LOCUS       NM_181402               3842 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus poly (ADP-ribose) polymerase family, member 11
            (Parp11), transcript variant 1, mRNA.
ACCESSION   NM_181402
VERSION     NM_181402.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3842)
  AUTHORS   Basavaraja,R., Zhang,H., Holczbauer,A., Lu,Z., Radaelli,E.,
            Assenmacher,C.A., George,S.S., Nallamala,V.C., Beiting,D.P.,
            Meyer-Ficca,M.L., Meyer,R.G., Guo,W., Fan,Y., Modzelewski,A.J.,
            Spiegelman,V.S., Cohen,M.S. and Fuchs,S.Y.
  TITLE     PARP11 inhibition inactivates tumor-infiltrating regulatory T cells
            and improves the efficacy of immunotherapies
  JOURNAL   Cell Rep Med 5 (7), 101649 (2024)
   PUBMED   39019005
REFERENCE   2  (bases 1 to 3842)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3842)
  AUTHORS   Zhang,H., Yu,P., Tomar,V.S., Chen,X., Atherton,M.J., Lu,Z.,
            Zhang,H.G., Li,S., Ortiz,A., Gui,J., Leu,N.A., Yan,F., Blanco,A.,
            Meyer-Ficca,M.L., Meyer,R.G., Beiting,D.P., Li,J., Nunez-Cruz,S.,
            O'Connor,R.S., Johnson,L.R., Minn,A.J., George,S.S., Koumenis,C.,
            Diehl,J.A., Milone,M.C., Zheng,H. and Fuchs,S.Y.
  TITLE     Targeting PARP11 to avert immunosuppression and improve CAR T
            therapy in solid tumors
  JOURNAL   Nat Cancer 3 (7), 808-820 (2022)
   PUBMED   35637402
REFERENCE   4  (bases 1 to 3842)
  AUTHORS   Guo,T., Zuo,Y., Qian,L., Liu,J., Yuan,Y., Xu,K., Miao,Y., Feng,Q.,
            Chen,X., Jin,L., Zhang,L., Dong,C., Xiong,S. and Zheng,H.
  TITLE     ADP-ribosyltransferase PARP11 modulates the interferon antiviral
            response by mono-ADP-ribosylating the ubiquitin E3 ligase beta-TrCP
  JOURNAL   Nat Microbiol 4 (11), 1872-1884 (2019)
   PUBMED   30988430
  REMARK    GeneRIF: Findings suggest that PARP11 is involved in regulating the
            IFN-I signaling pathway and antiviral efficacy by targeting
            beta-TrCP and degrading IFNAR1.
REFERENCE   5  (bases 1 to 3842)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 3842)
  AUTHORS   Meyer-Ficca,M.L., Ihara,M., Bader,J.J., Leu,N.A., Beneke,S. and
            Meyer,R.G.
  TITLE     Spermatid head elongation with normal nuclear shaping requires
            ADP-ribosyltransferase PARP11 (ARTD11) in mice
  JOURNAL   Biol Reprod 92 (3), 80 (2015)
   PUBMED   25673562
  REMARK    GeneRIF: PARP11 is a novel enzyme important for proper sperm head
            shaping and identifies it as a potential factor involved in
            idiopathic mammalian teratozoospermia.
REFERENCE   7  (bases 1 to 3842)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 3842)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121565.4 and AC173480.1.
            
            On Apr 7, 2018 this sequence version replaced NM_181402.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040269.1, SRR7345562.2215069.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AC121565.4         18605-18800         c
            197-317             AC121565.4         4275-4395           c
            318-446             AC121565.4         1597-1725           c
            447-567             AC121565.4         759-879             c
            568-643             AC173480.1         24408-24483
            644-716             AC173480.1         28016-28088
            717-847             AC173480.1         28171-28301
            848-999             AC173480.1         40098-40249
            1000-3842           AC173480.1         41591-44433
FEATURES             Location/Qualifiers
     source          1..3842
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 62.39 cM"
     gene            1..3842
                     /gene="Parp11"
                     /gene_synonym="5330431N24Rik; ARTD11; HIN1L; PARP-11"
                     /note="poly (ADP-ribose) polymerase family, member 11"
                     /db_xref="GeneID:101187"
                     /db_xref="MGI:MGI:2141505"
     exon            1..196
                     /gene="Parp11"
                     /gene_synonym="5330431N24Rik; ARTD11; HIN1L; PARP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            197..317
                     /gene="Parp11"
                     /gene_synonym="5330431N24Rik; ARTD11; HIN1L; PARP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            318..446
                     /gene="Parp11"
                     /gene_synonym="5330431N24Rik; ARTD11; HIN1L; PARP-11"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..1316
                     /gene="Parp11"
                     /gene_synonym="5330431N24Rik; ARTD11; HIN1L; PARP-11"
                     /EC_number="2.4.2.30"
                     /note="isoform 1 is encoded by transcript variant 1; poly
                     [ADP-ribose] polymerase 11; ADP-ribosyltransferase
                     diphtheria toxin-like 11; protein
                     mono-ADP-ribosyltransferase PARP11"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP11
                     isoform 1"
                     /protein_id="NP_852067.1"
                     /db_xref="CCDS:CCDS20565.1"
                     /db_xref="GeneID:101187"
                     /db_xref="MGI:MGI:2141505"
                     /translation="MFHKTEEFFPKKTDSDVDDMDTSDTQWGWFYLAECGKWHMFQPD
                     TNIQCSVSSEDIEKSFKTNPCGSISFTTSKFSYKIDFAEMKQMNLVTGKQRLIKRAPF
                     SISAFSYICENEAIPMPTHWENVNPDVPYQLVSLQNQTHEYNEVASLFGKTMDRNRIK
                     RIQRIQNLDLWEFFCRKKAQLKKKRGVPQINEQMLFHGTSSEFVEAICIHNFDWRING
                     VHGAVFGKGTYFARDAAYSSRFCKDDIKHGNTFQIHGVSLQQRHLFRTYKSMFLARVL
                     IGDYINGDSKYMRPPSKDGSYVNLYDSCVDDTWNPKIFVVFDANQIYPEYLIDFH"
     exon            447..567
                     /gene="Parp11"
                     /gene_synonym="5330431N24Rik; ARTD11; HIN1L; PARP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            568..643
                     /gene="Parp11"
                     /gene_synonym="5330431N24Rik; ARTD11; HIN1L; PARP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            644..716
                     /gene="Parp11"
                     /gene_synonym="5330431N24Rik; ARTD11; HIN1L; PARP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            717..847
                     /gene="Parp11"
                     /gene_synonym="5330431N24Rik; ARTD11; HIN1L; PARP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            848..999
                     /gene="Parp11"
                     /gene_synonym="5330431N24Rik; ARTD11; HIN1L; PARP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..3842
                     /gene="Parp11"
                     /gene_synonym="5330431N24Rik; ARTD11; HIN1L; PARP-11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3800..3805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Parp11"
                     /gene_synonym="5330431N24Rik; ARTD11; HIN1L; PARP-11"
                     /note="hexamer: ATTAAA"
     polyA_site      3820
                     /gene="Parp11"
                     /gene_synonym="5330431N24Rik; ARTD11; HIN1L; PARP-11"
                     /note="major polyA site"
ORIGIN      
        1 agtcgggagg ttcgatggtc cgaagacgcc agcttgtgac ggggaggggg agaaggaagg
       61 cttccgtaaa gggtgccttt cggtcctttc gctcctgggg accctcggaa aaagcccacc
      121 atatcgaccc cacggctagc ccctccccca ggctctctcc gctcgatttc gcaccgttat
      181 gtgggaagcg aatccgtgaa atggccaaac gggatgaaca gtgctggaag aagaaagcag
      241 aagtgtgcaa tagctaacgg ggcagtggag ttcacagttt aggtcattgt ctttattatc
      301 tggccaagac acataagaag atgtttcaca agacagagga gttctttccc aagaagacag
      361 acagcgatgt ggacgacatg gacacatcgg acacacagtg gggctggttc tacctggcgg
      421 aatgtgggaa gtggcacatg tttcagccgg ataccaacat tcaatgttca gttagcagtg
      481 aagatatcga aaaaagcttc aaaacaaacc cttgtggctc catttccttt actacttcca
      541 aattcagcta caagatagac tttgcagaaa tgaagcagat gaatcttgtc actgggaaac
      601 agcgcctaat aaagagggct cctttctcca tcagtgcctt cagttacatc tgtgagaatg
      661 aggccatccc catgccaacc cactgggaga acgtgaaccc tgacgttccc taccagctgg
      721 tttccctgca gaaccagacg cacgagtata atgaagtggc cagtcttttt gggaaaacaa
      781 tggatcggaa ccgaattaaa aggattcaaa ggatccaaaa cttagactta tgggagttct
      841 tttgcaggaa aaaggctcag ctcaagaaaa agagaggtgt cccccagatc aatgagcaga
      901 tgctatttca tggcaccagc agtgaatttg tggaagcaat ttgcattcac aactttgact
      961 ggagaatcaa tggtgtgcac ggggctgtct ttggaaaagg aacctatttc gctagagatg
     1021 ctgcgtactc cagtcgtttc tgcaaagatg acatcaagca cgggaacaca ttccagattc
     1081 atggggtcag cttgcagcag cgacatctgt tcagaaccta taaatccatg tttcttgctc
     1141 gagtgctaat tggtgattac ataaatggag actcgaaata catgagacct ccttccaaag
     1201 acgggagcta tgtgaatttg tatgacagct gtgtggatga cacctggaac ccaaagatct
     1261 ttgtggtttt tgatgccaac cagatctacc ctgagtacct gatagacttc cactgaccct
     1321 gcctcccagg ctcagtggtc agagctttgc tctctcatta caggaggatt tgatcctctg
     1381 tctcctagcc actaatataa atattggatt cttttgaaac agatacagaa aagaaagcgg
     1441 cctcagtata taaagaagta ctggctgtca ggttggttat atgttgttct gtttctgtct
     1501 gttccggttt tgttaaagac cgatgctgtt gccatcttaa catacaggag aaagagctac
     1561 ttctcaaaac agaataggtt gagtctctca ttaccatgat cagacagtct tcaaagtgca
     1621 cacgcatgtg accaggtcaa atgattttag tttttgtacc ctattaggag aactggactt
     1681 ttataaattg aattttggca ttattatcta tcaatgaaca tgtgactttg ttggtcttct
     1741 gaagggggaa ttaaaaatcc cgaaacagcc cctggtgctc agcgaagtaa gaaacaagga
     1801 cattgtctgc tgtgctggta ggtaagccag cagaagagag acagggcaga gcctgcttct
     1861 cactgctaga ggaaagtggt ctgtagcccc agagcagtgc acactattct cacccatctc
     1921 ccacagttga gctgagcact gctgctaagg gtcactagct cacagttcag cttcgagcag
     1981 tctgtcgtcc ctgccccaac ttatttattt cctttgtttt ccaagccctg cagaggcttt
     2041 attggtcctc ccacaacccc tgagacacac atagctgttc catggtgatt cctaagaacc
     2101 acacgtgtta atagttggtg tcattctctt ttgaatgatt gtgaagaaca tgagatgctg
     2161 ggaagaagtc tgatttcttc tttagagtag tgattgacaa cttccaaccc ctgagcagct
     2221 atgtgcaact gagagttgtg ctcgtggctt tgtgtacctg tctgtttgcc tgctgttctg
     2281 tcccaaagag gaagtgatct gtaccagcta actgcccagc ggttttctag cagagatgag
     2341 atagcactca ggcatgatgc taagtgttca agtgtcagac agggagctgc ctgtatgatt
     2401 gtctccccag cgctgctttt tccctgattc cttgtgggga aggaaggtca ttcctccagt
     2461 catatcaccc agaacctttt cctagctctc aatactgaat cttgtctctg ctatccccat
     2521 ccagctttgg gttcgaggac ttgagcacag gttagcttct ggtgcctgta ttgttctctt
     2581 cagtcactca aattgggaag catctagaaa gaatatatgt gtgaaacagg attatggata
     2641 gtggcttttg taaggatagc cattcattca gctttgtaaa ccatcagatt ctccttctgg
     2701 cccagaatgt gtgttatcgc acagtgggaa gtacaagagt ggctctcggg aaattatgca
     2761 cagtgctttg gcacacggtg gcaggaatga ctccctggct caaatgtgga ggtccaccat
     2821 tggtttaaga aaggctagaa aggacgcatt tcaaagccac cagtggtccc tgcagcagtg
     2881 cctgaaggca gagtggctag gttgcctggc cgctttcaag aatcagtgtt agaggcgttg
     2941 ggagttcaga gtgaacagtc tctcttctag ttcttttctc ctggttttgt ttttgtttgt
     3001 ttgtttgttt gtatgtgtgt gtgcgtgttt gtttgttttt ccagacaggg tttctctgtg
     3061 tagccctggc tgtcttggaa ctctctctgt agaccgaact ggcatgcaat gtgttaaagt
     3121 ccctcttaca tggctgtctg cccgccttcc tctccccccc accccccagc tccatgcaca
     3181 cttctctcaa tacttgaatg gaatgattgt tgtagttgag gttgtttcct tctagacctg
     3241 tgcatccgtg tcaaggtgac tgagaacgca ggcagtctgt gcaatcactc tcccgtgttg
     3301 gcatgcatga gggaggttgg gggggggggt gtcagagagg ccaccgtaaa gaagcattgc
     3361 accgctgttg ttgggacaga ctgccaaccc ccttcataag gaagacgtga tctcggtacg
     3421 tgttttaaaa tataataacg tagaagtcac tcgtgttaac gttgtactgt tttgtctgtt
     3481 ccatgtatag aagaacatca ctccctctgc tcatcccacg gagtgggagg gagagcaaag
     3541 ggagctcgtg cagagtggcg agctgtgccg caggctggct gaataaactc cattgagtac
     3601 aaacttgtcc tttctctgcg gggagtctag cctttgggta aaaagaaatg tgtttatggg
     3661 aaaatgtttt cctgaatctt ttatctccca ccaggaatgt ttgagattag tggattattt
     3721 catttctaga ctggtggtgg aggtggtgat ggagaattct gatattcaat gtctgagtgt
     3781 attgtttcta caattgttga ttaaagtttt ctgtatcagg tcttggctgc ctgtgtgtgc
     3841 ta
//
