LOCUS       NM_020569                920 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Mus musculus Parkinson disease (autosomal recessive, early onset) 7
            (Park7), mRNA.
ACCESSION   NM_020569
VERSION     NM_020569.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 920)
  AUTHORS   Lind-Holm Mogensen,F., Sousa,C., Ameli,C., Badanjak,K.,
            Pereira,S.L., Muller,A., Kaoma,T., Coowar,D., Scafidi,A.,
            Poovathingal,S.K., Tziortziou,M., Antony,P.M.A., Nicot,N.,
            Ginolhac,A., Vogt Weisenhorn,D.M., Wurst,W., Poli,A., Nazarov,P.V.,
            Skupin,A., Grunewald,A. and Michelucci,A.
  TITLE     PARK7/DJ-1 deficiency impairs microglial activation in response to
            LPS-induced inflammation
  JOURNAL   J Neuroinflammation 21 (1), 174 (2024)
   PUBMED   39014482
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 920)
  AUTHORS   Nam,Y., Na,J., Ma,S.X., Park,H., Park,H., Lee,E., Kim,H.,
            Jang,S.M., Ko,H.S. and Kim,S.
  TITLE     DJ-1 protects cell death from a mitochondrial oxidative stress due
            to GBA1 deficiency
  JOURNAL   Genes Genomics 46 (5), 519-529 (2024)
   PUBMED   38460098
  REMARK    GeneRIF: DJ-1 protects cell death from a mitochondrial oxidative
            stress due to GBA1 deficiency.
REFERENCE   3  (bases 1 to 920)
  AUTHORS   Guo,T., Zhou,L., Xiong,M., Xiong,J., Huang,J., Li,Y., Zhang,G.,
            Chen,G., Wang,Z.H., Xiao,T., Hu,D., Bao,A. and Zhang,Z.
  TITLE     N-homocysteinylation of DJ-1 promotes neurodegeneration in
            Parkinson's disease
  JOURNAL   Aging Cell 23 (5), e14124 (2024)
   PUBMED   38380563
  REMARK    GeneRIF: N-homocysteinylation of DJ-1 promotes neurodegeneration in
            Parkinson's disease.
REFERENCE   4  (bases 1 to 920)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 920)
  AUTHORS   Wang,J., Zhang,H., Chen,L., Fu,K., Yan,Y. and Liu,Z.
  TITLE     CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via
            facilitating STUB1-mediated PARK7 ubiquitination degradation
  JOURNAL   J Gastroenterol 59 (3), 229-249 (2024)
   PUBMED   38310161
  REMARK    GeneRIF: CircDCBLD2 alleviates liver fibrosis by regulating
            ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination
            degradation.
REFERENCE   6  (bases 1 to 920)
  AUTHORS   Bonifati,V., Rizzu,P., van Baren,M.J., Schaap,O., Breedveld,G.J.,
            Krieger,E., Dekker,M.C., Squitieri,F., Ibanez,P., Joosse,M., van
            Dongen,J.W., Vanacore,N., van Swieten,J.C., Brice,A., Meco,G., van
            Duijn,C.M., Oostra,B.A. and Heutink,P.
  TITLE     Mutations in the DJ-1 gene associated with autosomal recessive
            early-onset parkinsonism
  JOURNAL   Science 299 (5604), 256-259 (2003)
   PUBMED   12446870
REFERENCE   7  (bases 1 to 920)
  AUTHORS   Okada,M., Matsumoto,K., Niki,T., Taira,T., Iguchi-Ariga,S.M. and
            Ariga,H.
  TITLE     DJ-1, a target protein for an endocrine disrupter, participates in
            the fertilization in mice
  JOURNAL   Biol Pharm Bull 25 (7), 853-856 (2002)
   PUBMED   12132656
  REMARK    GeneRIF: DJ-1 participates in the fertilization
REFERENCE   8  (bases 1 to 920)
  AUTHORS   Mitsumoto,A. and Nakagawa,Y.
  TITLE     DJ-1 is an indicator for endogenous reactive oxygen species
            elicited by endotoxin
  JOURNAL   Free Radic Res 35 (6), 885-893 (2001)
   PUBMED   11811539
  REMARK    GeneRIF: DJ-1 is an indicator for endogenous reactive oxygen
            species elicited by endotoxin
REFERENCE   9  (bases 1 to 920)
  AUTHORS   Taira,T., Takahashi,K., Kitagawa,R., Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     Molecular cloning of human and mouse DJ-1 genes and identification
            of Sp1-dependent activation of the human DJ-1 promoter
  JOURNAL   Gene 263 (1-2), 285-292 (2001)
   PUBMED   11223268
REFERENCE   10 (bases 1 to 920)
  AUTHORS   Nagakubo,D., Taira,T., Kitaura,H., Ikeda,M., Tamai,K.,
            Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in
            cooperation with ras
  JOURNAL   Biochem Biophys Res Commun 231 (2), 509-513 (1997)
   PUBMED   9070310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA456587.1, AB015652.1 and CD776363.1.
            
            On Jun 20, 2008 this sequence version replaced NM_020569.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV047725.1, BI144795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                CA456587.1         39-109
            72-564              AB015652.1         19-511
            565-920             CD776363.1         1-356               c
FEATURES             Location/Qualifiers
     source          1..920
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 81.52 cM"
     gene            1..920
                     /gene="Park7"
                     /gene_synonym="DJ-1; Dj1"
                     /note="Parkinson disease (autosomal recessive, early
                     onset) 7"
                     /db_xref="GeneID:57320"
                     /db_xref="MGI:MGI:2135637"
     exon            1..139
                     /gene="Park7"
                     /gene_synonym="DJ-1; Dj1"
                     /inference="alignment:Splign:2.1.0"
     exon            140..245
                     /gene="Park7"
                     /gene_synonym="DJ-1; Dj1"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..725
                     /gene="Park7"
                     /gene_synonym="DJ-1; Dj1"
                     /EC_number="3.5.1.124"
                     /note="RNA-binding protein regulatory subunit; protein
                     DJ-1; protein deglycase DJ-1; maillard deglycase;
                     parkinsonism-associated deglycase; protein/nucleic acid
                     deglycase DJ-1"
                     /codon_start=1
                     /product="Parkinson disease protein 7 homolog"
                     /protein_id="NP_065594.2"
                     /db_xref="CCDS:CCDS18975.1"
                     /db_xref="GeneID:57320"
                     /db_xref="MGI:MGI:2135637"
                     /translation="MASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPV
                     QCSRDVMICPDTSLEDAKTQGPYDVVVLPGGNLGAQNLSESPMVKEILKEQESRKGLI
                     AAICAGPTALLAHEVGFGCKVTTHPLAKDKMMNGSHYSYSESRVEKDGLILTSRGPGT
                     SFEFALAIVEALVGKDMANQVKAPLVLKD"
     exon            246..347
                     /gene="Park7"
                     /gene_synonym="DJ-1; Dj1"
                     /inference="alignment:Splign:2.1.0"
     exon            348..407
                     /gene="Park7"
                     /gene_synonym="DJ-1; Dj1"
                     /inference="alignment:Splign:2.1.0"
     exon            408..477
                     /gene="Park7"
                     /gene_synonym="DJ-1; Dj1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..564
                     /gene="Park7"
                     /gene_synonym="DJ-1; Dj1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..903
                     /gene="Park7"
                     /gene_synonym="DJ-1; Dj1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      873..878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Park7"
                     /gene_synonym="DJ-1; Dj1"
                     /note="hexamer: AATAAA"
     polyA_site      903
                     /gene="Park7"
                     /gene_synonym="DJ-1; Dj1"
                     /note="major polyA site"
ORIGIN      
        1 tgacgcaggc cgaggcggaa gcgaggggtt gtgcgcagcc tcagtgcggg tggcgcgcat
       61 gcgtgctggg tacacgtcgg gtgcgaggtt cctgcggact agcggtggct tcgcgtgggt
      121 ggaggaggcg cggctgcagt ctttaagaaa tagaaatggc ttccaaaaga gctctggtca
      181 tcctggccaa aggagcagag gagatggaga cagtgattcc tgtggatgtc atgcggcgag
      241 ccgggatcaa agtcactgtt gcaggcttgg ctgggaagga ccccgtgcag tgtagccgtg
      301 atgtaatgat ttgtccagat accagtctgg aagatgcaaa aacgcaggga ccatacgatg
      361 tggtggttct tccaggagga aatctgggtg cacagaattt atctgagtcg cctatggtga
      421 aggagatcct caaggagcag gagagcagga agggcctcat agctgccatc tgtgcaggtc
      481 ctacggctct gttggctcac gaagtaggtt ttggatgcaa ggtcacaaca cacccactgg
      541 ctaaggacaa aatgatgaat ggcagtcact acagctactc agagagccgc gtggagaagg
      601 acggcctgat cctcaccagc cgcgggccgg ggaccagctt tgagtttgca ctagccattg
      661 tggaggcact cgtggggaaa gacatggcca accaagtgaa ggcaccgctt gttctcaaag
      721 actagagccc aagccctggg ccccacgctt gagcaggcat tggaagccca ctggtgtgtc
      781 cagagcccag ggaacctcag cagtagtatg tgaagcagcc gccacacggg gctctcatcc
      841 cgggtctgta tgtttctgaa ccttgctagt agaataaaca gtttaccaag ctcctgccag
      901 ctaaaaaaaa aaaaaaaaaa
//
