LOCUS       NM_172893               3322 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus poly (ADP-ribose) polymerase family, member 12
            (Parp12), mRNA.
ACCESSION   NM_172893
VERSION     NM_172893.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3322)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3322)
  AUTHORS   Kerr,C.M., Parthasarathy,S., Schwarting,N., O'Connor,J.J.,
            Pfannenstiel,J.J., Giri,E., More,S., Orozco,R.C. and Fehr,A.R.
  TITLE     PARP12 is required to repress the replication of a Mac1 mutant
            coronavirus in a cell- and tissue-specific manner
  JOURNAL   J Virol 97 (9), e0088523 (2023)
   PUBMED   37695054
  REMARK    GeneRIF: PARP12 is required to repress the replication of a Mac1
            mutant coronavirus in a cell- and tissue-specific manner.
REFERENCE   3  (bases 1 to 3322)
  AUTHORS   Cao,G., Guo,R., Chen,M., Sun,C. and Wang,J.
  TITLE     PARP12 regulates mouse oocyte meiotic maturation
  JOURNAL   J Cell Physiol 238 (7), 1580-1591 (2023)
   PUBMED   37305966
  REMARK    GeneRIF: PARP12 regulates mouse oocyte meiotic maturation.
REFERENCE   4  (bases 1 to 3322)
  AUTHORS   Li,L., Zhao,H., Liu,P., Li,C., Quanquin,N., Ji,X., Sun,N., Du,P.,
            Qin,C.F., Lu,N. and Cheng,G.
  TITLE     PARP12 suppresses Zika virus infection through PARP-dependent
            degradation of NS1 and NS3 viral proteins
  JOURNAL   Sci Signal 11 (535) (2018)
   PUBMED   29921658
  REMARK    GeneRIF: To screen for antiviral IFN-stimulated genes that
            restricted Zika virus replication, and identified PARP12 as a
            strong inhibitor of Zika virus replication. Findings suggest that
            PARP12 mediated the ADP-ribosylation of NS1 and NS3, nonstructural
            viral proteins that are involved in viral replication and
            modulating host defense responses.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3322)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 3322)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 3322)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   8  (bases 1 to 3322)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   9  (bases 1 to 3322)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human TIPARP gene within the
            CCNL amplicon at human chromosome 3q25.31
  JOURNAL   Int J Oncol 23 (2), 541-547 (2003)
   PUBMED   12851707
REFERENCE   10 (bases 1 to 3322)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036886.1, BC120733.1 and BC048927.1.
            
            On Apr 1, 2008 this sequence version replaced NM_172893.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036886.1, AK156623.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AK036886.1         4-170
            168-2552            BC120733.1         1-2385
            2553-3322           BC048927.1         1404-2173
FEATURES             Location/Qualifiers
     source          1..3322
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 17.85 cM"
     gene            1..3322
                     /gene="Parp12"
                     /gene_synonym="9930021O16; ARTD12; PARP-12; Zc3hdc1"
                     /note="poly (ADP-ribose) polymerase family, member 12"
                     /db_xref="GeneID:243771"
                     /db_xref="MGI:MGI:2143990"
     exon            1..543
                     /gene="Parp12"
                     /gene_synonym="9930021O16; ARTD12; PARP-12; Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..2326
                     /gene="Parp12"
                     /gene_synonym="9930021O16; ARTD12; PARP-12; Zc3hdc1"
                     /EC_number="2.4.2.30"
                     /note="zinc finger CCCH type domain containing 1; poly
                     ADP-ribose polymerase 12; poly [ADP-ribose] polymerase 12;
                     zinc finger CCCH domain-containing protein 1;
                     ADP-ribosyltransferase diphtheria toxin-like 12"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP12"
                     /protein_id="NP_766481.2"
                     /db_xref="CCDS:CCDS20019.1"
                     /db_xref="GeneID:243771"
                     /db_xref="MGI:MGI:2143990"
                     /translation="MAQAAVAVAEVTQLLCAAGGALELAELRRRLRTSLGTDALERLL
                     RDCGRFVVASRAVVAVGAGREAAAAASERLVLAVSSLRLCRAHQGPKPGCTGLCAQLH
                     LCKFLIYGNCKFLKTGKNCRNGHNLKTDHNLSVLRTHGVDHLTYTELCQLLLQNDPSL
                     LPDICLHYNKGDGPFGSCSFQKQCIKLHICQYFLQGECKFGTSCKRSHEFTNSESLEQ
                     LERLGLSSDLVSRLLSTYRNAYDIKNKGSALSKVSPSPAGPQGSSERKDSSGPVSPGT
                     PSQEESEQICLYHIRKSCSFQEKCHRVHFHLPYRWQFLDGGKWKDLDNMELIEEAYSN
                     PSKDRIVYTESAAGFHFDNLDFNSMKFGNTLARRLSTASSVTKPPHFILTTDWIWYWM
                     DEFGSWQEYGRQGSGHPVTTISSSDVERAYLAFCAPGADAQAATLKFQAGKHNYELHF
                     KAFLQKNLVYGTIRKVCRRPKYVSPQDVQMKQSCNTKLHGPKSIPDYWDPAALPDLGF
                     KKITLSSSSEEYQKVWNIFNRTLPFYFVQKIERIQNMGLWEVYQWQKCQMQKQNGGKE
                     VDERQLFHGTSANFVDAICQQNFDWRVCGLHGTSYGKGSYFARDAAYSHHYSKSDTHS
                     HMMFLARVLVGDFVRGSTSFVRPPAKEGQSNAFYDSCVNSMSDPTIFVVFEKHQVYPE
                     YLIQYSTSSKPPASPSIFVALGNLFTSRQ"
     exon            544..679
                     /gene="Parp12"
                     /gene_synonym="9930021O16; ARTD12; PARP-12; Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..980
                     /gene="Parp12"
                     /gene_synonym="9930021O16; ARTD12; PARP-12; Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1082
                     /gene="Parp12"
                     /gene_synonym="9930021O16; ARTD12; PARP-12; Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1206
                     /gene="Parp12"
                     /gene_synonym="9930021O16; ARTD12; PARP-12; Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1402
                     /gene="Parp12"
                     /gene_synonym="9930021O16; ARTD12; PARP-12; Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1544
                     /gene="Parp12"
                     /gene_synonym="9930021O16; ARTD12; PARP-12; Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1641
                     /gene="Parp12"
                     /gene_synonym="9930021O16; ARTD12; PARP-12; Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1717
                     /gene="Parp12"
                     /gene_synonym="9930021O16; ARTD12; PARP-12; Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1848
                     /gene="Parp12"
                     /gene_synonym="9930021O16; ARTD12; PARP-12; Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2000
                     /gene="Parp12"
                     /gene_synonym="9930021O16; ARTD12; PARP-12; Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..3229
                     /gene="Parp12"
                     /gene_synonym="9930021O16; ARTD12; PARP-12; Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3208..3213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Parp12"
                     /gene_synonym="9930021O16; ARTD12; PARP-12; Zc3hdc1"
                     /note="hexamer: AATAAA"
     polyA_site      3229
                     /gene="Parp12"
                     /gene_synonym="9930021O16; ARTD12; PARP-12; Zc3hdc1"
                     /note="major polyA site"
ORIGIN      
        1 gcggtcccca gctggcggcc ctaagacaag ggcgccggct cctcagctgc ggcccgaggg
       61 cgtggcaagg ccccacggct cctgttttcc cggccggagc ccgctttcgg tttcgtttcc
      121 ttccagcgaa acagtggggc ccggcccgtg aaaggcgccg ccgtccgtgc taagcctcag
      181 tccgacggcc atggcccagg ccgcggtggc agtggcagag gtgacccagc tgctgtgcgc
      241 ggcggggggc gccttggagt tggcggagct gcggcgccgc ttgcgaacca gcctggggac
      301 cgacgcgctg gagcggctgc tgcgggactg cgggcgcttc gtggtggcct cgcgggcggt
      361 cgtggccgtg ggcgcgggcc gggaggccgc ggcggcagcc tcggagcgct tggtgctggc
      421 cgtgtcgtcg ctgcgtctgt gccgcgcgca tcagggcccc aagccgggct gcaccgggct
      481 ctgcgcgcag ctgcatctct gcaagtttct catctacggc aactgcaagt tcctgaagac
      541 cgggaagaac tgtaggaatg gtcacaactt gaagactgat cacaacctga gtgtgttgag
      601 gacacatggt gttgaccacc tcacatatac tgagctttgc caactcttgc ttcagaatga
      661 cccttcactt ttgccagata tatgcctaca ctacaacaaa ggtgatggac ccttcggctc
      721 ttgctccttc caaaagcagt gcattaaact ccatatctgc cagtacttcc tacagggaga
      781 gtgcaagttt ggcacaagct gtaagaggtc ccatgagttc actaactctg agagtctgga
      841 gcagttggaa aggttgggct taagttctga cctggtgagc aggctactct ctacttaccg
      901 gaatgcatat gacatcaaga ataagggctc agccctcagc aaagtgtctc cttctcccgc
      961 aggtccacag gggagttctg aaagaaaaga cagttcaggt cctgtgtcac caggcactcc
     1021 tagccaggag gagagtgaac agatttgctt gtaccatatt cggaagagtt gtagcttcca
     1081 agaaaagtgc catcgagttc attttcattt accatatcgg tggcaattct tggatggagg
     1141 caaatggaag gatttggaca acatggagct tattgaagaa gcatatagca atcccagtaa
     1201 agacaggatt gtgtatacag agtcagctgc tggctttcac tttgataatt tagactttaa
     1261 ttccatgaag tttggtaata ctctggctcg ccgactctcc acagcttctt cagtcaccaa
     1321 acccccacat ttcatcctta ctactgactg gatttggtac tggatggatg agtttggttc
     1381 ttggcaggaa tatggacgac aaggctcagg gcaccctgtg accaccatca gcagcagtga
     1441 cgtggaaagg gcttacttgg cattctgtgc tccaggggct gatgcccagg cagccacctt
     1501 gaagttccag gctggaaaac acaactatga gttacacttc aaagcttttc tgcagaaaaa
     1561 ccttgtgtat ggcactatca gaaaggtttg tcgcagaccc aagtatgtgt ctccccagga
     1621 tgtgcagatg aagcagtcct gcaatactaa gttacacggc ccaaagagca tcccagacta
     1681 ctgggaccct gcagccctgc ctgacctggg atttaagaag atcactctga gttcttcctc
     1741 agaagagtat cagaaggtgt ggaacatctt caaccgtaca ctacctttct actttgttca
     1801 gaagatcgag cggatccaga acatgggcct gtgggaagtc taccagtggc aaaaatgtca
     1861 gatgcagaag caaaatgggg ggaaggaagt agacgagagg cagctgtttc atggtactag
     1921 tgccaacttc gtggatgcca tctgccagca gaactttgac tggcgggtct gtggtctgca
     1981 cggcacatcc tatggcaaag ggagctactt tgcgagagat gccgcctatt cgcaccacta
     2041 cagtaaatcc gacacacact ctcacatgat gttcctggcc cgggtgctgg tcggagattt
     2101 cgtcaggggc agcacttcct tcgtccgccc tccagccaag gaaggccaga gcaatgcctt
     2161 ctatgacagc tgcgtgaaca gcatgtccga cccaaccatc tttgtagttt ttgagaagca
     2221 ccaggtctac cccgagtacc tcattcaata ctctacctcc tccaagcccc cagctagccc
     2281 ctccatcttt gttgccctag gtaacttgtt cactagccgc cagtaagtat ggccaggatg
     2341 cattaggcgt ttctgccaca tctgtctgtc tggtggagct atttggaaag tctttctttc
     2401 tttttttttt ttaaacaaaa cttttaatga actcttgttt aatattggct tctcagtgaa
     2461 attacatttt tttctcccct agtgctgggg atggaataca gggctttgtg cttgctacaa
     2521 aagcactcta ccactgagct acaccccagc ccttttaaaa tgtttttatt atgaggcagg
     2581 gttttgctaa attatattct gcctcagtct cctgagcagc tggggttaaa agcctctata
     2641 accaggcccg acttgaagcc acaatcttaa tccttgtctg ataacagttt taggttttag
     2701 gtccttttag gttggcttat gatcttacca gtattgattg tgagcctaag tttgacttat
     2761 aatgatgtta gtattgtatt tttaactctt tgctgacttt gatgtttatt aagaccaagc
     2821 acagaattta tacatactgt tttatgaaat tgttgtaact gtgacgagtt tatgtctcta
     2881 taacaattct ggtttggagg gtcttgtggt ccagtttgct tttgtcagag tagcatagtg
     2941 gcctttgtgg aaggggacta caggggaggc ctcggcatca ctgtcacttt gacccctgct
     3001 ttggcactaa cttgggcagt tcttgctata agtgaaactt aactctccct ggcaggaaac
     3061 atacattagt gtctccctaa gtcctgggct tgacccataa gtgcctctac ccaaatccct
     3121 taagcacact ggacatcttc caggtgtgga ttttatgtca caatgagatt gaatacctgt
     3181 gcttcaaatg tcacgtgaga gtatggaaat aaaaagacaa tctgaagtaa aaaaaaaaaa
     3241 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3301 aaaaaaaaaa aaaaaaaaaa aa
//
