctgcc acccagaacc
     1021 ttatcaccaa catcttcagc aaagagatgt tcaagaatgc aatgaccctc atgaacctgg
     1081 atgtgaagaa gatgcccttg ggaaagctga ccaagcagca gattgcccgt ggcttcgagg
     1141 ccttggaagc tctagaggag gccatgaaaa accccacagg ggatggccag agcctggaag
     1201 agctctcctc ctgcttctac actgtcatcc cacacaactt cggccgcagc cgacccccgc
     1261 ccatcaactc ccctgatgtg cttcaggcca agaaggacat gctgctggtg ctagcggaca
     1321 tcgagttggc gcagaccttg caggcagccc ctggggagga ggaggagaaa gtggaagagg
     1381 tgccacaccc actggatcga gactaccagc tcctcaggtg ccagcttcaa ctgctggact
     1441 ccggggagtc cgagtacaag gcaatacaga cctacctgaa acagactggc aacagctaca
     1501 ggtgcccaga cctgcggcat gtttggaaag tgaaccgaga aggggaggga gacaggttcc
     1561 aggcccactc caaactgggc aatcggaggc tgctgtggca cggcaccaat gtggccgtgg
     1621 tggctgccat cctcaccagt gggctccgaa tcatgccaca ctcgggtggt cgtgttggca
     1681 agggtattta ttttgcctct gagaacagca agtcagctgg ctatgttacc accatgcact
     1741 gtgggggcca ccaggtgggc tacatgttcc tgggcgaggt ggccctcggc aaagagcacc
     1801 acatcaccat cgatgacccc agcttgaaga gtccaccctc tggctttgac agcgtcatcg
     1861 cccgaggcca aacggagccg gatcccgccc aggacattga actcgaactg gatgggcagc
     1921 cggtggtggt gccccaaggc ccgcctgtgc agtgcccgtc attcaaaagc tccagcttca
     1981 gccagagtga atacctcata tacaaggaga gccagtgtcg cctgcgctac ctgctggaga
     2041 ttcacctcta agctgcttgc cctccccagg tcctgccctg ccgagccatg atcttcaccc
     2101 tcctctccct ggctctcaca gcactttgtc tgcctcccag gaatataata catgccaggc
     2161 attggcacac accagtagcc tcagctactc agggggcaga ggcaagaaaa acactttatc
     2221 ctgggatctg gactctcacc taggctacat agtaacatgt gcctcaaaaa aaaaaaatta
     2281 caatgagtca aagccaaata acgttttgaa gcaggccatg attcactcct ataatcccag
     2341 tacttgggag gctgagacag gagaatcgct gtgagttcaa ggacaaccta ggtaaaatag
     2401 ttccacgtta gcctgagcta tagatgacct tgccttaaaa atatagaagc caatgttctg
     2461 gttagggatg gactgcacag cttagatcac ctaatgacac cgttgtcatc agtttacatg
     2521 aacagaatct acacacaatg acaaaatcac tcagcggcgt gttcatgaga atgtatcacc
     2581 atcgtgaagg gaaaacgact tttacattgt cgttatctat atatggtcag tgctgtgcaa
     2641 tagactctta aaactcattt ctcctgtccg actgaatttt gtacacacat cttcctaagc
     2701 cccgttgctc tttacttcgg agtccagctt ttttaaggcc ccacgtgtga gatcgtgtgg
     2761 cttttgtctt tctggacctg gctaacttgt cgtgcaagtt ctcccacgtt gtttcaaaca
     2821 acgccattct ttaaggctga ctagtaggcc cgtttgtgtt cacgtcctct ttgcctgttc
     2881 acccatcaag ggacacagcg tgatttgtga gttggttgtt gtgaatggtg ctttaaaaaa
     2941 aaaaaaaaaa aaaagcccca gc
//
