LOCUS       NM_001005767            1301 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus presenilin associated, rhomboid-like (Parl),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001005767 XM_354952
VERSION     NM_001005767.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1301)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1301)
  AUTHORS   Schumacher,S., Klose,L., Lambertz,J., Lutjohann,D., Biemann,R.,
            Kuerten,S. and Fester,L.
  TITLE     The mitochondrial protease PARL is required for spermatogenesis
  JOURNAL   Commun Biol 7 (1), 44 (2024)
   PUBMED   38182793
  REMARK    GeneRIF: The mitochondrial protease PARL is required for
            spermatogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1301)
  AUTHORS   Radaelli,E., Assenmacher,C.A., Verrelle,J., Banerjee,E., Manero,F.,
            Khiati,S., Girona,A., Lopez-Lluch,G., Navas,P. and Spinazzi,M.
  TITLE     Mitochondrial defects caused by PARL deficiency lead to arrested
            spermatogenesis and ferroptosis
  JOURNAL   Elife 12, e84710 (2023)
   PUBMED   37505079
  REMARK    GeneRIF: Mitochondrial defects caused by PARL deficiency lead to
            arrested spermatogenesis and ferroptosis.
            Erratum:[Elife. 2024 Sep 13;13:e103278. doi: 10.7554/eLife.103278..
            PMID: 39268597]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1301)
  AUTHORS   Deshwal,S., Onishi,M., Tatsuta,T., Bartsch,T., Cors,E., Ried,K.,
            Lemke,K., Nolte,H., Giavalisco,P. and Langer,T.
  TITLE     Mitochondria regulate intracellular coenzyme Q transport and
            ferroptotic resistance via STARD7
  JOURNAL   Nat Cell Biol 25 (2), 246-257 (2023)
   PUBMED   36658222
REFERENCE   5  (bases 1 to 1301)
  AUTHORS   Spinazzi,M., Radaelli,E., Horre,K., Arranz,A.M., Gounko,N.V.,
            Agostinis,P., Maia,T.M., Impens,F., Morais,V.A., Lopez-Lluch,G.,
            Serneels,L., Navas,P. and De Strooper,B.
  TITLE     PARL deficiency in mouse causes Complex III defects, coenzyme Q
            depletion, and Leigh-like syndrome
  JOURNAL   Proc Natl Acad Sci U S A 116 (1), 277-286 (2019)
   PUBMED   30578322
REFERENCE   6  (bases 1 to 1301)
  AUTHORS   Civitarese,A.E., MacLean,P.S., Carling,S., Kerr-Bayles,L.,
            McMillan,R.P., Pierce,A., Becker,T.C., Moro,C., Finlayson,J.,
            Lefort,N., Newgard,C.B., Mandarino,L., Cefalu,W., Walder,K.,
            Collier,G.R., Hulver,M.W., Smith,S.R. and Ravussin,E.
  TITLE     Regulation of skeletal muscle oxidative capacity and insulin
            signaling by the mitochondrial rhomboid protease PARL
  JOURNAL   Cell Metab 11 (5), 412-426 (2010)
   PUBMED   20444421
  REMARK    GeneRIF: Suppression of PARL protein in healthy myotubes lowered
            mitochondrial mass and insulin-stimulated glycogen synthesis and
            increased reactive oxygen species production.
REFERENCE   7  (bases 1 to 1301)
  AUTHORS   Jeyaraju,D.V., Cisbani,G., De Brito,O.M., Koonin,E.V. and
            Pellegrini,L.
  TITLE     Hax1 lacks BH modules and is peripherally associated to heavy
            membranes: implications for Omi/HtrA2 and PARL activity in the
            regulation of mitochondrial stress and apoptosis
  JOURNAL   Cell Death Differ 16 (12), 1622-1629 (2009)
   PUBMED   19680265
  REMARK    GeneRIF: results indicate a different function and mechanism of
            Hax1 in apoptosis and re-opens the question of whether mammalian
            PARL, in addition to apoptosis, regulates mitochondrial stress
            response through Omi/HtrA2 processing.
REFERENCE   8  (bases 1 to 1301)
  AUTHORS   Chao,J.R., Parganas,E., Boyd,K., Hong,C.Y., Opferman,J.T. and
            Ihle,J.N.
  TITLE     Hax1-mediated processing of HtrA2 by Parl allows survival of
            lymphocytes and neurons
  JOURNAL   Nature 452 (7183), 98-102 (2008)
   PUBMED   18288109
  REMARK    GeneRIF: Hax1, is required to suppress apoptosis in lymphocytes and
            neurons; suppression requires the interaction of Hax1 with the
            mitochondrial proteases Parl and HtrA2
            Erratum:[Nature. 2008 Apr 17;452(7189):900]
REFERENCE   9  (bases 1 to 1301)
  AUTHORS   Cipolat,S., Rudka,T., Hartmann,D., Costa,V., Serneels,L.,
            Craessaerts,K., Metzger,K., Frezza,C., Annaert,W., D'Adamio,L.,
            Derks,C., Dejaegere,T., Pellegrini,L., D'Hooge,R., Scorrano,L. and
            De Strooper,B.
  TITLE     Mitochondrial rhomboid PARL regulates cytochrome c release during
            apoptosis via OPA1-dependent cristae remodeling
  JOURNAL   Cell 126 (1), 163-175 (2006)
   PUBMED   16839884
  REMARK    GeneRIF: Parl-/- mitochondria display reduced levels of OPA1, and
            OPA1 specifically targeted to IMS complements Parl-/- cells,
            substantiating the importance of PARL in OPA1 processing.(PARL
            protein, mouse)
REFERENCE   10 (bases 1 to 1301)
  AUTHORS   McQuibban,G.A., Lee,J.R., Zheng,L., Juusola,M. and Freeman,M.
  TITLE     Normal mitochondrial dynamics requires rhomboid-7 and affects
            Drosophila lifespan and neuronal function
  JOURNAL   Curr Biol 16 (10), 982-989 (2006)
   PUBMED   16713954
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154526.2.
            
            On Mar 6, 2023 this sequence version replaced NM_001005767.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083153.1, AK151652.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AC154526.2         91542-91673
            133-328             AC154526.2         95556-95751
            329-469             AC154526.2         96149-96289
            470-518             AC154526.2         100480-100528
            519-614             AC154526.2         105930-106025
            615-764             AC154526.2         106813-106962
            765-835             AC154526.2         108047-108117
            836-937             AC154526.2         110857-110958
            938-1035            AC154526.2         111062-111159
            1036-1301           AC154526.2         113797-114062
FEATURES             Location/Qualifiers
     source          1..1301
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 12.4 cM"
     gene            1..1301
                     /gene="Parl"
                     /gene_synonym="D16Ertd607e; PRO2207; Psarl; PSARL1;
                     PSENIP2"
                     /note="presenilin associated, rhomboid-like"
                     /db_xref="GeneID:381038"
                     /db_xref="MGI:MGI:1277152"
     exon            1..132
                     /gene="Parl"
                     /gene_synonym="D16Ertd607e; PRO2207; Psarl; PSARL1;
                     PSENIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1147
                     /gene="Parl"
                     /gene_synonym="D16Ertd607e; PRO2207; Psarl; PSARL1;
                     PSENIP2"
                     /EC_number="3.4.21.105"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; presenilins-associated rhomboid-like protein,
                     mitochondrial; mitochondrial intramembrane-cleaving
                     protease PARL; presenilin-associated rhomboid-like
                     protein, mitochondrial"
                     /codon_start=1
                     /product="presenilin-associated rhomboid-like protein,
                     mitochondrial isoform 1 precursor"
                     /protein_id="NP_001005767.1"
                     /db_xref="CCDS:CCDS28044.1"
                     /db_xref="GeneID:381038"
                     /db_xref="MGI:MGI:1277152"
                     /translation="MALQGWVQRGWRCGPAWAPPLGGGYRELSATQAPRLLGRRFNLF
                     VQQKCGFRKAPRKVEPRRSDTGSSGEAYKRSALIPPLEETVFYPSPYPIRTLVKPFFF
                     TIGFTGCAFGSAAIWQYESLKSRVQSYFDGIKADWLDSIRPQKEGNLRKEINKWWNSL
                     SDGQRTVTGIIAANALVFCLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLF
                     HMAANMYVLWSFSSSIVNILGQEQFVAVYLSAGVISNFVSYVCKVATGRYGPSLGASG
                     AIMTVLAAVCTKIPEGRLAIIFLPVFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHL
                     GGALFGIWYITYGHELIWKNREPLVKIWHEIRTNGPKKGGGSK"
     exon            133..328
                     /gene="Parl"
                     /gene_synonym="D16Ertd607e; PRO2207; Psarl; PSARL1;
                     PSENIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            329..469
                     /gene="Parl"
                     /gene_synonym="D16Ertd607e; PRO2207; Psarl; PSARL1;
                     PSENIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            470..518
                     /gene="Parl"
                     /gene_synonym="D16Ertd607e; PRO2207; Psarl; PSARL1;
                     PSENIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..614
                     /gene="Parl"
                     /gene_synonym="D16Ertd607e; PRO2207; Psarl; PSARL1;
                     PSENIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            615..764
                     /gene="Parl"
                     /gene_synonym="D16Ertd607e; PRO2207; Psarl; PSARL1;
                     PSENIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            765..835
                     /gene="Parl"
                     /gene_synonym="D16Ertd607e; PRO2207; Psarl; PSARL1;
                     PSENIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            836..937
                     /gene="Parl"
                     /gene_synonym="D16Ertd607e; PRO2207; Psarl; PSARL1;
                     PSENIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1035
                     /gene="Parl"
                     /gene_synonym="D16Ertd607e; PRO2207; Psarl; PSARL1;
                     PSENIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1301
                     /gene="Parl"
                     /gene_synonym="D16Ertd607e; PRO2207; Psarl; PSARL1;
                     PSENIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1273..1278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Parl"
                     /gene_synonym="D16Ertd607e; PRO2207; Psarl; PSARL1;
                     PSENIP2"
                     /note="hexamer: AATAAA"
     polyA_site      1301
                     /gene="Parl"
                     /gene_synonym="D16Ertd607e; PRO2207; Psarl; PSARL1;
                     PSENIP2"
                     /note="major polyA site"
ORIGIN      
        1 agaggttggg aagatggcgt tgcaaggttg ggtacagcga ggctggcgct gcggtccggc
       61 gtgggcgcct cccttgggtg gcggctaccg ggagctctct gcgacccagg ccccgcggct
      121 gcttggacgc aggtttaact tgtttgttca gcaaaaatgt ggatttagaa aagcacccag
      181 gaaggttgaa cctcgaagat cagacacagg gtcgagtgga gaagcatata agagaagtgc
      241 cttgatcccg cctctggaag aaacagtctt ttacccttcc ccctatccta taagaacact
      301 cgtgaagccc tttttcttca ccattgggtt cacaggctgt gcatttgggt cagctgctat
      361 ttggcagtat gagtcactga aatccagggt tcagagttat tttgatggca taaaagctga
      421 ctggttggac agcatacggc cacaaaagga aggaaacctc agaaaggaga ttaacaagtg
      481 gtggaatagc ctaagtgatg gccagcggac tgtgacaggc atcatagctg cgaatgccct
      541 cgtcttctgc ttgtggagag tgccgtccct gcagcgaacc atgatcagat actttacatc
      601 caacccagca tccaaggttc tttgttctcc aatgttgctg tcaacgttca gtcatttctc
      661 cttattccac atggcagcaa atatgtatgt tttgtggagc ttctcatcta gcatcgtgaa
      721 catcctgggt caggagcagt ttgtggcagt gtatctgtct gcaggtgtta tttccaattt
      781 tgtcagctat gtgtgtaaag ttgccacagg aagatatgga ccttcacttg gtgcatcggg
      841 agcaatcatg actgtgcttg cagctgtctg caccaagatc ccagagggga ggctcgctat
      901 catcttcctc cctgtcttca ccttcacagc gggcaatgcc ttaaaagcca tcattgccat
      961 ggatacagct gggatgatcc tgggatggaa attttttgat catgcagccc atcttggggg
     1021 agctctcttt ggaatatggt atatcacgta tggacatgaa ctcatttgga agaacaggga
     1081 gcctctagtg aaaatctggc acgaaataag gactaatggc cccaagaaag gaggtggctc
     1141 taagtgaagc agagctggcc agtatgacgg tgcatctgat ccttgctgct tggaaagtct
     1201 cagcatcggc caccccagtg atttaaatgt cctccgtacg tgtctcctta gcaaattatg
     1261 gcaaagttgt gaaataaatg tttctatctc tagtttgtaa a
//
