LOCUS       NM_177460               2483 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus poly (ADP-ribose) polymerase family, member 16
            (Parp16), mRNA.
ACCESSION   NM_177460
VERSION     NM_177460.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2483)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2483)
  AUTHORS   Wang,J., Xu,J., Dong,Y., Su,Z., Su,H., Cheng,Q. and Liu,X.
  TITLE     ADP-ribose transferase PARP16 mediated-unfolded protein response
            contributes to neuronal cell damage in cerebral
            ischemia/reperfusion
  JOURNAL   FASEB J 37 (2), e22788 (2023)
   PUBMED   36692424
  REMARK    GeneRIF: ADP-ribose transferase PARP16 mediated-unfolded protein
            response contributes to neuronal cell damage in cerebral
            ischemia/reperfusion.
REFERENCE   3  (bases 1 to 2483)
  AUTHORS   Refaeli,I., Hughes,M.R., Wong,A.K., Bissonnette,M.L.Z.,
            Roskelley,C.D., Wayne Vogl,A., Barbour,S.J., Freedman,B.S. and
            McNagny,K.M.
  TITLE     Distinct Functional Requirements for Podocalyxin in Immature and
            Mature Podocytes Reveal Mechanisms of Human Kidney Disease
  JOURNAL   Sci Rep 10 (1), 9419 (2020)
   PUBMED   32523052
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2483)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2483)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 2483)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 2483)
  AUTHORS   Karlberg,T., Thorsell,A.G., Kallas,A. and Schuler,H.
  TITLE     Crystal structure of human ADP-ribose transferase ARTD15/PARP16
            reveals a novel putative regulatory domain
  JOURNAL   J Biol Chem 287 (29), 24077-24081 (2012)
   PUBMED   22661712
  REMARK    GeneRIF: ARTD15 features an alpha-helical domain that packs against
            its transferase domain without making direct contact with the
            NAD(+)-binding crevice or the donor loop.
REFERENCE   8  (bases 1 to 2483)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133475.1 and BY430063.1.
            
            On Oct 26, 2007 this sequence version replaced NM_177460.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133475.1, BC055447.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2481              AK133475.1         2-2482
            2482-2483           BY430063.1         422-423
FEATURES             Location/Qualifiers
     source          1..2483
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 35.17 cM"
     gene            1..2483
                     /gene="Parp16"
                     /gene_synonym="ARTD15; PARP-16"
                     /note="poly (ADP-ribose) polymerase family, member 16"
                     /db_xref="GeneID:214424"
                     /db_xref="MGI:MGI:2446133"
     exon            1..174
                     /gene="Parp16"
                     /gene_synonym="ARTD15; PARP-16"
                     /inference="alignment:Splign:2.1.0"
     exon            175..458
                     /gene="Parp16"
                     /gene_synonym="ARTD15; PARP-16"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..1253
                     /gene="Parp16"
                     /gene_synonym="ARTD15; PARP-16"
                     /EC_number="2.4.2.30"
                     /note="poly [ADP-ribose] polymerase 16;
                     ADP-ribosyltransferase diphtheria toxin-like 15; mono
                     [ADP-ribose] polymerase PARP16"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP16"
                     /protein_id="NP_803411.3"
                     /db_xref="CCDS:CCDS23286.1"
                     /db_xref="GeneID:214424"
                     /db_xref="MGI:MGI:2446133"
                     /translation="MQLSNRAAAREAASRDVLAADLRCSLFASALQSYKRDSVLRPFP
                     ASYARHDCKDFEALLADTGRLPNLKELLQSSRDTDKQAWDLVSWILSSKILTIHSAKK
                     AEFEKIQQLTGAPHTPVPTPDFLFEIEYFDPANSRFYETKGERDLIYAFHGSRLENFH
                     SIIHNGLHCHLNKTSLFGEGTYLTSDLSLALIYSPHGHGWQHSLLGPILSCVAVCEVI
                     DHPDVKCQIKKKDSKEIDRSRARIKHSEGGEIPPKYFVVTNNQLLRVKYLLVYSQKQP
                     KRASSQLSWLSSHWFVIMMSLYLLLLLIVSVTNSSVFHHFWNRVKR"
     exon            459..596
                     /gene="Parp16"
                     /gene_synonym="ARTD15; PARP-16"
                     /inference="alignment:Splign:2.1.0"
     exon            597..803
                     /gene="Parp16"
                     /gene_synonym="ARTD15; PARP-16"
                     /inference="alignment:Splign:2.1.0"
     exon            804..975
                     /gene="Parp16"
                     /gene_synonym="ARTD15; PARP-16"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1117
                     /gene="Parp16"
                     /gene_synonym="ARTD15; PARP-16"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..2483
                     /gene="Parp16"
                     /gene_synonym="ARTD15; PARP-16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1662..1667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Parp16"
                     /gene_synonym="ARTD15; PARP-16"
                     /note="hexamer: AATAAA"
     polyA_site      1697
                     /gene="Parp16"
                     /gene_synonym="ARTD15; PARP-16"
     regulatory      2463..2468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Parp16"
                     /gene_synonym="ARTD15; PARP-16"
                     /note="hexamer: AATAAA"
     polyA_site      2482
                     /gene="Parp16"
                     /gene_synonym="ARTD15; PARP-16"
                     /note="major polyA site"
ORIGIN      
        1 gagaattgcg gaggctgtaa ggtagagagg aaggtctttg ggtcggctac agtgtcttga
       61 gaaagtattg tgtcactccg accttcagtt ttccctgggt atcaagtggc ttcttgtgtg
      121 caacgtgtca gctccagagg aaaccgattt attcaacagg tggcaattcc caagctccac
      181 cccccgggct ggaaaacctg gcagcagacg gtctacggtc ccccgggccc aggccccgcg
      241 ctgcccctcc ttgtctcctc ccggccacgc gctacgagcc cgggatgcag ctctccaaca
      301 gggcagcagc cagggaggca gcgagccgcg acgtgctggc tgcggacctc cgctgcagcc
      361 tcttcgcctc ggcgctgcag agctacaagc gggactcggt gctgcggccc ttccccgcct
      421 cctacgcccg ccacgactgt aaggacttcg aggccctgct tgcggacact ggcaggttac
      481 ccaacttgaa ggaacttcta cagtcttcca gagacacaga caaacaggcc tgggacctgg
      541 tgagctggat tttatcctcc aagatcctga caatccacag tgccaagaag gcagagtttg
      601 aaaagatcca gcagctgacc ggcgcccctc acacacctgt ccccaccccg gatttcctat
      661 ttgaaattga gtactttgac ccggccaact ccagatttta tgagaccaaa ggagaacgag
      721 acctaatcta tgccttccat ggtagccgcc tagagaactt ccactccatc attcacaatg
      781 gcctgcactg ccacctgaac aagacttctc tgtttggaga ggggacctac ctcacaagtg
      841 acttgagcct ggccctcatt tatagtcctc atggccacgg gtggcaacat agccttcttg
      901 gcccgatcct gagctgcgta gctgtgtgtg aggtcatcga tcatccagat gtcaagtgcc
      961 aaatcaagaa gaaggattcc aaggaaatag accgcagccg agcaagaatc aagcacagcg
     1021 aggggggaga gatcccccct aagtactttg tagtcaccaa taaccagctt ctgcgggtga
     1081 agtacctgct ggtgtattcc cagaagcagc ccaagagggc ctcgagccag ctctcctggt
     1141 tgtccagcca ctggttcgtg atcatgatgt ccctgtatct gctgctgctg ctcatcgtga
     1201 gtgtcaccaa ctcctctgtg ttccaccact tctggaatcg tgtgaagaga tgatcccagg
     1261 tgcttggagt ggggccactc accgtgtgcc ttatggaaac ttgtcctcta cctcctgtgt
     1321 gtcacatccg gtcaggtcga gtctggggac catttgcagg ggtgcacagg acgagtttta
     1381 tatgccataa gtgtactgat tgcctttgtt gatgtgccca gacacaatcc agtcagtggg
     1441 ggatccctgg cccctcactt gtcagtttca ggggtgtcct accctctgct tcctcctaaa
     1501 tagtctaggg aggtggctct tcagccagag ccaaaggaaa aagtcctgct gcatttaaaa
     1561 gcaaagtgtc caagctgtcc gaggtgtgtt tacaattgcc cagatggagg ccggcccgga
     1621 tgctaatgcc ttttggaaga cagaatgtgt gcaacgggaa caataaatca ttaggcgact
     1681 gccttgtttt gactcaagac acccaagagg gactgtcgtg tttctcataa aaatatcagt
     1741 gggatcgttt gggaattcca tcggctttag tctgccggtg caaaacattt taacagtttt
     1801 ctcagatcaa caaccgtctc tgccacagct gtaccccctc cctccttaac cacacaagag
     1861 gaggagccac aggcgggata acaaaatgca gatttaacaa ctagcaactc tgtcatcttt
     1921 ttctaaaaat gaccaactgc tgattacagc tcaaacggaa ccaaatgttt gcgtttctgt
     1981 ttttgttgtc atttatttga caagttagcc tctatgagcc aaatagaggg ggagatgtgt
     2041 gaacctggag caccgagtgg ctacatccac agcctctttc tggtgttgtt atggagaagg
     2101 gtccaagcca taggctcacc agggtcctca ttcccacaaa gctgccttga tacccaacac
     2161 tctaggctct caggggcccg gcagccttca cagcagaggc ctgcctcagt gggccacggg
     2221 tctccatggg ctgagcctcc atccgagaag cctgaggttg agtggtaagc agaggcccag
     2281 ccatccttgc tgtggtgttt atccctcctt cctgccaggt ttcagcggca gaagacccct
     2341 gtctgctggg aatggagttt ccatagagga ggagaaaata atttttttcc tataatttgt
     2401 aaagcttgtg aaaaagccac tatcgtgatt ttttaaatca agtagtggga catttaaaaa
     2461 acaataaaga tattttccta aat
//
