LOCUS       NM_009632               1819 bp    mRNA    linear   ROD 29-MAY-2023
DEFINITION  Mus musculus poly (ADP-ribose) polymerase family, member 2 (Parp2),
            mRNA.
ACCESSION   NM_009632
VERSION     NM_009632.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1819)
  AUTHORS   Janko L, Toth E, Laczik M, Rauch B, Janka E, Balint BL and Bai P.
  TITLE     PARP2 poly(ADP-ribosyl)ates nuclear factor erythroid 2-related
            factor 2 (NRF2) affecting NRF2 subcellular localization
  JOURNAL   Sci Rep 13 (1), 7869 (2023)
   PUBMED   37188809
  REMARK    GeneRIF: PARP2 poly(ADP-ribosyl)ates nuclear factor erythroid
            2-related factor 2 (NRF2) affecting NRF2 subcellular localization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1819)
  AUTHORS   Galindo-Campos MA, Lutfi N, Bonnin S, Martinez C, Velasco-Hernandez
            T, Garcia-Hernandez V, Martin-Caballero J, Ampurdanes C, Gimeno R,
            Colomo L, Roue G, Guilbaud G, Dantzer F, Navarro P, Murga M,
            Fernandez-Capetillo O, Bigas A, Menendez P, Sale JE and Yelamos J.
  TITLE     Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell
            lymphoma in mice
  JOURNAL   Blood 139 (2), 228-239 (2022)
   PUBMED   34359075
  REMARK    GeneRIF: Distinct roles for PARP-1 and PARP-2 in c-Myc-driven
            B-cell lymphoma in mice.
REFERENCE   3  (bases 1 to 1819)
  AUTHORS   Kurgina TA, Moor NA, Kutuzov MM, Naumenko KN, Ukraintsev AA and
            Lavrik OI.
  TITLE     Dual function of HPF1 in the modulation of PARP1 and PARP2
            activities
  JOURNAL   Commun Biol 4 (1), 1259 (2021)
   PUBMED   34732825
  REMARK    GeneRIF: Dual function of HPF1 in the modulation of PARP1 and PARP2
            activities.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1819)
  AUTHORS   Kelleher AM, Setlem R, Dantzer F, DeMayo FJ, Lydon JP and Kraus WL.
  TITLE     Deficiency of PARP-1 and PARP-2 in the mouse uterus results in
            decidualization failure and pregnancy loss
  JOURNAL   Proc Natl Acad Sci U S A 118 (40) (2021)
   PUBMED   34580230
  REMARK    GeneRIF: Deficiency of PARP-1 and PARP-2 in the mouse uterus
            results in decidualization failure and pregnancy loss.
REFERENCE   5  (bases 1 to 1819)
  AUTHORS   Soni UK, Chadchan SB, Gupta RK, Kumar V and Kumar Jha R.
  TITLE     miRNA-149 targets PARP-2 in endometrial epithelial and stromal
            cells to regulate the trophoblast attachment process
  JOURNAL   Mol Hum Reprod 27 (6) (2021)
   PUBMED   34051087
  REMARK    GeneRIF: miRNA-149 targets PARP-2 in endometrial epithelial and
            stromal cells to regulate the trophoblast attachment process.
REFERENCE   6  (bases 1 to 1819)
  AUTHORS   Benchoua A, Couriaud C, Guegan C, Tartier L, Couvert P, Friocourt
            G, Chelly J, Menissier-de Murcia J and Onteniente B.
  TITLE     Active caspase-8 translocates into the nucleus of apoptotic cells
            to inactivate poly(ADP-ribose) polymerase-2
  JOURNAL   J Biol Chem 277 (37), 34217-34222 (2002)
   PUBMED   12065591
  REMARK    GeneRIF: Caspase-8 not only triggers and amplifies the apoptotic
            process at cytoplasmic sites but can also act as an executioner at
            nuclear levels where it cleaves PARP-2
REFERENCE   7  (bases 1 to 1819)
  AUTHORS   Schreiber V, Ame JC, Dolle P, Schultz I, Rinaldi B, Fraulob V,
            Menissier-de Murcia J and de Murcia G.
  TITLE     Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient
            base excision DNA repair in association with PARP-1 and XRCC1
  JOURNAL   J Biol Chem 277 (25), 23028-23036 (2002)
   PUBMED   11948190
REFERENCE   8  (bases 1 to 1819)
  AUTHORS   Ame JC, Schreiber V, Fraulob V, Dolle P, de Murcia G and Niedergang
            CP.
  TITLE     A bidirectional promoter connects the poly(ADP-ribose) polymerase 2
            (PARP-2) gene to the gene for RNase P RNA. structure and expression
            of the mouse PARP-2 gene
  JOURNAL   J Biol Chem 276 (14), 11092-11099 (2001)
   PUBMED   11133988
REFERENCE   9  (bases 1 to 1819)
  AUTHORS   Ame JC, Rolli V, Schreiber V, Niedergang C, Apiou F, Decker P,
            Muller S, Hoger T, Menissier-de Murcia J and de Murcia G.
  TITLE     PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose)
            polymerase
  JOURNAL   J Biol Chem 274 (25), 17860-17868 (1999)
   PUBMED   10364231
REFERENCE   10 (bases 1 to 1819)
  AUTHORS   Berghammer H, Ebner M, Marksteiner R and Auer B.
  TITLE     pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase
            gene related to truncated pADPRT homologues in plants and
            Caenorhabditis elegans
  JOURNAL   FEBS Lett 449 (2-3), 259-263 (1999)
   PUBMED   10338144
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC027184.15.
            
            [WARNING] On Jun 1, 2023 this sequence was replaced by NM_009632.4.
            
            On Mar 28, 2018 this sequence version replaced NM_009632.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062150.1, AF072521.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AC027184.15        119349-119420       c
            73-213              AC027184.15        117122-117262       c
            214-284             AC027184.15        116766-116836       c
            285-335             AC027184.15        115510-115560       c
            336-432             AC027184.15        112370-112466       c
            433-508             AC027184.15        111909-111984       c
            509-611             AC027184.15        111037-111139       c
            612-762             AC027184.15        110213-110363       c
            763-901             AC027184.15        109866-110004       c
            902-965             AC027184.15        108063-108126       c
            966-1100            AC027184.15        107848-107982       c
            1101-1228           AC027184.15        107548-107675       c
            1229-1328           AC027184.15        107295-107394       c
            1329-1427           AC027184.15        106760-106858       c
            1428-1552           AC027184.15        106417-106541       c
            1553-1819           AC027184.15        106035-106301       c
FEATURES             Location/Qualifiers
     source          1..1819
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.25 cM"
     gene            1..1819
                     /gene="Parp2"
                     /gene_synonym="ADPRT-2; Adprt2; Adprtl2; ARTD2; Aspartl2;
                     mPARP-2; pADPRT-2; PARP-2"
                     /note="poly (ADP-ribose) polymerase family, member 2"
                     /db_xref="GeneID:11546"
                     /db_xref="MGI:MGI:1341112"
     exon            1..72
                     /gene="Parp2"
                     /gene_synonym="ADPRT-2; Adprt2; Adprtl2; ARTD2; Aspartl2;
                     mPARP-2; pADPRT-2; PARP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1712
                     /gene="Parp2"
                     /gene_synonym="ADPRT-2; Adprt2; Adprtl2; ARTD2; Aspartl2;
                     mPARP-2; pADPRT-2; PARP-2"
                     /EC_number="2.4.2.30"
                     /note="ADP-ribosyltransferase (NAD+, poly(ADP-ribose)
                     polymerase)-like 2; poly[ADP-ribose] synthetase 2; NAD(+)
                     ADP-ribosyltransferase 2; poly[ADP-ribose] synthase 2;
                     ADP-ribosyltransferase (NAD+; poly (ADP-ribose)
                     polymerase) 2; ADP-ribosyltransferase diphtheria
                     toxin-like 2; DNA ADP-ribosyltransferase PARP2; protein
                     poly-ADP-ribosyltransferase PARP2"
                     /codon_start=1
                     /product="poly [ADP-ribose] polymerase 2"
                     /protein_id="NP_033762.1"
                     /db_xref="CCDS:CCDS27025.1"
                     /db_xref="GeneID:11546"
                     /db_xref="MGI:MGI:1341112"
                     /translation="MAPRRQRSGSGRRVLNEAKKVDNGNKATEDDSPPGKKMRTCQRK
                     GPMAGGKDADRTKDNRDSVKTLLLKGKAPVDPECAAKLGKAHVYCEGDDVYDVMLNQT
                     NLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKTGQHSLVTCSGDLNKAKEIFQKKF
                     LDKTKNNWEDRENFEKVPGKYDMLQMDYAASTQDESKTKEEETLKPESQLDLRVQELL
                     KLICNVQTMEEMMIEMKYDTKRAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALVE
                     ACNEFYTRIPHDFGLSIPPVIRTEKELSDKVKLLEALGDIEIALKLVKSERQGLEHPL
                     DQHYRNLHCALRPLDHESNEFKVISQYLQSTHAPTHKDYTMTLLDVFEVEKEGEKEAF
                     REDLPNRMLLWHGSRLSNWVGILSHGLRVAPPEAPITGYMFGKGIYFADMSSKSANYC
                     FASRLKNTGLLLLSEVALGQCNELLEANPKAQGLLRGKHSTKGMGKMAPSPAHFITLN
                     GSTVPLGPASDTGILNPEGYTLNYNEFIVYSPNQVRMRYLLKIQFNFLQLW"
     exon            73..213
                     /gene="Parp2"
                     /gene_synonym="ADPRT-2; Adprt2; Adprtl2; ARTD2; Aspartl2;
                     mPARP-2; pADPRT-2; PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            214..284
                     /gene="Parp2"
                     /gene_synonym="ADPRT-2; Adprt2; Adprtl2; ARTD2; Aspartl2;
                     mPARP-2; pADPRT-2; PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            285..335
                     /gene="Parp2"
                     /gene_synonym="ADPRT-2; Adprt2; Adprtl2; ARTD2; Aspartl2;
                     mPARP-2; pADPRT-2; PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            336..432
                     /gene="Parp2"
                     /gene_synonym="ADPRT-2; Adprt2; Adprtl2; ARTD2; Aspartl2;
                     mPARP-2; pADPRT-2; PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            433..508
                     /gene="Parp2"
                     /gene_synonym="ADPRT-2; Adprt2; Adprtl2; ARTD2; Aspartl2;
                     mPARP-2; pADPRT-2; PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            509..611
                     /gene="Parp2"
                     /gene_synonym="ADPRT-2; Adprt2; Adprtl2; ARTD2; Aspartl2;
                     mPARP-2; pADPRT-2; PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            612..762
                     /gene="Parp2"
                     /gene_synonym="ADPRT-2; Adprt2; Adprtl2; ARTD2; Aspartl2;
                     mPARP-2; pADPRT-2; PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            763..901
                     /gene="Parp2"
                     /gene_synonym="ADPRT-2; Adprt2; Adprtl2; ARTD2; Aspartl2;
                     mPARP-2; pADPRT-2; PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..965
                     /gene="Parp2"
                     /gene_synonym="ADPRT-2; Adprt2; Adprtl2; ARTD2; Aspartl2;
                     mPARP-2; pADPRT-2; PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1100
                     /gene="Parp2"
                     /gene_synonym="ADPRT-2; Adprt2; Adprtl2; ARTD2; Aspartl2;
                     mPARP-2; pADPRT-2; PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1228
                     /gene="Parp2"
                     /gene_synonym="ADPRT-2; Adprt2; Adprtl2; ARTD2; Aspartl2;
                     mPARP-2; pADPRT-2; PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1328
                     /gene="Parp2"
                     /gene_synonym="ADPRT-2; Adprt2; Adprtl2; ARTD2; Aspartl2;
                     mPARP-2; pADPRT-2; PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1427
                     /gene="Parp2"
                     /gene_synonym="ADPRT-2; Adprt2; Adprtl2; ARTD2; Aspartl2;
                     mPARP-2; pADPRT-2; PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1552
                     /gene="Parp2"
                     /gene_synonym="ADPRT-2; Adprt2; Adprtl2; ARTD2; Aspartl2;
                     mPARP-2; pADPRT-2; PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1819
                     /gene="Parp2"
                     /gene_synonym="ADPRT-2; Adprt2; Adprtl2; ARTD2; Aspartl2;
                     mPARP-2; pADPRT-2; PARP-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaagggatg atgacgtcgt ccttcaagag cgatggcgcc gcggcggcag agatcaggct
       61 ctggaaggcg agtgctaaat gaagccaaga aagttgataa tggcaacaaa gcaacagaag
      121 acgactctcc tcctggcaag aagatgcgca cgtgccagag aaaagggcct atggctggag
      181 ggaaggacgc agacaggaca aaagacaatc gagactctgt gaagaccttg ctgttaaagg
      241 gcaaagcccc tgtggaccca gagtgtgcag ccaagctggg aaaggctcat gtgtattgtg
      301 aaggagatga tgtctatgat gtcatgctaa atcaaaccaa tctccagttc aacaacaaca
      361 agtactacct tattcagctg ttagaagatg atgcccagag gaacttcagt gtttggatga
      421 ggtggggccg agttggaaag acggggcagc acagcttggt gacttgttct ggtgacctca
      481 acaaagcaaa agaaatattt cagaaaaaat tccttgacaa aactaaaaac aattgggagg
      541 accgtgagaa ctttgaaaaa gtacctggaa aatacgacat gttacagatg gactatgctg
      601 ccagcacgca ggatgaaagt aaaacaaaag aagaggaaac tttgaagcct gagtctcagc
      661 tggatcttcg agtccaggag ctgctaaagt tgatctgtaa cgtgcagacc atggaagaaa
      721 tgatgattga gatgaagtat gacaccaaga gagccccgct tggaaagctg acagtggcgc
      781 aaatcaaggc cggttaccag tctctcaaga agattgagga ctgcatccgc gctggccagc
      841 atgggcgagc gcttgttgaa gcgtgcaatg aattctacac caggatccct catgactttg
      901 gactctccat ccctccagta atccggacag agaaggaact gtcagacaaa gtaaaactgc
      961 tagaggcatt gggagacatt gaaattgccc ttaaactggt gaagtcagag cgccaaggcc
     1021 tagaacaccc actggaccaa cactatagaa acctacactg tgctttgcgt cctctggacc
     1081 atgaaagtaa tgagtttaag gtgatttctc agtacctaca gtctacgcat gctcctacac
     1141 acaaggacta tactatgacc ttgctggatg ttttcgaagt agagaaggaa ggggagaaag
     1201 aggccttcag ggaggacctt cctaacagga tgctgctctg gcatggatcc aggctgagta
     1261 actgggtggg gatcctgagc cacgggctta gagttgcccc acctgaggct cccatcacag
     1321 gttatatgtt tggaaaagga atctactttg ctgacatgtc ctccaagagt gccaattact
     1381 gctttgcctc tcgcctaaag aatacaggat tgcttcttct gtcagaggta gctctaggtc
     1441 agtgtaatga actactggag gccaatccta aagcacaagg attgcttcgg ggcaagcata
     1501 gcaccaaggg gatgggaaag atggctccca gccctgccca cttcatcacc ctgaatggga
     1561 gtacagtgcc cttaggacca gcaagtgaca caggaattct caatccagag gggtacaccc
     1621 tcaactacaa tgagtttatt gtttatagcc ccaaccaggt ccgtatgcga taccttctaa
     1681 agattcaatt taacttcctg cagctatggt gaatgttgat cagacaagcc agagagaata
     1741 taatcttcaa acaaaaacca agcaatatta tgttcttgaa ctttttgata ttttgtttaa
     1801 taaaatagta taaatctgt
//
